Identification of a pharmaceutical compound that partially corrects the Niemann-Pick C phenotype in cultured cells

Journal of Lipid Research

Volumn 43, Issue 10, 2002, Pages 1708-1717

  Liscum, Laura ^a   Arnio, Emily ^a   Anthony, Monique ^b   Howley, Andrea ^c   Sturley, Stephen L ^c   Agler, Michele ^b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Amphotericin B; Cholesterol; Cholesterol transport; High throughput screen; Niemann Pick C

Indexed keywords

AMPHOTERICIN B; CHOLESTEROL; CHOLESTEROL OXIDASE; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVALONIC ACID; MEVINOLIN; NP 25; NP 31; OLEIC ACID; PRAVASTATIN; TOLNAFTATE; TRIACYLGLYCEROL; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CELL CULTURE; CELL VIABILITY; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOTOXICITY; GRANULOSA CELL; LYSOSOME STORAGE DISEASE; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; OVARY CELL; PHENOTYPE; PRIORITY JOURNAL;

AMPHOTERICIN B; ANIMALS; BIOLOGICAL TRANSPORT; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL, LDL; DRUG EVALUATION, PRECLINICAL; FEMALE; GRANULOSA CELLS; LYSOSOMES; MICE; NIEMANN-PICK DISEASES; NITROVIN; PHENOTYPE; TRITIUM;

EID: 0036793407     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M200179-JLR200     Document Type: Article

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