Sex/gender medicine - The biological basis for personalized care in cardiovascular medicine

Circulation Journal

Volumn 73, Issue 10, 2009, Pages 1774-1782

  Arain, Faisal A ^a   Kuniyoshi, Fatima H ^a   Abdalrhim, Ahmed D ^a   Miller, Virginia M ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

Atherosclerosis; Autonomic nervous system; Heart failure; Hypertension

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ESTROGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; TESTOSTERONE;

ATHEROSCLEROSIS; AUTONOMIC INNERVATION; CARDIOVASCULAR DISEASE; CELL THERAPY; DRUG RESPONSE; GENDER; GENETIC VARIABILITY; HEART INFARCTION; HUMAN; HYPERTENSION; LOW DRUG DOSE; NONHUMAN; REVIEW; RISK FACTOR; SEX DIFFERENCE; STROKE;

ATHEROSCLEROSIS; AUTONOMIC NERVOUS SYSTEM; BIOMEDICAL RESEARCH; CARDIOVASCULAR DISEASES; FEMALE; HEART FAILURE; HUMANS; HYPERTENSION; INDIVIDUALIZED MEDICINE; MALE; PATIENT SELECTION; RISK ASSESSMENT; RISK FACTORS; SEX CHARACTERISTICS; SEX FACTORS;

EID: 70349857839     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-09-0588     Document Type: Review

References (134)

1. Blauwet LA, Redberg RF. The role of sex-specific results reporting in cardiovascular disease. Cardiol Rev 2007; 15: 275-278. (Pubitemid 350307635)
2. Shaw LJ, Bairey Merz CN, Pepine CJ, Reis SE, Bittner V, Kelsey SF, et al. Insights from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study. Part I: Gender differences in traditional and novel risk factors, symptom evaluation, and gender- optimized diagnostic strategies. J Am Coll Cardiol 2006; 47: S4-S20. (Pubitemid 43170826)
3. Vaccarino V, Parsons L, Every NR, Barron HV, Krumholz HM. Sex-based differences in early mortality after myocardial infarction: National Registry of Myocardial Infarction 2 Participants [see Comment]. N Engl J Med 1999; 341: 217-225.
4. King KM, Ghali WA, Faris PD, Curtis MJ, Galbraith PD, Graham MM, et al. Sex differences in outcomes after cardiac catheterization: Effect modification by treatment strategy and time [see Comment]. JAMA 2004; 291: 1220-1225.
5. Kannel WB, Sorlie P, McNamara PM. Prognosis after initial myocardial infarction: The Framingham study. Am J Cardiol 1979; 44: 53-59. (Pubitemid 9216892)
6. Becker RC, Terrin M, Ross R, Knatterud GL, Desvigne-Nickens P, Gore JM, et al. Comparison of clinical outcomes for women and men after acute myocardial infarction: The Thrombolysis in Myocardial Infarction Investigators [see Comment]. Ann Intern Med 1994; 120: 638-645.
7. Mallik S, Vaccarino V. Outcomes of thrombolytic therapy for acute myocardial infarction in women. Prog Cardiovasc Dis 2004; 47: 58-71. (Pubitemid 39420272)
8. Wizemann TM, Pardue ML. Exploring the biological contributions to human health: Does sex matter? [Board on Health Sciences Policy]. Washington, DC: Institute of Medicine; 2001.
9. Turner ME, Parkas J, Dunmire J, Ely D, Milsted A. Which Sry locus is the hypertensive Y Chromosome locus? Hypertension 2009; 53: 430-435.
10. Charchar FJ, Tomaszewski M, Strahorn P, Champagne B, Dominiczak AF. Y is there a risk to being male? Trends Endocrinol Metab 2003; 14: 163-168.
11. Arnold AP, Chen X. What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues? Front Neuroendocrinol 2009; 30: 1-9.
12. Resch U, Schichl YM, Sattler S, de Martin R. XIAP regulates intracellular ROS by enhancing antioxidant gene expression. Biochem Biophys Research Commun 2008; 375: 156-161.
