Disruption of the intracellular Ca2+ homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes

Biochemical and Biophysical Research Communications

Volumn 354, Issue 4, 2007, Pages 929-936

  Fu, Min ^a,b   Wu, Meng ^a   Wang, Ji Feng ^b   Qiao, Yan Jiang ^b   Wang, Zhao ^a  

^a Tsinghua University   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Aconitine; Arrhythmic cytotoxicity; Ca2+ handling proteins; Ca2+ homeostasis; Ca2+ dependent arrhythmia; Inhibitors; The cardiac EC coupling

Indexed keywords

ACONITINE; CALCIUM CHANNEL; CALCIUM ION; CELL PROTEIN; MESSENGER RNA; PROTEIN NCX; RUTHENIUM RED; RYANODINE RECEPTOR 2; THAPSIGARGIN; UNCLASSIFIED DRUG; VERAPAMIL; CAISEQUESTRIN 2, RAT; CALCIUM; CALCIUM BINDING PROTEIN; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; CARDIOTOXICITY; CONTROLLED STUDY; DETOXIFICATION; DRUG CYTOTOXICITY; GENETIC TRANSCRIPTION; HEART ARRHYTHMIA; HEART BEAT; HEART CONTRACTION; HEART EXCITATION; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE; HEART RATE; NEWBORN; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SARCOPLASMIC RETICULUM; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; HOMEOSTASIS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACONITUM;

ACONITINE; ANIMALS; ARRHYTHMIA; CALCIUM; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; HEART RATE; HOMEOSTASIS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; RUTHENIUM RED; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM-CALCIUM EXCHANGER; THAPSIGARGIN;

EID: 33846813735     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.01.082     Document Type: Article

References (28)

1. Sato H., Yamada C., Konno C., Ohizumi Y., Endo K., and Hikino H. Pharmacological actions of aconitine alkaloids. Tohoku J. Exp. Med. 128 (1979) 175-187
2. Hikino H., Konno C., Takata H., Yamada Y., Yamada C., Ohizumi Y., Sugio K., and Fujimura H. Antiinflammatory principles of Aconitum roots. J. Pharmacobiodyn. 3 (1980) 514-525
3. M. Benn, M. Jacyno, The toxicology and pharmacology of diterpenoid alkaloids, in: S.W. Pelletier (Ed.), Alkaloids: Chemical and Biological Perspectives, New York, 1983.
4. Berridge M.J., Bootman M.D., and Roderick H.L. Calcium signalling: dynamics, homeostasis and remodelling. Nat. Rev. Mol. Cell Biol. 4 (2003) 517-529
5. Scoote M., and Williams A.J. Myocardial calcium signalling and arrhythmia pathogenesis. Biochem. Biophys. Res. Commun. 322 (2004) 1286-1309
6. Fabiato A. Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. J. Gen. Physiol. 85 (1985) 291-320
7. Nakajima T., Kaneko Y., Taniguchi Y., Hayashi K., Takizawa T., Suzuki T., and Nagai R. The mechanism of catecholaminergic polymorphic ventricular tachycardia may be triggered activity due to delayed afterdepolarization. Eur. Heart J. 18 (1997) 530-531
8. G. Fontaine, R. Frank, J. Vedel, Y. Grosgogeat, C. Cabrol, J. Facquet, Stimulation studies and epicardial mapping in ventricular tachycardia. Study of mechanisms and selection for surgery, in: H.E. Kulbertus (Ed.), Re entrant arrhythmias., ed., MTP Publishing, Lancaster, PA, 1977.
9. Marks A.R., Reiken S., and Marx S.O. Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor?. Circulation 105 (2002) 272-275
10. Link G., Pinson A., and Hershko C. Heart cells in culture: a model of myocardial iron overload and chelation. J. Lab. Clin. Med. 106 (1985) 147-153
11. Zahabi A., and Deschepper C.F. Long-chain fatty acids modify hypertrophic responses of cultured primary neonatal cardiomyocytes. J. Lipid Res. 42 (2001) 1325-1330
12. Zhou C., Wen Z.X., Shi D.M., and Xie Z.P. Muscarinic acetylcholine receptors involved in the regulation of neural stem cell proliferation and differentiation in vitro. Cell Biol. Int. 28 (2004) 63-67
13. Temsah R.M., Netticadan T., Chapman D., Takeda S., Mochizuki S., and Dhalla N.S. Alterations in sarcoplasmic reticulum function and gene expression in ischemic-reperfused rat heart. Am. J. Physiol. 277 (1999) H584-H594
14. Bers D.M. Cardiac excitation-contraction coupling. Nature 415 (2002) 198-205
15. Scriven D.R., Dan P., and Moore E.D. Distribution of proteins implicated in excitation-contraction coupling in rat ventricular myocytes. Biophys. J. 79 (2000) 2682-2691
16. Franzini-Armstrong C., Protasi F., and Ramesh V. Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles. Biophys. J. 77 (1999) 1528-1539
17. 2+. Jpn. J. Physiol. 37 (1987) 59-79
18. 2+ exchange current in guinea-pig cardiac ventricular cells. Br. J. Pharmacol. 119 (1996) 555-563
19. Amran M.S., Hashimoto K., and Homma N. Effects of sodium-calcium exchange inhibitors, KB-R7943 and SEA0400, on aconitine-induced arrhythmias in guinea pigs in vivo, in vitro, and in computer simulation studies. J. Pharmacol. Exp. Ther. 310 (2004) 83-89
20. 2+ uptake and thapsigargin sensitivity in permeabilized rabbit and rat ventricular myocytes. Circ. Res. 73 (1993) 820-828
21. Franzini-Armstrong C., and Protasi F. Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions. Physiol. Rev. 77 (1997) 699-729
22. 2+ release channels. Int. Rev. Cytol. 183 (1998) 185-270
23. Berridge M.J., Bootman M.D., and Lipp P. Calcium-a life and death signal. Nature 395 (1998) 645-648
24. Moonga B.S., Li S., Iqbal J., Davidson R., Shankar V.S., Bevis P.J., Inzerillo A., Abe E., Huang C.L., and Zaidi M. Ca(2+) influx through the osteoclastic plasma membrane ryanodine receptor. Am. J. Physiol. Renal. Physiol. 282 (2002) F921-F932
25. Perez-Reyes E., Wei X.Y., Castellano A., and Birnbaumer L. Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes. J. Biol. Chem. 265 (1990) 20430-20436
26. Chu S.H., Sutherland K., Beck J., Kowalski J., Goldspink P., and Schwertz D. Sex differences in expression of calcium-handling proteins and beta-adrenergic receptors in rat heart ventricle. Life Sci. 76 (2005) 2735-2749
27. Zolk O., Munzel F., and Eschenhagen T. Effects of chronic endothelin-1 stimulation on cardiac myocyte contractile function. Am. J. Physiol. Heart Circ. Physiol. 286 (2004) H1248-H1257
28. Wang L.C., Ma H., He J.G., Liao X.X., Chen W.F., Leng X.Y., Ma L., Mai W.Y., Tao J., Zeng W.T., Liu J., Dong Y.G., Tang A.L., and Feng C. Effect of angiotensin converting enzyme inhibitor on the calcium transients and calcium handling proteins in ventricular myocytes from rats with heart failure. Chin. Med. J. (Engl.) 118 (2005) 731-737