Cellular senescence and longevity of osteophyte-derived mesenchymal stem cells compared to patient-matched bone marrow stromal cells

Journal of Cellular Biochemistry

Volumn 108, Issue 4, 2009, Pages 839-850

  Singh, Sanjleena ^a   Dhaliwal, Navdeep ^a   Crawford, Ross ^a   Xiao, Yin ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Longevity; Mesenchymal stem cell; Osteoarthritis; Osteophyte; Senescence; Telomerase activity; Telomere length

Indexed keywords

BETA GALACTOSIDASE; TELOMERASE;

AGED; APC GENE; ARTICLE; BMP2 GENE; BONE MARROW CELL; CCND2 GENE; CELL AGING; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; KARYOTYPE; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; OSTEOPHYTE; PRIORITY JOURNAL; SENESCENCE; STROMA CELL; TELOMERE;

AGED; BONE MARROW CELLS; CELL AGING; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOGENETICS; HUMANS; IMMUNOHISTOCHEMISTRY; KARYOTYPING; MESENCHYMAL STEM CELLS; OSTEOPHYTE; STROMAL CELLS; TELOMERASE; TELOMERE;

EID: 70350432914     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22312     Document Type: Article

References (47)

1. Aida J, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SS, Kammori M, Sawabe M, Arai T, Matsuura M, Fujiwara M, Kishimoto H, Takubo K. 2008. Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium. Exp Gerontol 43:833-839.
2. Baird DM. 2008. Mechanisms of telomeric instability. Cytogenet Genome Res 122:308-314.
3. Banfi A, Muraglia A, Dozin B, Mastrogiacomo M, Cancedda R, Quarto R. 2000. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. Exp Hematol 28:707-715. (Pubitemid 30398528)
4. Banfi A, Bianchi G, Notaro R, Luzzatto L, Cancedda R, Quarto R. 2002. Replicative aging and gene expression in long-term cultures of human bone marrow stromal cells. Tissue Eng 8:901-910. (Pubitemid 35397236)
5. Bernardo ME, Zaffaroni N, Novara F, Cometa AM, Avanzini MA, Moretta A, Montagna D, Maccario R, Villa R, Daidone MG, Zuffardi O, Locatelli F. 2007. Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms. Cancer Res 67:9142-9149. (Pubitemid 47535900)
6. Bienz M, Hamada F. 2004. Adenomatous polyposis coli proteins and cell adhesion. Curr Opin Cell Biol 16:528-535. (Pubitemid 39201237)
7. Blackburn EH. 2001. Switching and signaling at the telomere. Cell 106:661-673.
8. Britt-Compton B, Wyllie F, Rowson J, Capper R, Jones RE, Baird DM. 2009. Telomere dynamics during replicative senescence are not directly modulated by conditions of oxidative stress in IMR90 fibroblast cells. Biogerontology C [Epub ahead of print].
9. Broccoli D, Young JW, de Lange T. 1995. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 92:9082-9086.
10. Cawthon RM. 2002. Telomere measurement by quantitative PCR. Nucleic Acids Res 30:e47.
11. Colter DC, Class R, DiGirolamo CM, Prockop DJ. 2000. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci USA 97:3213-3218. (Pubitemid 30183281)
12. Counter CM, Gupta J, Harley CB, Leber B, Bacchetti S. 1995. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 85:2315-2320.
13. Dhaene K, Van Marck E, Parwaresch R. 2000. Telomeres, telomerase and cancer: An up-date. Virchows Arch 437:1-16.
14. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacock M, Campisi J. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363-9367.
15. Fehrer C, Brunauer R, Laschober G, Unterluggauer H, Reitinger S, Kloss F, Gully C, Gassner R, Lepperdinger G. 2007. Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan. Aging Cell 6:745-757. (Pubitemid 350131043)
16. Flores I, Canela A, Vera E, Tejera A, Cotsarelis G, Blasco MA. 2008. The longest telomeres: A general signature of adult stem cell compartments. Genes Dev 22:654-667. (Pubitemid 351342437)
17. Fromigue O, Marie PJ, Lomri A. 1998. Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation. J Cell Biochem 68:411-426. (Pubitemid 28080113)
18. Fujiwara T. 2009. Telomerase-specific virotherapy for human squamous cell carcinoma. Expert Opin Biol Ther 9:321-329.
19. Han C, Zhang X, Xu W, Wang W, Qian H, Chen Y. 2005. Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells. Int J Mol Med 16:205-213.
20. Hanna CW, Bretherick KL, Gair JL, Fluker MR, Stephenson MD, Robinson WP. 2009. Telomere length and reproductive aging. Hum Reprod 24:1206-1211.
