메뉴 건너뛰기




Volumn 117, Issue 4-5, 2009, Pages 176-184

Effects of the special extract ERr 731® from Rheum rhaponticum on estrogen-regulated targets in the uterotrophy model of ovariectomized rats

Author keywords

Climacteric; Estrogen receptor; Gene expression; Phyto Strol ; Proliferation; Uterus

Indexed keywords

COMPLEMENT COMPONENT C3; CYCLINE; ERR 731; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; KI 67 ANTIGEN; MESSENGER RNA; RHUBARB EXTRACT; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

EID: 70350326282     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.09.011     Document Type: Article
Times cited : (15)

References (53)
  • 1
    • 39649101096 scopus 로고    scopus 로고
    • Menopause
    • Nelson H.D. Menopause. Lancet 371 9614 (2008) 760-770
    • (2008) Lancet , vol.371 , Issue.9614 , pp. 760-770
    • Nelson, H.D.1
  • 2
    • 0042018741 scopus 로고    scopus 로고
    • Breast cancer and hormone-replacement therapy in the Million Women Study
    • Beral V. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362 9382 (2003) 419-427
    • (2003) Lancet , vol.362 , Issue.9382 , pp. 419-427
    • Beral, V.1
  • 4
    • 33748926108 scopus 로고    scopus 로고
    • Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial
    • Heger M., Ventskovskiy B.M., Borzenko I., Kneis K.C., Rettenberger R., Kaszkin-Bettag M., and Heger P.W. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause 13 5 (2006) 744-759
    • (2006) Menopause , vol.13 , Issue.5 , pp. 744-759
    • Heger, M.1    Ventskovskiy, B.M.2    Borzenko, I.3    Kneis, K.C.4    Rettenberger, R.5    Kaszkin-Bettag, M.6    Heger, P.W.7
  • 5
    • 64049099339 scopus 로고    scopus 로고
    • Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms
    • Hasper I., Ventskovskiy B.M., Rettenberger R., Heger P.W., Riley D.S., and Kaszkin-Bettag M. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause 16 1 (2009) 117-131
    • (2009) Menopause , vol.16 , Issue.1 , pp. 117-131
    • Hasper, I.1    Ventskovskiy, B.M.2    Rettenberger, R.3    Heger, P.W.4    Riley, D.S.5    Kaszkin-Bettag, M.6
  • 6
    • 0018986977 scopus 로고
    • Substrate specificity in vivo and in vitro in the formation of stilbenes. Biosynthesis of rhaponticin
    • Rupprich N., Hildebrand H., and Kindl H. Substrate specificity in vivo and in vitro in the formation of stilbenes. Biosynthesis of rhaponticin. Arch. Biochem. Biophys. 200 1 (1980) 72-78
    • (1980) Arch. Biochem. Biophys. , vol.200 , Issue.1 , pp. 72-78
    • Rupprich, N.1    Hildebrand, H.2    Kindl, H.3
  • 7
    • 35048834712 scopus 로고    scopus 로고
    • Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells
    • Moller F., Zierau O., Jandausch A., Rettenberger R., Kaszkin-Bettag M., and Vollmer G. Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells. Phytomedicine 14 11 (2007) 716-726
    • (2007) Phytomedicine , vol.14 , Issue.11 , pp. 716-726
    • Moller, F.1    Zierau, O.2    Jandausch, A.3    Rettenberger, R.4    Kaszkin-Bettag, M.5    Vollmer, G.6
  • 9
    • 0037174156 scopus 로고    scopus 로고
    • In vivo test systems for the quantitative and qualitative analysis of the biological activity of phytoestrogens
    • Diel P., Schmidt S., and Vollmer G. In vivo test systems for the quantitative and qualitative analysis of the biological activity of phytoestrogens. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 777 1-2 (2002) 191-202
    • (2002) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.777 , Issue.1-2 , pp. 191-202
