Up-regulation of GADD45α expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths

Apoptosis

Volumn 14, Issue 11, 2009, Pages 1341-1351

  Chiou, Shiun Kwei ^a   Hoa, Neil ^a  

^a VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

Apoptosis; Chemoprevention; Colon tumorigenesis; GADD45 ; Necrosis; NSAIDs

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 ALPHA; INDOMETACIN; MESSENGER RNA; SULINDAC SULFIDE; SULINDAC SULFONE; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; CELL CYCLE PROTEIN; DRUG DERIVATIVE; GADD45A PROTEIN, HUMAN; HYDROXAMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; NUCLEAR PROTEIN; SULINDAC; TRICHOSTATIN A;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CELL DEATH; CELL STRAIN CACO 2; CELL STRAIN HT29; COLON CANCER; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; COLON TUMOR; DRUG EFFECT; GENETICS; METABOLISM; NECROSIS; PATHOLOGY; UPREGULATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CACO-2 CELLS; CELL CYCLE PROTEINS; COLONIC NEOPLASMS; HUMANS; HYDROXAMIC ACIDS; INDOMETHACIN; NECROSIS; NUCLEAR PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; RNA, MESSENGER; SULINDAC; UP-REGULATION;

EID: 70349780839     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-009-0399-6     Document Type: Article

References (39)

