Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ET A receptors and ERK

British Journal of Pharmacology

Volumn 155, Issue 7, 2008, Pages 974-983

  Kobayashi, T ^a   Nogami, T ^a   Taguchi, K ^a   Matsumoto, T ^a   Kamata, K ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Angiotensin; Contraction; Diabetes; Endothelin; Hyperinsulinaemia

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANGIOTENSIN II; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; INSULIN; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; NULOTAN; UNCLASSIFIED DRUG;

ANGIOTENSIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTERY ENDOTHELIUM; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC HYPERTENSION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HYPERINSULINEMIA; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN TREATMENT; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES; SYSTOLIC BLOOD PRESSURE; VASOCONSTRICTION; WESTERN BLOTTING;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; AORTA; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; ENDOTHELIN-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HYPERTENSION; INSULIN; LOSARTAN; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN A; STREPTOZOCIN; VASOCONSTRICTION;

EID: 56749168571     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.327     Document Type: Article

References (41)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edn. Br J Pharmacol 153 (Suppl. 2): S1-S209.
2. Ballew JR, Fink GD (2001). Role of ET(A) receptors in experimental ANG II-induced hypertension in rats. Am J Physiol Regul Integr Comp Physiol 281: R150-R154.
3. Cohen RA (1995). The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. Prog Cardiovasc Dis 38: 105-128.
4. De Vriese AS, Verbeuren TJ, Van De Voorde J, Lameire NH, Vanhoutte PM (2000). Endothelial dysfunction in diabetes. Br J Pharmacol 130: 963-974.
5. Ding L, Chapman A, Boyd R, Wang HD (2007). ERK activation contributes to regulation of spontaneous contractile tone via superoxide anion in isolated rat aorta of angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol 292: H2997-H3005.
6. Eckel RH, Wassef M, Chait A, Sobel B, Barrett E, King G et al. (2002). Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes. Circulation 105: e138-e143.
7. Ergul A, Portik-Dobos V, Giulumian AD, Molero MM, Fuchs LC (2003). Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation. Am J Physiol Heart Circ Physiol 285: H2225-H2232.
8. Feener EP, King GL (1997). Vascular dysfunction in diabetes mellitus. Lancet 350: 9-13.
9. Gans RO, Bilo HJ, von Maarschalkerweerd WW, Heine RJ, Nauta JJ, Donker AJ (1991). Exogenous insulin augments in healthy volunteers the cardiovascular reactivity to noradrenaline but not to angiotensin II. J Clin Invest 88: 512-518.
10. Goto K, Hama H, Kasuya Y (1996). Molecular pharmacology and pathophysiological significance of endothelin. Jpn J Pharmacol 72: 261-290.
11. Hall JE, Brands MW, Zappe DH, Galicia MA (1995). Insulin resistance, hyperinsulinaemia, and hypertension: causes, consequences, or merely correlations? Proc Soc Exp Biol Med 208: 317-329.
12. Hong HJ, Chan P, Liu JC, Juan SH, Huang MT, Lin JG et al. (2004). Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells. Cardiovasc Res 61: 159-168.
13. Jesmin S, Hattori Y, Maeda S, Zaedi S, Sakuma I, Miyauchi T (2006). Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats. Am J Physiol Heart Circ Physiol 290: H2146-H2154.
14. Kamata K, Miyata N, Kasuya Y (1989). Impairment of endotheliumdependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats. Br J Pharmacol 97: 614-618.
15. Kanie N, Kamata K (2002). Effects of chronic administration of the novel endothelin antagonist J-104132 on endothelial dysfunction in streptozotocin-induced diabetic rat. Br J Pharmacol 135: 1935-1942.
16. Kanie N, Matsumoto T, Kobayashi T, Kamata K (2003). Relationship between peroxisome proliferators-activated receptors (PPAR alpha and PPAR gamma) and endothelial dependent relaxation in streptozotocin-induced diabetic rats. Br J Pharmacol 140: 23-32.
17. Kim B, Kim J, Bae YM, Cho SI, Kwon SC, Jung JY et al. (2004). p38 mitogen-activated protein kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats. Hypertension 43: 1086-1091.
18. Kirilov G, Dakovska L, Borisova AM, Krivoshiev S, Nentchev N (1994). Increased plasma endothelin levels in patients with insulin-dependent diabetes mellitus and end-stage vascular complications. Horm Metab Res 26: 119-120.