    • Diel, P.1    Schmidt, S.2    Vollmer, G.3
  • 10
    • 0025025812 scopus 로고
    • Uterine insulin-like growth factor-1: regulation of expression and its role in estrogen-induced uterine proliferation
    • Murphy L.J., and Ghahary A. Uterine insulin-like growth factor-1: regulation of expression and its role in estrogen-induced uterine proliferation. Endocr. Rev. 11 3 (1990) 443-453
    • (1990) Endocr. Rev. , vol.11 , Issue.3 , pp. 443-453
    • Murphy, L.J.1    Ghahary, A.2
  • 12
    • 0023619557 scopus 로고
    • Estrogen induces insulin-like growth factor-I expression in the rat uterus
    • Murphy L.J., Murphy L.C., and Friesen H.G. Estrogen induces insulin-like growth factor-I expression in the rat uterus. Mol. Endocrinol. 1 7 (1987) 445-450
    • (1987) Mol. Endocrinol. , vol.1 , Issue.7 , pp. 445-450
    • Murphy, L.J.1    Murphy, L.C.2    Friesen, H.G.3
  • 13
    • 0024583955 scopus 로고
    • Regulation of uterine insulin-like growth factor I mRNA and insulin-like growth factor II mRNA by estrogen in the rat
    • Norstedt G., Levinovitz A., and Eriksson H. Regulation of uterine insulin-like growth factor I mRNA and insulin-like growth factor II mRNA by estrogen in the rat. Acta Endocrinol. (Copenh.) 120 4 (1989) 466-472
    • (1989) Acta Endocrinol. (Copenh.) , vol.120 , Issue.4 , pp. 466-472
    • Norstedt, G.1    Levinovitz, A.2    Eriksson, H.3
  • 15
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • Gerdes J., Lemke H., Baisch H., Wacker H.H., Schwab U., and Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 133 4 (1984) 1710-1715
    • (1984) J. Immunol. , vol.133 , Issue.4 , pp. 1710-1715
    • Gerdes, J.1    Lemke, H.2    Baisch, H.3    Wacker, H.H.4    Schwab, U.5    Stein, H.6
  • 16
    • 0031045565 scopus 로고    scopus 로고
    • PCNA: structure, functions and interactions
    • Kelman Z. PCNA: structure, functions and interactions. Oncogene 14 6 (1997) 629-640
    • (1997) Oncogene , vol.14 , Issue.6 , pp. 629-640
    • Kelman, Z.1
  • 17
    • 0032569982 scopus 로고    scopus 로고
    • PCNA, a multifunctional ring on DNA
    • Tsurimoto T. PCNA, a multifunctional ring on DNA. Biochim. Biophys. Acta 1443 1-2 (1998) 23-39
    • (1998) Biochim. Biophys. Acta , vol.1443 , Issue.1-2 , pp. 23-39
    • Tsurimoto, T.1
  • 18
    • 0034052849 scopus 로고    scopus 로고
    • An update on estrogen receptors
    • Gustafsson J.A. An update on estrogen receptors. Semin. Perinatol. 24 1 (2000) 66-69
    • (2000) Semin. Perinatol. , vol.24 , Issue.1 , pp. 66-69
    • Gustafsson, J.A.1
  • 20
    • 0037314762 scopus 로고    scopus 로고
    • Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a "ying yang" relationship between ERalpha and ERbeta in mice
    • Lindberg M.K., Moverare S., Skrtic S., Gao H., Dahlman-Wright K., Gustafsson J.A., and Ohlsson C. Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a "ying yang" relationship between ERalpha and ERbeta in mice. Mol. Endocrinol. 17 2 (2003) 203-208
    • (2003) Mol. Endocrinol. , vol.17 , Issue.2 , pp. 203-208
    • Lindberg, M.K.1    Moverare, S.2    Skrtic, S.3    Gao, H.4    Dahlman-Wright, K.5    Gustafsson, J.A.6    Ohlsson, C.7
  • 21
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29 9 (2001) e45
    • (2001) Nucleic Acids Res. , vol.29 , Issue.9
    • Pfaffl, M.W.1
  • 22
    • 0141451919 scopus 로고    scopus 로고
    • The OECD program to validate the rat uterotrophic bioassay. Phase 2: coded single-dose studies
    • Kanno J., Onyon L., Peddada S., Ashby J., Jacob E., and Owens W. The OECD program to validate the rat uterotrophic bioassay. Phase 2: coded single-dose studies. Environ. Health Perspect. 111 12 (2003) 1550-1558
