Uterine effects of the phytoestrogen 6-(1,1-dimethylallyl)naringenin in rats

Planta Medica

Volumn 70, Issue 7, 2004, Pages 590-593

  Zierau, Oliver ^a   Geis, Renate B ^a   Tischer, Sandra ^a   Schwab, Pia ^a   Metz, Peter ^a   Vollmer, Günter ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6 (1,1 DIMETHYLALLYL)NARINGENIN; CASTOR OIL; COMPLEMENT COMPONENT C3; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA; PHYTOESTROGEN; PROGESTERONE RECEPTOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; ESTROGEN ACTIVITY; ESTROGEN DEFICIENCY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; NONHUMAN; OVARIECTOMY; RAT; RECEPTOR UPREGULATION; UPREGULATION; UTERUS FUNCTION; UTERUS WEIGHT;

ANIMALS; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLAVANONES; GENISTEIN; ISOFLAVONES; OVARIECTOMY; PHYTOESTROGENS; PHYTOTHERAPY; PLANT PREPARATIONS; RATS; RATS, WISTAR; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UTERUS;

ANIMALIA; CASTOR; RATTUS NORVEGICUS;

EID: 3543012035     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-827178     Document Type: Article

References (14)

1. Cos P, De Bruyne T, Apers S, Vanden Berghe D, Pieters L, Vlietinck AJ. Phytoestrogens: recent developments. Planta Medica 2003; 69: 589-99
2. Ososki AL, Kennelly EJ. Phytoestrogens: a review of the present state of research. Phytother Res. 2003; 17: 845-69
3. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998; 139: 4252-63
4. Whitten PL, Patisaul HB. Cross-species and interassay comparisons of phytoestrogen action. Environ Health Perspect 2001; 109: 5-20
5. Dixon RA, Ferreira D. Genistein. Phytochemistry 2002; 60: 205-11
6. Seo EK, Silva GL, Chai HB, Chagwedera TE, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Cytotoxic prenylated flavanones from Monates engleri. Phytochemistry 1997; 45: 509-15
7. Gester S, Metz P, Zierau O, Vollmer G. An efficient synthesis of the potent phytoestrogens 8-prenylnaringenin and 6-(1,1-dimethylallyl)naringenin by europium(III)-catalyzed Claisen rearrangement. Tetrahedron 2001; 57: 1015-8
8. Zierau O, Morrissey C, Watson RW, Schwab P, Kolba S, Metz P, Vollmer G. Antiandrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl) naringenin and 8-prenylnaringenin. Planta Medica 2003; 69: 856-8
9. Wober J, Weisswange I, Vollmer G. Stimulation of alkaline phosphatase activity in Ishikawa cells induced by various phytoestrogens and synthetic estrogens. J Steroid Biochem Mol Biol 2002; 83: 227-33
10. Zierau O, Gester S, Schwab P, Metz P, Kolba S, Wulf M, Vollmer G. Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl) naringenin and 8-prenylnaringenin. Planta Medica 2002; 68: 449-51
11. Diel P, Thomae RB, Caldarelli A, Zierau O, Kolba S, Schmidt S, Schwab P, Metz P, Vollmer G. Regulation of gene expression by 8-prenylnaringenin in uterus and liver of Wistar rats. Planta Medica 2004; 70: 39-44
12. Schaefer O, Humpel M, Fritzemeier KH, Bohlmann R, Schleuning WD. 8-Prenylnaringenin is a potent ERalpha selective phytoestrogen present in hops and beer. J Steroid Biochem Mol Biol 2003; 84: 359-60
13. Diel P, Schulz T, Smolnikar K, Strunck E, Vollmer G, Michna H. Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity. J Steroid Biochem Mol Biol 2000; 73: -10
14. Winer J, Jung CK, Shackel I, Williams PM. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem. 1999; 270: 41-9