Therapeutic role of low-carbohydrate ketogenic diet in diabetes

Nutrition

Volumn 25, Issue 11-12, 2009, Pages 1177-1185

  Al Khalifa, Alaa ^a   Mathew, Thazhumpal Chacko ^a   Al Zaid, Naji S ^a   Mathew, Elizabeth ^a   Dashti, Hussein M ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Biochemistry; Diabetes mellitus; Histology; Low carbohydrate ketogenic diet; Streptozotocin

Indexed keywords

GLUCOSE; STREPTOZOCIN;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HISTOCHEMISTRY; HISTOLOGY; KETOGENIC DIET; LOW CARBOHYDRATE DIET; MALE; MONITORING; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; URINE VOLUME;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DIET, CARBOHYDRATE-RESTRICTED; DIETARY CARBOHYDRATES; DRINKING; ENERGY INTAKE; GLYCOSURIA; ISLETS OF LANGERHANS; KETOGENIC DIET; KETONE BODIES; MALE; RATS; RATS, WISTAR; STREPTOZOCIN; URINATION;

ANIMALIA; RATTUS;

EID: 70349772150     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2009.04.004     Document Type: Article

References (50)

1. Abdella N., Al Arouj M., Al Nakhi A., Al Assoussi A., and Mousa M. Non-insulin-dependent diabetes in Kuwait: prevalence rates and associated risk factors. Diabetes Res Clin Pract 42 (1998) 187-196
2. Abdella N., Al Nakhi A., Al Arouj M., Al Assoussi A., and Mousa M. Impact of the 1997 American diabetes association criteria on classification of glucose tolerance among Kuwaitis below 50 years of age. Acta Diabetol 36 (1999) 133-140
3. Sparre T., Larseb M.R., Heding P.E., Karlsen A.E., Jensen O.N., and Pociot F. Unraveling the pathogenesis of type 1 diabetes with proteomics. Mol Cell Proteomics 4 (2005) 441-457
4. Malecki M.T. Type 2 diabetes mellitus and its complications: from the molecular biology to the clinical practice. Rev Diabet Stud 1 (2004) 5-8
5. Palumbo P.J. Glycemic control, mealtime glucose excursions and diabetic complications in type 2 diabetes mellitus. Mayo Clin Proc 76 (2001) 609-618
6. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 50 (2001) 536-546
7. Cardinal J.W., Margison G.P., Mynett K.J., Yates A.P., Cameron D.P., and Elder R.H. Increased susceptibility to streptozotocin-induced β-cell apoptosis and delayed autoimmine diabetes in alkylpurine-DNA- N-glycosylase-deficient mice. Mol Cell Biol 21 (2001) 5605-5613
8. Okamato H. Regulation of proinsulin synthesis in pancreatic islets and a new aspect to insulin dependent diabetes. Mol Cell Biochem 37 (1981) 43-61
9. Bough K.J., Gudi K., Han F.T., Rathod A.H., and Eagles D.A. An anticonvulsant profile of the ketogenic diet in the rat. Epilepsy Res 50 (2002) 313-325
10. Dashti H.M., Mathew T.C., Hussein T., Asfar S.K., Behbehani A.I., Al-Sayer H.M., and Al-Zaid N.S. Long term effects of ketogenic diet in obese subjects. Exp Clin Cardiol 9 (2004) 200-205
11. Dashti H.M., Bo-Abbas Y.Y., Mathew T.C., Hussein T., Behbehani A., Khoursheed M., et al. Ketogenic diet modifies the risk factors for heart disease in obese patients. Nutrition 19 (2003) 901-902
12. Neilsen J.V., Joensson E., and Nilsson A.K. Lasting improvement of hyperglycaemia and bodyweight: low-carbohydrate diet in type 2 diabetes. A brief report. Ups J Med Sci 110 (2005) 179-183
13. Freeman J., Veggiotti P., Lanzi G., Tagliabue A., and Perucca E. The ketogenic diet: from molecular mechanisms to clinical effects. Epilepsy Res 68 (2006) 145-180
