Modular Cre/lox system and genetic therapeutics for colorectal cancer

Journal of Biomedicine and Biotechnology

Volumn 2009, Issue , 2009, Pages

  Bordonaro, Michael ^a  

^a Janet Weis Children s Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CRE RECOMBINASE; FAS ASSOCIATED DEATH DOMAIN PROTEIN; WNT PROTEIN; INTEGRASE;

CANCER GENE THERAPY; CANCER GENETICS; CANCER MODEL; CANCER RESEARCH; CANCER STEM CELL; COLON CARCINOGENESIS; COLORECTAL CANCER; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; IN VITRO GENE TRANSFER; IN VIVO GENE TRANSFER; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PROMOTER REGION; REVIEW; COLORECTAL TUMOR; ENHANCER REGION; GENE THERAPY; GENETICS; METHODOLOGY;

COLORECTAL NEOPLASMS; ENHANCER ELEMENTS, GENETIC; GENE THERAPY; HUMANS; INTEGRASES; PROMOTER REGIONS, GENETIC;

EID: 70350011957     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2009/358230     Document Type: Review

References (56)

1. Su L.-K., Vogelstein B., Kinzler K. W., Association of the APC tumor suppressor protein with catenins Science 1993 262 5140 1734 1737
2. Munemitsu S., Albert I., Souza B., Rubinfeld D., Polakis P., Regulation of intracellular -catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein Proceedings of the National Academy of Sciences of the United States of America 1995 92 7 3046 3050
3. Molenaar M., van de Wetering M., Oosterwegel M., XTcf-3 transcription factor mediates -catenin-induced axis formation in Xenopus embryos Cell 1996 86 3 391 399
4. Behrens J., Von Kries J. P., Kuhl M., Functional interaction of -catenin with the transcriptional factor LEF-1 Nature 1996 382 638 642
5. Korinek V., Barker N., Morin P. J., Constitutive transcriptional activation by a -catenin-Tcf complex in APC(-/-) colon carcinoma Science 1997 275 5307 1784 1787 (Pubitemid 27136714)
6. Morin P. J., Sparks A. B., Korinek V., Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC Science 1997 275 1787 1790
7. Kinzler K. W., Vogelstein B., Lessons from hereditary colorectal cancer Cell 1996 87 2 159 170
8. Roose J., Clevers H., TCF transcription factors: molecular switches in carcinogenesis Biochimica et Biophysica Acta 1999 1424 2-3 M23 M37
9. Miyaki M., Iijima T., Kimura J., Frequent mutation of -catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer Cancer Research 1999 59 18 4506 4509
10. Bordonaro M., Lazarova D. L., Sartorelli A. C., Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk? Cell Cycle 2008 7 9 1178 1183
11. Bordonaro M., Lazarova D. L., Sartorelli A. C., Hyper-induction of Wnt activity: a new paradigm for the treatment of colorectal cancer? Oncology Research 2008 17 1 9
12. Meyerhardt J. A., Mayer R. J., Systemic therapy for colorectal cancer The New England Journal of Medicine 2005 352 5 476 487
13. Westpal E. M., von Melchner H., Gene therapy approaches for the selective killing of cancer cells Current Pharmaceutical Design 2002 8 19 1683 1694
14. Maxwell I. H., Maxwell F., Glode L. M., Regulated expression of a diphtheria toxin A-chain gene transfected into human cells: possible strategy for inducing cancer cell suicide Cancer Research 1986 46 9 4660 4664
15. Harrison G. S., Maxwell F., Long C. J., Rosen C. A., Glode L. M., Maxwell I. H., Activation of a diphtheria toxin A gene by expression of human immunodeficiency virus-1 Tat and Rex proteins in transfected cells Human Gene Therapy 1991 2 53 60
16. Maxwell I. H., Glode L. M., Maxwell F., Expression of the diphtheria toxin A-chain coding sequence under the control of promoters and enhancers from immunoglobulin genes as a means of directing toxicity to B-lymphoid cells Cancer Research 1991 51 16 4299 4304
17. Robinson D. F., Maxwell I. H., Suppression of single and double nonsense mutations introduced into the diphtheria toxin A-chain gene: a potential binary system for toxin gene therapy Human Gene Therapy 1995 6 2 137 143
18. Lidor Y. J., Lee W. E., Nilson J. H., In vitro expression of the diphtheria toxin A-chain gene under the control of human chorionic gonadotropin gene promoters as a means of directing toxicity to ovarian cancer cell lines American Journal of Obstetrics and Gynecology 1997 177 3 579 585
19. Cao G.-W., Qi Z.-T., Pan X., Gene therapy for human colorectal carcinoma using human CEA promoter controlled bacterial ADP-ribosylating toxin genes: PEA and DTA gene transfer World Journal of Gastroenterology 1998 4 16 388 391
20. Kondo S., Ishizaka Y., Okada T., FADD gene therapy for malignant gliomas in vitro and in vivo Human Gene Therapy 1998 9 11 1599 1608
21. Chen R.-H., McCormick F., Selective targeting to the hyperactive -catenin/T-cell factor pathway in colon cancer cells Cancer Research 2001 61 11 4445 4449
22. Qiao J., Doubrovin M., Sauter B. V., Tumor-specific transcriptional targeting of suicide gene therapy Gene Therapy 2002 9 3 168 175
23. Richards C. A., Austin E. A., Huber B. E., Transcriptional regulatory sequences of carcinoembryonic antigen: identification and use with cytosine deaminase for tumor-specific gene therapy Human Gene Therapy 1995 6 7 881 893
24. Ge K., Jiang Q., Xu D. H., Zheng Z. C., Liu X. Y., Experimental treatment for human colorectal carcinoma by tissue type specific expression of herpes simplex virus thymidine kinase gene Shi Yan Sheng Wu Xue Bao 1998 31 3 259 264
