메뉴 건너뛰기




Volumn 30, Issue 10, 2009, Pages 1670-1677

Oncogenic Ras, but not V600EB-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYCHOLESTEROL; B RAF KINASE; CHOLESTEROL; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

EID: 70349990685     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp188     Document Type: Article
Times cited : (21)

References (46)
  • 1
    • 0029077985 scopus 로고
    • The significance of the cholesterol biosynthetic pathway in cell growth and carcinogenesis (review)
    • Rao,K.N. (1995) The significance of the cholesterol biosynthetic pathway in cell growth and carcinogenesis (review). Anticancer Res., 15 309-314.
    • (1995) Anticancer Res , vol.15 , pp. 309-314
    • Rao, K.N.1
  • 2
    • 23744440323 scopus 로고    scopus 로고
    • Cholesteryl esters in malignancy
    • Tosi,M.R. et al. (2005) Cholesteryl esters in malignancy. Clin. Chim. Acta, 359, 27-45.
    • (2005) Clin. Chim. Acta , vol.359 , pp. 27-45
    • Tosi, M.R.1
  • 3
    • 14944372177 scopus 로고    scopus 로고
    • Up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in left-sided human colon cancer
    • Notarnicola,M. et al. (2004) Up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in left-sided human colon cancer. Anticancer Res., 24, 3837-3842.
    • (2004) Anticancer Res , vol.24 , pp. 3837-3842
    • Notarnicola, M.1
  • 4
    • 23344432149 scopus 로고    scopus 로고
    • Biochemical changes of mevalonate pathway in human colorectal cancer
    • Caruso,M.G. et al. (2005) Biochemical changes of mevalonate pathway in human colorectal cancer. Anticancer Res., 25, 3393-3397.
    • (2005) Anticancer Res , vol.25 , pp. 3393-3397
    • Caruso, M.G.1
  • 5
    • 0032766426 scopus 로고    scopus 로고
    • Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells
    • Agarwal,B. et al. (1999) Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. Clin. Cancer Res., 5, 2223-2229.
    • (1999) Clin. Cancer Res , vol.5 , pp. 2223-2229
    • Agarwal, B.1
  • 6
    • 0031784485 scopus 로고    scopus 로고
    • Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis
    • Alonso,D.F. et al. (1998) Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis. Breast Cancer Res. Treat., 50 83-93.
    • (1998) Breast Cancer Res. Treat , vol.50 , pp. 83-93
    • Alonso, D.F.1
  • 7
    • 3242662664 scopus 로고    scopus 로고
    • Combinatorial chemoprevention: Efficacy of lovostatin and exisulind on the formation and progression of aberrant crypt foci
    • Kim,K.P. et al. (2004) Combinatorial chemoprevention: Efficacy of lovostatin and exisulind on the formation and progression of aberrant crypt foci. Anticancer Res., 24, 1805-1811.
    • (2004) Anticancer Res , vol.24 , pp. 1805-1811
    • Kim, K.P.1
  • 8
    • 19444364509 scopus 로고    scopus 로고
    • Statins and the risk of colorectal cancer
    • Poynter,J.N. et al. (2005) Statins and the risk of colorectal cancer. N. Engl. J. Med., 352, 2184-2192.
    • (2005) N. Engl. J. Med , vol.352 , pp. 2184-2192
    • Poynter, J.N.1
  • 9
    • 33644846806 scopus 로고    scopus 로고
    • Use of statins and breast cancer: A meta-analysis of seven randomized clinical trials and nine observational studies
    • Bonovas,S. et al. (2005) Use of statins and breast cancer: A meta-analysis of seven randomized clinical trials and nine observational studies. J. Clin. Oncol., 23, 8606-8612.
    • (2005) J. Clin. Oncol , vol.23 , pp. 8606-8612
    • Bonovas, S.1
  • 10
    • 29944446607 scopus 로고    scopus 로고
    • Statins and cancer risk: A meta-analysis
    • Dale,K.M. et al. (2006) Statins and cancer risk: A meta-analysis. Jama, 295, 74-80.
