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Volumn 10, Issue 6, 1998, Pages 694-701

Spermatogonial stem cells

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEIN P53;

EID: 0031744069     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(98)80109-9     Document Type: Article
Times cited : (291)

References (67)
  • 1
    • 0007396619 scopus 로고
    • Proliferation and differentiation of undifferentiated spermatogonia in the mammalian testis
    • Potten C.S. Edinburgh: Churchill Livingstone
    • De Rooij DG. Proliferation and differentiation of undifferentiated spermatogonia in the mammalian testis. Potten CS. Stem cells. Their Identification and Characterization. 1983;89-117 Churchill Livingstone, Edinburgh.
    • (1983) Stem Cells. Their Identification and Characterization , pp. 89-117
    • De Rooij, D.G.1
  • 2
    • 0002025446 scopus 로고    scopus 로고
    • Regulation of proliferation and differentiation of stem cells in the male germ line
    • of special interest. Potten C.S. Academic Press London This reviews testicular development, and the growth factors which are present in the basal compartment of the seminiferous tubules and which are possibly involved in regulating spermatogonial proliferation and differentiation.
    • De Rooij DG, Van Dissel-Emiliani FMF. Regulation of proliferation and differentiation of stem cells in the male germ line. of special interest Potten CS. Stem Cells. 1997;283-313 Academic Press, London, This reviews testicular development, and the growth factors which are present in the basal compartment of the seminiferous tubules and which are possibly involved in regulating spermatogonial proliferation and differentiation.
    • (1997) Stem Cells , pp. 283-313
    • De Rooij, D.G.1    Van Dissel-Emiliani, F.M.F.2
  • 3
    • 0015027168 scopus 로고
    • The spermatogonial stem cell population in adult rats. I. Their morphology, proliferation and maturation
    • Huckins C. The spermatogonial stem cell population in adult rats. I. Their morphology, proliferation and maturation. Anat Rec. 169:1971;533-558.
    • (1971) Anat Rec , vol.169 , pp. 533-558
    • Huckins, C.1
  • 4
    • 0015025552 scopus 로고
    • Spermatogonial stem-cell renewal in the mouse
    • Oakberg EF. Spermatogonial stem-cell renewal in the mouse. Anat Rec. 169:1971;515-532.
    • (1971) Anat Rec , vol.169 , pp. 515-532
    • Oakberg, E.F.1
  • 5
    • 0031971972 scopus 로고    scopus 로고
    • Stem cells in the testis
    • 1 (first generation differentiating) spermatogonia and undifferentiated spermatogonia.
    • 1 (first generation differentiating) spermatogonia and undifferentiated spermatogonia.
    • (1998) Int J Exp Pathol , vol.79 , pp. 67-80
    • De Rooij, D.G.1
  • 6
    • 0030818772 scopus 로고    scopus 로고
    • Loss of telomerase activity during male germ cell differentiation
    • of outstanding interest. Demonstrates that A spermatogonia very strongly express telomerase and that this expression decreases with further development of the spermatogenic cells until expression disappears in late spermatids.
    • Ravindranath N, Dalal R, Solomon B, Djakiew D, Dym M. Loss of telomerase activity during male germ cell differentiation. of outstanding interest Endocrinology. 138:1997;4026-4029 Demonstrates that A spermatogonia very strongly express telomerase and that this expression decreases with further development of the spermatogenic cells until expression disappears in late spermatids.
    • (1997) Endocrinology , vol.138 , pp. 4026-4029
    • Ravindranath, N.1    Dalal, R.2    Solomon, B.3    Djakiew, D.4    Dym, M.5
  • 7
    • 0021142404 scopus 로고
    • Response to fission neutron irradiation of spermatogonial stem cells in different stages of the cycle of the seminiferous epithelium
    • Van Beek MEAB, Davids JAG, Van de Kant HJG, De Rooij DG. Response to fission neutron irradiation of spermatogonial stem cells in different stages of the cycle of the seminiferous epithelium. Radiat Res. 97:1984;556-569.
    • (1984) Radiat Res , vol.97 , pp. 556-569
    • Van Beek, M.E.A.B.1    Davids, J.A.G.2    Van De Kant, H.J.G.3    De Rooij, D.G.4
  • 9
    • 0345260209 scopus 로고    scopus 로고
    • Molecular biology of gametogenesis: Spermatogenesis
    • of special interest. B.C.J.M. Fauser, A.J. Rutherford, J.F. Straus, von Steirteghem A. Parthenon Publishing Carnforth Gives an overview of molecular and cellular aspects of mammalian spermatogenesis.
    • Baarends WM, Grootegoed JA. Molecular biology of gametogenesis: spermatogenesis. of special interest Fauser BCJM, Rutherford AJ, Straus JF, von Steirteghem A. Molecular Biology in Clinical Reproductive Medicine. 1998;Parthenon Publishing, Carnforth, Gives an overview of molecular and cellular aspects of mammalian spermatogenesis.
