Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4288-4296

  Zagórska, Agnieszka ^a   Jurczyk, Sławomir ^a   Pawłowski, Maciej ^a   Dybała, Małgorzata ^a   Nowak, Gabriel ^a   Tatarczyńska, Ewa ^b   Nikiforuk, Agnieszka ^b   Chojnacka Wójcik, Ewa ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

5 HT1A, 5 HT2A, D1, D2 receptor affinities; Anxiolytics antidepressants; Arylalkylpiperazines; Imidazo 2,1 f theophyllines; Theophylline

Indexed keywords

1,3 DIMETHYL 6,7 DIHYDROIMIDAZO[2,1 F]PURINE 2,4 (1H,3H) DIONE 7 CARBOXYLIC ACID; 7 METHYL 8 [3 (N4 2' METHOXYPHENYL)PIPERAZIN N1 YL PROPYL] 1,3 DIMETHYL (1H,8H) IMIDAZO[2,1 F]PURINE 2,4 DIONE; 7 METHYL 8 [3 (N4 3' CHLOROPHENYL)PIPERAZIN N1 YL PROPYL]1,3 DIMETHYL (1H,8H) IMIDAZO[2,1 F]PURINE 2,4 DIONE; 7 METHYL 8 [3 (N4 PHENYL)PIPERAZIN N1 YL PROPYL] 1,3 DIMETHYL (1H,8H) IMIDAZO[2,1 F]PURINE 2,4 DIONE; 7 PHENYL 8 [3 (N4 2' METHOXYPHENYL)PIPERAZIN N1 YL PROPYL] 1,3 DIMETHYL (1H,8H) IMIDAZO[2,1 F]PURINE 2,4 DIONE; 7 PHENYL 8 [3 (N4 3' CHLOROPHENYL)PIPERAZIN N1 YL PROPYL]1,3 DIMETHYL (1H,8H) IMIDAZO[2,1 F]PURINE 2,4 DIONE; 7 PHENYL 8 [3 (N4 PHENYL)PIPERAZIN N1 YL PROPYL] 1,3 DIMETHYL (1H,8H) IMIDAZO[2,1 F]PURINE 2,4 DIONE; 8 [3 (N4 2' METHOXYPHENYL)PIPERAZIN N1 YL PROPYL] 1,3 DIMETHYL (1H,8H) IMIDAZO[2,1 F]PURINE 2,4 DIONE; 8 [3 (N4 3' CHLOROPHENYL)PIPERAZIN N1 YL PROPYL] 1,3 DIMETHYL (1H,8H) IMIDAZO[2,1 F]PURINE 2,4 DIONE; 8 [3 (N4 PHENYL)PIPERAZIN N1 YL PROPYL] 1,3 DIMETHYL (1H,8H) IMIDAZO[2,1 F]PURINE 2,4 DIONE; AMIDE; ANTIDEPRESSANT AGENT; DIAZEPAM; IMIPRAMINE; N 2 [(N4 PHENYL)PIPERAZIN N1 YL]ETHYL AMIDE; N 2 [N4 (2 METHOXY)PHENYL PIPERAZIN N1 YL]ETHYL AMIDE; N 2 [N4 (3 CHLORO)PHENYL PIPERAZIN N1 YL]ETHYL AMIDE; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BODY TEMPERATURE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FORCED SWIMMING TEST; LOCOMOTION; MALE; MOUSE; NONHUMAN; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANTIDEPRESSIVE AGENTS; BODY TEMPERATURE; CEREBRAL CORTEX; IMIDAZOLES; MALE; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PIPERAZINES; PROTEIN BINDING; PURINES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, DOPAMINE D2; THEOPHYLLINE;

EID: 70349778479     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.07.014     Document Type: Article

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