Replicative aging and gene expression in long-term cultures of human bone marrow stromal cells

Tissue Engineering

Volumn 8, Issue 6, 2002, Pages 901-910

  Banfi, Andrea ^a,b,c,d   Bianchi, Giordano ^a,b,c   Notaro, Rosario ^a   Luzzatto, Lucio ^a   Cancedda, Ranieri ^a,b,c   Quarto, Rodolfo ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL AGING; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CELL ISOLATION; CELL KINETICS; CELL LINEAGE; CELL PROLIFERATION; CHONDROGENESIS; ENZYME ACTIVITY; EVALUATION; FREQUENCY MODULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIFESPAN; MESENCHYME CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STROMA CELL; TELOMERE; TISSUE ENGINEERING;

ADOLESCENT; ADULT; BONE MARROW CELLS; CELL AGING; CELL CULTURE TECHNIQUES; CELL DIVISION; CHILD; CHILD, PRESCHOOL; GENE EXPRESSION; HUMANS; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STROMAL CELLS; TELOMERASE;

EID: 0036892057     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/107632702320934001     Document Type: Article

References (54)

1. Bentley, S.A. Bone marrow connective tissue and the haemopoietic microenvironment. Br. J. Haematol. 50, 1, 1982.
2. Tavassoli, M., and Friedenstein, A. Hemopoietic stromal microenvironment. Am. J. Hematol. 15, 195, 1983.
3. Dexter, T.M. Stromal cell associated haemopoiesis. J. Cell Physiol. Suppl. 1, 87, 1982.
4. Beresford, J.N. Osteogenic stem cells and the stromal system of bone marrow. Clin. Orthop. 240, 270, 1989.
5. Brockbank, K.G., de Jong, J.P., Piersma, A.H., and Voerman, J.S. Hemopoiesis on purified bone-marrow-derived reticular fibroblast in vitro. Exp. Hematol. 14, 386, 1986.
6. Caplan, A.I. Mesenchymal stem cells. J. Orthop. Res. 9, 641, 1991.
7. Friedenstein, A.J., Deriglasova, U.F., Kulagina, N.N., Panasuk, A.F., Rudakowa, S.F., Luria, E.A., and Ruadkow, I.A. Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp. Hematol. 2, 83, 1974.
8. Beresford, J.N., Bennett, J.H., Devlin, C., Leboy, P.S., and Owen, M.E. Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J. Cell Sci. 102, 341, 1992.
9. Muraglia, A., Cancedda, R., and Quarto, R. Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. J. Cell Sci. 113, 1161, 2000.
10. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., and Marshak, D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143, 1999.
11. Kuznetsov, S.A., Krebsbach, P.H., Satomura, K., Kerr, J., Riminucci, M., Benayahu, D., and Robey, P.G. Singlecolony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J. Bone Miner. Res. 12, 1335, 1997.
12. Quarto, R., Mastrogiacomo, M., Cancedda, R., Kutepov, S.M., Mukhachev, V., Lavroukov, A., Kon, E., and Marcacci, M. Repair of large bone defects with the use of autologous bone marrow stromal cells. N. Engl. J. Med. 344, 385, 2001.
13. Bianco, P., Riminucci, M., Gronthos, S., and Robey, P.G. Bone marrow stromal stem cells: Nature, biology, and potential applications. Stem Cells 19, 180, 2001.
14. Horwitz, E.M., Prockop, D.J., Gordon, P.L., Koo, W.W., Fitzpatrick, L.A., Neel, M.D., McCarville, M.E., Orchard, P.J., Pyeritz, R.E., and Brenner, M.K. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood 97, 1227, 2001.
15. Prockop, D.J. Marrow stromal cells as stem cells for non-hematopoietic tissues. Science 276, 71, 1997.
16. Haynesworth, S.E., Goshima, J., Goldberg, V.M., and Caplan, A.I. Characterization of cells with osteogenic potential from human marrow. Bone 13, 81, 1992.
17. Galotto, M., Berisso, G., Delfino, L., Podesta, M., Ottaggio, L., Dallorso, S., Dufour, C., Ferrara, G.B., Abbondandolo, A., Dini, G., Bacigalupo, A., Cancedda, R., and Quarto, R. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp. Hematol. 27, 1460, 1999.
18. Owen, M. Marrow stromal stem cells. J. Cell Sci. Suppl. 10, 63, 1988.
19. Martin, I., Muraglia, A., Campanile, G., Cancedda, R., and Quarto, R. Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 138, 4456, 1997.
20. Wright, W.E., Shay, J.W., and Piatyszek, M.A. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res. 23, 3794, 1995.
21. Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L., Coviello, G.M., Wright, W.E., Weinrich, S.L., and Shay, J.W. Specific association of human telomerase activity with immortal cells and cancer [see comments]. Science 266, 2011, 1994.
22. Notaro, R., Cimmino, A., Tabarini, D., Rotoli, B., and Luzzatto, L. In vivo telomere dynamics of human hematopoietic stem cells. Proc. Natl. Acad. Sci. U.S.A. 94, 13782, 1997.
23. Brown, W.R., MacKinnon, P.J., Villasante, A., Spurr, N., Buckle, V.J., and Dobson, M.J. Structure and polymorphism of human telomere-associated DNA. Cell 63, 119, 1990.
24. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction. Anal. Biochem. 162, 156, 1987.
