3-(ω-aminoalkyl)-5,5-dialkyl(or spirocycloalkyl-1',5-)hydantoins as new 5-HT(1A) and 5-HT(2A) receptor ligands

Archiv der Pharmazie

Volumn 329, Issue 6, 1996, Pages 283-290

  Byrtus, Hanna ^a   Pawłowski, Maciej ^a   Charakchieva Minol, Sijka ^b   Duszyńska, Beata ^b   Mokrosz, Maria J ^b   Mokrosz, Jerzy L ^b   Zejc, Alfred ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

3 ( aminoalkyl) spiro cycloalkyl 1',5 hydantoins ; 3 ( aminoalkyl) 5,5 dialkylhydantoins; 5 HT(1A) 5 HT(2A) selectivity ratio; 5 HT(1A) and 5 HT(2A) receptor ligands

Indexed keywords

ETOPERIDONE; HYDANTOIN DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; TRAZODONE;

ANIMAL TISSUE; ARTICLE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

AMINES; ANTIDEPRESSIVE AGENTS; HYDANTOINS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PIPERIDINES; PROTEIN BINDING; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; TRAZODONE;

EID: 0030035850     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19963290604     Document Type: Article

References (31)

1. C. Avendano-López, G. González-Trigo in Advances in Heterocyclic Chemistry (Ed.: A. R. Katrizky), Academic Press, Inc., Orlando, 1985, vol. 38, chapter 4.
2. W.O. Foye, Principles of Medicinal Chemistry, Lea & Febiger, Philadelphia, 1989.
3. A. Zejc, M. Pawlowski, Pol. J. Pharmacol. Pharm. 1980, 32, 173-178.
4. R.L. Hudkins, D.L. DeHaven-Hudkins, Bioorg. Med. Chem. Lett. 1994, 4, 2185-2188.
5. M.A. Abou-Gharbia, G.P. Stack (American Home Products). US 4,675,403. 1987 [Chem. Abstr. 1987, 107, 198327].
6. T.A. Pugsley, S.M. Myers, Y.-H. Shih, J. Cardiovasc. Pharmacol. 1989, 13, 455-464.
7. E. Zifa, G. Fillion, Pharmacol. Rev. 1992, 44, 401-458.
8. R.K. Raghupathi, L. Rydelek-Fitzgerald, M. Teitler, R.A. Glennon, J. Med. Chem. 1991, 34, 2633-2638.
9. A. Orjales, L. Alonso-Cires, L. Labaeaga, R. Corcóstequi, J. Med. Chem. 1995, 38, 1273-1277.
10. M.H. Paluchowska, A. Dereń-Wesolek, S. Charakchieva-Minol, E. Chojnacka-Wójcik, J.L. Mokrosz, Med. Chem. Res. 1995, 5, 479-486.
11. J.L. Mokrosz, M.H. Paluchowska, A. Kłodzińska, S. Charakchieva-Minol, E. Chojnacka-Wójcik, Arch. Pharm. (Weinheim) 1995, 328, 770-774.
12. H.Y. Meltzer, S. Matsubara, J.-C. Lee, Psychopharmacol. Bull. 1989, 25, 390-392.
13. H.Y. Meltzer, S. Matsubara, J.-C. Lee, J. Pharmacol. Exp. Ther. 1989, 251, 238-246.
14. J.L. Mokrosz, E. Chojnacka-Wójcik, A. Dereń-Wesołek, A. Kłodzińska, M. Mackowiak, Z. Bielecka, M.H. Paluchowska, Drug Des. Discovery 1994, 11, 197-203.
15. R.A. Glennon, R.B. Westkaemper, P. Bartyzel in Serotonin Receptor Subtypes: Basic and Clinical Aspects (Ed.: S. J. Peroutka), Wiley-Liss, New York, 1991, pp. 19-64.
16. R.A. Glennon, M. Dukat, Curr. Drugs: Serotonin 1992, 1-45.
17. J.L. Mokrosz, A.J. Bojarski, M. Mackowiak, Z. Bielecka, J. Boksa, Pharmazie 1994, 49, 328-333.
18. J.L. Mokrosz, M.J. Mokrosz, S. Charakchieva-Minol, M.H. Paluchowska, A.J. Bojarski, B. Duszyńska, Arch. Pharm. (Weinheim) 1995, 328, 143-148.
19. J.L. Mokrosz, B. Duszyńska, M.H. Paluchowska, S. Charakchieva-Minol, M.J. Mokrosz, Arch. Pharm. (Weinheim) 1995, 328, 623-625.
20. S. Misztal, A. Bojarski, M. Mackowiak, J. Boksa, Z. Bielecka, J.L. Mokrosz, Med. Chem. Res. 1992, 2, 82-87.
21. J. Boksa, B. Duszyńska, J.L. Mokrosz, Pharmazie 1995, 50, 220-221.
22. M.F. Hibert, I. McDermott, D.N. Middlemiss, A.K. Mir, J.R. Fozard, Eur. J. Med. Chem. 1989, 24, 31-37.
23. J.L. Mokrosz, M.J. Mokrosz, A.J. Bojarski, S. Charakchieva-Minol, Pharmazie 1994, 49, 781-782.
24. J.L. Mokrosz, A.J. Bojarski, S. Charakchieva-Minol, B. Duszyńska, M.J. Mokrosz, Arch. Pharm. (Weinheim) 1995, 328, 604-608.
25. J.L. Mokrosz, A. Dereń-Wesołek, E. Tatarczyńska, B. Duszyńska, A.J. Bojarski, M.J. Mokrosz, E. Chojnacka-Wójcik, J. Med. Chem. 1996, 39, 1125-1129.
26. M. Abou-Gharbia, U.R. Patel, M.B. Webb, J.A. Moyer, T.H. Andree, E.A. Muth, J. Med. Chem. 1988, 31, 1382-1392.
27. M.J. Mokrosz, B. Duszyńska, A.J. Bojarski, J.L. Mokrosz, Bioorg. Med. Chem. 1995, 3, 533-538.
28. A.M. Ismaiel, K. Arruda, M. Teitler, R.A. Glennon, J. Med. Chem. 1995, 38, 1196-1202.
29. H.D. Höltje, U.K. Jendretzki, Arch. Pharm. (Weinheim) 1995, 328, 577-584.
30. L.H. Goodson, J.L. Honigberg, J.J. Lehman, W.H. Burton, J. Org. Chem. 1960, 25, 1920-1925.
31. A.J. Bojarski, M.T. Cegła, S. Charakchieva-Minol, M.J. Mokrosz, M. Mackowiak, S. Misztal, J.L. Mokrosz, Pharmazie 1993, 48, 289-294.