Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics

Journal of Medicinal Chemistry

Volumn 52, Issue 20, 2009, Pages 6494-6498

  Cosner, Casey C ^a   Markiewicz, John T ^a   Bourbon, Pauline ^a   Mariani, Christopher J ^a   Wiest, Olaf ^a   Rujoi, Madalina ^b   Rosenbaum, Anton I ^b   Huang, Amy Y ^b   Maxfield, Frederick R ^b   Helquist, Paul ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 [(5 (4 BROMOPHENYL)FURAN 2 YL)METHYLENE] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H PYRROL 1 YL)BENZOIC ACID; ACYL COENZYME A; LOW DENSITY LIPOPROTEIN; N ARYL 3 ALKYLIDENEPYRROLINONE DERIVATIVE; PYRROLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOTINYLATION; CONTROLLED STUDY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; NIEMANN PICK DISEASE; NONHUMAN;

ANIMALS; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; HUMANS; NIEMANN-PICK DISEASE, TYPE C; PYRROLES;

EID: 70350050816     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900707n     Document Type: Article

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