25. 24a. Rickard, D.J., Kassem, M., Hefferan, T.E., Sarkar, G., Spelsberg, T.C., and Riggs, B.L. Isolation and characterization of osteoblast precursor cells from human bone marrow. J. Bone Miner. Res. 11, 312, 1996.
26. 24b. Bellahcene, A., Antoine, N., Clausse, N., Tagliabue, E., Fisher, L.W., Kerr, J.M., Jares, P., and Castronovo, V. Detection of bone sialoprotein in human breast cancer tissue and cell lines at both protein and messenger ribonucleic acid levels. Lab. Invest. 75, 203, 1996.
27. 24c. Johnstone, B., Hering, T.M., Caplan, A.I., Goldberg, V.M., and Yoo, J.U. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp. Cell Res. 238, 265, 1998.
28. 24d. Hicok, K.C., Thomas, T., Gori, F., Rickard, D.J., Spelsberg, T.C., and Riggs, B.L. Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma. J. Bone Miner. Res. 13, 205, 1998.
29. Galotto, M., Campanile, G., Banfi, A., Trugli, M., and Cancedda, R. Chondrocyte and osteoblast differentiation stage-specific monoclonal antibodies as a tool to investigate the initial bone formation in developing chick embryo. Eur. J. Cell Biol. 67, 99, 1995.
30. Zakian, V.A. Life and cancer without telomerase. Cell 91, 1, 1997.
31. Onyia, J.E., Clapp, D.W., Long, H., and Hock, J.M. Osteoprogenitor cells as targets for ex vivo gene transfer. J. Bone Miner. Res. 13, 20, 1998.
32. Banfi, A., Muraglia, A., Dozin, B., Mastrogiacomo, M., Cancedda, R., and Quarto, R. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. Exp. Hematol. 28, 707, 2000.
33. Greider, C.W., and Blackburn, E.H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405, 1985.
34. Bodnar, A.G., Ouellette, M., Frolkis, M., Holt, S.E., Chiu, C.P., Morin, G.B., Harley, C.B., Shay, J.W., Lichtsteiner, S., and Wright, W.E. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349, 1998.
35. Reddel, R.R., Bryan, T.M., and Murnane, J.P. Immortalized cells with no detectable telomerase activity: A review. Biochemistry (Moscow) 62, 1254, 1997.
36. Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S., and Reddel, RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240, 1995.
37. Bryan, T.M., Englezou, A., Dalla-Pozza, L., Dunham, M.A., and Reddel, R.R. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat. Med. 3, 1271, 1997.
38. Wright, W.E., Piatyszek, M.A., Rainey, W.E., Byrd, W., and Shay, J.W. Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet. 18, 173, 1996.
39. Shay, J.W., and Bacchetti, S. A survey of telomerase activity in human cancer. Eur. J. Cancer 33, 787, 1997.
40. Holt, S.E., and Shay, J.W. Role of telomerase in cellular proliferation and cancer. J. Cell Physiol. 180, 10, 1999.
41. Hiyama, K., Hirai, Y., Kyoizumi, S., Akiyama, M., Hiyama, E., Piatyszek, M.A., Shay, J.W., Ishioka, S., and Yamakido, M. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J. Immunol. 155, 3711, 1995.
42. Chiu, C.P., Dragowska, W., Kim, N.W., Vaziri, H., Yui, J., Thomas, T.E., Harley, C.B., and Lansdorp, P.M. Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells 14, 239, 1996.
43. Johnson, F.B., Marciniak, R.A., and Guarente, L. Telomeres, the nucleolus and aging. Curr. Opin. Cell Biol. 10, 332, 1998.
44. Morrison, S.J., Shah, N.M., and Anderson, D.J. Regulatory mechanisms in stem cell biology. Cell 88, 287, 1997.
45. Harley, C.B., Futcher, A.B., and Greider, C.W. Telomeres shorten during ageing of human fibroblasts. Nature 345, 458, 1990.
46. Lindsey, J., McGill, N.I., Lindsey, L.A., Green, D.K., and Cooke, H.J. In vivo loss of telomeric repeats with age in humans. Mutat. Res. 256, 45, 1991.
47. Allsopp, R.C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E.V., Futcher, A.B., Greider, C.W., and Harley, C.B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 89, 10114, 1992.
48. Harley, C.B., Telomere loss: Mitotic clock or genetic time bomb? Mutat. Res. 256, 271, 1991.
49. Campisi, J. From cells to organisms: Can we learn about aging from cells in culture? Exp. Gerontol. 36, 607, 2001.
50. Counter, C.M. The roles of telomeres and telomerase in cell life span. Mutat. Res. 366, 45, 1996.
51. Slagboom, P.E., Droog, S., and Boomsma, D.I. Genetic determination of telomere size in humans: A twin study of three age groups. Am. J. Hum. Genet. 55, 876, 1994.
52. Bruder, S.P., Jaiswal, N., and Haynesworth, S.E. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J. Cell Biochem. 64, 278, 1997.
53. Mansukhani, A., Bellosta, P., Sahni, M., and Basilico, C. Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts. J. Cell Biol. 149, 1297, 2000.
54. van der Plas, A., Aarden, E.M., Feijen, J.H., de Boer, A.H., Wiltink, A., Alblas, M.J., de Leij, L., and Nijweide, P.J. Characteristics and properties of osteocytes in culture. J. Bone Miner. Res. 9, 1697, 1994.