13. Bhuiyan MS, Fukunaga K. Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: Current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury. Cardiovasc Ther 2008; 26: 224-232.
14. Price RA, Li WD, Kilker R. An X-chromosome scan reveals a locus for fat distribution in chromosome region Xp21-22. Diabetes 2002; 51: 1989-1991. (Pubitemid 34564316)
15. Avner P, Heard E. X-chromosome inactivation: Counting, choice and initiation. Nat Rev Genet 2001; 2: 59-67. (Pubitemid 33674770)
16. Singh ND, Petrov DA. Evolution of gene function on the X chromosome versus the autosomes. Genome Dyn 2007; 3: 101-118.
17. Itoh Y, Melamed E, Yang X, Kamp K, Wang S, Yehya N, et al. Dosage compensation is less effective in birds man in mammals. J Biol 2007; 6: 2. (Pubitemid 46474683)
18. Arnold AP. Sex chromosomes and brain gender. Nat Rev Drug Neurosci 2004; 5: 701-708.
19. Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, et al. Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res 2006; 16: 995-1004. (Pubitemid 44162259)
20. Shearman AM, Cooper JA, Kotwinski PJ, Humphries SE, Mendelsohn ME, Housman DE, et al. Estrogen receptor alpha gene variation and the risk of stroke. Stroke 2005; 36: 2281-2282. (Pubitemid 41429261)
21. Pollak A, Rokach A, Blumenfeld A, Rosen LJ, Resnik L, Dresner Pollak R. Association of oestrogen receptor alpha gene polymorphism with the angiographic extent of coronary artery disease. Eur Heart J 2004; 25: 240-245. (Pubitemid 38235161)
22. Alessio AM, Hoehr NF, Siqueira LH, Ozelo MC, de Padua Mansur A, Annichino-Bizzacchi JM. Association between estrogen receptor alpha and beta gene polymorphisms and deep vein thrombosis. Thromb Res 2007; 120: 639-645. (Pubitemid 47268039)
23. Schuit S, Oei HS, Witteman J, Geurts van Kessel C, van Meurs J, Nijhuis R, et al. Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction. JAMA 2004; 291: 2969-2977. (Pubitemid 38802686)
24. Sudhir K, Chou TM, Chatterjee K, Smith EP, Williams TC, Kane JP, et al. Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man. Circulation 1997; 96: 3774-3777. (Pubitemid 27513460)
25. Reckelhoff JF. Gender differences in the regulation of blood pressure. Hypertension 2001; 37: 1199-1208.
26. Reyes D, Lew SQ, Kimmel PL. Gender differences in hypertension and kidney disease. Med Clin North Am 2005; 89: 613-630. (Pubitemid 40332400)
27. Lott ME, Hogeman C, Herr M, Bhagat M, Sinoway LI. Sex differences in limb vasoconstriction responses to increases in transmural pressures. Am J Physiol Heart Circ Physiol 2009; 296: H186-H194.
28. Dart AM, Du XJ, Kingwell BA. Gender, sex hormones and autonomic nervous control of the cardiovascular system. Cardiovasc Res 2002; 53: 678-687.
29. Shoemaker JK, Hogeman CS, Khan M, Kimmerly DS, Sinoway LI. Gender affects sympathetic and hemodynamic response to postural stress. Am J Physiol Heart Circ Physiol 2001; 281: H2028-H2035. (Pubitemid 33121746)
30. Franke WD, Johnson CP, Steinkamp JA, Wang R, Halhwill JR. Cardiovascular and autonomic responses to lower body negative pressure: Do not explain gender differences in orthostatic tolerance. Clin Auton Res 2003; 13: 36-44. (Pubitemid 36549855)
31. Tank J, Diedrich A, Szczech E, Luft FC, Jordan J. Baroreflex regulation of heart rate and sympathetic vasomotor tone in women and men. Hypertension 2005; 45: 1159-1164. (Pubitemid 40770321)
32. Fu Q, Okazaki K, Shibata S, Shook RP, VanGunday TB, Galbreath MM, et al. Menstrual cycle effects on sympathetic neural responses to upright tilt. J Physiol 2009; 587: 2019-2031.