    • (1998) Molecular Biology in Clinical Reproductive Medicine
    • Baarends, W.M.1    Grootegoed, J.A.2
  • 11
    • 0023835079 scopus 로고
    • Rat testis during 2,5-hexanedione intoxication and recovery. I. Dose response and the reversibility of germ cell loss
    • Boekelheide K. Rat testis during 2,5-hexanedione intoxication and recovery. I. Dose response and the reversibility of germ cell loss. Toxicol Appl Pharmacol. 92:1988;18-27.
    • (1988) Toxicol Appl Pharmacol , vol.92 , pp. 18-27
    • Boekelheide, K.1
  • 12
    • 0029044373 scopus 로고
    • Stem cell kinetics in rat testis after irreversible injury induced by 2,5-hexanedione
    • Allard EK, Hall SJ, Boekelheide K. Stem cell kinetics in rat testis after irreversible injury induced by 2,5-hexanedione. Biol Reprod. 53:1995;186-192.
    • (1995) Biol Reprod , vol.53 , pp. 186-192
    • Allard, E.K.1    Hall, S.J.2    Boekelheide, K.3
  • 13
    • 0029988507 scopus 로고    scopus 로고
    • Fate of germ cells in 2,5-hexanedione-induced testicular injury. II. Atrophy persists due to a reduced stem cell mass and ongoing apoptosis
    • Allard EK, Boekelheide K. Fate of germ cells in 2,5-hexanedione-induced testicular injury. II. Atrophy persists due to a reduced stem cell mass and ongoing apoptosis. Toxicol Appl Pharmacol. 137:1996;149-156.
    • (1996) Toxicol Appl Pharmacol , vol.137 , pp. 149-156
    • Allard, E.K.1    Boekelheide, K.2
  • 14
    • 0029872649 scopus 로고    scopus 로고
    • Failure of spermatogenesis to recover despite the presence of A spermatogonia in the irradiated LBNF1 rat
    • Kangasniemi M, Huhtaniemi I, Meistrich ML. Failure of spermatogenesis to recover despite the presence of A spermatogonia in the irradiated LBNF1 rat. Biol Reprod. 54:1996;1200-1208.
    • (1996) Biol Reprod , vol.54 , pp. 1200-1208
    • Kangasniemi, M.1    Huhtaniemi, I.2    Meistrich, M.L.3
  • 15
    • 0029816118 scopus 로고    scopus 로고
    • Exogenous stem cell factor (SCF) compensates for altered endogenous SCF expression in 2,5-hexanedione-induced testicular atrophy in rats
    • Allard EK, Blanchard KT, Boekelheide K. Exogenous stem cell factor (SCF) compensates for altered endogenous SCF expression in 2,5-hexanedione-induced testicular atrophy in rats. Biol Reprod. 55:1996;185-193.
    • (1996) Biol Reprod , vol.55 , pp. 185-193
    • Allard, E.K.1    Blanchard, K.T.2    Boekelheide, K.3
  • 16
    • 0030968289 scopus 로고    scopus 로고
    • Protection from procarbazine-induced testicular damage by hormonal pretreatment does not involve arrest of spermatogonial proliferation
    • of special interest. Hormone treatments that suppress sperm production enhance the recovery of spermatogenesis after gonadal exposure to various cytotoxic agents. While it was generally assumed that the mechanism of protection involved an arrest of spermatogonial kinetics, no decrease or inhibition in spermatogonial cell numbers and bromodeoxyuridine incorporation were observed. Thus, changes in spermatogonial numbers or suppression of their proliferation cannot account for protection of spermatogenesis from exposure to cytotoxic agents.
    • Meistrich ML, Wilson G, Zhang Y, Kurdoglu B, Terry NH. Protection from procarbazine-induced testicular damage by hormonal pretreatment does not involve arrest of spermatogonial proliferation. of special interest Cancer Res. 57:1997;1091-1097 Hormone treatments that suppress sperm production enhance the recovery of spermatogenesis after gonadal exposure to various cytotoxic agents. While it was generally assumed that the mechanism of protection involved an arrest of spermatogonial kinetics, no decrease or inhibition in spermatogonial cell numbers and bromodeoxyuridine incorporation were observed. Thus, changes in spermatogonial numbers or suppression of their proliferation cannot account for protection of spermatogenesis from exposure to cytotoxic agents.
    • (1997) Cancer Res , vol.57 , pp. 1091-1097
    • Meistrich, M.L.1    Wilson, G.2    Zhang, Y.3    Kurdoglu, B.4    Terry, N.H.5
  • 17
    • 0031056570 scopus 로고    scopus 로고
    • Hormone treatment after irradiation stimulates recovery of rat spermatogenesis from surviving spermatogonia
    • of outstanding interest. In LBNF rats, after irradiation there is a depletion of the seminiferous epithelium followed by recovery from surviving spermatogonial stem cells. Thereafter, surprisingly, spermatogenesis deteriorates and ultimately actively dividing A spermatogonia remain unable to produce more differentiated cells. Suppression of gonadotropin and testosterone levels through GnRH agonist (GnRH-Ag) treatment or continuous treatment with testosterone markedly stimulates the recovery of spermatogenesis. Sperm counts in GnRH-treated rats were 100-fold higher than in untreated rats. Since all of the hormone treatments suppress intratesticular testosterone, it is suggested that high levels of testosterone inhibit differentiation and their suppression may stimulate recovery.
