The application of microbore UPLC/oa-TOF-MS and 1H NMR spectroscopy to the metabonomic analysis of rat urine following the intravenous administration of pravastatin

Journal of Pharmaceutical and Biomedical Analysis

Volumn 44, Issue 4, 2007, Pages 845-852

  Lenz, E M ^a   Williams, R E ^a   Sidaway, J ^a   Smith, B W ^b   Plumb, R S ^b   Johnson, K A ^b   Rainville, P ^b   Shockcor, J ^b   Stumpf, C L ^b   Granger, J H ^b   Wilson, I D ^a  

^a ASTRAZENECA   (United Kingdom)

^b WATERS CORPORATION   (United States)

Author keywords

1H NMR spectroscopy; Biomarkers; Hepatotoxicity; LC MS; Metabonomics; Microbore columns; Pravastatin; TOF MS; UPLC

Indexed keywords

BILE ACID; CREATINE; PRAVASTATIN; PROTON; TAURINE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL CHEMISTRY; CONTINUOUS INFUSION; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MASS SPECTROMETRY; METABONOMIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RAT STRAIN; SIGNAL NOISE RATIO; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; WISTAR HANNOVER RAT;

ANIMALS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INJECTIONS, INTRAVENOUS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PRAVASTATIN; RATS; RATS, WISTAR;

EID: 34547138959     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.04.035     Document Type: Article

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