Ocimum sanctum induces apoptosis in A549 lung cancer cells and suppresses the in vivo growth of lewis lung carcinoma cells

Phytotherapy Research

Volumn 23, Issue 10, 2009, Pages 1385-1391

  Magesh, Venkataraman ^a   Lee, Jang Choon ^a   Kwang, Seok Ahn ^a   Lee, Hyo Jung ^a   Lee, Hyo Jeong ^a   Lee, Eun Ok ^a   Bum, Sang Shim ^a   Hee, Jae Jung ^a   Jin, Sung Kim ^a   Dae, Keun Kim ^b   Choi, Seung Hoon ^a   Ahn, Kyoo Seok ^a   Kim, Sung Hoon ^a  

^a Kyung Hee University   (South Korea)

^b Woosuk University   (South Korea)

Author keywords

A549; Apoptosis; Lewis lung carcinoma; Ocimum sanctum

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OCIMUM SANCTUM EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BASIL; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; LEWIS CARCINOMA; LUNG CANCER; MOUSE; NONHUMAN; OCIMUM SANCTUM; PLANT LEAF; PROTEIN CLEAVAGE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, LEWIS LUNG; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; OCIMUM; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2;

ANIMALIA; MUS; OCIMUM TENUIFLORUM;

EID: 70349908546     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2784     Document Type: Article

References (39)