    • Meistrich ML, Kangasniemi M. Hormone treatment after irradiation stimulates recovery of rat spermatogenesis from surviving spermatogonia. of outstanding interest J Androl. 18:1997;80-87 In LBNF rats, after irradiation there is a depletion of the seminiferous epithelium followed by recovery from surviving spermatogonial stem cells. Thereafter, surprisingly, spermatogenesis deteriorates and ultimately actively dividing A spermatogonia remain unable to produce more differentiated cells. Suppression of gonadotropin and testosterone levels through GnRH agonist (GnRH-Ag) treatment or continuous treatment with testosterone markedly stimulates the recovery of spermatogenesis. Sperm counts in GnRH-treated rats were 100-fold higher than in untreated rats. Since all of the hormone treatments suppress intratesticular testosterone, it is suggested that high levels of testosterone inhibit differentiation and their suppression may stimulate recovery.
    • (1997) J Androl , vol.18 , pp. 80-87
    • Meistrich, M.L.1    Kangasniemi, M.2
  • 18
    • 0031938329 scopus 로고    scopus 로고
    • Hormonal stimulation of the recovery of spermatogenesis following chemo- Or radiotherapy
    • of special interest. Review on the possibilities of protecting the seminiferous epithelium from damage inflicted by irradiation and cytotoxic drugs using hormone treatment.
    • Meistrich ML. Hormonal stimulation of the recovery of spermatogenesis following chemo- or radiotherapy. of special interest APMIS. 106:1998;37-45 Review on the possibilities of protecting the seminiferous epithelium from damage inflicted by irradiation and cytotoxic drugs using hormone treatment.
    • (1998) APMIS , vol.106 , pp. 37-45
    • Meistrich, M.L.1
  • 19
    • 0028067646 scopus 로고
    • Sustained suppression of the pituitary-gonadal axis by leuprolin three-month depot microspheres in rats and dogs
    • Okada H, Doken Y, Ogawa Y, Toguchi H. Sustained suppression of the pituitary-gonadal axis by leuprolin three-month depot microspheres in rats and dogs. Pharmacol Res. 11:1994;1199-1203.
    • (1994) Pharmacol Res , vol.11 , pp. 1199-1203
    • Okada, H.1    Doken, Y.2    Ogawa, Y.3    Toguchi, H.4
  • 20
    • 0344397328 scopus 로고
    • From white spots to stem cells: The role of the Kit receptor in mammalian development
    • Fleischman RA. From white spots to stem cells: the role of the Kit receptor in mammalian development. Trends Genet. 15:1993;205-206.
    • (1993) Trends Genet , vol.15 , pp. 205-206
    • Fleischman, R.A.1
  • 21
    • 0025611985 scopus 로고
    • Gonadal expression of c-kit encoded at the W locus of the mouse
    • Manova K, Nocka K, Besmer P, Bachvarova RF. Gonadal expression of c-kit encoded at the W locus of the mouse. Development. 110:1990;1057-1069.
    • (1990) Development , vol.110 , pp. 1057-1069
    • Manova, K.1    Nocka, K.2    Besmer, P.3    Bachvarova, R.F.4
  • 22
    • 0026094395 scopus 로고
    • Role of c-kit in mouse spermatogenesis: Identification of spermatogonia as a specific site of c-kit expression and function
    • Yoshinaga K, Nishikawa S, Osawa M, Hayashi S, Kunisada T, Fujimoto T, Nishikawa SI. Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function. Development. 113:1991;689-699.
    • (1991) Development , vol.113 , pp. 689-699
    • Yoshinaga, K.1    Nishikawa, S.2    Osawa, M.3    Hayashi, S.4    Kunisada, T.5    Fujimoto, T.6    Nishikawa, S.I.7
  • 23
    • 0030456865 scopus 로고    scopus 로고
    • Isolation of highly purified type A spermatogonia from prepuberal rat testis
    • Morena AR, Boitani C, Pesce M, De Felici M, Stefanini M. Isolation of highly purified type A spermatogonia from prepuberal rat testis. J Androl. 17:1996;708-717.
    • (1996) J Androl , vol.17 , pp. 708-717
    • Morena, A.R.1    Boitani, C.2    Pesce, M.3    De Felici, M.4    Stefanini, M.5
  • 24
    • 85011500653 scopus 로고    scopus 로고
    • Leuprolide, a gonadotropin-releasing hormone agonist, reestablishes spermatogenesis after 2,5-hexanedione-induced irreversible testicular injury in the rat, resulting in normalized stem cell factor expression
    • of outstanding interest Shows that at the start of spermatogenesis Sertoli cells shift the production of stem cell factor (SCF) from the soluble form to the membrane-bound form. In 2,5-hexanedione-treated rats with deteriorated spermatogenesis the Sertoli cells predominantly produce soluble SCF. Suppression of gonadotropic hormones in these rats causes a recovery of spermatogenesis and in the Sertoli cells an increased production of membrane-bound SCF takes place. Hence, the quality of the spermatogenic process correlates with the production of membrane bound SCF.