33. Hogarth AJ, Mackintosh AF, Mary DA. Gender-related differences in the sympathetic vasoconstrictor drive of normal subjects. Clin Sci (Lond) 2007; 112: 353-361.
34. Minson CT, Halliwill JR, Young TM, Joyner MJ. Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 2000; 101: 862-868.
35. Hunt BE, Taylor A, Hamner JW, Gagnon M, Lipsitz LA. Estrogen replacement therapy improves baroreflex regulation of vascular sympathetic outflow in postmenopausal women. Circulation 2001; 103: 2909-2914. (Pubitemid 32578127)
36. Saleh TM, Connell BJ. Role of oestrogen in the central regulation of autonomic function. Clin Exp Pharmacol Physiol 2007; 34: 827-832. (Pubitemid 47083965)
37. Miller VM, Duckles SP. Vascular actions of estrogens: Functional implications. Pharmacol Rev 2008; 60: 210-241.
38. Herbison AE, Simonian SX, Thanky NR, Bicknell RJ. Oestrogen modulation of noradrenaline neurotransmission. Novartis Found Symp 2000; 230: 74-85; discussion 85-93.
39. Kelly MJ, Qiu J, Ronnekleiv OK. Estrogen signaling in the hypothalamus. Vitam Horm 2005; 71: 123-145.
40. Vanderhorst VG, Gustafsson JA, Ulfhake B. Estrogen receptor- alpha and -beta immunoreactive neurons in the brainstem and spinal cord of male and female mice: Relationships to monoaminergic, cholinergic, and spinal projection systems. J Comp Neurol 2005; 488: 152-179. (Pubitemid 40846457)
41. Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach JH, Joyner MJ. Sex differences in sympathetic neural-hemodynamic balance: Implications for human blood pressure regulation. Hypertension 2009; 53: 571-576.
42. Ng AV, Callister R, Johnson DG, Seals DR. Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension 1993; 21: 498-503. (Pubitemid 23095164)
43. Narkiewicz K, Phillips BG, Kato M, Hering D, Bieniaszewski L, Somers VK. Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity. Hypertension 2005; 45: 522-525. (Pubitemid 40411253)
44. 123I-Metaiodobenzylguanidine (MIBG) Imaging. Circ J 2009; 73: 310-315.
45. Ivanova T, Beyer C. Estrogen regulates tyrosine hydroxylase expression in the neonate mouse midbrain. J Neurobiol 2003; 54: 638-647. (Pubitemid 36232669)
46. Pendergast JS, Tuesta LM, Bethea JR. Oestrogen receptor beta contributes to the transient sex difference in tyrosine hydroxylase expression in the mouse locus coeruleus. J Neuroendocrinol 2008; 20: 1155-1164.
47. Zacharia LC, Jackson EK, Gillespie DG, Dubey RK. Catecholamines abrogate antimitogenic effects of 2-hydroxyestradiol on human aortic vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2001; 21: 1745-1750. (Pubitemid 34219777)
48. Hamlet MA, Rorie DK, Tyce GM. Effects of estradiol on release and disposition of norepinephrine from nerve endings. Am J Physiol 1980; 239: H450-H456.
49. Du XJ, Dart AM, Riemersma RA, Oliver MF. Sex difference in presynaptic adrenergic inhibition of norepinephrine release during normoxia and ischemia in the rat heart. Circ Res 1991; 68: 827-835.
50. Hassan M, Li Q, Brumback B, Lucey DG, Bestland M, Eubanks G, et al. Comparison of peripheral arterial response to mental stress in men versus women with coronary artery disease. Am J Cardiol 2008; 102: 970-974.
51. Owens JF, Stoney CM, Matthews KA. Menopausal status influences ambulatory blood pressure levels and blood pressure changes during mental stress. Circulation 1993; 88: 2794-2802.