    • (2006) Jama , vol.295 , pp. 74-80
    • Dale, K.M.1
  • 11
    • 28844490054 scopus 로고    scopus 로고
    • Statins and cancer prevention
    • Demierre,M.F. et al. (2005) Statins and cancer prevention. Nat. Rev. Cancer, 5, 930-942.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 930-942
    • Demierre, M.F.1
  • 12
    • 0033557949 scopus 로고    scopus 로고
    • Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach
    • Dimitroulakos,J. et al. (1999) Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach. Blood, 93, 1308-1318.
    • (1999) Blood , vol.93 , pp. 1308-1318
    • Dimitroulakos, J.1
  • 13
    • 0032973711 scopus 로고    scopus 로고
    • Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death
    • Michikawa,M. et al. (1999) Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. J. Neurochem., 72, 2278-2285.
    • (1999) J. Neurochem , vol.72 , pp. 2278-2285
    • Michikawa, M.1
  • 14
    • 4644309414 scopus 로고    scopus 로고
    • Membrane cholesterol interferes with neuronal apoptosis induced by soluble oligomers but not fibrils of amyloid-beta peptide
    • Sponne,I. et al. (2004) Membrane cholesterol interferes with neuronal apoptosis induced by soluble oligomers but not fibrils of amyloid-beta peptide. Faseb J., 18, 836-838.
    • (2004) Faseb J , vol.18 , pp. 836-838
    • Sponne, I.1
  • 15
    • 33645457007 scopus 로고    scopus 로고
    • Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesteroldepleting agents
    • quiz 1404-1405
    • Li,Y.C. et al. (2006) Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesteroldepleting agents. Am. J. Pathol., 168, 1107-1118; quiz 1404-1405.
    • (2006) Am. J. Pathol , vol.168 , pp. 1107-1118
    • Li, Y.C.1
  • 16
    • 34347246377 scopus 로고    scopus 로고
    • Cholesterol level of lipid raft microdomains regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK signal transduction
    • Oh,H.Y. et al. (2007) Cholesterol level of lipid raft microdomains regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK signal transduction. Prostate, 67, 1061-1069.
    • (2007) Prostate , vol.67 , pp. 1061-1069
    • Oh, H.Y.1
  • 17
    • 0034736137 scopus 로고    scopus 로고
    • 25-Hydroxycholesterol activates a cytochrome c release-mediated caspase cascade
    • Yang,L. et al. (2000) 25-Hydroxycholesterol activates a cytochrome c release-mediated caspase cascade. Biochem. Biophys. Res. Commun. 278, 557-563.
    • (2000) Biochem. Biophys. Res. Commun , vol.278 , pp. 557-563
    • Yang, L.1
  • 18
    • 0347093316 scopus 로고    scopus 로고
    • AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis
    • Rusinol,A.E. et al. (2004) AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis. J. Biol. Chem., 279, 1392-1399.
    • (2004) J. Biol. Chem , vol.279 , pp. 1392-1399
    • Rusinol, A.E.1
  • 19
    • 33745840555 scopus 로고    scopus 로고
    • RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion
    • Calleros,L. et al. (2006) RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion. Apoptosis, 11, 1161-1173.
    • (2006) Apoptosis , vol.11 , pp. 1161-1173
    • Calleros, L.1
  • 20
    • 2342562556 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in apoptosis regulation
    • Wada,T. et al. (2004) Mitogen-activated protein kinases in apoptosis regulation. Oncogene, 23, 2838-2849.
    • (2004) Oncogene , vol.23 , pp. 2838-2849
    • Wada, T.1
  • 21
    • 0029851730 scopus 로고    scopus 로고
    • Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs
    • Osborn,M.T. et al. (1996) Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs. J. Biol. Chem., 271, 30950-30955.
