Tripterine prevents endothelial barrier dysfunction by inhibiting endogenous peroxynitrite formation

British Journal of Pharmacology

Volumn 157, Issue 6, 2009, Pages 1014-1023

  Wu, Feng ^a   Han, Min ^a   Wilson, John X ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Cytokines; Endothelial cells; Hsp90; Inflammation; INOS; Lipopolysaccharide; NADPH oxidase; Permeability; Peroxynitrite; Tripterine

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 NITROTYROSINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOCYNIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA ACTIN; CELASTROL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GAMMA INTERFERON; I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE 2; LINSIDOMINE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NITRIC OXIDE; PEROXYNITRITE; PHOSPHOPROTEIN PHOSPHATASE 2A; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL FUNCTION; BLOOD VESSEL PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; DRUG INHIBITION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; CAPILLARY PERMEABILITY; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; PEROXYNITROUS ACID; TRITERPENES;

EID: 70350342901     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00292.x     Document Type: Article

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