    • Blanchard KT, Lee J, Boekelheide K. Leuprolide, a gonadotropin-releasing hormone agonist, reestablishes spermatogenesis after 2,5-hexanedione-induced irreversible testicular injury in the rat, resulting in normalized stem cell factor expression. Endocrinology. 139:1998;236-244. of outstanding interest Shows that at the start of spermatogenesis Sertoli cells shift the production of stem cell factor (SCF) from the soluble form to the membrane-bound form. In 2,5-hexanedione-treated rats with deteriorated spermatogenesis the Sertoli cells predominantly produce soluble SCF. Suppression of gonadotropic hormones in these rats causes a recovery of spermatogenesis and in the Sertoli cells an increased production of membrane-bound SCF takes place. Hence, the quality of the spermatogenic process correlates with the production of membrane bound SCF.
    • (1998) Endocrinology , vol.139 , pp. 236-244
    • Blanchard, K.T.1    Lee, J.2    Boekelheide, K.3
  • 25
    • 0026058850 scopus 로고
    • White-spotting mutations affect the regenerative differentiation of testicular germ cells: Demonstration by experimental cryptorchidism and its surgical reversal
    • Koshimizu U, Sawada K, Tajima Y, Watanabe D, Nishimune Y. White-spotting mutations affect the regenerative differentiation of testicular germ cells: demonstration by experimental cryptorchidism and its surgical reversal. Biol Reprod. 45:1991;642-648.
    • (1991) Biol Reprod , vol.45 , pp. 642-648
    • Koshimizu, U.1    Sawada, K.2    Tajima, Y.3    Watanabe, D.4    Nishimune, Y.5
  • 27
    • 84939663814 scopus 로고
    • Cytological changes in the testis of vitamin A deficient rats. I. Quantitation of germinal cells in the seminiferous tubules
    • Mitranond V, Sobhon P, Tosukhowong P, Chindaduangrat W. Cytological changes in the testis of vitamin A deficient rats. I. Quantitation of germinal cells in the seminiferous tubules. Acta Anat. 103:1979;159-168.
    • (1979) Acta Anat , vol.103 , pp. 159-168
    • Mitranond, V.1    Sobhon, P.2    Tosukhowong, P.3    Chindaduangrat, W.4
  • 30
    • 0018676393 scopus 로고
    • Spermatogenic response to vitamin A in vitamin A deficient rats
    • Huang HFS, Hembree WC. Spermatogenic response to vitamin A in vitamin A deficient rats. Biol Reprod. 21:1979;891-904.
    • (1979) Biol Reprod , vol.21 , pp. 891-904
    • Huang, H.F.S.1    Hembree, W.C.2
  • 31
    • 0023269868 scopus 로고
    • Retinol-induced stage synchronization in seminiferous tubules of the rat
    • Morales C, Griswold MD. Retinol-induced stage synchronization in seminiferous tubules of the rat. Endocrinology. 121:1987;432-434.
    • (1987) Endocrinology , vol.121 , pp. 432-434
    • Morales, C.1    Griswold, M.D.2
  • 32
    • 0025277718 scopus 로고
    • The origin of the synchronization of the seminiferous epithelium in vitamin A-deficient rats after vitamin A replacement
    • Van Pelt AMM, De Rooij DG. The origin of the synchronization of the seminiferous epithelium in vitamin A-deficient rats after vitamin A replacement. Biol Reprod. 42:1990;677-682.
    • (1990) Biol Reprod , vol.42 , pp. 677-682
    • Van Pelt, A.M.M.1    De Rooij, D.G.2
  • 33
    • 0025979947 scopus 로고
    • Retinoic acid is able to reinitiate spermatogenesis in vitamin A-deficient rats and high, replicate doses support the full development of spermatogenic cells
    • Van Pelt AMM, De Rooij DG. Retinoic acid is able to reinitiate spermatogenesis in vitamin A-deficient rats and high, replicate doses support the full development of spermatogenic cells. Endocrinology. 128:1991;697-704.
    • (1991) Endocrinology , vol.128 , pp. 697-704
    • Van Pelt, A.M.M.1    De Rooij, D.G.2
  • 34
    • 0030053685 scopus 로고    scopus 로고
    • 4-Oxo-retinoic acid: A potent inducer of in vivo proliferation of growth arrested A spermatogonia in the vitamin A deficient mouse testis
    • Gaemers IC, Van Pelt AMM, Van der Saag PT, De Rooij DG. 4-Oxo-retinoic acid: a potent inducer of in vivo proliferation of growth arrested A spermatogonia in the vitamin A deficient mouse testis. Endocrinology. 137:1996;479-485.
    • (1996) Endocrinology , vol.137 , pp. 479-485
    • Gaemers, I.C.1    Van Pelt, A.M.M.2    Van Der Saag, P.T.3    De Rooij, D.G.4
  • 35
    • 0031733787 scopus 로고    scopus 로고
    • The effect of 9-cis-retinoic acid on proliferation and differentiation of A spermatogonia and nuclear retinoic acid receptor gene expression in the vitamin-A deficient mouse testis
    • of special interest In the vitamin A deficient mouse testis spermatogenesis is arrested at the differentiation of undifferentiated spermatogonia stage. In this situation, 9-cis-retinoic acid is able to cause a reinitiation of spermatogenesis but is less efficient than retinoic acid and even inhibits the action of retinoic acid upon simultaneous administration.
