Intermolecular cross-talk between the prostaglandin E 2 receptor (EP) 3 subtype and thromboxane A 2 receptor signalling in human erythroleukaemic cells: RESEARCH PAPER

British Journal of Pharmacology

Volumn 158, Issue 3, 2009, Pages 830-847

  Reid, Helen M ^a   Kinsella, B Therese ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Agonist; Human; Receptor; Thromboxane

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 17 PHENYL TRINORPROSTAGLANDIN E2; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; CALCIUM; INOSITOL 1,4,5 TRISPHOSPHATE; PERTUSSIS TOXIN; PHOSPHOLIPASE C BETA; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E1 RECEPTOR; PROSTAGLANDIN E2 DERIVATIVE; PROSTAGLANDIN E3 RECEPTOR; PROSTAGLANDIN E4 RECEPTOR; PROTEIN KINASE B; RECEPTOR SUBTYPE; THROMBOXANE A2 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; CALCIUM; CELL LINE; CELL LINE, TUMOR; DINOPROSTONE; ENZYME ACTIVATION; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; PHOSPHOLIPASE C BETA; PROTEIN ISOFORMS; RECEPTOR CROSS-TALK; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; SIGNAL TRANSDUCTION;

EID: 70350043896     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00351.x     Document Type: Article

References (78)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to receptors and channels (GRAC), 3rd edn. Br J Pharmacol 153 (Suppl. 2 S1 S209.
2. Alfranca A, Iniguez MA, Fresno M, Redondo JM (2006). Prostanoid signal transduction and gene expression in the endothelium: role in cardiovascular diseases. Cardiovasc Res 70 : 446 456.
3. An S, Yang J, So SW, Zeng L, Goetzl EJ (1994). Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. Biochemistry 33 : 14496 14502.
4. Baltensperger K, Porzig H (1997). The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells. J Biol Chem 272 : 10151 10159.
5. Baryawno N, Sveinbjornsson B, Eksborg S, Orrego A, Segerstrom L, Oqvist CO et al. (2008). Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. Neuro Oncol 10 : 661 674.
6. Benjamin ER, Haftl SL, Xanthos DN, Crumley G, Hachicha M, Valenzano KJ (2004). A miniaturized column chromatography method for measuring receptor-mediated inositol phosphate accumulation. J Biomol Screen 9 : 343 353.
7. Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF (1983). Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J 212 : 473 482.
8. Bilson HA, Mitchell DL, Ashby B (2004). Human prostaglandin EP3 receptor isoforms show different agonist-induced internalization patterns. FEBS Lett 572 : 271 275.
9. Bos CL, Richel DJ, Ritsema T, Peppelenbosch MP, Versteeg HH (2004). Prostanoids and prostanoid receptors in signal transduction. Int J Biochem Cell Biol 36 : 1187 1205.
10. Breyer MD, Breyer RM (2001). G protein-coupled prostanoid receptors and the kidney. Annu Rev Physiol 63 : 579 605.
11. Breyer RM, Bagdassarian CK, Myers SA, Breyer MD (2001). Prostanoid receptors: subtypes and signaling. Annu Rev Pharmacol Toxicol 41 : 661 690.
12. Bunemann M, Lee KB, Pals-Rylaarsdam R, Roseberry AG, Hosey MM (1999). Desensitization of G-protein-coupled receptors in the cardiovascular system. Annu Rev Physiol 61 : 169 192.
13. Coleman RA, Smith WL, Narumiya S (1994). International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46 : 205 229.
14. Coyle AT, Kinsella BT (2005). Characterization of promoter 3 of the human thromboxane A receptor gene. A functional AP-1 and octamer motif are required for basal promoter activity. FEBS J 272 : 1036 1053.
15. Coyle AT, Kinsella BT (2006). Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells. Biochem Pharmacol 71 : 1308 1323.
16. Coyle AT, Miggin SM, Kinsella BT (2002). Characterization of the 5′ untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP). Differential promoter utilization by the TP isoforms. Eur J Biochem 269 : 4058 4073.
17. Coyle AT, O'Keeffe MB, Kinsella BT (2005). 15-deoxy Delta12,14- prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells. FEBS J 272 : 4754 4773.
18. Dey I, Lejeune M, Chadee K (2006). Prostaglandin E2 receptor distribution and function in the gastrointestinal tract. Br J Pharmacol 149 : 611 623.
19. Foley JF, Kelley LP, Kinsella BT (2001). Prostaglandin D(2) receptor-mediated desensitization of the alpha isoform of the human thromboxane A(2) receptor. Biochem Pharmacol 62 : 229 239.
20. Funk CD, Furci L, FitzGerald GA, Grygorczyk R, Rochette C, Bayne MA et al. (1993). Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem 268 : 26767 26772.
21. Gannon AM, Kinsella BT (2008). Regulation of the human thromboxane A2 receptor gene by Sp1, Egr1, NF-E2, GATA-1 and Ets-1 in megakaryocytes. J Lipid Res 49 : 2590 2604.