52. Morimoto K, Morikawa M, Kimura H, Ishii N, Takamata A, Hara Y, et al. Mental stress induces sustained elevation of blood pressure and lipid peroxidation in postmenopausal women. Life Sci 2008; 82: 99-107. (Pubitemid 350251397)
53. Safar ME, Smulyan H. Central blood pressure and hypertension. Hypertension 2008; 51: 819-820.
54. Rana BK, Insel PA, Payne SH, Abel K, Beutler E, Ziegler MG, et al. Population-based sample reveals gene-gender interactions in blood pressure in white Americans. Hypertension 2007; 49: 96-106. (Pubitemid 46360347)
55. McCredie RJ, McCrohon JA, Turner L, Griffiths KA, Handelsman DJ, Celermajer DS. Vascular reactivity is impaired in genetic females taking high-dose androgens. J Am Coll Cardiol 1998; 32: 1331-1335. (Pubitemid 28522391)
56. New G, Timmins KL, Duffy SJ, Tran BT, O'Brien RC, Harper RW, et al. Long-term estrogen therapy improves vascular function in male to female transsexuals. J Am Coll Cardiol 1997; 29: 1437-1444. (Pubitemid 27272434)
57. Bunck MC, Toorians AW, Lips P, Gooren LJ. The effects of the aromatase inhibitor anastrozole on bone metabolism and cardiovascular risk indices in ovariectomized, androgen-treated female-to-male transsexuals. Eur J Endocrinol 2006; 154: 569-575.
58. Bush DE, Jones CE, Bass KM, Walters GK, Bruza JM, Ouyang P. Estrogen replacement reverses endothelial dysfunction in post- menopausal women. Am J Med 1998; 104: 552-558. (Pubitemid 28328768)
59. Emre A, Sahin S, Erzik C, Nurkalem Z, Oz D, Cirakoglu B, et al. Effect of hormone replacement therapy on plasma lipoproteins and apolipoproteins, endothelial function and myocardial perfusion in postmenopausal women with estrogen receptor-alpha IVS1-397 C/C genotype and established coronary artery disease. Cardiology 2006; 106: 44-50. (Pubitemid 43999332)
60. Silvestri A, Gambacciani M, Vitale C, Monteleone P, Ciaponi M, Fini M, et al. Different effect of hormone replacement therapy, DHEAS and tibolone on endothelial function in postmenopausal women with increased cardiovascular risk. Maturitas 2005; 50: 305-311.
61. Girdler SS, Hinderliter AL, Wells EC, Sherwood A, Grewen KM, Light KC. Transdermal versus oral estrogen therapy in postmenopausal smokers: Hemodynamic and endothelial effects. Obstet Gynecol 2004; 103: 169-180. (Pubitemid 39248483)
62. Yeboah J, Reboussin DM, Waters D, Kowalchuk G, Herrington DM. Effects of estrogen replacement with and without medroxyprogesterone acetate on brachial flow-mediated vasodilator responses in postmenopausal women with coronary artery disease. Am Heart J 2007; 153: 439-444. (Pubitemid 46328751)
63. Kalantaridou S, Naka K, Bechlioulis A, Makrigiannakis A, Michalis L, Chrousos P. Premature ovarian failure, endothelial dysfunction and estrogen-progestogen replacement. Trends Endocrinol Metab 2006; 17: 101-109.