    • (1996) J. Biol. Chem , vol.271 , pp. 30950-30955
    • Osborn, M.T.1
  • 22
    • 0036131785 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase/ stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycininduced apoptosis in HL-60 cells
    • Stadheim,T.A. et al. (2002) c-Jun N-terminal kinase/ stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycininduced apoptosis in HL-60 cells. Leuk. Res., 26 55-65.
    • (2002) Leuk. Res , vol.26 , pp. 55-65
    • Stadheim, T.A.1
  • 23
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song,G. et al. (2005) The activation of Akt/PKB signaling pathway and cell survival. J. Cell Mol. Med., 9, 59-71.
    • (2005) J. Cell Mol. Med , vol.9 , pp. 59-71
    • Song, G.1
  • 24
    • 0032490124 scopus 로고    scopus 로고
    • Kirsten Ras mutation in patients with colorectal cancer: The multicenter "RASCAL" study
    • Andreyev,H.J. et al. (1998) Kirsten Ras mutation in patients with colorectal cancer: The multicenter "RASCAL" study. J. Natl. Cancer Inst., 90, 675-684.
    • (1998) J. Natl. Cancer Inst , vol.90 , pp. 675-684
    • Andreyev, H.J.1
  • 25
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies,H. et al. (2002) Mutations of the BRAF gene in human cancer. Nature, 417, 949-954.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 26
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward,J. (2003) Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer, 3, 11-22.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 27
    • 51249098983 scopus 로고    scopus 로고
    • B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival
    • Matos,P. et al. (2008) B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival. Gastroenterology, 135, 899-906.
    • (2008) Gastroenterology , vol.135 , pp. 899-906
    • Matos, P.1
  • 28
    • 38949208776 scopus 로고    scopus 로고
    • BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations
    • Preto,A. et al. (2008) BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. J. Pathol., 214, 320-327.
    • (2008) J. Pathol , vol.214 , pp. 320-327
    • Preto, A.1
  • 29
    • 0035099881 scopus 로고    scopus 로고
    • S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
    • Chiloeches,A. et al. (2001) S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. Mol. Cell Biol., 21, 2423-2434.
    • (2001) Mol. Cell Biol , vol.21 , pp. 2423-2434
    • Chiloeches, A.1
  • 30
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein,J.L. et al. (1990) Regulation of the mevalonate pathway. Nature, 343, 425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1
  • 31
    • 0031015580 scopus 로고    scopus 로고
    • Effect of mevalonate availability on the association of G-protein alpha-subunits with the plasma membrane in GH4C1 cells
    • Chiloeches,A. et al. (1997) Effect of mevalonate availability on the association of G-protein alpha-subunits with the plasma membrane in GH4C1 cells. FEBS Lett., 401, 68-72.
    • (1997) FEBS Lett , vol.401 , pp. 68-72
    • Chiloeches, A.1
  • 32
    • 0028948382 scopus 로고
    • Multiple Ras functions can contribute to mammalian cell transformation
    • White,M.A. et al. (1995) Multiple Ras functions can contribute to mammalian cell transformation. Cell, 80, 533-541.
    • (1995) Cell , vol.80 , pp. 533-541
    • White, M.A.1
  • 33
    • 4143139930 scopus 로고    scopus 로고
    • Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38
    • Jans,R. et al. (2004) Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38. J. Invest. Dermatol., 123, 564-573.
    • (2004) J. Invest. Dermatol , vol.123 , pp. 564-573
    • Jans, R.1
  • 34
    • 34548649570 scopus 로고    scopus 로고
    • Cholesterol inhibits MMP-9 expression in human epidermal keratinocytes and HaCaT cells
    • Kim,S. et al. (2007) Cholesterol inhibits MMP-9 expression in human epidermal keratinocytes and HaCaT cells. FEBS Lett., 581 3869-3874.
    • (2007) FEBS Lett , vol.581 , pp. 3869-3874
    • Kim, S.1
  • 35
    • 24044439753 scopus 로고    scopus 로고
    • Membrane rafts segregate pro- from antiapoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily
    • Remacle-Bonnet,M. et al. (2005) Membrane rafts segregate pro- from antiapoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. Am. J. Pathol., 167, 761-773.
