Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis

Journal of Infectious Diseases

Volumn 181, Issue 1, 2000, Pages 385-389

  Seah, G T ^a   Scott, G M ^b   Rook, G A W ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; MESSENGER RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CYTOKINE PRODUCTION; HOST SUSCEPTIBILITY; HUMAN; IMMUNOPATHOGENESIS; LUNG TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; ALTERNATIVE SPLICING; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-13; INTERLEUKIN-4; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUBERCULOSIS, PULMONARY;

EID: 0033955022     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315200     Document Type: Article

References (14)

1. 1. Schauf V, Rom WN, Smith KA, et al. Cytokine gene activation and modified responsiveness to interleukin-2 in the blood of tuberculosis patients. J Infect Dis 1993;168:1056-9.
2. 2. Zhang M, Lin Y, Iyer DV, Gong J, Abrams JS, Barnes PF. T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect Immun 1995;63:3231-4.
3. 3. Hernandez Pando R, Orozcoe H, Sampieri A, et al. Correlation between the kinetics of Th1, Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis. Immunology 1996;89:26-33.
4. 4. North RJ. Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis. Clin Exp Immunol 1998;113:55-8.
5. 5. Zurawski G, de Vries JE. Interleukin-13, an interleukin-4-like cytokine that acts on monocytes and B cells but not on T-cells. Immunol Today 1994;15:19.
6. 6. Alms WJ, Atamas SP, Yurovsky VV, White B. Generation of a variant of human interleukin-4 by alternative splicing. Mol Immunol 1996;33:361-70.
7. 7. Arinobu Y, Atamas SP, Otsuka T, et al. Antagonistic effects of an alternative splice variant of human IL-4, IL-4δ2, on IL-4 activities in human monocytes and B cells. Cell Immunol 1999;191:161-7.
8. 8. Seah GT, Rook GAW. A sensitive, non-radioactive quantitative method for measuring IL-4 and IL-4δ2 mRNA in unstimulated cells from multiple clinical samples, using nested RT-PCR. J Immunol Methods 1999;228:139-49.
9. 9. Del Prete G, Maggi E, Parronchi P. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988;140:4193-8.
10. 10. Torres M, Herrera T, Villareal H, Rich EA, Sada E. Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30-kilodalton antigen of Mycobacterium tuberculosis. Infect Immun 1998;66:176-80.
11. 11. McKenzie GJ, Fallon PG, Emson CL, Grencis RK, McKenzie AN. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2 mediated responses. J Exp Med 1999;189:1565-72.
12. 12. Muller KM, Jaunin F, Masouye I, Saurat JH, Hauser C. Th2 cells mediate IL-4-dependent local tissue inflammation. J Immunol 1993;150:5576-84.
13. 13. Hernandez-Pando R, Rook GAW. The role of TNFα in T cell -mediated inflammation depends on the Th1/Th2 cytokine balance. Immunology 1994;82:591-5.
14. 14. Lawrence CE, Paterson JCM, Higgins LM, MacDonald TT, Kennedy MW, Garside P. IL-4-regulated enteropathy in an intestinal nematode infection. Eur J Immunol 1998;28:2672-84.