Pro-interleukin (IL)-1β shares a core region of stability as compared with mature IL-1β while maintaining a distinctly different configurational landscape: A comparative hydrogen/deuterium exchange mass spectrometry study

Journal of Biological Chemistry

Volumn 284, Issue 38, 2009, Pages 26137-26148

  Hailey, Kendra L ^a   Li, Sheng ^a   Andersen, Mette D ^a,b   Roy, Melinda ^a   Woods Jr , Virgil L ^a,c   Jennings, Patricia A ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NOVO NORDISK A S   (Denmark)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE STATE; BIOLOGICAL ACTIVITIES; C-TERMINAL REGIONS; CASPASES; COMPARATIVE STUDIES; CORE REGION; CYTOKINES; DEUTERIUM EXCHANGE; ENZYMATIC DIGESTIONS; HYDROGEN/DEUTERIUM EXCHANGE; INNATE IMMUNE RESPONSE; INTERLEUKIN-1; MATURE PROTEINS; N-TERMINALS; NMR STUDIES; RECEPTOR BINDING INTERFACE; REFOLDING;

DEUTERIUM; DICHROISM; MASS SPECTROMETERS; MASS SPECTROMETRY; PROTEIN FOLDING;

CIRCULAR DICHROISM SPECTROSCOPY;

DEUTERIUM; HYDROGEN; INTERLEUKIN 1BETA; INTERLEUKIN 1; INTERLEUKIN 1 PRECURSOR; PROTEIN PRECURSOR;

ARTICLE; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; HUMAN; LIFE CYCLE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; RECEPTOR BINDING; CHEMISTRY; COMPARATIVE STUDY; DEUTERIUM HYDROGEN EXCHANGE; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

VERTEBRATA;

DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; INTERLEUKIN-1; INTERLEUKIN-1BETA; PROTEIN PRECURSORS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70350002095     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.027375     Document Type: Article

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