The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes: RESEARCH PAPER

British Journal of Pharmacology

Volumn 158, Issue 3, 2009, Pages 907-919

  Nagai, K ^a,b   Takahashi, Y ^a   Mikami, I ^a   Fukusima, T ^b   Oike, H ^a   Kobori, M ^a  

^a NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

CD40; Cell to cell interaction; Fisetin; Granzyme B; Human mast cell line (HMC 1); Inflammation; Intercellular adhesion molecule 1 (ICAM 1); Mast cells; NF B; T cells

Indexed keywords

CD40 ANTIGEN; FISETIN; FLAVONE DERIVATIVE; GRANZYME B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MEMBRANE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL INTERACTION; CELL SPREADING; COCULTURE; CONTROLLED STUDY; DNA MICROARRAY; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE MEMBRANE; MAST CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD40; CELL DEGRANULATION; CELL LINE; CELL LINE, TUMOR; CELL MEMBRANE; FLAVONOIDS; GRANZYMES; HUMANS; I-KAPPA B KINASE; INTERCELLULAR ADHESION MOLECULE-1; MAST CELLS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PERFORIN; PHOSPHORYLATION; T-LYMPHOCYTES;

EID: 70350075820     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00365.x     Document Type: Article

References (61)

1. Alkalay I, Yaron A, Hatzubai A, Orian A, Ciechanover A, Ben-Neriah Y (1995). Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 92 : 10599 10603.
2. Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N (2000). Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 130 : 2243 2250.
3. Azzolina A, Bongiovanni A, Lampiasi N (2003). Substance P induces TNF-alpha and IL-6 production through NF kappa B in peritoneal mast cells. Biochim Biophys Acta 1643 : 75 83.
4. Bachelet I, Levi-Schaffer F (2007). Mast cells as effector cells: a co-stimulating question. Trends Immunol 28 : 360 365.
5. Baram D, Vaday G, Salamon P, Drucker I, Hershkoviz R, Mekori Y (2001). Human mast cells release metalloproteinase-9 on contact with activated T cells: juxtacrine regulation by TNF-alpha. J Immunol 167 : 4008 4016.
6. Bennett S, Carbone F, Karamalis F, Flavell R, Miller J, Heath W (1998). Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393 : 478 480.
7. Bhattacharyya S, Drucker I, Reshef T, Kirshenbaum A, Metcalfe D, Mekori Y (1998). Activated T lymphocytes induce degranulation and cytokine production by human mast cells following cell-to-cell contact. J Leukoc Biol 63 : 337 341.
8. Biedermann T, Kneilling M, Mailhammer R, Maier K, Sander C, Kollias G et al. (2000). Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. J Exp Med 192 (10 1441 1452.
9. Borrow P, Tishon A, Lee S, Xu J, Grewal I, Oldstone M et al. (1996). CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response. J Exp Med 183 : 2129 2142.
10. Brill A, Baram D, Sela U, Salamon P, Mekori Y, Hershkoviz R (2004). Induction of mast cell interactions with blood vessel wall components by direct contact with intact T cells or T cell membranes in vitro. Clin Exp Allergy 34 : 1725 1731.
11. Butterfield J, Weiler D, Dewald G, Gleich G (1988). Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk Res 12 : 345 355.
12. Buzza M, Zamurs L, Sun J, Bird C, Smith A, Trapani J et al. (2005). Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem 280 : 23549 23558.
13. Choy J, Hung V, Hunter A, Cheung P, Motyka B, Goping I et al. (2004). Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation. Arterioscler Thromb Vasc Biol 24 : 2245 2250.
14. Church M, Levi-Schaffer F (1997). The human mast cell. J Allergy Clin Immunol 99 : 155 160.
15. Fischer M, Harvima I, Carvalho R, Möller C, Naukkarinen A, Enblad G et al. (2006). Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J Clin Invest 116 : 2748 2756.
16. Friedman M, Kaliner M (1985). In situ degranulation of human nasal mucosal mast cells: ultrastructural features and cell-cell associations. J Allergy Clin Immunol 76 : 70 82.
