Proliferation, angiogenesis and apoptosis-associated proteins are molecular targets for chemoprevention of MNNG-induced gastric carcinogenesis by ethanolic Ocimum sanctum leaf extract

Singapore Medical Journal

Volumn 48, Issue 7, 2007, Pages 645-651

  Manikandan, P ^a   Vidjaya Letchoumy, P ^a   Prathiba, D ^b   Nagini, Siddavaram ^a  

^a ANNAMALAI UNIVERSITY   (India)

^b SRI RAMACHANDRA UNIVERSITY   (India)

Author keywords

Apoptosis; Cell proliferation; Chemoprevention; Gastric cancer; N methyl n nitro N nitrosoguanidine; Ocimum sanctum

Indexed keywords

CASPASE 3; CYCLINE; CYTOCHROME C; CYTOKERATIN; GLUTATHIONE TRANSFERASE P1; METHYLNITRONITROSOGUANIDINE; OCIMUM SANCTUM EXTRACT; PROTEIN BAX; PROTEIN BCL 2; VASCULOTROPIN; ANTINEOPLASTIC AGENT; PLANT EXTRACT; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG MECHANISM; HISTOPATHOLOGY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; STOMACH CARCINOMA; ANIMAL; BASIL; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DISEASE MODEL; DRUG EFFECT; NEOVASCULARIZATION (PATHOLOGY); PHYTOTHERAPY; PLANT LEAF; RANDOMIZED CONTROLLED TRIAL; SQUAMOUS CELL CARCINOMA; STOMACH TUMOR; WISTAR RAT;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; CHEMOPREVENTION; DISEASE MODELS, ANIMAL; MALE; METHYLNITRONITROSOGUANIDINE; NEOVASCULARIZATION, PATHOLOGIC; OCIMUM; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; STOMACH NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34547428891     PISSN: 00375675     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol 2006; 12:354-62.
2. Veronesi U, Bonanni B. Chemoprevention: from research to clinical oncology. Eur J Cancer 2005; 41:1833-41.
3. Newberne PM, Charnley G, Adams K, et al. Gastric carcinogenesis: a model for the identification of risk factors. Cancer Lett 1987; 38:149-63.
4. Kaneko M, Morimura K, Nishikawa T, et al. Different genetic alterations in rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens. Carcinogenesis 2002; 23:1729-35.
5. Abe M, Yamashita S, Kuramoto T, et al. Global expression analysis of N-methyl-N′-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays. Carcinogenesis 2003; 24:861-7.
6. Velmurugan B, Mani A, Nagini S. Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis. Eur J Cancer Prev 2005; 14:387-93.
7. Subapriya R, Nagini S. Ethanolic neem leaf protects against N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in Wistar rats. Asian Pac J Cancer Prev 2003; 4:215-23.
8. Gupta SK, Prakash J, Srivastava S. Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant. Indian J Exp Biol 2002; 40:765-73.
9. Manikandan P, Senthil Murugan R, Abbas H, Abraham SK, Nagini S. The protective effects of ethanolic Ocimum sanctum (OS) leaf extract against 7,12-dimethylbenz[a]anthracene (DMBA)-induced genotoxicity, oxidative stress, and imbalance in xenobioticmetabolising enzymes. J Med Food. In press.
10. Karthikeyan K, Ravichandran D, Govindasamy S. Chemopreventive effect of Ocimum sanctum on DMBA-induced hamster buccal pouch carcinogenesis. Oral Oncol 1999; 35:112-9.
11. Aruna K, Sivaramakrishnan VM. Anticarcinogenic effects of some Indian plant products. Food Chem Toxicol 1992; 30:953-6.
12. Saravanan K, Nagarajan B. Genotoxicity assessment in vivo in gastric carcinogenesis. Med Sci Res 1993; 21:119-21.
13. Tabuchi Y, Ogino T, Mitsuno T, Sugiyama T. Possible role of mucosal damage in stomach carcinogenesis with N-methyl-N′-nitro-N-nitrosoguanidine in the rat. J Natl Cancer Inst 1974; 52:1589-94.
14. Saito T, Sasaki O, Tamada R, Iwamatasu M, Inokuchi K. Sequential studies of development of gastric carcinoma in dogs induced by N-methyl-N′-nitro- N-nitrosoguanidine. Cancer 1978; 42:1246-54.
15. JÓnsson ZO, Hindges R, Hübscher U. Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen. EMBO J 1998; 17:2412-25.
16. Hall PA, Levison DA, Woods AL, et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 1990; 162:285-94.
17. Ruscoe JE, Rosario LA, Wang T, et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther 2001; 298:339-45.
18. Takahashi M, Shirai T, Fukushima S, et al. Ulcer formation and associated tumor production in multiple sites within the stomach and duodenum of rats treated with N-methyl-N′-nitro-Nnitrosoguanidine. J Natl Cancer Inst 1981; 67:473-9.
19. Goel RK, Sairam K, Dorababu M, Prabha T, Rao ChV. Effect of standardized extract of Ocimum sanctum Linn. on gastric mucosal offensive and defensive factors. Indian J Exp Biol 2005; 43:715-21.
20. Dharmani P, Kuchibhotla VK, Maurya R, et al. Evaluation of antiulcerogenic and ulcer-healing properties of Ocimum sanctum Linn. J Ethnopharmacol 2004; 93:197-206.
21. Hsu S, Singh B, Schuster G. Induction of apoptosis in oral cancer cells: agents and mechanisms for potential therapy and prevention. Oral Oncol 2004; 40:461-73.
22. Ghosh R, Nadiminty N, Fitzpatrick JE, et al. Eugenol causes melanoma growth suppression through inhibition of E2F1 transcriptional activity. J Biol Chem 2005; 28:5812-9.
23. Es-saady D, Simon A, Ollier M, et al. Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest. Cancer Lett 1996; 106:193-7.
24. He L, Mo H, Hadisusilu S, Qureshi AA, Elson CE. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr 1997; 127:668-74.
25. Yoo CB, Han KT, Cho KS, et al. Eugenol isolated from the essential oil of Eugenia caryophyllata induces a reactive oxygen species-mediated apoptosis in HL-60 human promyelocytic leukemia cells. Cancer Lett 2005; 225:41-52.
26. Hsu YL, Kuo PL, Lin CC. Proliferative inhibition of cell cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small lung cancer A549 cells. Life Sci 2004; 75:2303-16.
27. Wang IK, Lin-Shiau SY, Lin JK. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 1999; 35:1517-25.
28. Lee WJ, Wu LF, Chen WK, Wang CJ, Tseng TH. Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. Chem Biol Interact 2006; 160:123-33.