22. Geilen CC, Wieprecht M, Wieder T, Reutter W (1992). A selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-bromocinnamyl(amino)ethyl]-5- isoquinolinesulfonamide (H-89), inhibits phosphatidylcholine biosynthesis in HeLa cells. FEBS Lett 309 : 381 384.
23. Gorman CM, Gies D, McCray G (1990). Transient production of proteins using an adenovirus transformed cell line. DNA Protein Eng Tech 2 : 3 10.
24. Grynkiewicz G, Poenic M, Tsien RY (1985). A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260 : 3440 3450.
25. Habib A, Vezza R, Creminon C, Maclouf J, FitzGerald GA (1997). Rapid, agonist-dependent phosphorylation in vivo of human thromboxane receptor isoforms. Minimal involvement of protein kinase C. J Biol Chem 272 : 7191 7200.
26. Habib A, FitzGerald GA, Maclouf J (1999). Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets. J Biol Chem 274 : 2645 2651.
27. Hardy AR, Jones ML, Mundell SJ, Poole AW (2004). Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets. Blood 104 : 1745 1752.
28. Hirata M, Hayashi Y, Ushikubi F, Yokota Y, Kageyama R, Nakanishi S et al. (1991). Cloning and expression of cDNA for a human thromboxane A2 receptor. Nature 349 : 617 620. (Pubitemid 21912117)
29. Hirata T, Ushikubi F, Kakizuka A, Okuma M, Narumiya S (1996). Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. J Clin Invest 97 : 949 956.
30. Kelley-Hickie LP, Kinsella BT (2004). EP1- and FP-mediated cross-desensitization of the alpha (alpha) and beta (beta) isoforms of the human thromboxane A2 receptor. Br J Pharmacol 142 : 203 221.
31. Kelley-Hickie LP, Kinsella BT (2006). Homologous desensitization of signalling by the beta (beta) isoform of the human thromboxane A2 receptor. Biochim Biophys Acta 1761 : 1114 1131.
32. Kelley-Hickie LP, O'Keeffe MB, Reid HM, Kinsella BT (2007). Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling. Biochim Biophys Acta 1773 : 970 989.
33. Kinsella BT (2001). Thromboxane A2 signalling in humans: a 'Tail' of two receptors. Biochem Soc Trans 29 : 641 654.
34. Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. J Pharmacol Exp Ther 281 : 957 964.
35. Kotani M, Tanaka I, Ogawa Y, Usui T, Mori K, Ichikawa A et al. (1995). Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions. Mol Pharmacol 48 : 869 879.
36. Kotani M, Tanaka I, Ogawa Y, Usui T, Tamura N, Mori K et al. (1997). Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). Genomics 40 : 425 434.
37. Kotani M, Tanaka I, Ogawa Y, Suganami T, Matsumoto T, Muro S et al. (2000). Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus. J Clin Endocrinol Metab 85 : 4315 4322.
38. Kubo S, Takahashi HK, Takei M, Iwagaki H, Yoshino T, Tanaka N et al. (2004). E-prostanoid (EP)2/EP4 receptor-dependent maturation of human monocyte-derived dendritic cells and induction of helper T2 polarization. J Pharmacol Exp Ther 309 : 1213 1220.
39. Lefkowitz RJ (1998). G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J Biol Chem 273 : 18677 18680.
40. Li Z, Zhang G, Le Breton GC, Gao X, Malik AB, Du X (2003). Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. J Biol Chem 278 : 30725 30731.
41. Liu HN, Molina-Holgado E, Almazan G (1997). Glutamate-stimulated production of inositol phosphates is mediated by Ca2+ influx in oligodendrocyte progenitors. Eur J Pharmacol 338 : 277 287.
42. Long MW, Heffner CH, Williams JL, Peters C, Prochownik EV (1990). Regulation of megakaryocyte phenotype in human erythroleukemia cells. J Clin Invest 85 : 1072 1084.
43. Ma H, Hara A, Xiao CY, Okada Y, Takahata O, Nakaya K et al. (2001). Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E receptor subtype EP(3). Circulation 104 : 1176 1180.
44. Martin P, Papayannopoulou T (1982). HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression. Science 216 : 1233 1235.
45. Matsuoka T, Narumiya S (2007). Prostaglandin receptor signaling in disease. ScientificWorldJournal 7 : 1329 1347.
46. Miggin SM, Kinsella BT (1998). Expression and tissue distribution of the mRNAs encoding the human thromboxane A2 receptor (TP) alpha and beta isoforms. Biochim Biophys Acta 1425 : 543 559.
47. Miggin SM, Kinsella BT (2002a). Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences. J Biol Chem 277 : 27053 27064.
48. Miggin SM, Kinsella BT (2002b). Regulation of extracellular signal-regulated kinase cascades by alpha- and beta-isoforms of the human thromboxane A(2) receptor. Mol Pharmacol 61 : 817 831.
49. Narumiya S, FitzGerald GA (2001). Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest 108 : 25 30.
50. Narumiya S, Sugimoto Y, Ushikubi F (1999). Prostanoid receptors: structures, properties, and functions. Physiol Rev 79 : 1193 1226.
51. Norel X (2007). Prostanoid receptors in the human vascular wall. ScientificWorldJournal 7 : 1359 1374.
