Complex N-linked glycans on Asn-89 of Kaposi sarcoma herpes virus-encoded interleukin-6 mediate optimal function by affecting cytokine protein conformation

Journal of Biological Chemistry

Volumn 284, Issue 43, 2009, Pages 29269-29282

  Dela Cruz, Charles S ^a   Viswanathan, Srinivas R ^a   El Guindy, Ayman S ^a   Shedd, Duane ^a   Miller, George ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; CYTOKINES; ENDOGLYCOSIDASE; GLYCANS; INTERLEUKIN-6; INTRACELLULAR PRODUCTION; KAPOSI SARCOMA-ASSOCIATED HERPESVIRUS; N-LINKED; N-LINKED GLYCANS; N-LINKED GLYCOSYLATION; OPTIMAL FUNCTION; PROTEIN CONFORMATION; PROTEIN FUNCTIONS; TRYPTIC DIGESTION;

ESTERIFICATION; OPTIMIZATION; TUMORS;

GLYCOSYLATION;

GLYCAN; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ALPHA; MANNOSE;

ARTICLE; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN STABILITY;

ANTIBODIES, VIRAL; CELL LINE, TUMOR; CYTOKINE RECEPTOR GP130; GLUCOSIDASES; GLYCOSYLATION; HERPESVIRUS 8, HUMAN; HUMANS; INTERLEUKIN-6; MUTATION; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-6; VIRAL PROTEINS;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8;

EID: 70350399480     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.039115     Document Type: Article

References (31)

1. Dela Cruz, C. S., Lee, Y., Viswanathan, S. R., El-Guindy, A. S., Gerlach, J., Nikiforow, S., Shedd, D., Gradoville, L., and Miller, G. (2004) J. Exp. Med. 199, 503-514
2. Alcami, A. (2003) Nat. Rev. Immunol. 3, 36-50
3. Nicholas, J., Ruvolo, V. R., Burns, W. H., Sandford, G., Wan, X., Ciufo, D., Hendrickson, S. B., Guo, H. G., Hayward, G. S., and Reitz, M. S. (1997) Nat. Med. 3, 287-292
4. Moore, P. S., Boshoff, C., Weiss, R. A., and Chang, Y. (1996) Science 274, 1739-1744
5. Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., and Chrousos, G. P. (1998) Ann. Intern. Med. 128, 127-137
6. Burger, R., Neipel, F., Fleckenstein, B., Savino, R., Ciliberto, G., Kalden, J. R., and Gramatzki, M. (1998) Blood 91, 1858-1863
7. Molden, J., Chang, Y., You, Y., Moore, P. S., and Goldsmith, M. A. (1997) J. Biol. Chem. 272, 19625-19631
8. Hoischen, S. H., Vollmer, P., März, P., Ozbek, S., Götze, K. S., Peschel, C., Jostock, T., Geib, T., Müllberg, J., Mechtersheimer, S., Fischer, M., Grötzinger, J., Galle, P. R., and Rose-John, S. (2000) Eur. J. Biochem. 267, 3604-3612
9. Jones, K. D., Aoki, Y., Chang, Y., Moore, P. S., Yarchoan, R., and Tosato, G. (1999) Blood 94, 2871-2879
10. Meads, M. B., and Medveczky, P. G. (2004) J. Biol. Chem. 279, 51793-51803
11. Nicholas, J. (2007) Front Biosci. 12, 265-281
12. Deng, H., Chu, J. T., Rettig, M. B., Martinez-Maza, O., and Sun, R. (2002) Blood 100, 1919-1921
13. Pati, S., Cavrois, M., Guo, H. G., Foulke, J. S., Jr., Kim, J., Feldman, R. A., and Reitz, M. (2001) J. Virol. 75, 8660-8673
14. Somers, W., Stahl, M., and Seehra, J. S. (1997) EMBO J. 16, 989-997
15. Chow, D., He, X., Snow, A. L., Rose-John, S., and Garcia, K. C. (2001) Science 291, 2150-2155
16. Taga, T., and Kishimoto, T. (1997) Annu. Rev. Immunol. 15, 797-819
17. Simpson, R. J., Hammacher, A., Smith, D. K., Matthews, J. M., and Ward, L. D. (1997) Protein Sci. 6, 929-955
18. Boulanger, M. J., Chow, D. C, Brevnova, E., Martick, M., Sandford, G., Nicholas, J., and Garcia, K. C. (2004) J. Mol. Biol. 335, 641-654
19. Osborne, J., Moore, P. S., and Chang, Y. (1999) Hum. Immunol. 60, 921-927
20. Hideshima, T., Chauhan, D., Teoh, G., Raje, N., Treon, S. P., Tai, Y. T., Shima, Y., and Anderson, K. C. (2000) Clin. Cancer Res. 6, 1180-1189
21. Chatterjee, M., Osborne, J., Bestetti, G., Chang, Y., and Moore, P. S. (2002) Science 298, 1432-1435
22. Chang, P. J., Shedd, D., Gradoville, L., Cho, M. S., Chen, L. W., Chang, J., and Miller, G. (2002) J. Virol. 76, 3168-3178
23. El-Guindy, A. S., Heston, L., Endo, Y., Cho, M. S., and Miller, G. (2002) J. Virol. 76, 11199-11208
24. Harrison, R. L., and Jarvis, D. L. (2006) Adv. Virus Res. 68, 159-191
25. Aoki, Y., Narazaki, M., Kishimoto, T., and Tosato, G. (2001) Blood 98, 3042-3049
26. Boulanger, M. J., Chow, D. C., Brevnova, E. E., and Garcia, K. C. (2003) Science 300, 2101-2104
27. Chen, D., and Nicholas, J. (2006) J. Virol. 80, 9811-9821
28. Chen, D., Sandford, G., and Nicholas, J. (2009) J. Virol. 83, 722-733
29. Adam, N., Rabe, B., J, S., J, G., Rose-John, S., and Scheller, J. (2009) J. Virology
30. High, S., Lecomte, F. J., Russell, S. J., Abell, B. M., and Oliver, J. D. (2000) FEBS Lett. 476, 38-41
31. Ellgaard, L., and Helenius, A. (2001) Curr. Opin. Cell Biol. 13, 431-437