17. Gaga M, Ong Y, Benyahia F, Aizen M, Barkans J, Kay A (2008). Skin reactivity and local cell recruitment in human atopic and nonatopic subjects by CCL2/MCP-1 and CCL3/MIP-1alpha. Allergy 63 : 703 711.
18. Galli S, Tsai M, Piliponsky A (2008). The development of allergic inflammation. Nature 454 : 445 454.
19. Gilfillan A, Tkaczyk C (2006). Integrated signalling pathways for mast-cell activation. Nat Rev Immunol 6 : 218 230.
20. Heusel J, Wesselschmidt R, Shresta S, Russell J, Ley T (1994). Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76 : 977 987.
21. Hirano T, Higa S, Arimitsu J, Naka T, Shima Y, Ohshima S et al. (2004). Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. Int Arch Allergy Immunol 134 : 135 140.
22. Inamura N, Mekori Y, Bhattacharyya S, Bianchine P, Metcalfe D (1998). Induction and enhancement of Fc(epsilon)RI-dependent mast cell degranulation following coculture with activated T cells: dependency on ICAM-1- and leukocyte function-associated antigen (LFA)-1-mediated heterotypic aggregation. J Immunol 160 : 4026 4033.
23. Kawai M, Hirano T, Higa S, Arimitsu J, Maruta M, Kuwahara Y et al. (2007). Flavonoids and related compounds as anti-allergic substances. Allergol Int 56 : 113 123.
24. Kirshenbaum A, Akin C, Wu Y, Rottem M, Goff J, Beaven M et al. (2003). Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcR1 or FcγR1. Leuk Res 27 : 677 682. (Pubitemid 36683255)
25. Kobori M, Nakayama H, Fukushima K, Ohnishi-Kameyama M, Ono H, Fukushima T et al. (2008). Bitter gourd suppresses lipopolysaccharide-induced inflammatory responses. J Agric Food Chem 56 : 4004 4011.
26. Krishnaswamy G, Lakshman T, Miller A, Srikanth S, Hall K, Huang S et al. (1997). Multifunctional cytokine expression by human mast cells: regulation by T cell membrane contact and glucocorticoids. J Interferon Cytokine Res 17 : 167 176.
27. Lee S, Fitzgerald S, Huang S, Li C, Chi D, Milhorn D et al. (2004). Molecular regulation of interleukin-13 and monocyte chemoattractant protein-1 expression in human mast cells by interleukin-1beta. Am J Respir Cell Mol Biol 31 : 283 291.
28. Lew M (2007). Good statistical practice in pharmacology. Problem 2. Br J Pharmacol 152 (3 299 303. (Pubitemid 47511253)
29. Lowin B, Hahne M, Mattmann C, Tschopp J (1994). Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370 : 650 652.
30. Marquardt D, Walker L (2000). Dependence of mast cell IgE-mediated cytokine production on nuclear factor-kappaB activity. J Allergy Clin Immunol 105 : 500 505.
31. Mekori Y, Metcalfe D (2000). Mast cells in innate immunity. Immunol Rev 173 : 131 140.
32. Melgarejo E, Medina M, Sánchez-Jiménez F, Botana L, Domínguez M, Escribano L et al. (2007). Epigallocatechin-3-gallate interferes with mast cell adhesiveness, migration and its potential to recruit monocytes. Cell Mol Life Sci 64 : 2690 2701.
33. Middleton EJ, Kandaswami C, Theoharides T (2000). The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52 : 673 751.
34. Molin D, Fischer M, Xiang Z, Larsson U, Harvima I, Venge P et al. (2001). Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin's disease. Br J Haematol 114 : 616 623.
35. Morimoto Y, Yasuhara T, Sugimoto A, Inoue A, Hide I, Akiyama M et al. (2003). Anti-allergic substances contained in the pollen of Cryptomeria japonica possess diverse effects on the degranulation of RBL-2H3 cells. J Pharmacol Sci 92 (3 291 295.
36. Moschonas A, Kouraki M, Knox P, Thymiakou E, Kardassis D, Eliopoulos A (2008). CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. Mol Cell Biol 28 : 6208 6222.
37. Nakae S, Suto H, Kakurai M, Sedgwick J, Tsai M, Galli S (2005). Mast cells enhance T cell activation: importance of mast cell-derived TNF. Proc Natl Acad Sci USA 102 (18 6467 6472.