21. Harle-Bachor C, Boukamp P. 1996. Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci USA 93:6476-6481. (Pubitemid 26230331)
22. Hayflick L. 1985. The cell biology of aging. Clin Geriatr Med 1:15-27.
23. Hishida T, Naito K, Osada S, Nishizuka M, Imagawa M. 2008. Crucial roles of D-type cyclins in the early stage of adipocyte differentiation. Biochem Biophys Res Commun 370:289-294.
24. Hiyama K, Hirai Y, Kyoizumi S, Akiyama M, Hiyama E, Piatyszek MA, Shay JW, Ishioka S, Yamakido M. 1995. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 155:3711-3715.
25. Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. 2006. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24:1294-1301. (Pubitemid 44464698)
26. Kim KM, Calabrese P, Tavare S, Shibata D. 2004. Enhanced stem cell survival in familial adenomatous polyposis. Am J Pathol 164:1369-1377. (Pubitemid 38387802)
27. Kunkel TA, Bebenek K. 2000. DNA replication fidelity. Annu Rev Biochem 69:497-529.
28. Lecanda F, Avioli LV, Cheng SL. 1997. Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2. J Cell Biochem 67:386-396. (Pubitemid 27509474)
29. Mareddy S, Crawford R, Brooke G, Xiao Y. 2007. Clonal isolation and characterization of bone marrow stromal cells from patients with osteoarthritis. Tissue Eng 13:819-829. (Pubitemid 46651512)
30. Osyczka AM, Leboy PS. 2005. Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling. Endocrinology 146:3428-3437.
31. Parsch D, Fellenberg J, Brummendorf TH, Eschlbeck AM, Richter W. 2004. Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes. J Mol Med 82:49-55. (Pubitemid 38168101)
32. Popescu NC, Zimonjic DB. 2002. Chromosome and gene alterations in breast cancer as markers for diagnosis and prognosis as well as pathogenetic targets for therapy. Am J Med Genet 115:142-149.
33. Proctor A, Brownhill SC, Burchill SA. 2009. The promise of telomere length, telomerase activity and its regulation in the translocation-dependent cancer ESFT; clinical challenges and utility. Biochim Biophys Acta 1792:260-274.
34. Rubin H. 2002. The disparity between human cell senescence in vitro and lifelong replication in vivo. Nat Biotechnol 20:675-681. (Pubitemid 34734133)
35. Satija NK, Gurudutta GU, Sharma S, Afrin F, Gupta P, Verma YK, Singh VK, Tripathi RP. 2007. Mesenchymal stem cells: Molecular targets for tissue engineering. Stem Cells Dev 16:7-23. (Pubitemid 46362588)
36. Schmelzer E, Reid LM. 2009. Human telomerase activity, telomerase and telomeric template expression in hepatic stem cells and in livers from fetal and postnatal donors. Eur J Gastroenterol Hepatol [Epub ahead of print].
37. Serakinci N, Graakjaer J, Kolvraa S. 2008. Telomere stability and telomerase in mesenchymal stem cells. Biochimie 90:33-40. (Pubitemid 350216217)
38. Shaker OG, Hammam O, Salehd A, El Leithy T, Wishahi M. 2009. Possible role of telomerase and sFas in pathogenesis of various bladder lesions associated with schistosomiasis. Clin Biochem 42:864-872.
39. Simmons PJ, Torok-Storb B. 1991. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood 78:55-62.
40. Singh S, Jones BJ, Crawford R, Xiao Y. 2008. Characterization of a mesenchymal-like stem cell population from osteophyte tissue. Stem Cells Dev 17:245-254. (Pubitemid 351630176)
41. van der Kraan PM, van den Berg WB. 2007. Osteophytes: Relevance and biology. Osteoarthritis Cartilage 15:237-244.
42. Wagner W, Horn P, Castoldi M, Diehlmann A, Bork S, Saffrich R, Benes V, Blake J, Pfister S, Eckstein V, Ho AD. 2008. Replicative senescence of mesenchymal stem cells: A continuous and organized process. PLoS ONE 3:e2213.
43. Wu YH, Cheng ML, Ho HY, Chiu DT, Wang TC. 2009. Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. J Biomed Sci 16:18.
44. Yang Q. 2008. Cellular senescence, telomere recombination and maintenance. Cytogenet Genome Res 122:211-218.
45. Yudoh K, Nishioka K. 2004. Telomerized presenescent osteoblasts prevent bone mass loss in vivo. Gene Ther 11:909-915. (Pubitemid 38786605)
46. Zhang ZX, Guan LX, Zhang K, Wang S, Cao PC, Wang YH, Wang Z, Dai LJ. 2007. Cytogenetic analysis of human bone marrow-derived mesenchymal stem cells passaged in vitro. Cell Biol Int 31:645-648. (Pubitemid 46660640)
47. Zimmermann S, Voss M, Kaiser S, Kapp U, Waller CF, Martens UM. 2003. Lack of telomerase activity in human mesenchymal stem cells. Leukemia 17:1146-1149 . (Pubitemid 36722246)