64. Koledova W, Khalil RA. Sex hormone replacement therapy and modulation of vascular function in cardiovascular disease. Expert Rev Cardiovasc Ther 2007; 5: 777-789. (Pubitemid 47050186)
65. Gallagher PE, Li P, Lenhart JR, Chappell MC, Brosnihan KB. Estrogen regulation of angiotensin-converting enzyme mRNA. Hypertension 1999; 33: 323-328. (Pubitemid 29065679)
66. Nickenig G, Bäumer AT, Grohè C, Kahlert S, Strehlow K, Rosenkranz S, et al. Estrogen modulates AT1 receptor gene expression in vitro and in vivo. Circulation 1998; 97: 2197-2201. (Pubitemid 28265380)
67. Imanishi T, Hano T, Nishio I. Estrogen reduces angiotensin II- induced acceleration of senescence in endothelial progenitor cells. Hypertens Res 2005; 28: 263-271. (Pubitemid 40812612)
68. Wajchenberg BL. Subcutaneous and visceral adipose tissue: Their relation to me metabolic syndrome. Endocr Rev 2000; 21: 697-738. (Pubitemid 32113289)
69. Kato M, Dote K, Sasaki S, Ueda K, Nakano Y, Naganuma T, et al. Impact of metabolic syndrome on coronary plaque vulnerability in Japanese women with acute coronary syndrome. Circ J 2008; 72: 940-945. (Pubitemid 351879915)
70. Vitale C, Mendelsohn ME, Rosano GM. Gender differences in the cardiovascular effect of sex hormones. Nat Rev Cardiol 2009; 6: 532-542.
71. Kobayashi J, Nishimura K, Matoba M, Maekawa N, Mabuchi H. Generation and gender differences in the components contributing to the diagnosis of the metabolic syndrome according to the Japanese criteria. Circ J 2007; 71: 1734-1737. (Pubitemid 350240094)
72. Regitz-Zagrosek V, Lehmkuhl E, Weickert MO. Gender differences in the metabolic syndrome and their role for cardiovascular disease. Clin Res Cardiol 2006; 95: 136-147.
73. Regitz-Zagrosek V, Lehmkuhl E. Heart failure and its treatment in women: Role of hypertension, diabetes, and estrogen. Herz 2005; 30: 356-367. (Pubitemid 41238953)
74. Regitz-Zagrosek V, Lehmkuhl E, Lehmkuhl HB, Hetzer R. Gender aspects in heart failure: Pathophysiology and medical therapy. Arch Mal Coeur Vaiss 2004; 97: 899-908. (Pubitemid 39307093)
75. Safar ME, Smulyan H. Coronary ischemic disease, arterial stiffness, and pulse pressure. Am J Hypertens 2004; 17: 724-726. (Pubitemid 39091556)
76. Harris DJ, Douglas PS. Enrollment of women in cardiovascular clinical trials funded by the National Heart, Lung, and Blood Institute. N Engl J Med 2000; 343: 475-480.
77. Regitz-Zagrosek V. Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov 2006; 5: 425-438. (Pubitemid 43904934)
78. Lloyd-Jones DM, Wilson PWF, Larson MG, Beiser A, Leip EP, D'Agostino RB, et al. Framingham risk score and prediction of lifetime risk for coronary heart disease. Am J Cardiol 2004; 94: 20-24. (Pubitemid 38813447)
79. Lakoski SG, Greenland P, Wong ND, Schreiner PJ, Herrington DM, Kronmal RA, et al. Coronary artery calcium scores and risk for cardiovascular events in women classified as "low risk" based on Framingham risk score: The Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med 2007; 167: 2437-2442.
80. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336: 973-979. (Pubitemid 27152782)
81. Ridker PM, Buring JE, Jessie S, Mathew M, Hennekens CH. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 1998; 98: 731-733.
82. Ridker PM, Stampfer MJ, Rifai N. Novel risk factors for systemic atherosclerosis: A comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(s), and standard cholesterol screening as predictors of peripheral arterial disease. JAMA 2001; 285: 2481-2485. (Pubitemid 32433842)
83. Miller VM, Redfield MM, McConnell JP. Use of BNP and CRP as biomarkers in assessing cardiovascular disease: Diagnosis versus risk. Curr Vasc Pharmacol 2007; 5: 15-25.