1. Anandjiwala S, Kalola J, Rajani M. 2006. Quantification of eugenol, luteolin, ursolic acid, and oleanolic acid in black (Krishna Tulasi) and green (Sri Tulasi) varieties of Ocimum sanctum Linn. using high-performance thin-layer chromatography. J AOAC Int 89: 1467-1474. (Pubitemid 46009901)
2. Aruna K, Sivaramakrishnan VM. 1992. Anticarcinogenic effects of some Indian plant products. Food Chem Toxicol 30: 953-956. (Pubitemid 23014794)
3. Balachandran P, Govindarajan R. 2005. Cancer - an ayurvedic perspective. Pharmacol Res 51: 19-30.
4. Balanehru S, Nagarajan B. 1992. Intervention of adriamycin induced free radical damage. Biochem Int 28: 735-744. (Pubitemid 23027093)
5. Boulares AH, Zoltoski AJ, Yakovlev A, Xu M, Smulson ME. 2001. Roles of DNA fragmentation factor and poly(ADPribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. J Biol Chem 276: 38185-38192. (Pubitemid 37384074)
6. Brognard J, Clark AS, Ni Y, Dennis PA. 2001. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 61: 3986-3997. (Pubitemid 32720961)
7. Broker LE, Kruyt FA, Giaccone G. 2005. Cell death independent of caspases: a review. Clin Cancer Res 11: 3155-3162. (Pubitemid 40627860)
8. Chen RH, Su YH, Chuang RL, Chang TY. 1998. Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. Oncogene 17: 1959-1968.
9. Chowdhury AR, Sharma S, Mandal S, Goswami A, Mukhopadhyay S, Majumder HK. 2002. Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J 366: 653-661. (Pubitemid 35001710)
10. Devi PU, Ganasoundari A. 1995. Radioprotective effect of leaf extract of Indian medicinal plant Ocimum sanctum. Indian J Exp Biol 33: 205-208.
11. Downward J. 1998. Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10: 262-267. (Pubitemid 28174769)
12. Fontham ET. 1990. Protective dietary factors and lung cancer. Int J Epidemiol 19(Suppl 1): S32-S42. (Pubitemid 20321518)
13. Franke TF, Kaplan DR, Cantley LC. 1997. PI3K: downstream AKTion blocks apoptosis. Cell 88: 435-437.
14. Fraser M, Leung BM, Yan X, Dan HC, Cheng JQ, Tsang BK. 2003. p53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells. Cancer Res 63: 7081-7088. (Pubitemid 37413443)
15. Grana X, Reddy EP. 1995. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11: 211-219.
16. Hengartner MO. 2000. The biochemistry of apoptosis. Nature 407: 770-776.
17. Hickman JA. 1992. Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11: 121-139.
18. Ichikawa H, Nakamura Y, Kashiwada Y, Aggarwal BB. 2007. Anticancer drugs designed by mother nature: ancient drugs but modern targets. Curr Pharm Des 13: 3400-3416. (Pubitemid 350201674)
19. Jemal A, Siegel R, Ward E et al. 2006. Cancer statistics, 2006. CA Cancer J Clin 56: 106-130.
20. Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J. 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J 16: 2783-2793. (Pubitemid 27226215)
21. Kim JH, Jin YR, Park BS et al. 2005. Luteolin prevents PDGF-BB-induced proliferation of vascular smooth muscle cells by inhibition of PDGF beta-receptor phosphorylation. Biochem Pharmacol 69: 1715-1721.
22. Kim JH, Lee EO, Lee HJ et al. 2007. Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann N Y Acad Sci 1095: 598-611.
23. Kim SH, Ahn BZ, Ryu SY. 1998. Antitumour effects of ursolic acid isolated from Oldenlandia diffusa. Phytother Res 12: 553-556.
24. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC. 1994. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346-347. (Pubitemid 24300618)
25. Lee EO, Lee HJ, Hwang HS et al. 2006. Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities. Carcinogenesis 27: 2059-2069.
26. Lee SH, Kim HS, Park WS et al. 2002. Non-small cell lung cancers frequently express phosphorylated Akt; an immunohistochemical study. Apmis 110: 587-592.
27. Manikandan P, Vidjaya Letchoumy P, Prathiba D, Nagini S. 2007. Proliferation, angiogenesis and apoptosis-associated proteins are molecular targets for chemoprevention of MNNG-induced gastric carcinogenesis by ethanolic Ocimum sanctum leaf extract. Singapore Med J 48: 645-651.
28. Parkin DM. 2001. Global cancer statistics in the year 2000. Lancet Oncol 2: 533-543. (Pubitemid 33586866)
29. Prakash J, Gupta SK. 2000. Chemopreventive activity of Ocimum sanctum seed oil. J Ethnopharmacol 72: 29-34. (Pubitemid 30680032)
30. Ranga RS, Sowmyalakshmi S, Burikhanov R, Akbarsha MA, Chendil D. 2005. A herbal medicine for the treatment of lung cancer. Mol Cell Biochem 280: 125-133. (Pubitemid 41829808)
31. Sharma JN, Srivastava KC, Gan EK. 1994. Suppressive effects of eugenol and ginger oil on arthritic rats. Pharmacology 49: 314-318.
32. Singh S, Majumdar DK, Yadav MR. 1996. Chemical and pharmacological studies on fixed oil of Ocimum sanctum. Indian J Exp Biol 34: 1212-1215. (Pubitemid 26411243)
33. Sporn MB, Suh N. 2000. Chemoprevention of cancer. Carcinogenesis 21: 525-530.
34. Susin SA, Lorenzo HK, Zamzami N et al. 1999. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441-446. (Pubitemid 29078912)
35. Thornberry NA, Lazebnik Y. 1998. Caspases: enemies within. Science 281: 1312-1316.
36. Willett WC. 1994. Diet and health: what should we eat? Science 264: 532-537.
37. Wolf BB, Green DR. 1999. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J Biol Chem 274: 20049-20052. (Pubitemid 129519463)
38. Yoo CB, Han KT, Cho KS et al. 2005. Eugenol isolated from the essential oil of Eugenia caryophyllata induces a reactive oxygen species-mediated apoptosis in HL-60 human promyelocytic leukemia cells. Cancer Lett 225: 41-52.
39. Zhu W, Wang XM, Zhang L, Li XY, Wang BX. 2005. Pharmacokinetic of rhein in healthy male volunteers following oral and retention enema administration of rhubarb extract: a single dose study. Am J Chin Med 33: 839-850. (Pubitemid 43124508)