    • Gaemers IC, Sonneveld E, Van Pelt AMM, Schrans BGHJ, Themmen APN, Van der Saag PT, De Rooij DG. The effect of 9-cis-retinoic acid on proliferation and differentiation of A spermatogonia and nuclear retinoic acid receptor gene expression in the vitamin-A deficient mouse testis. Endocrinology. 139:1998;4269-4276. of special interest In the vitamin A deficient mouse testis spermatogenesis is arrested at the differentiation of undifferentiated spermatogonia stage. In this situation, 9-cis-retinoic acid is able to cause a reinitiation of spermatogenesis but is less efficient than retinoic acid and even inhibits the action of retinoic acid upon simultaneous administration.
    • (1998) Endocrinology , vol.139 , pp. 4269-4276
    • Gaemers, I.C.1    Sonneveld, E.2    Van Pelt, A.M.M.3    Schrans, B.G.H.J.4    Themmen, A.P.N.5    Van Der Saag, P.T.6    De Rooij, D.G.7
  • 36
    • 0031838680 scopus 로고    scopus 로고
    • Differential expression pattern of retinoid X receptors in adult murine testicular cells implies varying roles for these receptors in spermatogenesis
    • of outstanding interest. Demonstrates by way of immunohistochemistry that A spermatogonia express the alpha, beta and gamma nuclear retinoid X receptors.
    • Gaemers IC, Van Pelt AMM, Van der Saag PT, Hoogerbrugge JW, Themmen APN, De Rooij DG. Differential expression pattern of retinoid X receptors in adult murine testicular cells implies varying roles for these receptors in spermatogenesis. of outstanding interest Biol Reprod. 58:1998;1351-1356 Demonstrates by way of immunohistochemistry that A spermatogonia express the alpha, beta and gamma nuclear retinoid X receptors.
    • (1998) Biol Reprod , vol.58 , pp. 1351-1356
    • Gaemers, I.C.1    Van Pelt, A.M.M.2    Van Der Saag, P.T.3    Hoogerbrugge, J.W.4    Themmen, A.P.N.5    De Rooij, D.G.6
  • 38
    • 0023153572 scopus 로고
    • The regulation of the density of spermatogonia in the seminiferous epithelium of the Chinese hamster. I. Undifferentiated spermatogonia
    • De Rooij DG, Janssen JM. The regulation of the density of spermatogonia in the seminiferous epithelium of the Chinese hamster. I. Undifferentiated spermatogonia. Anat Rec. 217:1987;124-130.
    • (1987) Anat Rec , vol.217 , pp. 124-130
    • De Rooij, D.G.1    Janssen, J.M.2
  • 39
    • 0023103587 scopus 로고
    • The regulation of the density of spermatogonia in the seminiferous epithelium of the Chinese hamster. II. Differentiating spermatogonia
    • De Rooij DG, Lok D. The regulation of the density of spermatogonia in the seminiferous epithelium of the Chinese hamster. II. Differentiating spermatogonia. Anat Rec. 217:1987;131-136.
    • (1987) Anat Rec , vol.217 , pp. 131-136
    • De Rooij, D.G.1    Lok, D.2
  • 40
    • 0344397326 scopus 로고    scopus 로고
    • Cell loss during spermatogenesis: Apoptosis or necrosis?
    • of outstanding interest. S. Hamamah, R. Mieusset, F. Olivenes, P. Jouannet, Frydman R. Springer Verlag New York Describes the morphology of the apoptotic process during spermatogenesis and reviews the circumstances under which apoptosis takes place.
    • Russell LD. Cell loss during spermatogenesis: apoptosis or necrosis? of outstanding interest Hamamah S, Mieusset R, Olivenes F, Jouannet P, Frydman R. Male Sterility for Motility Disorders: Etiological Factors and Treatment. 1998;Springer Verlag, New York, Describes the morphology of the apoptotic process during spermatogenesis and reviews the circumstances under which apoptosis takes place.
    • (1998) Male Sterility for Motility Disorders: Etiological Factors and Treatment
    • Russell, L.D.1
  • 41
    • 0028859541 scopus 로고    scopus 로고
    • Bax-deficient mice with lymphoid hyperplasia and male germ cell death
    • Korsmeyer SJ. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science. 270:1995;96-99.
    • (1995) Science , vol.270 , pp. 96-99
    • Korsmeyer, S.J.1
  • 42
    • 0030916669 scopus 로고    scopus 로고
    • The proto-oncogene Bcl-2 and its role in regulating apoptosis
    • of special interest. Discusses present knowledge on Bcl-2 and family members and apoptosis in general.
    • Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. of special interest Nat Med. 3:1997;614-620 Discusses present knowledge on Bcl-2 and family members and apoptosis in general.
    • (1997) Nat Med , vol.3 , pp. 614-620
    • Kroemer, G.1
  • 43
    • 0029043811 scopus 로고
    • Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 production suggests a unique role for Mcl-1 in control of programmed cell death in vivo
    • Krajewski S, Bodrug S, Krajewska M, Shabaik A, Gascoyne R, Berean K, Reed JC. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol. 146:1995;1309-1319.
