Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain

Developmental Biology

Volumn 335, Issue 1, 2009, Pages 166-178

  Stottmann, R W ^a   Tran, P V ^a   Turbe Doan, A ^a   Beier, D R ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Intraflagellar transport; Mouse; Sonic hedgehog; Telencephalon; Ttc21b; Zona limitans intrathalimica

Indexed keywords

BINDING PROTEIN; SONIC HEDGEHOG PROTEIN; TETRATRICOPEPTIDE REPEAT DOMAIN 21B PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; FOREBRAIN; MOUSE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 70349783742     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2009.08.023     Document Type: Article

References (49)

1. Aoto K., Nishimura T., Eto K., and Motoyama J. Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. Dev. Biol. 251 (2002) 320-332
2. Belo J.A., Bouwmeester T., Leyns L., Kertesz N., Gallo M., Follettie M., and De Robertis E.M. Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech. Dev. 68 (1997) 45-57
3. Borello U., Cobos I., Long J.E., Murre C., and Rubenstein J.L. FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural. Dev. 3 (2008) 17
4. Corbit K.C., Shyer A.E., Dowdle W.E., Gaulden J., Singla V., Chen M.H., Chuang P.T., and Reiter J.F. Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat. Cell. Biol. 10 (2008) 70-76
5. Crossley P.H., and Martin G.R. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121 (1995) 439-451
6. Danielian P.S., Muccino D., Rowitch D.H., Michael S.K., and McMahon A.P. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 8 (1998) 1323-1326
7. Echelard Y., Epstein D.J., St-Jacques B., Shen L., Mohler J., McMahon J.A., and McMahon A.P. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75 (1993) 1417-1430
8. Eggenschwiler J.T., and Anderson K.V. Cilia and developmental signaling. Annu. Rev. Cell. Dev. Biol. 23 (2007) 345-373
9. Garcia-Garcia M.J., Eggenschwiler J.T., Caspary T., Alcorn H.L., Wyler M.R., Huangfu D., Rakeman A.S., Lee J.D., Feinberg E.H., Timmer J.R., and Anderson K.V. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 5913-5919
10. Garel S., Huffman K.J., and Rubenstein J.L. Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants. Development 130 (2003) 1903-1914
11. Gerdes J.M., Liu Y., Zaghloul N.A., Leitch C.C., Lawson S.S., Kato M., Beachy P.A., Beales P.L., DeMartino G.N., Fisher S., Badano J.L., and Katsanis N. Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat. Genet. 39 (2007) 1350-1360
12. Goodrich L.V., Johnson R.L., Milenkovic L., McMahon J.A., and Scott M.P. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 10 (1996) 301-312
13. Goodrich L., Milenkovic L., Higgins K., and Scott M. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277 (1997) 1109-1113
14. Gray P.A., Fu H., Luo P., Zhao Q., Yu J., Ferrari A., Tenzen T., Yuk D.I., Tsung E.F., Cai Z., Alberta J.A., Cheng L.P., Liu Y., Stenman J.M., Valerius M.T., Billings N., Kim H.A., Greenberg M.E., McMahon A.P., Rowitch D.H., Stiles C.D., and Ma Q. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science 306 (2004) 2255-2257
15. Grove E.A., Tole S., Limon J., Yip L., and Ragsdale C.W. The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development 125 (1998) 2315-2325
16. Gutin G., Fernandes M., Palazzolo L., Paek H., Yu K., Ornitz D.M., McConnell S.K., and Hebert J.M. FGF signalling generates ventral telencephalic cells independently of SHH. Development 133 (2006) 2937-2946
17. Herron B.J., Lu W., Rao C., Liu S., Peters H., Bronson R.T., Justice M.J., McDonald J.D., and Beier D.R. Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat. Genet. 30 (2002) 185-189
18. Hogan B., Beddington R., Costantini F., and Lacy E. Manipulating the Mouse Embryo (1994), Cold Spring Harbor Press, New York
19. Huang X., Litingtun Y., and Chang C. Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly. Hum. Mol. Genetics 16 (2007) 1454-1468
20. Huangfu D., Liu A., Rakeman A.S., Murcia N.S., Niswander L., and Anderson K.V. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426 (2003) 83-87
21. Hui C.C., Slusarski D., Platt K.A., Holmgren R., and Joyner A.L. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm-and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol. 162 (1994) 402-413
22. Kaufman M.H. The Atlas of Mouse Development (1992), Academic Press, Inc., San Diego
23. Kiecker C., and Lumsden A. Hedgehog signaling from the ZLI regulates diencephalic regional identity. Nat. Neurosci. 7 (2004) 1242-1249
