Superoxide attenuates macrophage apoptosis by NF-κB and AP-1 activation that promotes cyclooxygenase-2 expression

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2858-2866

  Von Knethen, Andreas ^a   Callsen, Dagmar ^a   Brüne, Bernhard ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIMETHOXY 1,4 NAPHTHOQUINONE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SUPEROXIDE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; APOPTOSIS; CELL LINE; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOENZYMES; MACROPHAGES; MICE; NAPHTHOQUINONES; NF-KAPPA B; NITRIC OXIDE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SUPEROXIDES; TRANSCRIPTION FACTOR AP-1; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033198247     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Smith, W. L., R. M. Garavito, and D. L. DeWitt. 1996. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J. Biol. Chem. 271:33157.
2. Vane, J. R., Y. S. Bakhle, and R. M. Botting. 1998. Cyclooxygenases 1 and 2. Annu. Rev. Pharmacol. Toxicol. 38:97.
3. Chinery, R., R. D. Beauchamp, Y. Shyr, S. C. Kirkland, R. J. Coffey, and J. D. Morrow. 1998. Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. Cancer Res. 58: 2323.
4. Levy, G. N. 1997. Prostaglandin H synthases, nonsteroidal antiinflammatory drugs, and colon cancer. FASEB J. 11:234.
5. Von Knethen, A., and B. Brüne. 1997. Cyclooxygenase-2: an essential regulator of NO-mediated apoptosis. FASEB J. 11:887.
6. Wunsch, H. 1998. COX provides missing link in mechanism of aspirin in colon cancer. Lancet 351:1864.
7. Tsujii, M., S. Kawano, S. Tsuji, H. Sawaoka, M. Hori, and R. N. DuBois. 1998. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93: 705.
8. 2: distinct roles of Cyclooxygenase-1 and -2. J. Biol. Chem. 272:25693.
9. Herschman, H. R., S. T. Reddy, and W. Xie. 1997. Function and regulation of prostaglandin synthase-2. Adv. Exp. Med. Biol. 407:61.
10. MacMicking, J., Q. W. Xie, and C. Nathan. 1997. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15:323.
11. James, P. E., O. Y. Grinberg, and H. M. Swartz. 1998. Superoxide production by phagocytosing macrophages in relation to the intracellular distribution of oxygen. J. Leukocyte Biol. 64:78.
12. Aliprantis, A. O., G. Diez-Roux, L. C. Mulder, A. Zychlinsky, and R. A. Lang. 1996. Do macrophages kill through apoptosis? Immunol. Today 17:573.
13. Zwacka, R. M., W. Zhou, Y. Zhang, C. J. Darby, L. Dudus, J. Halldorson, L. Oberley, and J. F. Engelhardt. 1998. Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation. Nat. Med. 4:698.
14. Hwang, D., B. C. Jang, G. Yu, and M. Boudreau. 1997. Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen-activated protein kinase and NF-κB signaling pathways in macrophages. Biochem. Pharmacol. 54:87.
15. D'Acquisto, F., T. Iuvone, L. Rombola, L. Sautebin, M. Di Rosa, and R. Camuccio. 1997. Involvement of NF-κB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages. FEBS Lett. 418:175.
16. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
17. Baichwal, V. R., and P. A. Baeuerle. 1997. Activate NF-κB or die? Curr. Biol. 7:94.
18. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J. 12:2005.
19. Beg, A. A., and D. Baltimore. 1996. An essential role for NF-κB in preventing TNF-α induced cell death. Science 274:782.
20. Schouten, G. J., A. C. Vertegaal, S. T. Whiteside, A. Israel, M. Toebes, J. C. Dorsman, A. J. van der Eb, and A. Zantema. 1997. IκBa is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. EMBO J. 16:3133.
21. Malinin, N. L., M. P. Boldin, A. V. Kovalenko, and D. Wallach. 1997. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385:540.
22. Van Dam, H., D. Wilhelm, I. Herr, A. Steffen, P. Herrlich, and P. Angel. 1995. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14:1798.