14. Prentice A.M. Manipulation of dietary fat and energy density and subsequent effects on substrate flux and food intake. Am J Clin Nutr 67 suppl (1998) S535-S541
15. Al-Zaid N.S., Dashti H.M., Mathew T.C., and Juggi J.S. Low carbohydrate ketogenic diet enhances cardiac tolerance to global ischaemia. Acta Cardiol 62 (2007) 381-389
16. Sydney C., and Werner M.D. Comparison between weight reduction on a high calorie, high fat diet and on an isocaloric regimen high in carbohydrate. N Engl J Med 252 (1955) 661-665
17. Wolever T.M. Dietary carbohydrates and insulin action in humans. Br J Nutr 83 suppl 1 (2000) S97-S102
18. Mathew T.C., Al-Bader M., Bou-Resli M.N., Dashti H.M., and Al-Zaid N.S. Alteration of brain zinc level in rat pups of zinc supplemented mothers. Trace Elements and Electrolytes 23 (2006) 231-236
19. Shetty A., Rashmi R., Rajan M., Sambaiah K., and Salimath P. Antidiabetic influence of quercetin in streptozotocin-induced diabetic rats. Nutr Res 24 (2003) 373-381
20. Ugochukwu N.H., and Figgers C.L. Modulation of the flux patterns in carbohydrate metabolism in the livers of streptozotocin-induced diabetic rats by dietary caloric restriction. Pharmacol Res 54 (2006) 172-180
21. McNeill J. Experimental models of diabetes. 1st ed (1999), CRC Press, Boca Raton, FL p. 3-17
22. Drury R.A.B., and Wallington E.A. Carlton's histological technique. 5th ed (1980), Oxford University Press, New York p. 173-4
23. Willi S.M., Martin K., Datko F.M., and Brant B.P. Treatment of type 2 diabetes in childhood using a very low calorie diet. Diabetes Care 27 (2004) 348-353
24. Yancy W.S., Foy M., Chalecki A.M., Vernon M.C., and Westman E.C. A low-carbohydrate, ketogenic diet to treat type 2 diabetes. Nutr Metab 2 (2005) 34
25. Ma Y., Olendzki B., Hafner A.R., Chiriboga D.E., Culver A.L., Andersen V.A., et al. Low-carbohydrate and high-fat intake among adult patients with poorly controlled type 2 diabetes mellitus. Nutrition 22 (2006) 1129-1136
26. Dashti H.M., Mathew T.C., Khadada M., Al-Mousawi M., Talib H., Asfar S.K., et al. Beneficial effects of ketogenic diet in obese diabetic subjects. Mol Cell Biochem 302 (2007) 249-256
27. McAuley K.A., Hopkins C.M., Smith K.J., McLay R.T., Williams S.M., Taylor R.W., and Mann J.I. Comparison of high-fat and high-protein diets with high-carbohydrate diet in insulin-resistant obese women. Diabetologia 48 (2005) 8-16
28. Gannon M.C., and Nuttall F.Q. Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes. Diabetes 53 (2004) 2375-2382
29. Parillo M., Rivellese A.A., Ciardullo A.V., Capaldo B., Giacco A., Genovese S., and Riccardi G. A high-monounsaturated-fat/low-carbohydrate diet improves peripheral insulin sensitivity in non-insulin-dependent diabetic patients. Metabolism 41 (1992) 1373-1378
30. Allick G., Bisschop P.H., Ackermans M.T., Endert E., Meijer A.J., Kuipers F., et al. A low-carbohydrate/high-fat diet improves glucoregulation in type 2 diabetes mellitus by reducing postabsorptive glycogenolysis. J Clin Endocrinol Metab 89 (2004) 6193-6197
31. Schmidt F.H., Siegel E.G., and Trapp V.E. Metabolic and hormonal investigations in long-term Streptozotocin Diabetic Rats on different dietary regimens. Diabetologia 18 (1980) 161-168
