Metabolic engineering with a morphine biosynthetic P450 in opium poppy surpasses breeding

Metabolic Engineering

Volumn 9, Issue 2, 2007, Pages 169-176

  Frick, Susanne ^a,b   Kramell, Robert ^a   Kutchan, Toni M ^a,b  

^a LEIBNIZ INSTITUTE OF PLANT BIOCHEMISTRY   (Germany)

^b DONALD DANFORTH PLANT SCIENCE CENTER   (United States)

Author keywords

Metabolic engineering; Morphine biosynthesis; Opium poppy; P450 enzyme; Somatic embryogenesis; Transformation

Indexed keywords

METABOLIC ENGINEERING; MORPHINE BIOSYNTHESIS; OPIUM POPPY; P450 ENZYME; SOMATIC EMBRYOGENESIS; TRANSFORMATION;

BIOSYNTHESIS; DNA; ENZYMES; GENES; GENETIC ENGINEERING; LATEXES; METABOLITES; NITROGEN COMPOUNDS; TISSUE CULTURE;

METABOLISM;

ALKALOID; BENZYLISOQUINOLINE DERIVATIVE; COMPLEMENTARY DNA; CYTOCHROME P450; GENE PRODUCT; MONOOXYGENASE (S) N METHYLCOCLAURINE 3' HYDROXYLASE; MORPHINE; OPIATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; GENE CONTROL; GENE OVEREXPRESSION; MEDICINAL PLANT; METABOLIC ENGINEERING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSGENE;

AGRICULTURE; CYTOCHROME P-450 ENZYME SYSTEM; GENETIC ENHANCEMENT; MORPHINE; PAPAVER; PLANT PROTEINS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; TRANSFECTION;

PAPAVER SOMNIFERUM;

EID: 33847279410     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2006.10.004     Document Type: Article

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