Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4622-4636

  Bhandari, Shashikant V ^a   Dangre, Sudarshan C ^a   Bothara, Kailash G ^a   Patil, Ajit A ^a   Sarkate, Aniket P ^a   Lokwani, Deepak K ^a   Gore, Suraj T ^a   Deshmane, Bhavana J ^a   Raparti, Vyankatesh T ^a   Khachane, Chetan V ^a  

^a AISSMS COLLEGE OF PHARMACY   (India)

Author keywords

1,5 Diarylpyrazolin 3 one; Analgesic; Anti inflammatory; Docking; Nitric oxide; Non ulcerogenic; Vasodilatory

Indexed keywords

2 [2 [4 [5 (4 NITROPHENYL) 3 OXO 2,3 DIHYDROPYRAZOL 1 YL]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 2 OXO 2 [2 [4 (3 OXO 5 PHENYL 2,3 DIHYDROPYRAZOL 1 YL)BENZOYL]HYDRAZINYL]ETHYLNITRATE; 3 [2 [4 [5 (2 HYDROXYPHENYL) 3 OXO 2,3 DIHYDROPYRAZOL 1 YL]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 3 [2 [4 [5 (2 METHOXYPHENYL) 3 OXO 2,3 DIHYDROPYRAZOL 1 YL]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 3 [2 [4 [5 (4 CHLOROPHENYL) 3 OXO 2,3 DIHYDROPYRAZOL 1 YL]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; CELECOXIB; CYCLOOXYGENASE 2; DICLOFENAC; ETHYL 1 [4 [2 [2 (NITROOXY)ACETYL]HYDRAZINECARBONYL]PHENYL] 3 OXO 5 PHENYL 2,3 DIHYDRO 1H PYRAZOL 4 CARBOXYLATE; ETHYL 1 [4 [2 [2 (NITROOXY)ACETYL]HYDRAZINECARBONYL]PHENYL] 5 (2 HYDROXYPHENYL) 3 OXO 2,3 DIHYDROPYRAZOL 4 CARBOXYLATE; ETHYL 1 [4 [2 [2 (NITROOXY)ACETYL]HYDRAZINECARBONYL]PHENYL] 5 (2 METHOXYPHENYL) 3 OXO 2,3 DIHYDROPYRAZOL 4 CARBOXYLATE; ETHYL 1 [4 [2 [2 (NITROOXY)ACETYL]HYDRAZINECARBONYL]PHENYL] 5 (4 CHLOROPHENYL) 3 OXO 2,3 DIHYDROPYRAZOL 4 CARBOXYLATE; ETHYL 1 [4 [2 [2 (NITROOXY)ACETYL]HYDRAZINECARBONYL]PHENYL] 5 (4 NITROPHENYL) 3 OXO 2,3 DIHYDROPYRAZOL 4 CARBOXYLATE; IBUPROFEN; INDOMETACIN; NITRIC OXIDE; NITRIC OXIDE DONOR; NONSTEROID ANTIINFLAMMATORY AGENT; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HISTOPATHOLOGY; HYDROGEN BOND; MALE; MOUSE; NONHUMAN; PAW EDEMA; RAT; STOMACH PROTECTION; ULCEROGENESIS; WRITHING TEST;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2; EDEMA; FEMALE; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRIC OXIDE; PAIN MEASUREMENT; PROTEIN BINDING; PYRAZOLES; RATS; RATS, WISTAR; STOMACH; ULCER; VASODILATOR AGENTS;

EID: 70349976958     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.06.035     Document Type: Article

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