32. Eizirik D.L., Tze W.J., Tai J., and Migliorini R.H. Effects of a high protein diet on the evolution of diabetes in streptozotocin-induced and spontaneously diabetic "BB" Wistar rats. Acta Diabetol Lat 23 (1986) 107-116
33. Henry R.R., Brechtel G., and Lim K.H. Effects of ketone bodies on carbohydrate metabolism in non-insulin-dependent (type II) diabetes mellitus. Metabolism 39 (1990) 853-858
34. Müller M.J., Paschen U., and Seitz H.J. Effect of ketone bodies on glucose production and utilization in the miniature pig. J Clin Invest 74 (1984) 249-261
35. Rodriguez R.R., and Krehl W.A. The influence of diet and insulin on the incidence of cataracts in diabetic rats. Yale J Biol Med 24 (1951) 103-108
36. Siegel E.G., Trapp V.E., Wollheim C.B., Renold A.E., and Schmidt F.H. Beneficial effects of low-carbohydrate-high protein diets in long-term diabetic rats. Metabolism 29 (1980) 421-428
37. Nuttall F.Q., Gannon M.C., Saeed A., Jordan K., and Hoover H. The metabolic response of subjects with type 2 diabetes to a high-protein, weight-maintenance diet. J Clin Endocrinol 88 (2003) 3577-3583
38. Mostafa M.G., Nasir T.A., and Islam K.M. Effect of high protein carbohydrate free diet on the evolution of diabetes mellitus on in rats. Bangladesh Med Res Counc Bull 19 (1993) 8-14
39. Brunzell J.D., Lerner R.L., Hazzard W.R., Porte D., and Bierman E.L. Improved glucose tolerance with high carbohydrate feeding in mild diabetes. N Engl J Med 284 (1971) 521-524
40. Beck-Nielsen H., Pedersen O., and Schwartz Sørensen N. Effects of diet on the cellular insulin binding and the insulin sensitivity in young healthy subjects. Diabetologia 15 (1978) 289-296
41. Storlien L.H., James D.E., Burleigh K.M., Chisholm D.J., and Kraegen E.W. Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure and obesity in rats. Am J Physiol 251 (1986) E576-E583
42. Chisholm K., and O'Dea K. Effect of short-term consumption of a high-fat, low-carbohydrate diet on metabolic control in insulin-deficient diabetic rats. Metabolism 36 (1987) 237-243
43. Voss A.C., Maki K.C., Garvey W.T., Hustead D.S., Alish C., Fix B., and Mustad V.A. Effect of two carbohydrate-modified tube-feeding formulas on metabolic responses in patients with type 2 diabetes. Nutrition 24 (2008) 990-997
44. Aughsteen A.A. An ultrastructural study on the effect of streptozotocin on the islets of Langerhans in mice. J Electron Microsc (Tokyo) 49 (2000) 681-690
45. Galgani J.E., Uauy R.D., Aguirre C.A., and Díaz E.O. Effect of the dietary fat quality on insulin sensitivity. Br J Nutr 100 (2008) 471-479
46. Low C.C., Grossman E.B., and Gumbiner B. Potentiation of effects of weight loss by monounsaturated fatty acids in obese NIDDM patients. Diabetes 45 (1996) 569-575
47. Kennedy L., Mehl T.D., Riley W.J., and Merimee T.J. Non-enzymatically glycosylated serum protein in diabetes mellitus: an index of short-term glycaemia. Diabetologia 21 (1981) 94-98
48. 1c analyzer. Clin Chem 43 (1997) 968-975
49. Falk R.E., Cederbaum S.D., Blass J.P., Gibson G.E., Kark R.A., and Carrel R.E. Ketonic diet in the management of pyruvate dehydrogenase deficiency. Pediatrics 58 (1976) 713-721
50. Freeman J., Veggiotti P., Lanzi G., Tagliabue A., and Perucca E. The ketogenic diet: from molecular mechanisms to clinical effects. Epilepsy Res 68 (2006) 145-180