Geometric Disassembly of Dendrimers: Dendritic Amplification

Journal of the American Chemical Society

Volumn 125, Issue 51, 2003, Pages 15688-15689

  Szalai, Michael L ^a   Kevwitch, Robert M ^a   McGrath, Dominic V ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 BIS(HYDROXYMETHYL)PHENOL; DENDRIMER; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DEGRADATION; FRAGMENTATION REACTION; SYNTHESIS; ULTRAVIOLET SPECTROSCOPY;

EID: 0346365082     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0386694     Document Type: Article

References (13)

1. (a) Newkome, G. R.; Moorefield, C. N.; Vögde, F. Dendrimers and Dendrons: Concepts, Syntheses, Applications; VCH: New York, 2001.
2. (b) Fréchet, J. M. J.; Tomalia, D. A. Dendrimers and Other Dendritic Polymers; John Wiley: New York, 2002.
3. Li, S.; Szalai, M. L.; Kevwitch, R. M.; McGrath, D. V. J. Am. Chem. Soc. 2003, 125, 10516-10517.
4. Szalai, M. L.; McGrath, D. V. Polym. Mater. Sci. Eng. 2003, 89, 406-407.
5. (a) Wan, P.; Barker, B.; Diao, L.; Fischer, M.; Shi, Y.; Yang, C. Can. J. Chem. 1996, 74, 465-475.
6. (b) Veldhuyzen, W. F.; Shallop, A. J.; Jones, R. A.; Rokita, S. E. J. Am. Chem. Soc. 2001, 123, 11126-11132 and references therein.
7. 4 in DMSO (4.0 mg/1.0 mL). Monitoring of the reaction on an Ocean Optics CCD Array spectrometer began exactly 75 s following the final addition.
8. 6.
9. c, the multiplicity of the core subunit.
10. Tomalia, D. A.; Naylor, A. M.; Goddard, W. A. Angew. Chem., Int. Ed. Engl. 1990, 29, 138-175.
11. Hawker, C. J.; Malmström, E. E.; Frank, C. W.; Kampf, J. P. J. Am. Chem. Soc. 1997, 119, 9903-9904.
12. During the editorial review of this manuscript, two independent literature reports appeared introducing the concept of geometric dendrimer disassembly, although both used different chemical structures and trigger groups than reported herein: (a) de Groot, F. H. M.; Albrecht, C.; Koekkoek, R. ; Beusker, P. H.; Scheeren, H. W. Angew. Chem., Int. Ed. 2003, 42, 4490-4494.
13. (b) Amir, R. J.; Pessah, N.; Shamis, M.; Shabat, D. Angew. Chem., Int. Ed. 2003, 42, 4494-4499.