Analysis of fish IL-1β and derived peptide sequences indicates conserved structures with species-specific IL-1 receptor binding: Implications for pharmacological design

Current Pharmaceutical Design

Volumn 10, Issue 31, 2004, Pages 3857-3871

  Koussounadis, Antonis I ^a   Ritchie, David W ^a   Kemp, Graham J L ^b   Secombes, Chris J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

trefoil fold; ICE cut site; Interleukin 1; Interleukin 1 receptor; Interleukin 1 receptor accessory protein comparative immunology

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; HYBRID PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR II; INTERLEUKIN 1 TRAP; INTERLEUKIN 1BETA; INTERLEUKIN RECEPTOR; METHOTREXATE; PEPTIDE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CLINICAL TRIAL; COMPLEX FORMATION; DRUG DESIGN; DRUG TARGETING; FISH; GENETIC CONSERVATION; HUMAN; INFLAMMATORY DISEASE; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; PUBLICATION; RECEPTOR BINDING; REVIEW; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; VERTEBRATE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CLINICAL TRIALS, PHASE II; CONSERVED SEQUENCE; DRUG DESIGN; FISHES; HUMANS; INTERLEUKIN-1; MOLECULAR SEQUENCE DATA; RECEPTORS, INTERLEUKIN-1; SEQUENCE ANALYSIS, PROTEIN; SPECIES SPECIFICITY;

EID: 9944262882     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612043382585     Document Type: Review

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