24. Kuschel S., Ruther U., and Theil T. A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon. Dev. Biol. 260 (2003) 484-495
25. Lakso M., Pichel J.G., Gorman J.R., Sauer B., Okamoto Y., Lee E., Alt F.W., and Westphal H. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 5860-5865
26. Lewis A.J., Simon E.M., Barkovich A.J., Clegg N.J., Delgado M.R., Levey E., and Hahn J.S. Middle interhemispheric variant of holoprosencephaly: a distinct cliniconeuroradiologic subtype. Neurology 59 (2002) 1860-1865
27. Maretto S., Cordenonsi M., Dupont S., Braghetta P., Broccoli V., Hassan A.B., Volpin D., Bressan G.M., and Piccolo S. Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 3299-3304
28. May S.R., Ashique A.M., Karlen M., Wang B., Shen Y., Zarbalis K., Reiter J., Ericson J., and Peterson A.S. Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287 (2005) 378-389
29. McMahon J.A., and McMahon A.P. Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene. Development 107 (1989) 643-650
30. McMahon A.P., Ingham P.W., and Tabin C.J. Developmental roles and clinical significance of hedgehog signaling. Curr. Top. Dev. Biol. 53 (2003) 1-114
31. Nanni L., Ming J.E., Bocian M., Steinhaus K., Bianchi D.W., de Die-Smulders C., Giannotti A., Imaizumi K., Jones K.L., Del Campo M., Martin R.A., Meinecke P., Pierpont M.E.M., Robin N.H., Young I.D., Roessler E., and Muenke M. The mutational spectrum of the Sonic Hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly. Hum. Mol. Genetics. 13 (1999) 2488-2749
32. Porteus M.H., Bulfone A., Ciaranello R.D., and Rubenstein J.L. Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain. Neuron 7 (1991) 221-229
33. Pulitzer S.B., Simon E.M., Crombleholme T.M., and Golden J.S. Prenatal MR findings of the middle interhemispheric variant of holoprosencephaly. Am. J. Neuroradiol. 25 (2004) 1034-1036
34. Rash B.G., and Grove E.A. Patterning the dorsal telencephalon: a role for sonic hedgehog?. J. Neurosci. 27 (2007) 11595-11603
35. Roelink H., and Nusse R. Expression of two members of the Wnt family during mouse development-restricted temporal and spatial patterns in the developing neural tube. Genes Dev. 5 (1991) 381-388
36. Sasaki H., and Hogan B.L. Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118 (1993) 47-59
37. Sheng H.Z., Bertuzzi S., Chiang C., Shawlot W., Taira M., Dawid I., and Westphal H. Expression of murine Lhx5 suggests a role in specifying the forebrain. Dev. Dyn. 208 (1997) 266-277
38. Shimamura K., Hartigan D.J., Martinez S., Puelles L., and Rubenstein J.L. Longitudinal organization of the anterior neural plate and neural tube. Development 121 (1995) 3923-3933
39. Simon E.M., Hevner R.F., Pinter J.D., Clegg N.J., Delgado M., Kinsman S.L., Hahn J.S., and Barkovich A.J. The middle interhemispheric variant of holoprosencephaly. Am. J. Neuroradiol. 23 (2002) 151-156
40. Sommer L., Ma Q., and Anderson D.J. neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol. Cell. Neurosci. 8 (1996) 221-241
41. Storm E.E., Rubenstein J.L., and Martin G.R. Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 1757-1762
42. Storm E.E., Garel S., Borello U., Hebert J.M., Martinez S., McConnell S.K., Martin G.R., and Rubenstein J.L. Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development 133 (2006) 1831-1844
43. Tole S., Ragsdale C.W., and Grove E.A. Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev. Biol. 217 (2000) 254-265
44. Tran P.V., Haycraft C.J., Besschetnova T.Y., Turbe-Doan A., Stottmann R.W., Herron B.J., Chesebro A.L., Qiu H., Scherz P.J., Shah J.V., Yoder B.K., and Beier D.R. THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat. Genet. 40 (2008) 403-410
45. Vieira C., and Martinez S. Sonic hedgehog from the basal plate and the zona limitans intrathalamica exhibits differential activity on diencephalic molecular regionalization and nuclear structure. Neuroscience 143 (2006) 129-140
46. Vieira C., Garda A.L., Shimamura K., and Martinez S. Thalamic development induced by Shh in the chick embryo. Dev. Biol. 284 (2005) 351-363
47. Wawersik S., Purcell P., Rauchman M., Dudley A.T., Robertson E.J., and Maas R. BMP7 acts in murine lens placode development. Dev. Biol. 207 (1999) 176-188
48. Zeltser L.M. Shh-dependent formation of the ZLI is opposed by signals from the dorsal diencephalon. Development 132 (2005) 2023-2033
49. Zhou Q., Wang S., and Anderson D.J. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 25 (2000) 331-343