메뉴 건너뛰기




Volumn 28, Issue 9, 2007, Pages 1859-1866

Loss of p27Kip1 enhances tumor progression in chronic hepatocyte injury-induced liver tumorigenesis with widely ranging effects on Cdk2 or Cdc2 activation

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; CYCLIN E1; PROTEIN P27; UNCLASSIFIED DRUG;

EID: 34848868173     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm079     Document Type: Article
Times cited : (12)

References (28)
  • 1
    • 0030894449 scopus 로고    scopus 로고
    • Liver regeneration
    • Michalopoulos,G.K. et al. (1997) Liver regeneration. Science 276, 60-66.
    • (1997) Science , vol.276 , pp. 60-66
    • Michalopoulos, G.K.1
  • 2
    • 0034742547 scopus 로고    scopus 로고
    • Loss of p27(Kip1) enhances the transplantation efficiency of hepatocytes transferred into diseased livers
    • Karnezis,A.N. et al. (2001) Loss of p27(Kip1) enhances the transplantation efficiency of hepatocytes transferred into diseased livers. J. Clin. Invest., 108, 383-390.
    • (2001) J. Clin. Invest , vol.108 , pp. 383-390
    • Karnezis, A.N.1
  • 3
    • 0347086153 scopus 로고    scopus 로고
    • p27Kip1 inactivation provides a proliferative advantage to transplanted hepatocytes in DPPIV/Rag2 double knockout mice after repeated host liver injury
    • Yuan,R.H. et al. (2003) p27Kip1 inactivation provides a proliferative advantage to transplanted hepatocytes in DPPIV/Rag2 double knockout mice after repeated host liver injury. Cell Transplant., 12, 907-919.
    • (2003) Cell Transplant , vol.12 , pp. 907-919
    • Yuan, R.H.1
  • 4
    • 0037381639 scopus 로고    scopus 로고
    • p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver
    • Luedde,T. et al. (2003) p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology, 37, 833-841.
    • (2003) Hepatology , vol.37 , pp. 833-841
    • Luedde, T.1
  • 5
    • 0032511848 scopus 로고    scopus 로고
    • The murine gene p27Kip1 is haplo-insufficient for tumour suppression
    • Fero,M.L. et al. (1998) The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature, 396, 177-180.
    • (1998) Nature , vol.396 , pp. 177-180
    • Fero, M.L.1
  • 6
    • 14944354142 scopus 로고    scopus 로고
    • Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner
    • King,T.J. et al. (2005) Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner. Oncogene, 24, 1718-1726.
    • (2005) Oncogene , vol.24 , pp. 1718-1726
    • King, T.J.1
  • 7
    • 0034691586 scopus 로고    scopus 로고
    • Decreased expression of p27 protein is associated with advanced tumor stage in hepatocellular carcinoma
    • Tannapfel,A. et al. (2000) Decreased expression of p27 protein is associated with advanced tumor stage in hepatocellular carcinoma. Int. J. Cancer, 89, 350-355.
    • (2000) Int. J. Cancer , vol.89 , pp. 350-355
    • Tannapfel, A.1
  • 8
    • 0034869599 scopus 로고    scopus 로고
    • Expression of p27(KIP1) and p21(WAF1/CIP1) in primary hepatocellular carcinoma: Clinicopathologic correlation and survival analysis
    • Qin,L.F. et al. (2001) Expression of p27(KIP1) and p21(WAF1/CIP1) in primary hepatocellular carcinoma: Clinicopathologic correlation and survival analysis. Hum. Pathol., 32, 778-794.
    • (2001) Hum. Pathol , vol.32 , pp. 778-794
    • Qin, L.F.1
  • 9
    • 0032995914 scopus 로고    scopus 로고
    • Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: P27 independently predicts the recurrence
    • Ito,Y. et al. (1999) Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: P27 independently predicts the recurrence. Hepatology, 30, 90-99.
    • (1999) Hepatology , vol.30 , pp. 90-99
    • Ito, Y.1
  • 10
    • 1642544603 scopus 로고    scopus 로고
    • Focus on hepatocellular carcinoma
    • Bruix,J. et al. (2004) Focus on hepatocellular carcinoma. Cancer Cell, 5, 215-219.
    • (2004) Cancer Cell , vol.5 , pp. 215-219
    • Bruix, J.1
  • 11
    • 0023037176 scopus 로고
    • Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice
    • Chisari,F.V. et al. (1986) Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J. Virol., 60, 880-887.
    • (1986) J. Virol , vol.60 , pp. 880-887
    • Chisari, F.V.1
  • 12
    • 0024818649 scopus 로고
    • Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice
    • Chisari,F.V. et al. (1989) Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59, 1145-1156.
    • (1989) Cell , vol.59 , pp. 1145-1156
    • Chisari, F.V.1
  • 13
