Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells

Journal of Lipid Research

Volumn 47, Issue 2, 2006, Pages 284-301

  Pipalia, Nina H ^a   Huang, Amy ^a   Ralph, Harold ^a   Rujoi, Madalina ^a   Maxfield, Frederick R ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Filipin; High content screening; Lysosomal storage

Indexed keywords

CHEMICAL COMPOUND; CHOLESTEROL; FILIPIN;

ANIMAL CELL; ARTICLE; AUTOMATION; CELL COMPOSITION; CELL CULTURE; CELL ORGANELLE; CHO CELL; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; FLUORESCENCE; IMAGING; LYSOSOME; MICROSCOPY; NIEMANN PICK DISEASE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SCREENING; SYNTHESIS; TOXICITY;

ANDROSTENES; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL SURVIVAL; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FIBROBLASTS; FILIPIN; HETEROCYCLIC COMPOUNDS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HETEROCYCLIC COMPOUNDS, 2-RING; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MICROSCOPY; MICROSCOPY, FLUORESCENCE; MOLECULAR STRUCTURE; MUTATION; NIEMANN-PICK DISEASES; STAINING AND LABELING;

EID: 33244458202     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M500388-JLR200     Document Type: Article

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