84. Ramadan MM, Mahfouz EM, Gomaa GF, El-Diasty TA, Alldawi L, Ikrar T, et al. Evaluation of coronary calcium score by multidetector computer tomography in relation to endothelial function and inflammatory markers in asymptomatic individuals. Circ J 2008; 72: 778-785. (Pubitemid 351716684)
85. Matsumura K, Ohtsubo T, Oniki H, Fujii K, Iida M. Gender-related association of serum uric acid and left ventricular hypertrophy in hypertension. Circ J 2006; 70: 885-888. (Pubitemid 43979127)
86. Niizeki T, Takeishi Y, Takabatake N, Shibata Y, Konta T, Kato T, et al. Circulating levels of heart-type fatty acid-binding protein in a general Japanese population: Effects of age, gender and physiologic characteristics. Circ J 2007; 71: 1452-1457. (Pubitemid 47378449)
87. Yamaguchi J, Kasanuki H, Ishii Y, Yagi M, Nagashima M, Fujii S, et al. Serum creatinine on admission predicts long-term mortality in acute myocardial infarction patients undergoing successful primary angioplasty: Data from the Heart Institute of Japan Acute Myocardial Infarction (HIJAMI) Registry. Circ J 2007; 71: 1354-1359. (Pubitemid 47378433)
88. Jayachandran M, Litwiller RD, Owen WG, Heit JA, Behrenbeck TR, Mulvagh SL, et al. Characterization of blood borne microparticles as markers of premature coronary calcification in recently menopausal women. Am J Physiol Heart Circ Physiol 2008; 295: 931-938.
89. Lakoski SG, Cushman M, Blumenthal RS, Kronmal R, Arnett D, D'Agostino RB Jr, et al. Implications of C-reactive protein or coronary artery calcium score as an adjunct to global risk assessment for primary prevention of CHD. Atherosclerosis 2007; 193: 401-407. (Pubitemid 47058104)
90. Raggi P, Shaw LJ, Berman DS, Callister TQ. Gender-based differences in the prognostic value of coronary calcification. J Women's Health 2004; 13: 273-283. (Pubitemid 38660524)
91. Bellasi A, Lacey C, Taylor AJ, Raggi P, Wilson PWF, Budoff MJ, et al. Comparison of prognostic usefulness of coronary artery calcium in men versus women (results from a meta- and pooled analysis estimating all-cause mortality and coronary heart disease death or myocardial infarction). Am J Cardiol 2007; 100: 409-414. (Pubitemid 47094687)
92. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987; 316: 1371-1375. (Pubitemid 17079680)
93. Shaw LJ, Shaw RE, Merz CNB, Brindis RG, Klein LW, Nallamothu B, et al. Impact of ethnicity and gender differences on angiographic coronary artery disease prevalence and in-hospital mortality in the American College of Cardiology-National Cardiovascular Data Registry. Circulation 2008; 117: 1787-1801.
94. Shah PK. Molecular mechanisms of plaque instability. Curr Opin Lipidol 2007; 18: 492-499.
95. Wong ND, Pio J, Valencia R, Thakal G. Distribution of C-reactive protein and its relation to risk factors and coronary heart disease risk estimation in the National Health and Nutrition Examination Survey (NHANES) III. Prev Cardiol 2001; 4: 109-114. (Pubitemid 32613801)
96. Burke AP, Farb A, Malcom GT, Liang Y, Smialek J, Virmani R. Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women [see Comment]. Circulation 1998; 97: 2110-2116. (Pubitemid 28262117)
97. Farb A, Burke AP, Tang AL, Liang TY, Mannan P, Smialek J, et al. Coronary plaque erosion without rupture into a lipid core: A frequent cause of coronary thrombosis in sudden coronary death. Circulation 1996; 93: 1354-1363. (Pubitemid 26099346)
98. Sugiyama S, Kugiyama K, Aikawa M, Nakamura S, Ogawa H, Libby P. Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: Involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis [see Comment]. Arterioscler Thromb Vasc Biol 2004; 24: 1309-1314. (Pubitemid 38880026)
99. Durand E, Scoazec A, Lafont A, Boddaert J, Al Hajzen A, Addad F, et al. In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation: A clue to the understanding of the mechanisms of thrombotic plaque erosion. Circulation 2004; 109: 2503-2506.