    • (2003) Environ. Health Perspect. , vol.111 , Issue.12 , pp. 1550-1558
    • Kanno, J.1    Onyon, L.2    Peddada, S.3    Ashby, J.4    Jacob, E.5    Owens, W.6
  • 23
    • 0041698394 scopus 로고    scopus 로고
    • The OECD program to validate the rat uterotrophic bioassay. Phase 2: dose-response studies
    • Kanno J., Onyon L., Peddada S., Ashby J., Jacob E., and Owens W. The OECD program to validate the rat uterotrophic bioassay. Phase 2: dose-response studies. Environ. Health Perspect. 111 12 (2003) 1530-1549
    • (2003) Environ. Health Perspect. , vol.111 , Issue.12 , pp. 1530-1549
    • Kanno, J.1    Onyon, L.2    Peddada, S.3    Ashby, J.4    Jacob, E.5    Owens, W.6
  • 24
    • 3042662336 scopus 로고    scopus 로고
    • The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expression
    • Diel P., Geis R.B., Caldarelli A., Schmidt S., Leschowsky U.L., Voss A., and Vollmer G. The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expression. Mol. Cell Endocrinol. 221 1-2 (2004) 21-32
    • (2004) Mol. Cell Endocrinol. , vol.221 , Issue.1-2 , pp. 21-32
    • Diel, P.1    Geis, R.B.2    Caldarelli, A.3    Schmidt, S.4    Leschowsky, U.L.5    Voss, A.6    Vollmer, G.7
  • 27
    • 0035935731 scopus 로고    scopus 로고
    • Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues
    • Meyers M.J., Sun J., Carlson K.E., Marriner G.A., Katzenellenbogen B.S., and Katzenellenbogen J.A. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J. Med. Chem. 44 24 (2001) 4230-4251
    • (2001) J. Med. Chem. , vol.44 , Issue.24 , pp. 4230-4251
    • Meyers, M.J.1    Sun, J.2    Carlson, K.E.3    Marriner, G.A.4    Katzenellenbogen, B.S.5    Katzenellenbogen, J.A.6
  • 29
    • 0030801841 scopus 로고    scopus 로고
    • Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
    • Paech K., Webb P., Kuiper G.G., Nilsson S., Gustafsson J., Kushner P.J., and Scanlan T.S. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 277 5331 (1997) 1508-1510
    • (1997) Science , vol.277 , Issue.5331 , pp. 1508-1510
    • Paech, K.1    Webb, P.2    Kuiper, G.G.3    Nilsson, S.4    Gustafsson, J.5    Kushner, P.J.6    Scanlan, T.S.7
  • 31
    • 0031816540 scopus 로고    scopus 로고
    • Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists
    • Barkhem T., Carlsson B., Nilsson Y., Enmark E., Gustafsson J., and Nilsson S. Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. Mol. Pharmacol. 54 1 (1998) 105-112
    • (1998) Mol. Pharmacol. , vol.54 , Issue.1 , pp. 105-112
    • Barkhem, T.1    Carlsson, B.2    Nilsson, Y.3    Enmark, E.4    Gustafsson, J.5    Nilsson, S.6
  • 32
    • 0035947563 scopus 로고    scopus 로고
    • Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens
    • An J., Tzagarakis-Foster C., Scharschmidt T.C., Lomri N., and Leitman D.C. Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J. Biol. Chem. 276 21 (2001) 17808-17814
    • (2001) J. Biol. Chem. , vol.276 , Issue.21 , pp. 17808-17814
    • An, J.1    Tzagarakis-Foster, C.2    Scharschmidt, T.C.3    Lomri, N.4    Leitman, D.C.5
  • 33
    • 0029927693 scopus 로고    scopus 로고
    • Sex steroid regulation of insulin-like growth factor system gene expression and proliferation in primate myometrium
    • Adesanya O.O., Zhou J., and Bondy C.A. Sex steroid regulation of insulin-like growth factor system gene expression and proliferation in primate myometrium. J. Clin. Endocrinol. Metab. 81 5 (1996) 1967-1974
