Exposure to uteroplacental insufficiency reduces the expression of signal transducer and activator of transcription 3 and proopiomelanocortin in the hypothalamus of newborn rats

Pediatric Research

Volumn 66, Issue 2, 2009, Pages 208-211

  Puglianiello, Antonella ^a   Germani, Daniela ^a   Cianfarani, Stefano ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN RECEPTOR; MESSENGER RNA; PROOPIOMELANOCORTIN; STAT3 PROTEIN; STAT3 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; BIRTH WEIGHT; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; HYPOTHALAMUS; METABOLISM; NEWBORN; NONHUMAN; PLACENTA INSUFFICIENCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UTERINE ARTERY; ANIMAL; BODY WEIGHT; GENETICS; HUMAN; INTRAUTERINE GROWTH RETARDATION; PHYSIOLOGY; PREGNANCY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; FEMALE; FETAL GROWTH RETARDATION; HUMANS; HYPOTHALAMUS; PLACENTAL INSUFFICIENCY; PREGNANCY; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 70349898725     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3181a9e7fd     Document Type: Article

References (31)

1. Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ 1989 Weight in infancy and death from ischaemic heart disease. Lancet 2:577-580
2. Barker DJ, Osmond C, Golding J, Kuh D, Wadswoith ME 1989 Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 298:564-567
3. Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM 1993 Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidemia (syndrome X): relation to reduced fetal growth. Diabetologia 36:62-67
4. Barker DJ 1995 Fetal origins of coronary heart disease. BMJ 311:171-174
5. 5. Eriksson JG, Forsen T, Tuomilehto J, Osmond G, Barker DJ 2001 Early growth and coronary heart disease in later life: a longitudinal study. BMJ 322:949-953 (Pubitemid 32374683)
6. Geremia C, Cianfarani S 2004 Insulin sensitivity in children born small for gestational age (SGA). Rev Diabet Stud 1:58-65
7. 7. Fowden AL, Giussani DA, Forhead AJ 2005 Endocrine and metabolic programming during intrauterine development. Early Hum Dev 81:723-734 (Pubitemid 41253517)
8. Unterman T, Lascon R, Gotway M, Oehler D, Gounis A, Simmons RA, Ogata ES 1990 Circulating levels of insulin-like growth factor binding protein-1 (IGFBP-I.) and hepatic mRNA are increased in the small for gestational, age fetal, rat. Endocrinology 127:2035-2037
9. 9. Simmons RA, Templeton LJ, Gertz SJ 2001 Intrauterine growth retardation leads to the development of type 2 diabetes in rat. Diabetes 50:2279-2286 (Pubitemid 33641912)
10. Puglianiello A, Cianfarani S 2006 Central control of glucose homeostasis. Rev Diabet Stud 3:54-60
11. Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L 2002 Central, administration of oleic acid inhibits glucose production and food intake. Diabetes 51:271-275
12. 12. Obici S, Zhang BB, Karkanias Q, Rossetti L 2002 Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8:1376-1382 (Pubitemid 36019422)
13. Elmquist JK, Marcus JN 2003 Rethinking the central causes of diabetes. Nat Med 9:645-647
14. Prodi E, Obici S 2006 The brain, as a molecular target for diabetic therapy. Endocrinology 147:2664-2669
15. 15. Lim CP, Cao X 2006 Structure, function, and regulation of STAT proteins. Mol Biosyst 2:536-550 (Pubitemid 44583902)
16. 16. Gao Q,Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI, Fu XY 2004 Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl. Acad Sci USA 101:46614666 (Pubitemid 38437467)
17. Cui Y, Huang L, Elefteriou F, Yang G, Shelton JM, Giles JE, Oz OK, Pourbahrami T, Lu CY, Richardson JA, Karsenty G, Li. C 2004 Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol 24:258-269
18. Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hon M 2004 Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem. Biophys Res Commun 31.9:1159-1170
19. 19. Lee JY, Hennighausen L 2005 The transcription factor STAT3 is dispensable for pancreatic beta-cell development and function. Biochem Biophys Res Commun 334:764-768 (Pubitemid 41033187)
20. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC 1996 Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sei USA 93:6231-6235
21. Darnell JE 1996 Reflections on STAT3, STAT5, and STAT6 as fat STATs. Proc Natl Acad Sci USA. 93:6221-6224
22. Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM 1996 Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet 14:95-97
23. Myers MQ, Cowley MA, Münzberg H 2008 Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70:537-556
24. Simmons RA, Gounis AS, Bangalore SA, Ogata ES 1992 Intrauterine growth retardation: fetal glucose transport is diminished in lung but spared in brain. Pediatr Res 31:59-63
25. 25. Puglianiello A, Germani D, Antignani S, Scalia Tomba G, Cianfarani S 2007 Changes in the expression of hypothalamic lipid sensing genes in rat model of intrauterine growth, retardation (IUGR). Pediatr Res 61:433-437 (Pubitemid 46569296)
26. 26. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW 2006 Central nervous system control of food intake and body weight. Nature 443:289-295 (Pubitemid 44435142)
27. Gluckman PD, Hanson MA 2004 Living with the past: evolution, development, and patterns of disease. Science 305:1733-1736
28. 28. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:1.65-168 (Pubitemid 27034218)
29. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvaťh TL, Roger Cone RD, Low MJ 2001 Leptin activates anorexigenic POMC neurons through aneural network in the arcuate nucleus. Nature 411:480-484
30. Smith JT, Waddell BJ 2003 Leptin distribution, and metabolism, in the pregnant rat: transplacental leptin passage increases in late gestation nut is reduced by excess glucocorticoids. Endocrinology 144:3024-3030
31. Desai M, Gayle D, Han G, Ross MG 2007 Programmed hyperphagia due to reduced anorexigenic mechanisms in intrauterine growth-restricted offspring. Reprod Sci 14:329-337