23. Wilhelm, D., H. van Dam, I. Herr, B. Baumann, P. Herrlich, and P. Angel. 1995. Both ATF-2 and c-Jun are phosphorylated by stress-activated protein kinases in response to UV irradiation. Immunobiology 193:143.
24. Liebermann, D. A., B. Gregory, and B. Hoffman. 1998. AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int. J. Oncol. 12:685.
25. Karin, M. 1995. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:16483.
26. Karin, M., L. Zg, and E. Zandi. 1997. AP-1 function and regulation. Curr. Opin. Cell Biol. 9:240.
27. Xie, W., B. S. Fletcher, R. D. Andersen, and H. R. Herschman. 1994. v-src induction of the T1S10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element. Mol. Cell. Biol. 14:6531.
28. Xie, W., and H. R. Herschman. 1995. v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor. J. Biol. Chem. 270:27622.
29. Gantner, F., R. Kupferschmidt, C. Schudt, A. Wendel, and A. Hatzelmann. 1997. In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumor necrosis factor-α release by PDE inhibitors. Br. J. Pharmacol. 121:221.
30. Hla, T., and K. Neilson. 1992. Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. USA 89:7384.
31. Tokunaga, K., Y. Nakamura, K. Sakata, K. Fujimori, M. Ohkubo, K. Sawada, and S. Sakiyama. 1987. Enhanced expression of a glyceraldehyde-3-phosphate dehy-drogenase gene in human lung cancers. Cancer Res. 47:5616.
32. Schoonbroodt, S., S. Legrand Poels, M. Best Belpomme, and J. Piette. 1997. Activation of the NF-κB transcription factor in a T-lymphocytic cell line by hypochlorous acid. Biochem. J. 321:777.
33. Camandola, S., G. Leonarduzzi, T. Musso, L. Varesio, R. Carini, A. Scavazza, E. Chiarpotto, P.A. Baeuerle, and G. Poli. 1996. Nuclear factor κB is activated by arachidonic acid but not by eicosapentaenoic acid. Biochem. Biophys. Res. Commun. 229:643.
34. Yamamoto, K., T. Arakawa, N. Ueda, and S. Yamamoto. 1995. Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor a-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 270:31315.
35. Angel, P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and M. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729.
36. Funk, W. D., D. T. Pak, R. H. Karas, W. E. Wright, and J. W. Shay. 1992. A transcriptionally active DNA-binding site for human p53 protein complexes. Mol. Cell. Biol. 12:2866.
37. 2+ concentration. Arch. Biochem. Biophys. 269:365.
38. Burton, K. 1956. A study of the conditions and mechanism of the diphenylamine reaction for the estimation of deoxyribonucleic acid. Biochem. J. 62:315.
39. Brown, P. H., T. K. Chen, and M. J. Birrer. 1994. Mechanism of action of a dominant-negative mutant of c-Jun. Oncogene 9:791.
40. Brown, P. H., R. Alani, L. H. Preis, E. Szabo, and M. J. Birrer. 1993. Suppression of oncogene-induced transformation by a deletion mutant of c-jun. Oncogene 8:877.
41. Arakawa, T., O. Laneuville, C. O. Miller, K. M. Lakkides, B. A. Wingerd, D. L. DeWitt, and W. L. Smith. 1996. Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells: structure and expression of the murine prostaglandin EP4 receptor gene. J. Biol. Chem. 271:29569.
42. Messmer, U. K., E. G. Lapetina, and B. Brüne. 1995. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds. Mol. Pharmacol. 47:757.
43. Albina, J. E., S. Cui, R. B. Mateo, and J. S. Reichner. 1993. Nitric oxide-mediated apoptosis in murine peritoneal macrophages J. Immunol. 150:5080.
44. Dypbukt, J. M., M. Ankarcrona, M. Burkitt, A. Sjoholm, K. Strom, S. Orrenius, and P. Nicotera. 1994. Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells: the role of intracellular polyamines. J. Biol. Chem. 269:30553.