    • (1995) Am J Pathol , vol.146 , pp. 1309-1319
    • Krajewski, S.1    Bodrug, S.2    Krajewska, M.3    Shabaik, A.4    Gascoyne, R.5    Berean, K.6    Reed, J.C.7
  • 44
    • 0030975776 scopus 로고    scopus 로고
    • An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis
    • L or Bcl-2 proteins in the male germinal cells show a highly abnormal adult spermatogenesis accompanied by sterility. Photographs of adult testes of transgenic mice show many spermatogonia and few spermatocytes.
    • L or Bcl-2 proteins in the male germinal cells show a highly abnormal adult spermatogenesis accompanied by sterility. Photographs of adult testes of transgenic mice show many spermatogonia and few spermatocytes.
    • (1997) EMBO J , vol.16 , pp. 2262-2270
    • Rodriguez, I.1    Ody, C.2    Araki, K.3    Garcia, I.4    Vassalli, P.5
  • 45
    • 0030003958 scopus 로고    scopus 로고
    • Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia
    • Furuchi T, Masuko K, Nishimune Y, Obinata M, Matsui Y. Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia. Development. 122:1996;1703-1709.
    • (1996) Development , vol.122 , pp. 1703-1709
    • Furuchi, T.1    Masuko, K.2    Nishimune, Y.3    Obinata, M.4    Matsui, Y.5
  • 46
    • 4244174264 scopus 로고    scopus 로고
    • Regulation of apoptosis in the testis
    • of special interest. S. Hamamah, R. Mieusset, F. Olivenes, P. Jouannet, Frydman R. Springer Verlag New York This paper shows for the first time a strong immunohistochemical staining with an antibody that binds to both the long and short form of Bcl-x in spermatogonia in the human testis. This suggests the involvement of Bcl-x in the regulation of spermatogonial apoptosis.
    • Beumer TL, De Rooij DG. Regulation of apoptosis in the testis. of special interest Hamamah S, Mieusset R, Olivenes F, Jouannet P, Frydman R. Male Sterility for Motility Disorders: Etiological Factors and Treatment. 1998;Springer Verlag, New York, This paper shows for the first time a strong immunohistochemical staining with an antibody that binds to both the long and short form of Bcl-x in spermatogonia in the human testis. This suggests the involvement of Bcl-x in the regulation of spermatogonial apoptosis.
    • (1998) Male Sterility for Motility Disorders: Etiological Factors and Treatment
    • Beumer, T.L.1    De Rooij, D.G.2
  • 48
    • 0031906439 scopus 로고    scopus 로고
    • Testicular degeneration in Bclw-deficient mice
    • of special interest. Mice deficient for the apoptosis-promoting protein Bclw exhibit sterility associated with progressive testicular degeneration. Germ-cell defects are first observed at 19 days after birth and spermatogenesis is blocked during late spermiogenesis in young adults. Gradual depletion of all stages of germ cells results in a Sertoli-cell-only phenotype by approximately six months of age. Subsequently, almost all Sertoli cells are lost from the seminiferous tubules and in the interstitial tissue, in between the seminiferous tubules, the numbers of testosterone producing Leydig cells is reduced. Expression of the Bclw protein in the testis appears to be restricted to elongating spermatids and Sertoli cells.
    • Ross AJ, Waymire KG, Moss JE, Parlow AF, Skinner MK, Russell LD, MacGregor GR. Testicular degeneration in Bclw-deficient mice. of special interest Nat Genet. 18:1998;251-256 Mice deficient for the apoptosis-promoting protein Bclw exhibit sterility associated with progressive testicular degeneration. Germ-cell defects are first observed at 19 days after birth and spermatogenesis is blocked during late spermiogenesis in young adults. Gradual depletion of all stages of germ cells results in a Sertoli-cell-only phenotype by approximately six months of age. Subsequently, almost all Sertoli cells are lost from the seminiferous tubules and in the interstitial tissue, in between the seminiferous tubules, the numbers of testosterone producing Leydig cells is reduced. Expression of the Bclw protein in the testis appears to be restricted to elongating spermatids and Sertoli cells.
    • (1998) Nat Genet , vol.18 , pp. 251-256
    • Ross, A.J.1    Waymire, K.G.2    Moss, J.E.3    Parlow, A.F.4    Skinner, M.K.5    Russell, L.D.6    MacGregor, G.R.7
  • 49
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • of special interest. Reviews the characteristics of p53.
    • Levine AJ. P53, the cellular gatekeeper for growth and division. of special interest Cell. 88:1997;323-331 Reviews the characteristics of p53.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 51
    • 0027263715 scopus 로고
    • Expression of p53 protein in spermatogenesis is confined to the tetraploid pachytene primary spermatocytes
    • Schwartz D, Goldfinger N, Rotter V. Expression of p53 protein in spermatogenesis is confined to the tetraploid pachytene primary spermatocytes. Oncogene. 8:1993;1487-1494.
