Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells

International Journal of Cancer

Volumn 94, Issue 3, 2001, Pages 414-419

  Goto, Hiroyuki ^a   Osaki, Tadashi ^a,b   Kijima, Takashi ^a   Nishino, Kazumi ^a   Kumagai, Toru ^a   Funakoshi, Toshiki ^a   Kimura, Hiromi ^a   Takeda, Yoshito ^a   Yoneda, Tsutomu ^a   Tachibana, Isao ^a   Hayashi, Seiji ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adenoviral vector; CEA promoter; Cre loxP system; Gene therapy; Peritonitis carcinomatosa

Indexed keywords

BETA GALACTOSIDASE; CARCINOEMBRYONIC ANTIGEN; GANCICLOVIR; RECOMBINASE; THYMIDINE KINASE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOMATOUS PERITONITIS; CONTROLLED STUDY; DIARRHEA; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PERITONEUM; PERITONEUM CANCER; PRIORITY JOURNAL; TUMOR GROWTH; WEIGHT REDUCTION;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; BODY WEIGHT; CARCINOEMBRYONIC ANTIGEN; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; GANCICLOVIR; GENE THERAPY; GENES, REPORTER; HUMANS; INTEGRASES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS; PROMOTER REGIONS (GENETICS); TIME FACTORS; TUMOR CELLS, CULTURED; VIRAL PROTEINS;

EID: 0035501565     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1474     Document Type: Article

References (19)

1. Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: A phase 1 trial
2. Phase 1 study of direct administration of a replication deficient adenovirus vector containing the E. coli cystosine deaminase gene to metastasic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine
3. A controlled trial of intratumoral ONYX-015, a selectively replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer [see comments]
4. Balancing the science budget
5. Gene therapy death prompts review of adenovirus vector [news]
6. Serologic markers in the diagnosis and management of pancreatic carcinoma
7. Serial plasma carcinoembryonic antigen measurement for monitoring patients with advanced lung cancer during chemotherapy
8. Cancer of the stomach. A patient care study by the American College of Surgeons
9. Multimodality management of regionally advanced non-small-cell lung cancer
10. In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma
11. Enhanced selective gene expression by adenovirus vector using Cre/loxP regulation system for human carcinoembryonic antigen-producing carcinoma
12. Application of the Cre recombinase/loxP system further enhances antitumor effects in cell type-specific gene therapy against carcinoembryonic antigen-producing cancer
13. Enhanced and specific gene expression via tissue-specific production of Cre recombinase using adenovirus vector
14. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites
15. Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements
16. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
17. Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene
18. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
19. Topics in clinical pharmacology: Ganciclovir