45. Br̈ne, B., C. Gölkel, and A. von Knethen. 1996. Cytokine and low-level nitric oxide prestimulation block p53 accumulation and apoptosis of RAW 264.7 macrophages. Biochem. Biophys. Res. Commun. 229:396.
46. Newton, R., D. A. Stevens, L. A. Hart, M. Lindsay, I. M. Adcock, and P. J. Barnes. 1997. Superinduction of COX-2 mRNA by cycloheximide and interleukin-1β involves increased transcription and correlates with increased NF-κB and JNK activation. FEBS Lett. 418:135.
47. Tsujii, M., and R. N. DuBois. 1995. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83:493.
48. Adderley, S. R., and D. J. Fitzgerald. 1999. Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2. J. Biol. Chem. 274:5038.
49. Goossens, V., J. Grooten, K. De Vos, and W. Fiers. 1995. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc. Natl. Acad. Sci. USA 92:8115.
50. O'Donnell, V. B., S. Spycher, and A. Azzi. 1995. Involvement of oxidants and oxidant-generating enzyme(s) in tumor-necrosis-factor-α-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain. Biochem. J. 310:133.
51. 2 for platelet-derived growth factor signal transduction. Science 270:296.
52. Homburg, C. H., and D. Roos. 1996. Apoptosis of neutrophils. Curr. Opin. Hematol. 3:94.
53. Vazquez-Torres, A., and E. Balish. 1997. Macrophages in resistance to candidiasis. Micmbiol. Mol. Biol. Rev. 61:170.
54. Savill, J. 1997. Apoptosis in resolution of inflammation. J. Leukocyte Biol. 61:375.
55. Wang, X., J. L. Martindale, Y. Liu, and N. J. Holbrook. 1998. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem. J. 333:291.
56. Quillet-Mary, A., J. P. Jaffrezou, V. Mansat, C. Bordier, J. Naval, and G. Laurent. 1997. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J. Biol. Chem. 272:21388.
57. 2 formation. J. Biol. Chem. 271:31496.
58. Sharma, H. W., J. R. Perez, K. Higgins Sochaski, R. Hsiao, and R. Narayanan. 1996. Transcription factor decoy approach to decipher the role of NF-κB in oncogenesis. Anticancer Res. 16:61.
59. Von Knethen, A., A. Lotero, and B. Brüne. 1998. Etoposide and cisplatin induced apoplosis in activated RAW 264.7 macrophages is attenuated by cAMP-induced gene expression. Oncogene 17:387.
60. Schmedtje, J. F., W. L. Liu, R. N. DuBois, and M. S. Runge. 1997. Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells. J. Biol. Chem. 272:601.
61. Manna, S. K., H. J. Zhang, T. Yan, L. W. Oberley, and B. B. Aggarwal. 1998. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1. J. Biol. Chem. 273:13245.
62. Lander, H. M. 1997. An essential role for free radicals and derived species in signal transduction. FASEB J. 11:118.
63. Nakamura, H., K. Nakamura, and J. Yodoi. 1997. Redox regulation of cellular activation. Annu. Rev. Immunol. 15:351.
64. Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, and A. R. Saltiel. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:27489.
65. Badger, A. M., J. N. Bradbeer, B. Votta, J. C. Lee, J. L. Adams, and D. E. Griswold. 1996. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 279:1453.
66. Zamora, R., K. E. Matthys, and P. Herrlich. 1997. The protective role of thiols against nitric oxide-mediated cytotoxicity in murine macrophage J774 cells. Eur. J. Pharmacol. 321:87.
67. Cook, J. A. 1998. Molecular basis of endotoxin tolerance. Ann. NY Acad. Sci. 851:426.
68. Cavaillon, J. M. 1995. The nonspecific nature of endotoxin tolerance. Trends Microbiol. 3:320.
69. Ziegler-Heitbrock, H. W. 1995. Molecular mechanism in tolerance to lipopolysaccharide. J. Inflamm. 45:13.