38. Nakae S, Ho LH, Yu M, Monteforte R, Iikura M, Suto H et al. (2007). Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice. J Allergy Clin Immunol 120 (1 48 55.
39. Naschberger E, Werner T, Vicente A, Guenzi E, Töpolt K, Leubert R et al. (2004). Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells. Biochem J 379 : 409 420.
40. Nishimoto H, Lee S, Hong H, Potter K, Maeda-Yamamoto M, Kinoshita T et al. (2005). Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor. Blood 106 : 4241 4248.
41. Okayama Y, Ra C, Saito H (2007). Role of mast cells in airway remodeling. Curr Opin Immunol 19 : 687 693.
42. Palmqvist C, Wardlaw A, Bradding P (2007). Chemokines and their receptors as potential targets for the treatment of asthma. Br J Pharmacol 151 : 725 736.
43. Pardo J, Wallich R, Ebnet K, Iden S, Zentgraf H, Martin P et al. (2007). Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin. Cell Death Differ 14 : 1768 1779.
44. Park H, Lee S, Oh J, Lee M, Yoon K, Park B et al. (2007). Anti-inflammatory activity of fisetin in human mast cells (HMC-1). Pharmacol Res 55 : 31 37.
45. Park H, Lee S, Son H, Park S, Kim M, Choi E et al. (2008). Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch Pharm Res 31 (10 1303 1311.
46. Peng Y, Power M, Li B, Lin T (2005). Inhibition of IKK down-regulates antigen + IgE-induced TNF production by mast cells: a role for the IKK-IkappaB-NF-kappaB pathway in IgE-dependent mast cell activation. J Leukoc Biol 77 : 975 983.
47. Qin H, Wilson C, Lee S, Zhao X, Benveniste E (2005). LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia. Blood 106 : 3114 3122.
48. Renshaw B, Fanslow W, Armitage R, Campbell K, Liggitt D, Wright B et al. (1994). Humoral immune responses in CD40 ligand-deficient mice. J Exp Med 180 : 1889 1900.
49. Ridge J, Di Rosa F, Matzinger P (1998). A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393 : 474 478.
50. Salamon P, Shoham N, Gavrieli R, Wolach B, Mekori Y (2005). Human mast cells release Interleukin-8 and induce neutrophil chemotaxis on contact with activated T cells. Allergy 60 : 1316 1319.
51. Salamon P, Shoham N, Puxeddu I, Paitan Y, Levi-Schaffer F, Mekori Y (2008). Human mast cells release oncostatin M on contact with activated T cells: possible biologic relevance. J Allergy Clin Immunol 121 : 448 455. e445.
52. Schoenberger S, Toes R, van der Voort E, Offringa R, Melief C (1998). T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393 : 480 483.
53. Secor V, Secor W, Gutekunst C, Brown M (2000). Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J Exp Med 191 (5 813 822.
54. Shimada Y, Hasegawa M, Kaburagi Y, Hamaguchi Y, Komura K, Saito E et al. (2003). L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. J Immunol 170 : 4325 4334.
55. Smith T, Weis J (1996). Mucosal T cells and mast cells share common adhesion receptors. Immunol Today 17 : 60 63.
56. Stopfer P, Männel D, Hehlgans T (2004). Lymphotoxin-beta receptor activation by activated T cells induces cytokine release from mouse bone marrow-derived mast cells. J Immunol 172 : 7459 7465.
57. Strik M, de Koning P, Kleijmeer M, Bladergroen B, Wolbink A, Griffith J et al. (2007). Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation. Mol Immunol 44 : 3462 3472.
58. Tsang C, Wong C, Ip W, Lam C (2005). Synergistic effect of SCF and TNF-alpha on the up-regulation of cell-surface expression of ICAM-1 on human leukemic mast cell line (HMC)-1 cells. J Leukoc Biol 78 : 239 247.
59. Tschopp C, Spiegl N, Didichenko S, Lutmann W, Julius P, Virchow J (2006). Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. Blood 108 : 2290 2299.
60. Williams C, Grayer R (2004). Anthocyanins and other flavonoids. Nat Prod Rep 21 : 539 573.
61. Wong C, Tsang C, Ip W, Lam C (2006). Molecular mechanisms for the release of chemokines from human leukemic mast cell line (HMC)-1 cells activated by SCF and TNF-alpha: roles of ERK, p38 MAPK, and NF-kappaB. Allergy 61 : 289 297.