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , Issue.5 , pp. 1967-1974
    • Adesanya, O.O.1    Zhou, J.2    Bondy, C.A.3
  • 34
    • 0028200830 scopus 로고
    • Estrogen regulation of the estrogen receptor and insulinlike growth factor-I in the rat uterus: a potential coupling between effects of estrogen and IGF-I
    • Sahlin L., Norstedt G., and Eriksson H. Estrogen regulation of the estrogen receptor and insulinlike growth factor-I in the rat uterus: a potential coupling between effects of estrogen and IGF-I. Steroids 59 7 (1994) 421-430
    • (1994) Steroids , vol.59 , Issue.7 , pp. 421-430
    • Sahlin, L.1    Norstedt, G.2    Eriksson, H.3
  • 36
    • 34548395018 scopus 로고    scopus 로고
    • Effects of the chemically synthesized flavanone 7-(O-prenyl)naringenin-4′-acetate on the estrogen signaling pathway in vivo and in vitro
    • Kretzschmar G., Vollmer G., Schwab P., Tischer S., Metz P., and Zierau O. Effects of the chemically synthesized flavanone 7-(O-prenyl)naringenin-4′-acetate on the estrogen signaling pathway in vivo and in vitro. J. Steroid Biochem. Mol. Biol. 107 1-2 (2007) 114-119
    • (2007) J. Steroid Biochem. Mol. Biol. , vol.107 , Issue.1-2 , pp. 114-119
    • Kretzschmar, G.1    Vollmer, G.2    Schwab, P.3    Tischer, S.4    Metz, P.5    Zierau, O.6
  • 37
    • 0020429850 scopus 로고
    • Characterization of the somatomedin-C/insulin-like growth factor I (SM-C/IGF-I) receptor on cultured human fibroblast monolayers: regulation of receptor concentrations by SM-C/IGF-I and insulin
    • Rosenfeld R.G., and Dollar L.A. Characterization of the somatomedin-C/insulin-like growth factor I (SM-C/IGF-I) receptor on cultured human fibroblast monolayers: regulation of receptor concentrations by SM-C/IGF-I and insulin. J. Clin. Endocrinol. Metab. 55 3 (1982) 434-440
    • (1982) J. Clin. Endocrinol. Metab. , vol.55 , Issue.3 , pp. 434-440
    • Rosenfeld, R.G.1    Dollar, L.A.2
  • 38
    • 0020026033 scopus 로고
    • Insulin-induced loss of insulin-like growth factor-I receptors on IM-9 lymphocytes
    • Rosenfeld R.G., Hintz R.L., and Dollar L.A. Insulin-induced loss of insulin-like growth factor-I receptors on IM-9 lymphocytes. Diabetes 31 5 Pt 1 (1982) 375-381
    • (1982) Diabetes , vol.31 , Issue.5 PART 1 , pp. 375-381
    • Rosenfeld, R.G.1    Hintz, R.L.2    Dollar, L.A.3
  • 40
    • 3543012035 scopus 로고    scopus 로고
    • Uterine effects of the phytoestrogen 6-(1,1-dimethylallyl)naringenin in rats
    • Zierau O., Geis R.B., Tischer S., Schwab P., Metz P., and Vollmer G. Uterine effects of the phytoestrogen 6-(1,1-dimethylallyl)naringenin in rats. Planta Med. 70 7 (2004) 590-593
    • (2004) Planta Med. , vol.70 , Issue.7 , pp. 590-593
    • Zierau, O.1    Geis, R.B.2    Tischer, S.3    Schwab, P.4    Metz, P.5    Vollmer, G.6
  • 41
    • 0026092213 scopus 로고
    • Structural features of the human C3 gene: intron/exon organization, transcriptional start site, and promoter region sequence
    • Vik D.P., Amiguet P., Moffat G.J., Fey M., Amiguet-Barras F., Wetsel R.A., and Tack B.F. Structural features of the human C3 gene: intron/exon organization, transcriptional start site, and promoter region sequence. Biochemistry 30 4 (1991) 1080-1085
    • (1991) Biochemistry , vol.30 , Issue.4 , pp. 1080-1085
    • Vik, D.P.1    Amiguet, P.2    Moffat, G.J.3    Fey, M.4    Amiguet-Barras, F.5    Wetsel, R.A.6    Tack, B.F.7
  • 42
    • 0033037866 scopus 로고    scopus 로고
    • Ligand-independent activation of steroid receptors: new roles for old players
