Rational design of highly active and selective ligands for the α5β1 integrin receptor

ChemBioChem

Volumn 9, Issue 9, 2008, Pages 1397-1407

  Heckmann, Dominik ^a   Meyer, Axel ^a   Laufer, Burkhardt ^a   Zahn, Grit ^b   Stragies, Roland ^b   Kessler, Horst ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Jerini AG   (Germany)

Author keywords

Antiangiogenic; Antitumor agents; Integrins; Rational design; Structure activity relationships

Indexed keywords

AMINOALCOHOL; AROMATIC CARBOXYLIC ACID; GONADORELIN[6 DEXTRO [3 (2 NAPHTHYL)ALANINE] 10 AZAGLYCINE]; INTEGRIN RECEPTOR; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5 RECEPTOR; ANGIOGENESIS INHIBITOR; DRUG DERIVATIVE; GLYCINE; HETEROCYCLIC COMPOUND; LIGAND; TYROSINE; VERY LATE ACTIVATION ANTIGEN 5; VITRONECTIN RECEPTOR;

ANTIANGIOGENIC ACTIVITY; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG POTENTIATION; ENZYME SPECIFICITY; METABOLISM; NEOPLASM; PROTEIN CONFORMATION; RETINA MACULA DEGENERATION; SEQUENCE HOMOLOGY; SYNTHESIS;

ANGIOGENESIS INHIBITORS; AZA COMPOUNDS; BINDING SITES; DRUG DESIGN; GLYCINE; INTEGRIN ALPHA5BETA1; INTEGRIN ALPHAVBETA3; LIGANDS; MACULAR DEGENERATION; MODELS, MOLECULAR; NEOPLASMS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TYROSINE;

EID: 49249138843     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800045     Document Type: Article

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