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr,C.J. (1996) Cancer cell cycles. Science, 274, 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 14
    • 0141749113 scopus 로고    scopus 로고
    • Cdk2 dethroned as master of S phase entry
    • Hinds,P.W. (2003) Cdk2 dethroned as master of S phase entry. Cancer Cell, 3, 305-307.
    • (2003) Cancer Cell , vol.3 , pp. 305-307
    • Hinds, P.W.1
  • 15
    • 0041327168 scopus 로고    scopus 로고
    • Proliferation of cancer cells despite CDK2 inhibition
    • Tetsu,O. et al. (2003) Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell, 3, 233-245.
    • (2003) Cancer Cell , vol.3 , pp. 233-245
    • Tetsu, O.1
  • 16
    • 23144451917 scopus 로고    scopus 로고
    • Cdc2-cyclin E complexes regulate the G1/S phase transition
    • Aleem,E. et al. (2005) Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat. Cell Biol., 7, 831-836.
    • (2005) Nat. Cell Biol , vol.7 , pp. 831-836
    • Aleem, E.1
  • 17
    • 20444410393 scopus 로고    scopus 로고
    • Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1)
    • Martin,A. et al. (2005) Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell, 7, 591-598.
    • (2005) Cancer Cell , vol.7 , pp. 591-598
    • Martin, A.1
  • 18
    • 15844384256 scopus 로고    scopus 로고
    • A syndrome of multiorgan hyperplasia with features of gigantism, tumorignesis, and female sterility in p27Kip1-deficient mice
    • Fero,M.L. et al. (1996) A syndrome of multiorgan hyperplasia with features of gigantism, tumorignesis, and female sterility in p27Kip1-deficient mice. Cell, 85, 733-744.
    • (1996) Cell , vol.85 , pp. 733-744
    • Fero, M.L.1
  • 19
    • 0025334672 scopus 로고
    • Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice
    • Dunsford,H.A. et al. (1990) Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice. Cancer Res. 50, 3400-3407.
    • (1990) Cancer Res , vol.50 , pp. 3400-3407
    • Dunsford, H.A.1
  • 20
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27Kip1 display incresased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • Nakayama,K. et al. (1996) Mice lacking p27Kip1 display incresased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell, 85, 707-720.
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1
  • 21
    • 15844415946 scopus 로고    scopus 로고
    • Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1
    • Kiyokawa,H. et al. (1996) Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. Cell, 85 721-732.
    • (1996) Cell , vol.85 , pp. 721-732
    • Kiyokawa, H.1
  • 22
    • 33846212350 scopus 로고    scopus 로고
    • Cell cycle kinases in cancer
    • Malumbres,M. et al. (2007) Cell cycle kinases in cancer. Curr. Opin. Genet. Dev., 17, 60-65.
    • (2007) Curr. Opin. Genet. Dev , vol.17 , pp. 60-65
    • Malumbres, M.1
  • 23
    • 0028179669 scopus 로고
    • p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest
    • Polyak,Y. et al. (1994) p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev., 8, 9-22.
    • (1994) Genes Dev , vol.8 , pp. 9-22
    • Polyak, Y.1
  • 24
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21
    • Toyoshima,H. et al. (1994) p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell, 78, 67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1
  • 25
    • 33645221414 scopus 로고    scopus 로고
    • Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1
    • Chien,W.M. et al. (2006) Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1. Proc. Natl. Acad. Sci. USA, 103, 4122-4127.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 4122-4127
    • Chien, W.M.1
  • 26
    • 11844259459 scopus 로고    scopus 로고
    • Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate
    • Shaffer,D.R. et al. (2005) Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate. Proc. Natl. Acad Sci. USA, 102, 210-215.
    • (2005) Proc. Natl. Acad Sci. USA , vol.102 , pp. 210-215
    • Shaffer, D.R.1
  • 27
    • 7444229923 scopus 로고    scopus 로고
    • A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry
    • Matsumoto,Y. et al. (2004) A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science, 306, 885-888.
    • (2004) Science , vol.306 , pp. 885-888
    • Matsumoto, Y.1
  • 28
    • 1942466518 scopus 로고    scopus 로고
    • p27Kip1 modulates cell migration through the regulation of RhoA activation
    • Besson,A. et al. (2004) p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev., 18, 862-876.
    • (2004) Genes Dev , vol.18 , pp. 862-876
    • Besson, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.