19. Kobayashi T, Hayashi Y, Taguchi K, Matsumoto T, Kamata K (2006). Angiotensin II enhances contractile responses via PI3-kinase p110{delta} pathway in aortas from diabetic rats with systemic hyperinsulinemia. Am J Physiol Heart Circ Physiol 291: H846-H853.
20. Kobayashi T, Kamata K (1999). Effect of insulin treatment on smooth muscle contractility and endothelium-dependent relaxation in rat aortae from established STZ-induced diabetes. Br J Pharmacol 127: 835-842.
21. Kobayashi T, Kamata K (2001). Effect of chronic insulin treatment on NO metabolism and endothelium-dependent relaxation in aortae from established STZ-induced diabetic rats. Atherosclerosis 155: 313-320.
22. 2+-ATPase function in aortas from diabetic rats. Free Radic Biol Med 43: 431-443.
23. Koide M, Kawahara Y, Tsuda T, Ishida Y, Shii K, Yokoyama M (1992). Endothelin-1 stimulates tyrosine phosphorylation and the activities of two mitogen-activated protein kinases in cultured vascular smooth muscle cells. J Hypertens 10: 1173-1182.
24. Koivisto VA, Stevens LK, Mattock M, Ebeling P, Muggeo M, Stephenson J et al. (1996). Cardiovascular disease and its risk factors in IDDM in Europe. EURODIAB IDDM Complications Study Group. Diabetes Care 19: 689-697.
25. Matsumoto T, Kobayashi T, Kamata K (2006). Mechanisms underlying lysophosphatidylcholine-induced potentiation of vascular contractions in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat aorta. Br J Pharmacol 149: 931-941.
26. Meloche S, Landry J, Huot J, Houle F, Marceau F, Giasson E (2000). p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle. Am J Physiol Heart Circ Physiol 279: H741-H751.
27. Mundy AL, Haas E, Bhattacharya I, Widmer CC, Kretz M, Hofmann-Lehmann R et al. (2007). Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: implications for diet-induced obesity. Cardiovasc Res 73: 368-375.
28. Nishikibe M, Ohta H, Okada M, Ishikawa K, Hayama T, Fukuroda T et al. (1999). Pharmacological properties of J-104132 (L-753, 037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist. J Pharmacol Exp Ther 289: 1262-1270.
29. Orchard TJ, Olson JC, Erbey JR, Williams K, Forrest KY, Smithline Kinder L et al. (2003). Insulin resistance-related factors, but not glycemia, predict coronary artery disease in type 1 diabetes: 10-year follow-up data from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes Care 26: 1374-1379.
30. Ortiz MC, Sanabria E, Manriquez MC, Romero JC, Juncos LA (2001). Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. Hypertension 37: 505-510.
31. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K et al. (2001). Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22: 153-183.
32. Poston L, Taylor PD (1995). Endothelium-mediated vascular function in insulin-dependent diabetes mellitus. Clin Sci 88: 245-255.
33. Reaven GM (1995). Pathophysiology of insulin resistance in human disease. Physiol Rev 75: 473-486.
34. Roberts RE (2001). Role of the extracellular signal-regulated kinase (Erk) signal transduction cascade in alpha(2) adrenoceptor-mediated vasoconstriction in porcine palmar lateral vein. Br J Pharmacol 133: 859-866.
35. Snell-Bergeon JK, Hokanson JE, Jensen L, MacKenzie T, Kinney G, Dabelea D et al. (2003). Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic control. Diabetes Care 26: 2923-2928.
36. Taguchi K, Kobayashi T, Hayashi Y, Matsumoto T, Kamata K (2007). Enalapril improves impairment of SERCA-derived relaxation and enhancement of tyrosine nitration in diabetic rat aorta. Eur J Pharmacol 556: 121-128.
37. Takeda K, Ichiki T, Tokunou T, Iino N, Takeshita A (2001). 15-Deoxy-delta 12, 14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells. J Biol Chem 276: 48950-48955.
38. Touyz RM, El Mabrouk M, He G, Wu XH, Schiffrin EL (1999). Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells. Circ Res 84: 505-515.
39. Yamboliev IA, Wiesmann KM, Singer CA, Hedges JC, Gerthoffer WT (2000). Phosphatidylinositol 3-kinases regulate ERK and p38 MAP kinases in canine colonic smooth muscle. Am J Physiol Cell Physiol 279: C352-C360.
40. Yang Z, Krasnici N, Luscher TF (1999). Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade. Circulation 100: 5-8.
41. Yogi A, Callera GE, Montezano AC, Aranha AB, Tostes RC, Schiffrin EL et al. (2007). Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 27: 1960-1967.