25. Kwong K. Y., Zou Y., Day C.-P., Hung M.-C., The suppression of colon cancer cell growth in nude mice by targeting -catenin/TCF pathway Oncogene 2002 21 54 8340 8346
26. Nyati M. K., Sreekumar A., Li S., High and selective expression of yeast cytosine deaminase under a carcinoembryonic antigen promoter-enhancer Cancer Research 2002 62 8 2337 2342
27. Fuerer C., Iggo R., Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the Wnt signaling pathway Gene Therapy 2002 9 270 281
28. Malerba M., Daeffler L., Rommelaere J., Iggo R. D., Replicating parvoviruses that target colon cancer cells Journal of Virology 2003 77 12 6683 6691
29. Lazarova D. L., Bordonaro M., Carbone R., Sartorelli A. C., Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate International Journal of Cancer 2004 110 4 523 531
30. Bordonaro M., Lazarova D. L., Sartorelli A. C., The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors Experimental Cell Research 2007 313 8 1652 1666
31. Kaczmarczyk S. J., Green J. E., A single vector containing modified cre recombinase and LOX recombination sequences for inducible tissue-specific amplification of gene expression Nucleic Acids Research 2001 29 12 E56
32. Ueda K., Iwahashi M., Nakamori M., Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/5-fluorocytosine enhanced by the Cre/loxP system in the orthotopic gastric carcinoma model Cancer Research 2001 61 16 6158 6162
33. Bordonaro M., Lazarova D. L., Sartorelli A. C., Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells Nucleic Acids Research 2004 32 8 2660 2674
34. Bordonaro M., Lazarova D. L., Carbone R., Sartorelli A. C., Modulation of Wnt-specific colon cancer cell kill by butyrate and lithium Oncology Research 2004 14 9 427 438
35. Chinnalyan A. M., ORourke K., Tewari M., Dixit V. M., FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis Cell 1995 81 4 505 512
36. Bucholtz F., Principles of site-specific recombinase (SSR) technology Journal of Visualized Experiments 2008 15 718
37. Kijima T., Osaki T., Nishino K., Application of the Cre recombinase/loxP system further enhances antitumor effects in cell type-specific gene therapy against carcinoembryonic antigen-producing cancer Cancer Research 1999 59 19 4906 4911
38. Ueda K., Iwahashi M., Nakamori M., Nakamura M., Yamaue H., Tanimura H., Enhanced selective gene expression by adenovirus vector using Cre/loxP regulation system for human carcinoembryonic antigen-producing carcinoma Oncology 2000 59 3 255 265
39. Goto H., Osaki T., Kijima T., Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells International Journal of Cancer 2001 94 3 414 419
40. Aoki M., Hecht A., Kruse U., Kemler R., Vogt P. K., Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1 Proceedings of the National Academy of Sciences of the United States of America 1999 96 1 139 144
41. Evans C. H., Ghivizzani S. C., Robbins P. D., Arthritis gene therapys first death Arthritis Research Therapy 2008 10 3 110
42. Hollon T., Researchers and regulators reflect on first gene therapy death Nature Medicine 2000 6 1 6
43. Silberner J., A gene therapy death The Hastings Center Report 2000 30 2 6
44. Ditto A. J., Shah P. N., Lopina S. T., Yun Y. H., Nanospheres formulated from L-tyrosine phosphate as a potential intracellular delivery device International Journal of Pharmaceutics 2008 368 199 206
45. Luo D., Woodrow-Mumford K., Belcheva N., Saltzman W. M., Controlled DNA delivery systems Pharmaceutical Research 1999 16 8 1300 1308
46. Patil V. R., Campbell C. J., Yun Y. H., Slack S. M., Goetz D. J., Particle diameter influences adhesion under flow Biophysical Journal 2001 80 4 1733 1743
47. Dickerson J. B., Blackwell J. E., Ou J. J., Patil V. R., Goetz D. J., Limited adhesion of biodegradable microspheres to E- and P-selectin under flow Biotechnology and Bioengineering 2001 73 6 500 509
48. Pardal R., Clarke M. F., Morrison S. J., Applying the principles of stem-cell biology to cancer Nature Reviews Cancer 2003 3 12 895 902
49. Brabletz T., Jung A., Spaderna S., Hlubek F., Kirchner T., Migrating cancer stem cellsan integrated concept of malignant tumour progression Nature Reviews Cancer 2005 5 9 744 749
50. Reya T., Clevers H., Wnt signalling in stem cells and cancer Nature 2005 434 7035 843 850 (Pubitemid 40558990)
51. Scoville D. H., Sato T., He X. C., Li L., Current view: intestinal stem cells and signaling Gastroenterology 2008 134 3 849 864
52. Hinoi T., Akyol A., Theisen B. K., Mouse model of colonic adenoma-carcinoma progression based on somatic Apc activation Cancer Research 2007 67 9721 9730
53. Hnasko T. S., Perez F. A., Scouras A. D., Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia Proceedings of the National Academy of Sciences of the United States of America 2006 103 23 8858 8863
54. Kinoshita K., Iimuro Y., Fujimoto J., Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis Gut 2007 56 3 396 404
55. Ueda K., Iwahashi M., Nakamori M., Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer Surgery 2003 133 3 309 317
56. Maeda M., Namikawa K., Kobayashi I., Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system Brain Research 2006 1081 1 34 43