    • (1993) Oncogene , vol.8 , pp. 1487-1494
    • Schwartz, D.1    Goldfinger, N.2    Rotter, V.3
  • 52
    • 0029890017 scopus 로고    scopus 로고
    • Expression of p53 in normal and gamma-irradiated rat testis suggests a role for p 53 in meiotic recombination and repair
    • Sjöblom T, Lähdetie J. Expression of p53 in normal and gamma-irradiated rat testis suggests a role for p 53 in meiotic recombination and repair. Oncogene. 12:1996;2499-2505.
    • (1996) Oncogene , vol.12 , pp. 2499-2505
    • Sjöblom, T.1    Lähdetie, J.2
  • 53
    • 0031846479 scopus 로고    scopus 로고
    • The role of the tumor suppressor p53 in spermatogenesis
    • 1 spermatogonia is increased but not that of preleptotene spermatocytes, indicating that p53 is involved in the regulation of the proliferation of undifferentiated spermatogonia but does not play a role in germ cell density regulation.
    • 1 spermatogonia is increased but not that of preleptotene spermatocytes, indicating that p53 is involved in the regulation of the proliferation of undifferentiated spermatogonia but does not play a role in germ cell density regulation.
    • (1998) Cell Death Differ , vol.5 , pp. 669-677
    • Beumer, T.L.1    Roepers-Gajadien, H.L.2    Van Buul, P.P.W.3    Gill-Gomez, G.4    Gademan, I.S.5    Rutgers, D.H.6    De Rooij, D.G.7
  • 55
    • 0030453081 scopus 로고    scopus 로고
    • P53 deficiency produces fewer regenerating spermatogenic tubules after irradiation
    • Hendry JH, Adeeko A, Potten CS, Morris ID. P53 deficiency produces fewer regenerating spermatogenic tubules after irradiation. Int J Radiat Biol. 70:1996;677-682.
    • (1996) Int J Radiat Biol , vol.70 , pp. 677-682
    • Hendry, J.H.1    Adeeko, A.2    Potten, C.S.3    Morris, I.D.4
  • 56
    • 0031892878 scopus 로고    scopus 로고
    • Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice
    • of outstanding interest. Demonstrates that, in the mouse, p53 deficiency increases the resistance of differentiating spermatogonia (but not of spermatogonial stem cells) to radiation. Lethally irradiated spermatogonia do not undergo apoptosis within 24 hours.
    • Hasegawa M, Zhang Y, Niibe H, Terry NHA, Meistrich ML. Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice. of outstanding interest Radiat Res. 149:1998;263-270 Demonstrates that, in the mouse, p53 deficiency increases the resistance of differentiating spermatogonia (but not of spermatogonial stem cells) to radiation. Lethally irradiated spermatogonia do not undergo apoptosis within 24 hours.
    • (1998) Radiat Res , vol.149 , pp. 263-270
    • Hasegawa, M.1    Zhang, Y.2    Niibe, H.3    Terry, N.H.A.4    Meistrich, M.L.5
  • 57
    • 0031883862 scopus 로고    scopus 로고
    • The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis
    • of special interest. Double strand breaks in the DNA, induced by irradiation, are known to trigger apoptosis in a number of cell types via a p53-dependent pathway. It is shown that irradiation-induced spermatogonial apoptosis is also p53-dependent. In contrast, the apoptotic elimination of spermatocytes with synaptic errors proved to be p53-independent.
    • Odorisio T, Rodriguez TA, Evans EP, Clarke AR, Burgoyne PS. The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis. of special interest Nat Genet. 18:1998;257-261 Double strand breaks in the DNA, induced by irradiation, are known to trigger apoptosis in a number of cell types via a p53-dependent pathway. It is shown that irradiation-induced spermatogonial apoptosis is also p53-dependent. In contrast, the apoptotic elimination of spermatocytes with synaptic errors proved to be p53-independent.
    • (1998) Nat Genet , vol.18 , pp. 257-261
    • Odorisio, T.1    Rodriguez, T.A.2    Evans, E.P.3    Clarke, A.R.4    Burgoyne, P.S.5
  • 58
    • 0030611983 scopus 로고    scopus 로고
    • WAF1 expression during spermatogenesis of the normal and X-irradiated rat
    • WAF1 expression in spermatogonia.
    • WAF1 expression in spermatogonia.
    • (1997) Int J Radiat Biol , vol.73 , pp. 283-291
    • West, A.1    Lähdetie, J.2
  • 59
    • 0027942611 scopus 로고
    • Spermatogenesis following male germ-cell transplantation
    • Brinster RL, Zimmerman JW. Spermatogenesis following male germ-cell transplantation. Proc Natl Acad Sci USA. 91:1994;11298-11302.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11298-11302
    • Brinster, R.L.1    Zimmerman, J.W.2
  • 60
    • 0027960421 scopus 로고
    • Germline transmission of donor haplotype following spermatogonial transplantation
    • Brinster RL, Avarbock MR. Germline transmission of donor haplotype following spermatogonial transplantation. Proc Natl Acad Sci USA. 91:1994;11303-11307.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11303-11307
    • Brinster, R.L.1    Avarbock, M.R.2
  • 61
    • 0028062826 scopus 로고
    • Commentary: Spermatogonial stem cells of the testis
    • Dym M. Commentary: spermatogonial stem cells of the testis. Proc Natl Acad Sci USA. 91:1994;11287-11289.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11287-11289
    • Dym, M.1
  • 62
    • 0030469809 scopus 로고    scopus 로고
    • Ultrastructural observations of spermatogenesis following transplantation of rat testis cells into mouse seminiferous tubules
    • Russell LD, Brinster RL. Ultrastructural observations of spermatogenesis following transplantation of rat testis cells into mouse seminiferous tubules. J Androl. 17:1996;615-627.