100. Sambola A, Osende J, Hathcock J, Degen M, Nemerson Y, Fuster V, et al. Role of risk factors in the modulation of tissue factor activity and blood thrombogenicity. Circulation 2003; 107: 973-977. (Pubitemid 36258719)
101. Haque SF, Matsubayashi H, Izumi S, Sugi T, Arai T, Kondo A, et al. Sex difference in platelet aggregation detected by new aggregometry using light scattering. Endocr J 2001; 48: 33-41. (Pubitemid 32230383)
102. Schwertz DW, Penckofer S. Sex differences and the effects of sex hormones on hemostasis and vascular reactivity [erratum Heart Lung 2002; 31: 101]. Heart Lung 2001; 30: 401-426; quiz 427-428.
103. Liu PY, Death AK, Handelsman DJ. Androgens and cardiovascular disease. Endocr Rev 2003; 24: 313-340.
104. Ling S, Komesaroff PA, Sudhir K. Cardiovascular physiology of androgens and androgen testosterone therapy in postmenopausal women. Endocr Metab Immune Disord Drug Targets 2009; 9: 29-37.
105. Sudhir K, Komesaroff PA. Cardiovascular actions of estrogens in men. J Clin Endocrinol Metab 1999; 84: 3411-3415.
106. Clarkson TB. Estrogen effects on arteries vary with stage of reproductive life and extent of subclinical atherosclerosis progression. Menopause 2007; 14: 373-384.
107. Rocca W, Grossardt B, Andrade M, Malkasian G, Melton LI. Survival patterns after oophorectomy in premenopausal women: A population-based cohort study. Lancet Oncol 2006; 7: 821-828. (Pubitemid 44464065)
108. Shuster LT, Gostout BS, Grossardt BR, Rocca WA. Prophylactic oophorectomy in premenopausal women and long-term health. Menopause Int 2008; 14: 111-116.
109. Bush TL, Barrett-Connor E, Cowan LD, Criqui MH, Wallace RB, Suchindran CM, et al. Cardiovascular mortality and noncontraceptive use of estrogen in women: Results from the Lipid Research Clinics Program Follow-up Study. Circulation 1987; 75: 1102-1109. (Pubitemid 17081015)
110. Harman SM, Brinton EA, Cedars M, Lobo R, Manson JE, Merriam GR, et al. KEEPS: The Kronos Early Estrogen Prevention Study. Climacteric 2005; 8: 3-12. (Pubitemid 40675116)
111. Manson J, Allison M, Rossouw JE, Carr J, Langer R, Hsia J, et al. Estrogen therapy and coronary-artery calcification. N Engl J Med 2007; 356: 2591-2602.
112. Hodis H, Mack W, Lobo R, Shoupe D, Sevanian A, Mahrer P, et al. Estrogen in the prevention of atherosclerosis: A randomized, double-blind, placebo-controlled trial. Ann Intern Med 2001; 135: 939-953. (Pubitemid 33131615)
113. Hodis HN, Mack WJ. Postmenopausal hormone therapy and cardiovascular disease in perspective. Clin Obstet Gynecol 2008; 51: 564-580.
114. Mendelsohn ME, Karas RH. Molecular and cellular basis of cardiovascular gender differences. Science 2005; 308: 1583-1587.
115. Ridker PM, Cook NR, Lee IM, Gordon D, Gaziano JM, Manson JE, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women [see Comment]. N Engl J Med 2005; 352: 1293-1304. (Pubitemid 41061541)
116. Splawinska B, Furmaga W, Kuzniar J, Stawiarski M, Pikor I, Szmigiel Z, et al. Formation of prostacyclin-sensitive platelet aggregates in human whole blood in vitro. Part II: The occurrence of the phenomenon in males suffering from acute myocardial infarction. Scand J Clin Lab Invest 1987; 47: 125-130. (Pubitemid 17050194)
117. Bolego C, Cignarella A, Ruzza R, Zaarour C, Messi E, Zanisi M, et al. Differential effects of low- and high-dose estrogen treatments on vascular responses in female rats. Life Sci 1997; 60: 2291-2302.
