Studies on in vitro and in vivo transdermal flux enhancement of methotrexate by a combinational approach in comparison to oral delivery Enhanced transdermal versus oral delivery

Drug Development and Industrial Pharmacy

Volumn 35, Issue 11, 2009, Pages 1281-1292

  Prasad, Rachna ^a,b   Anand, Sneh ^a,b   Khar, Roop K ^c   Dinda, Amit K ^b   Koul, Veena ^a,b  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c HAMDARD UNIVERSITY   (India)

Author keywords

ATRFTIR; Chemical enhancers; MDC iontophoresisMethotrexate; SEM; Skin histopathology; Transdermal delivery

Indexed keywords

ACETIC ACID ETHYL ESTER; ALCOHOL; MENTHOL; METHOTREXATE; PENETRATION ENHANCING AGENT; TERPENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; HISTOPATHOLOGY; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; IONTOPHORESIS; MOUSE; NONHUMAN; REFLECTOMETRY; SCANNING ELECTRON MICROSCOPY; SKIN;

ACETATES; ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BIOPHYSICAL PROCESSES; DRUG CARRIERS; ETHANOL; HYDROGELS; IONTOPHORESIS; MENTHOL; METHOTREXATE; MICE; MICROSCOPY, ELECTRON, SCANNING; SKIN; SKIN ABSORPTION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 70350303880     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639040902882322     Document Type: Article

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