    • (1996) J Androl , vol.17 , pp. 615-627
    • Russell, L.D.1    Brinster, R.L.2
  • 63
    • 0031028582 scopus 로고    scopus 로고
    • Transplantation of testis germinal cells into mouse seminiferous tubules
    • of outstanding interest. Gives a very detailed and beautiful description of the spermatogonial stem cell transplantation procedure. Three possibilities are shown: injection of the stem cells into the seminiferous tubules, the efferent ducts and the rete testis. This article can be used as a practical guide to the procedure.
    • Ogawa T, Aréchaga JM, Avarbock MR, Brinster RL. Transplantation of testis germinal cells into mouse seminiferous tubules. of outstanding interest Int J Dev Biol. 41:1997;111-122 Gives a very detailed and beautiful description of the spermatogonial stem cell transplantation procedure. Three possibilities are shown: injection of the stem cells into the seminiferous tubules, the efferent ducts and the rete testis. This article can be used as a practical guide to the procedure.
    • (1997) Int J Dev Biol , vol.41 , pp. 111-122
    • Ogawa, T.1    Aréchaga, J.M.2    Avarbock, M.R.3    Brinster, R.L.4
  • 64
    • 84907036431 scopus 로고
    • Testicular DNA synthesis in vivo: Comparison between unilaterally cryptorchid testis and contralateral intact testis in mouse
    • Nishimune Y, Haneji T. Testicular DNA synthesis in vivo: comparison between unilaterally cryptorchid testis and contralateral intact testis in mouse. Arch Androl. 6:1981;61-65.
    • (1981) Arch Androl , vol.6 , pp. 61-65
    • Nishimune, Y.1    Haneji, T.2
  • 65
    • 0023769517 scopus 로고
    • Juvenile spermatogonial depletion (jsd): A genetic defect of germ cell proliferation of male mice
    • Beamer WG, Cunliffe-Beamer TL, Shultz KL, Langley SH, Roderick TH. Juvenile spermatogonial depletion (jsd): a genetic defect of germ cell proliferation of male mice. Biol Reprod. 38:1988;899-908.
    • (1988) Biol Reprod , vol.38 , pp. 899-908
    • Beamer, W.G.1    Cunliffe-Beamer, T.L.2    Shultz, K.L.3    Langley, S.H.4    Roderick, T.H.5
  • 66
    • 0026515192 scopus 로고
    • Loss of sperm in juvenile spermatogonial depletion (jsd) mutant mice is ascribed to a defect of intratubular environment to support germ cell differentiation
    • Mizunuma M, Dohmae K, Tajima Y, Koshimizu U, Watanabe D, Nishimune Y. Loss of sperm in juvenile spermatogonial depletion (jsd) mutant mice is ascribed to a defect of intratubular environment to support germ cell differentiation. J Cell Physiol. 150:1992;188-193.
    • (1992) J Cell Physiol , vol.150 , pp. 188-193
    • Mizunuma, M.1    Dohmae, K.2    Tajima, Y.3    Koshimizu, U.4    Watanabe, D.5    Nishimune, Y.6
  • 67
    • 0030668167 scopus 로고    scopus 로고
    • Cessation of spermatogenesis in juvenile spermatogonial depletion (jsd/jsd) mice
    • of special interest. It is shown that, at three weeks of age, in mice homozygous for the jsd (juvenile spermatogonial depletion) allele, most seminiferous tubular cross-sections show spermatocytes but fewer cross-sections show spermatids than in wild-type mice. At six weeks of age in jsd/jsd mouse testes, fewer B spermatogonia are formed than in wild-type mice. Already at three weeks of age in jsd/jsd mice tubular cross-sections showing only A spermatogonia are present.
    • Kojima Y, Kominami K, Dohmae K, Nonomura N, Miki T, Okuyama A, Nishimune Y, Okabe M. Cessation of spermatogenesis in juvenile spermatogonial depletion (jsd/jsd) mice. of special interest Int J Urol. 4:1997;500-507 It is shown that, at three weeks of age, in mice homozygous for the jsd (juvenile spermatogonial depletion) allele, most seminiferous tubular cross-sections show spermatocytes but fewer cross-sections show spermatids than in wild-type mice. At six weeks of age in jsd/jsd mouse testes, fewer B spermatogonia are formed than in wild-type mice. Already at three weeks of age in jsd/jsd mice tubular cross-sections showing only A spermatogonia are present.
    • (1997) Int J Urol , vol.4 , pp. 500-507
    • Kojima, Y.1    Kominami, K.2    Dohmae, K.3    Nonomura, N.4    Miki, T.5    Okuyama, A.6    Nishimune, Y.7    Okabe, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.