118. Barber D, Miller V. Endothelium-dependent vasoconstrictors. In: Rubanyi G, ed. Endothelial cell research. Berkshire, UK: Harwood Academic Publishers; 1998; 167-185.
119. Fogelberg M, Vesterqvist O, Diczfalusy U, Henriksson P. Experimental atherosclerosis: Effects of oestrogen and atherosclerosis on thromboxane and prostacyclin formation. Eur J Clin Invest 1990; 20: 105-110. (Pubitemid 20056281)
120. Matsuda K, Ruff A, Morinelli TA, Mathur RS, Halushka PV. Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets. Am J Physiol 1994; 267: H887-H893. (Pubitemid 2149617)
121. Schror K, Morinelli TA, Masuda A, Matsuda K, Mathur RS, Halushka PV. Testosterone treatment enhances thromboxane A2 mimetic induced coronary artery vasoconstriction in guinea pigs. Eur J Clin Invest 1994; 24: 50-52. (Pubitemid 24223523)
122. Miller VM, Lewis DA, Barber DA. Gender differences and endothelium- and platelet-derived factors in the coronary circulation. Clin Exper Pharmacol Physiol 1999; 26: 132-136.
123. Miettinen TA, Pyorala K, Olsson AG, Musliner TA, Cook TJ, Faergeman O, et al. Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: Findings from the Scandinavian Simvastatin Survival Study (4S) [see Comment]. Circulation 1997; 96: 4211-4218. (Pubitemid 28007446)
124. Sasaki J, Kita T, Mabuchi H, Matsuzaki M, Matsuzawa Y, Nakaya N, et al. Gender difference in coronary events in relation to risk factors in Japanese hypercholesterolemic patients treated with low- dose simvastatin. Circ J 2006; 70: 810-814. (Pubitemid 43979114)
125. Karp I, Chen SF, Pilote L. Sex differences in the effectiveness of statins after myocardial infarction. Can Med Assoc J 2007; 176: 333-338. (Pubitemid 46256357)
126. Regitz-Zagrosek V. Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov 2006; 5: 425-438. (Pubitemid 43904934)
127. Ho KK, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: The Framingham Study. J Am Coll Cardiol 1993; 22: 6A- 13A. (Pubitemid 23285789)
128. Hoetzer GL, MacEneaney OJ, Irmiger HM, Keith R, Van Guilder GP, Stauffer BL, et al. Gender differences in circulating endothelial progenitor cell colony-forming capacity and migratory activity in middle-aged adults. Am J Cardiol 2007; 99: 46-48. (Pubitemid 44969339)
129. Crisostomo PR, Wang M, Herring CM, Markel TA, Meldrum KK, Lillemoe KD, et al. Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: Role of the 55 kDa TNF receptor (TNFR1). J Mol Cell Cardiol 2007; 42: 142-149. (Pubitemid 44958625)
130. Crisostomo PR, Markel TA, Wang M, Lahm T, Lillemoe KD, Meldrum DR. In the adult mesenchymal stem cell population, source gender is a biologically relevant aspect of protective power. Surgery 2007; 142: 215-221.
131. Nelson WD, Zenovich AG, Ott HC, Stolen C, Caron GJ, Panoskaltsis- Mortari A, et al. Sex-dependent attenuation of plaque growth after treatment with bone marrow mononuclear cells. Circ Res 2007; 101: 1319-1327. (Pubitemid 350294649)
132. Zenovich AG, Panoskaltsis-Mortari A, Caron GJ, Kolb AG, Fremming R, Nelson WD, et al. Sex-based differences in vascular repair with bone marrow cell therapy: Relevance of regulatory and Th2-type cytokines. Transplant Proc 2008; 40: 641-643.
133. Shabbir A, Zisa D, Suzuki G, Lee T. Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: A noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol 2009; 296: H1888-H1897.
134. Shigeta A, Tanabe N, Shimizu H, Hoshino S, Maruoka M, Sakao S, et al. Gender differences in chronic thromboembolic pulmonary hypertension in Japan. Circ J 2008; 72: 2069-2074.