1. AJ Fornace Jr DW Nebert MC Hollander, et al. 1989 Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents Mol Cell Biol 9 4196 4203 2573827 1:CAS:528:DyaK3cXitlSmtb4%3D
2. A Abdollahi KA Lord B Hoffman-Liebermann, et al. 1991 Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines Oncogene 6 165 167 1899477 1:CAS:528:DyaK3MXltVOgu7s%3D
3. C Beadling KW Johnson KA Smith 1993 Isolation of interleukin 2-induced immediate-early genes Proc Natl Acad Sci USA 90 2719 2723 10.1073/pnas.90.7.2719 7681987 10.1073/pnas.90.7.2719 1:CAS:528:DyaK3sXitlajs78%3D
4. Q Zhan 2005 GADD45A, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage Mutat Res 569 133 143 10.1016/j.mrfmmm.2004.06. 055 15603758 1:CAS:528:DC%2BD2cXhtVyqsLzI (Pubitemid 39643263)
5. MC Hollander MS Sheikh DV Bulavin, et al. 1999 Genomic instability in Gadd45a-deficient mice Nat Genet 23 176 184 10.1038/13802 10508513 10.1038/13802 1:CAS:528:DyaK1MXmtlOhtb0%3D (Pubitemid 29455389)
6. Y Naito H Kajikawa K Mizushima, et al. 2005 Rebamipide, a gastro-protective drug, inhibits indomethacin-induced apoptosis in cultured rat gastric mucosal cells: association with the inhibition of growth arrest and DNA damage-induced 45 alpha expression Dig Dis Sci 50 Suppl 1 S104 S112 10.1007/s10620-005-2814-3 16184411 10.1007/s10620-005-2814-3 1:CAS:528:DC%2BD2MXht1Sisb3I (Pubitemid 41380806)
7. MC Hollander O Kovalsky JM Salvador, et al. 2001 Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency Cancer Res 61 2487 2491 11289119 1:CAS:528:DC%2BD3MXisVSlu7Y%3D
8. LF Zerbini Y Wang A Czibere, et al. 2004 NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival Proc Natl Acad Sci USA 101 13618 13623 10.1073/pnas.0402069101 15353598 10.1073/pnas.0402069101 1:CAS:528: DC%2BD2cXnvFehs7w%3D (Pubitemid 39238452)
9. J Hildesheim DV Bulavin MR Anver, et al. 2002 Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53 Cancer Res 62 7305 7315 12499274 1:CAS:528: DC%2BD3sXhtV2jtg%3D%3D
10. MJ Thun 1994 Aspirin, NSAIDs, and digestive tract cancers Cancer Metastasis Rev 13 269 277 10.1007/BF00666097 7712589 10.1007/BF00666097 1:STN:280:DyaK2M3ivVWksQ%3D%3D
11. FM Giardiello 1994 Sulindac and polyp regression Cancer Metastasis Rev 13 279 283 10.1007/BF00666098 7712590 10.1007/BF00666098 1:STN:280: DyaK2M3ivVWktg%3D%3D
12. JR Vane RM Botting 1998 Mechanism of action of nonsteroidal anti-inflammatory drugs Am J Med 104 2S 8S 10.1016/S0002-9343(97)00203-9 9572314 10.1016/S0002-9343(97)00203-9 1:CAS:528:DyaK1cXivFajur4%3D discussion 21S-22S. Review (Pubitemid 28186987)
13. WK Leung AH Bai VY Chan, et al. 2004 Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells Gut 53 331 338 10.1136/gut.2003.021105 14960510 10.1136/gut.2003.021105 1:CAS:528:DC%2BD2cXitlersLw%3D (Pubitemid 38241325)
14. S Jayadev HL Hayter N Andrieu, et al. 1997 Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells J Biol Chem 272 17196 17203 10.1074/jbc.272.27.17196 9202042 10.1074/jbc.272.27.17196 1:CAS:528:DyaK2sXksVeltrY%3D (Pubitemid 27289833)
15. J Wang X Lv J Shi, et al. 2006 Ceramide induces apoptosis via a peroxisome proliferator-activated receptor gamma-dependent pathway Apoptosis 11 2043 2052 10.1007/s10495-006-0191-9 17036198 10.1007/s10495-006-0191-9 1:CAS:528:DC%2BD28XhtFKmtrrJ (Pubitemid 44691586)
16. L Scorrano D Penzo V Petronilli, et al. 2001 Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha apoptotic signaling J Biol Chem 276 12035 12040 10.1074/jbc.M010603200 11134037 10.1074/jbc.M010603200 1:CAS:528: DC%2BD3MXjtFylt74%3D
17. MJ Yin Y Yamamoto RB Gaynor 1998 The anti-inflammatory agents aspirin and salicylate inhibit the activity of I (kappa) B-kinase-beta Nature 396 77 80 10.1038/23948 9817203 10.1038/23948 1:CAS:528:DyaK1cXnsVSjur0%3D (Pubitemid 28520452)
18. BC Wong X Jiang XM Fan, et al. 2003 Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer Oncogene 22 1189 1197 10.1038/sj.onc.1206234 12606945 10.1038/sj.onc.1206234 1:CAS:528:DC%2BD3sXhsVyqtrw%3D (Pubitemid 36363382)
19. XM Zhou BC Wong XM Fan, et al. 2001 Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak Carcinogenesis 22 1393 1397 10.1093/carcin/22.9.1393 11532860 10.1093/carcin/22.9.1393 1:CAS:528:DC%2BD3MXmvVymt7Y%3D
20. CC Ho XW Yang TL Lee, et al. 2003 Activation of p53 signalling in acetylsalicylic acid-induced apoptosis in OC2 human oral cancer cells Eur J Clin Invest 33 875 882 10.1046/j.1365-2362.2003.01240.x 14511359 10.1046/j.1365-2362.2003.01240.x 1:CAS:528:DC%2BD3sXos1Wrtr0%3D (Pubitemid 37215043)