    • Cenni B., and Picard D. Ligand-independent activation of steroid receptors: new roles for old players. Trends Endocrinol. Metab. 10 2 (1999) 41-46
    • (1999) Trends Endocrinol. Metab. , vol.10 , Issue.2 , pp. 41-46
    • Cenni, B.1    Picard, D.2
  • 43
    • 0031932603 scopus 로고    scopus 로고
    • Cross-talk between peptide growth factor and estrogen receptor signaling pathways
    • Smith C.L. Cross-talk between peptide growth factor and estrogen receptor signaling pathways. Biol. Reprod. 58 3 (1998) 627-632
    • (1998) Biol. Reprod. , vol.58 , Issue.3 , pp. 627-632
    • Smith, C.L.1
  • 44
    • 33751521711 scopus 로고    scopus 로고
    • Hormonal activity of combinations of genistein, bisphenol A and 17beta-estradiol in the female Wistar rat
    • Schmidt S., Degen G.H., Seibel J., Hertrampf T., Vollmer G., and Diel P. Hormonal activity of combinations of genistein, bisphenol A and 17beta-estradiol in the female Wistar rat. Arch. Toxicol. 80 12 (2006) 839-845
    • (2006) Arch. Toxicol. , vol.80 , Issue.12 , pp. 839-845
    • Schmidt, S.1    Degen, G.H.2    Seibel, J.3    Hertrampf, T.4    Vollmer, G.5    Diel, P.6
  • 46
    • 0037972896 scopus 로고    scopus 로고
    • Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus
    • Frasor J., Barnett D.H., Danes J.M., Hess R., Parlow A.F., and Katzenellenbogen B.S. Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus. Endocrinology 144 7 (2003) 3159-3166
    • (2003) Endocrinology , vol.144 , Issue.7 , pp. 3159-3166
    • Frasor, J.1    Barnett, D.H.2    Danes, J.M.3    Hess, R.4    Parlow, A.F.5    Katzenellenbogen, B.S.6
  • 48
    • 0141995803 scopus 로고    scopus 로고
    • Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model
    • Skliris G.P., Munot K., Bell S.M., Carder P.J., Lane S., Horgan K., Lansdown M.R., Parkes A.T., Hanby A.M., Markham A.F., and Speirs V. Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model. J. Pathol. 201 2 (2003) 213-220
    • (2003) J. Pathol. , vol.201 , Issue.2 , pp. 213-220
    • Skliris, G.P.1    Munot, K.2    Bell, S.M.3    Carder, P.J.4    Lane, S.5    Horgan, K.6    Lansdown, M.R.7    Parkes, A.T.8    Hanby, A.M.9    Markham, A.F.10    Speirs, V.11
  • 50
    • 0035408472 scopus 로고    scopus 로고
    • Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma
    • Leav I., Lau K.M., Adams J.Y., McNeal J.E., Taplin M.E., Wang J., Singh H., and Ho S.M. Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma. Am. J. Pathol. 159 1 (2001) 79-92
    • (2001) Am. J. Pathol. , vol.159 , Issue.1 , pp. 79-92
    • Leav, I.1    Lau, K.M.2    Adams, J.Y.3    McNeal, J.E.4    Taplin, M.E.5    Wang, J.6    Singh, H.7    Ho, S.M.8
  • 52
    • 0030747070 scopus 로고    scopus 로고
    • Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha
    • Pettersson K., Grandien K., Kuiper G.G., and Gustafsson J.A. Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha. Mol. Endocrinol. 11 10 (1997) 1486-1496
    • (1997) Mol. Endocrinol. , vol.11 , Issue.10 , pp. 1486-1496
    • Pettersson, K.1    Grandien, K.2    Kuiper, G.G.3    Gustafsson, J.A.4
  • 53
    • 0030752456 scopus 로고    scopus 로고
    • Estrogen receptors alpha and beta form heterodimers on DNA
    • Cowley S.M., Hoare S., Mosselman S., and Parker M.G. Estrogen receptors alpha and beta form heterodimers on DNA. J. Biol. Chem. 272 32 (1997) 19858-19862
    • (1997) J. Biol. Chem. , vol.272 , Issue.32 , pp. 19858-19862
    • Cowley, S.M.1    Hoare, S.2    Mosselman, S.3    Parker, M.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.