메뉴 건너뛰기




Volumn 45, Issue 17, 2006, Pages 2703-2706

DNA recognition with large calixarene dimers

Author keywords

Calixarenes; DNA; Intercalation; Major groove; Supramolecular chemistry

Indexed keywords

CALIXARENES; INTERCALATION; MAJOR GROOVES;

EID: 33746216308     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200502946     Document Type: Article
Times cited : (70)

References (42)
  • 3
    • 0001537244 scopus 로고    scopus 로고
    • For cationic DNA binders as transfection agents, see: A. D. Miller, Angew. Chem. 1998, 110, 1862-1880;
    • (1998) Angew. Chem. , vol.110 , pp. 1862-1880
    • Miller, A.D.1
  • 4
    • 0032479769 scopus 로고    scopus 로고
    • liposomes
    • Angew. Chem. Int. Ed. 1998, 37, 1768-1785, (liposomes);
    • (1998) Angew. Chem. Int. Ed. , vol.37 , pp. 1768-1785
  • 6
    • 0037091001 scopus 로고    scopus 로고
    • dendrimers
    • Angew. Chem. Int. Ed. 2002, 41, 1329-1334, (dendrimers);
    • (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 1329-1334
  • 8
    • 0001743059 scopus 로고    scopus 로고
    • Eds.: K. Nakanishi, D. Barton, Elsevier, New York
    • For a review on DNA intercalators, see: W. D. Wilson in Comprehensive Natural Products Chemistry (Eds.: K. Nakanishi, D. Barton), Elsevier, New York, 1999, pp. 427-476.
    • (1999) Comprehensive Natural Products Chemistry , pp. 427-476
    • Wilson, W.D.1
  • 15
    • 0037053890 scopus 로고    scopus 로고
    • For bulky adamantyl polyamines with a pronounced DNA preference, see: N. Lomadze, H.-J. Schneider, Tetrahedron Lett. 2002, 43, 4403-4405.
    • (2002) Tetrahedron Lett. , vol.43 , pp. 4403-4405
    • Lomadze, N.1    Schneider, H.-J.2
  • 30
    • 33746203865 scopus 로고    scopus 로고
    • Courtesy of the Carell group, LMU Munich, Germany
    • Courtesy of the Carell group, LMU Munich, Germany.
  • 31
    • 0001511660 scopus 로고
    • P. Job, Ann. Chim. 1928, 9, 113-203;
    • (1928) Ann. Chim. , vol.9 , pp. 113-203
    • Job, P.1
  • 33
    • 33746232057 scopus 로고    scopus 로고
    • note
    • a ≈ 7.0 for the last two deprotonation steps. Thus, at neutral pH, it seems probable that each calixarene unit carries no more than one positive charge. This value might be slightly altered by the considerable methanol content in most solvent mixtures.
  • 35
    • 0345352683 scopus 로고    scopus 로고
    • Angew. Chem. Int. Ed. 2003, 42, 1486-1490) or GPC measurements would perhaps identify small oligomeric aggregates. However, it is also conceivable, that these are only formed after docking onto the DNA strand.
    • (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 1486-1490
  • 36
    • 33746204158 scopus 로고    scopus 로고
    • note
    • -1). This highly fluorescent reporter molecule was subsequently replaced by the unlabeled native DNA in a competition experiment (indicator displacement assay, IDA).
  • 40
    • 33746187037 scopus 로고    scopus 로고
    • note
    • The minor groove of RNA is much more shallow, but has the same diameter as its major groove. It cannot, therefore, be ruled out that the calixarene dimer also binds to this well accessible cleft; such a recognition mode would also explain the high observed stoichiometry factor of 30:1.
  • 42
    • 0034641332 scopus 로고    scopus 로고
    • -1 for calf thymus DNA, as referenced in the literature. The noncompetitive method introduced by Boger et al. seems not to be applicable, because the intercepts with the x-axis point to large binding site sizes of > 2 (compare the high stoichiometries found in fluorescence titrations): D. L. Boger, B. E. Fink, M. P. Hedrick, J. Am. Chem. Soc. 2000, 122, 6382-6394.
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 6382-6394
    • Boger, D.L.1    Fink, B.E.2    Hedrick, M.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.