52. Norel X, de Montpreville V, Brink C (2004). Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. Prostaglandins Other Lipid Mediat 74 : 101 112.
53. Papayannopoulou T, Nakamoto B, Yokochi T, Chait A, Kannagi R (1983). Human erythroleukemia cell line (HEL) undergoes a drastic macrophage-like shift with TPA. Blood 62 : 832 845.
54. Rasheed H, Saeed SA (2004). Involvement of thromboxane A2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation. Exp Mol Med 36 : 220 225.
55. Raychowdhury MK, Yukawa M, Collins LJ, McGrail SH, Kent KC, Ware JA (1994a). Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor. J Biol Chem 269 : 19256 19261.
56. Raychowdhury MK, Yukawa M, Collins LJ, McGrail SH, Kent KC, Ware JA (1994b). Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor. J Biol Chem 269 : 19256 19261.
57. Raychowdhury MK, Yukawa M, Collins LJ, McGrail SH, Kent KC, Ware JA (1995). Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor. J Biol Chem 270 : 7011.
58. Reid HM, Kinsella BT (2003). The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin. J Biol Chem 278 : 51190 51202.
59. Sasaki Y, Takahashi T, Tanaka I, Nakamura K, Okuno Y, Nakagawa O et al. (1997). Expression of prostacyclin receptor in human megakaryocytes. Blood 90 : 1039 1046.
60. Schmid A, Thierauch KH, Schleuning WD, Dinter H (1995). Splice variants of the human EP3 receptor for prostaglandin E2. Eur J Biochem 228 : 23 30.
61. Schwaner I, Offermanns S, Spicher K, Seifert R, Schultz G (1995). Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL. Biochim Biophys Acta 1265 : 8 14.
62. Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, Coadwell J et al. (1997). The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89 : 105 114.
63. Sugimoto Y, Narumiya S (2007). Prostaglandin E receptors. J Biol Chem 282 : 11613 11617.
64. Takahashi HK, Iwagaki H, Tamura R, Katsuno G, Xue D, Sugita S et al. (2005). Differential effect of prostaglandins E1 and E2 on lipopolysaccharide- induced adhesion molecule expression on human monocytes. Eur J Pharmacol 512 : 223 230. (Pubitemid 40544357)
65. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M et al. (1991). The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266 : 15771 15781.
66. Vezza R, Habib A, FitzGerald GA (1999). Differential signaling by the thromboxane receptor isoforms via the novel GTP-binding protein, Gh. J Biol Chem 274 : 12774 12779.
67. van der Vuurst H, van Willigen G, van Spronsen A, Hendriks M, Donath J, Akkerman JW (1997). Signal transduction through trimeric G proteins in megakaryoblastic cell lines. Arterioscler Thromb Vasc Biol 17 : 1830 1836.
68. van der Vuurst H, Hendriks M, Lapetina EG, van Willigen G, Akkerman JW (1998). Maturation of megakaryoblastic cells is accompanied by upregulation of G(s)alpha-L subtype and increased cAMP accumulation. Thromb Haemost 79 : 1014 1020.
69. Walsh M, Foley JF, Kinsella BT (2000a). Investigation of the role of the carboxyl-terminal tails of the alpha and beta isoforms of the human thromboxane A(2) receptor (TP) in mediating receptor : effector coupling. Biochim Biophys Acta 1496 : 164 182.
70. Walsh MT, Kinsella BT (2000). Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors. Br J Pharmacol 131 : 601 609.
71. Walsh MT, Foley JF, Kinsella BT (2000b). The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for prostacyclin-mediated desensitization. J Biol Chem 275 : 20412 20423.
72. Wilson SJ, Roche AM, Kostetskaia E, Smyth EM (2004). Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation. J Biol Chem 279 : 53036 53047.
73. Wu H, Turner JT, Halenda SP (1991). Activation of phospholipase D by E-series prostaglandins in human erythroleukemia cells. J Pharmacol Exp Ther 258 : 607 612.
74. Wu H, James-Kracke MR, Halenda SP (1992). Direct relationship between intracellular calcium mobilization and phospholipase D activation in prostaglandin E-stimulated human erythroleukemia cells. Biochemistry 31 : 3370 3377.
75. Yamamoto H, Maruyama T, Sakata K, Koketsu M, Kobyashi M, Yoshida H et al. (1999). Novel four selective agonists for prostaglandin E receptor subtypes. Prostaglandins Other Lipid Mediat 59 : 150.
76. Yamane H, Sugimoto Y, Tanaka S, Ichikawa A (2000). Prostaglandin E(2) receptors, EP2 and EP4, differentially modulate TNF-alpha and IL-6 production induced by lipopolysaccharide in mouse peritoneal neutrophils. Biochem Biophys Res Commun 278 : 224 228.
77. Yang J, Xia M, Goetzl EJ, An S (1994). Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2. Biochem Biophys Res Commun 198 : 999 1006.
78. Yang J, Wu J, Jiang H, Mortensen R, Austin S, Manning DR et al. (2002). Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem 277 : 46035 46042.