Energetic landscape of α-lytic protease optimizes longevity through kinetic stability

Nature

Volumn 415, Issue 6869, 2002, Pages 343-346

  Jaswal, Sheila S ^a,b   Sohl, Julie L ^a   Davis, Jonathan H ^a,c   Agard, David A ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b YALE UNIVERSITY   (United States)

^c Lexigen Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DEGRADATION; THERMODYNAMIC STABILITY;

PROTEOLYTIC SENSITIVITIES;

PROTEINS;

BACTERIAL ENZYME; PROTEINASE;

BIOCHEMISTRY; PROTEIN;

ARTICLE; CATALYST; ENERGY TRANSFER; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; THERMODYNAMICS;

ANIMALS; ENZYME STABILITY; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; PICHIA; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; RATS; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; THERMODYNAMICS; WATER;

BACTERIA (MICROORGANISMS);

EID: 0037122769     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/415343a     Document Type: Article

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