21. SK Chiou T Tanigawa T Akahoshi, et al. 2005 Survivin: a novel target for indomethacin-induced gastric injury Gastroenterology 28 63 73 10.1053/j.gastro.2004.10.008 10.1053/j.gastro.2004.10.008 (Pubitemid 40039959)
22. LF Zerbini A Czibere Y Wang, et al. 2006 A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells Cancer Res 66 11922 11931 10.1158/0008-5472.CAN-06-2068 17178890 10.1158/0008-5472.CAN-06-2068 1:CAS:528:DC%2BD28Xhtlagu7vL (Pubitemid 46094205)
23. Z Chen S Clark M Birkeland, et al. 2002 Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells Cancer Lett 188 127 140 10.1016/S0304-3835(02)00322-1 12406558 10.1016/S0304-3835(02)00322-1 1:CAS:528:DC%2BD38Xot1Wquro%3D (Pubitemid 35299421)
24. X Li X Ding TE Adrian 2004 Arsenic trioxide causes redistribution of cell cycle, caspase activation, and GADD expression in human colonic, breast, and pancreatic cancer cells Cancer Invest 22 389 400 10.1081/CNV-200029068 15493360 10.1081/CNV-200029068 1:CAS:528:DC%2BD2cXmvF2ju7w%3D (Pubitemid 39310909)
25. RN Bhattacharjee KS Park S Uematsu, et al. 2005 Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest FEBS Lett 579 6604 6610 10.1016/j.febslet.2005.10.053 16297916 10.1016/j.febslet.2005.10.053 1:CAS:528:DC%2BD2MXht1OlurnP (Pubitemid 41682447)
26. CS Williams AP Goldman H Sheng, et al. 1999 Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth Neoplasia 1 170 176 10.1038/sj.neo.7900024 10933052 10.1038/sj.neo.7900024 1:CAS:528: DyaK1MXmslGgu7o%3D
27. FG Bottone Jr JM Martinez JB Collins, et al. 2003 Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis J Biol Chem 278 25790 25801 10.1074/jbc.M301002200 12734198 10.1074/jbc.M301002200 1:CAS:528:DC%2BD3sXlt1Cls7g%3D (Pubitemid 36835337)
28. MW Pfaffl 2001 A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 e45 10.1093/nar/29.9.e45 11328886 10.1093/nar/29.9.e45 1:STN:280:DC%2BD38nis12jtw%3D%3D
29. T Zhang JZ Fields SM Ehrlich, et al. 2004 The chemopreventive agent sulindac attenuates expression of the antiapoptotic protein survivin in colorectal carcinoma cells J Pharmacol Exp Ther 308 434 437 10.1124/jpet.103. 059378 14610217 10.1124/jpet.103.059378 1:CAS:528:DC%2BD2cXhtlSqtL8%3D (Pubitemid 38134201)
30. SK Chiou S Mandayam 2007 NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis Biochem Pharmacol 74 1485 1495 10.1016/j.bcp.2007.07.024 17727822 10.1016/j.bcp.2007.07. 024 1:CAS:528:DC%2BD2sXhtF2msLnE (Pubitemid 47575492)
31. S Elmore 2007 Apoptosis: a review of programmed cell death Toxicol Pathol 35 495 516 10.1080/01926230701320337 17562483 10.1080/01926230701320337 1:CAS:528:DC%2BD2sXmtlWmtb4%3D (Pubitemid 46911891)
32. MJ Thun SJ Henley C Patrono 2002 Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues Natl Cancer Inst 94 252 266 1:CAS:528:DC%2BD38Xit1ygtb8%3D
33. MA Hull SH Gardner G Hawcroft 2003 Activity of the non-steroidal anti-inflammatory drug indomethacin against colorectal cancer Cancer Treat Rev 29 309 320 10.1016/S0305-7372(03)00014-8 12927571 10.1016/S0305-7372(03)00014-8 1:CAS:528:DC%2BD3sXmsVCns7c%3D (Pubitemid 37069661)
34. Dronamraju SS, Coxhead JM, et al. (2008) Cell kinetics and gene expression changes in colorectal cancer patients given resistant starch-a randomised controlled trial. Gut 2008(Oct):31. Epub ahead of print
35. A Lal M Gorospe 2006 Egad, more forms of gene regulation: the gadd45a story Cell Cycle 5 1422 1425 16775423 1:CAS:528:DC%2BD28XpvF2qsrY%3D
36. Q Zhan IT Chen MJ Antinore, et al. 1998 p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding Mol Cell Biol 18 2768 2778 9566896 1:CAS:528:DyaK1cXis1Gnu78%3D
37. HF Liu PW Hsiao JI Chao 2008 Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells Chem Biol Interact 176 48 57 10.1016/j.cbi.2008.07.012 18760266 10.1016/j.cbi.2008.07.012 1:CAS:528:DC%2BD1cXhtF2rtL%2FM
38. Y Moon FG Bottone Jr MF McEntee, et al. 2005 Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1 Mol Cancer Ther 4 1551 1558 10.1158/1535-7163.MCT-05-0213 16227405 10.1158/1535-7163.MCT-05-0213 1:CAS:528:DC%2BD2MXhtFWhtLnN (Pubitemid 41556438)
39. R Thyss V Virolle V Imbert, et al. 2005 NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death EMBO J 24 128 137 10.1038/sj.emboj.7600501 15616591 10.1038/sj.emboj.7600501 1:CAS:528:DC%2BD2MXlvVKksA%3D%3D (Pubitemid 40188470)