    • (2005) Am. J. Pathol , vol.167 , pp. 761-773
    • Remacle-Bonnet, M.1
  • 36
    • 1542380581 scopus 로고    scopus 로고
    • Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB
    • Habelhah,H. et al. (2004) Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB. EMBO J., 23, 322-332.
    • (2004) EMBO J , vol.23 , pp. 322-332
    • Habelhah, H.1
  • 37
    • 0347362786 scopus 로고    scopus 로고
    • Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux
    • Nofer,J.R. et al. (2003) Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux. J. Biol. Chem., 278, 53055-53062.
    • (2003) J. Biol. Chem , vol.278 , pp. 53055-53062
    • Nofer, J.R.1
  • 38
    • 33746663482 scopus 로고    scopus 로고
    • Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers
    • Xia,H.H. et al. (2006) Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers. Cancer Lett., 241, 268-274.
    • (2006) Cancer Lett , vol.241 , pp. 268-274
    • Xia, H.H.1
  • 39
    • 0036278927 scopus 로고    scopus 로고
    • The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3′-kinase, in human colon cancer cells
    • Semba,S. et al. (2002) The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3′-kinase, in human colon cancer cells. Clin. Cancer Res., 8, 1957-1963.
    • (2002) Clin. Cancer Res , vol.8 , pp. 1957-1963
    • Semba, S.1
  • 40
    • 9644281593 scopus 로고    scopus 로고
    • Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway
    • Yamaguchi,K. et al. (2004) Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway. J. Biol. Chem., 279, 49617-49623.
    • (2004) J. Biol. Chem , vol.279 , pp. 49617-49623
    • Yamaguchi, K.1
  • 41
    • 34447134174 scopus 로고    scopus 로고
    • Cholesterol sensitivity of endogenous and myristoylated Akt
    • Adam,R.M. et al. (2007) Cholesterol sensitivity of endogenous and myristoylated Akt. Cancer Res., 67, 6238-6246.
    • (2007) Cancer Res , vol.67 , pp. 6238-6246
    • Adam, R.M.1
  • 42
    • 0038342509 scopus 로고    scopus 로고
    • AKT2 inhibition of cisplatin-induced JNK/ p38 and Bax activation by phosphorylation of ASK1: Implication of AKT2 in chemoresistance
    • Yuan,Z.Q. et al. (2003) AKT2 inhibition of cisplatin-induced JNK/ p38 and Bax activation by phosphorylation of ASK1: Implication of AKT2 in chemoresistance. J. Biol. Chem., 278, 23432-23440.
    • (2003) J. Biol. Chem , vol.278 , pp. 23432-23440
    • Yuan, Z.Q.1
  • 43
    • 0037423289 scopus 로고    scopus 로고
    • Negative regulation ofmixed lineage kinase 3 by protein kinase B/AKT leads to cell survival
    • Barthwal,M.K. et al. (2003) Negative regulation ofmixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J. Biol. Chem., 278, 3897-3902.
    • (2003) J. Biol. Chem , vol.278 , pp. 3897-3902
    • Barthwal, M.K.1
  • 44
    • 0035891320 scopus 로고    scopus 로고
    • Inhibition of JNK activation through NF-kappaB target genes
    • Tang,G. et al. (2001) Inhibition of JNK activation through NF-kappaB target genes. Nature, 414, 313-317.
    • (2001) Nature , vol.414 , pp. 313-317
    • Tang, G.1
  • 45
    • 0141953270 scopus 로고    scopus 로고
    • A JNK-dependent pathway is required for TNFalpha-induced apoptosis
    • Deng,Y. et al. (2003) A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell, 115, 61-70.
    • (2003) Cell , vol.115 , pp. 61-70
    • Deng, Y.1
  • 46
    • 26244464326 scopus 로고    scopus 로고
    • PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
    • Porstmann,T. et al. (2005) PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene, 24, 6465-6481.
    • (2005) Oncogene , vol.24 , pp. 6465-6481
    • Porstmann, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.