Intravesical Botulinum Toxin A Administration Inhibits COX-2 and EP4 Expression and Suppresses Bladder Hyperactivity in Cyclophosphamide-Induced Cystitis in Rats

European Urology

Volumn 56, Issue 1, 2009, Pages 159-167

  Chuang, Yao Chi ^a   Yoshimura, Naoki ^b   Huang, Chao Cheng ^a   Wu, Moya ^a   Chiang, Po Hui ^a   Chancellor, Michael B ^c  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

Bladder; Botulinum toxin; COX2; EP4; Interstitial cystitis

Indexed keywords

BOTULINUM TOXIN A; CYCLOOXYGENASE 2; CYCLOPHOSPHAMIDE; EP4 RECEPTOR; PROSTAGLANDIN E RECEPTOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLADDER; BLADDER CONTRACTION; CONTROLLED STUDY; CYSTOMETRY; FEMALE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INTERSTITIAL CYSTITIS; LUMBAR SPINE; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; SACRAL SPINAL CORD; TISSUE SECTION; TREATMENT DURATION; WESTERN BLOTTING;

ADMINISTRATION, INTRAVESICAL; ANIMALS; BOTULINUM TOXIN TYPE A; CYCLOOXYGENASE 2 INHIBITORS; CYCLOPHOSPHAMIDE; CYSTITIS; FEMALE; MUCOUS MEMBRANE; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E; SPINAL CORD; URINARY BLADDER; URINARY BLADDER, OVERACTIVE;

EID: 67349231358     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2008.05.007     Document Type: Article

References (28)

1. Wesselmann U. Interstitial cystitis: a chronic visceral pain syndrome. Urology 57 (2001) 32-39
2. Van de Merwe J.P., Nordling J., Bouchelouche P., et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol 53 (2008) 60-67
3. Chancellor M.B., and Yoshimura N. Treatment of interstitial cystitis. Urology 63 3 Suppl 1 (2004) 85-92
4. 2 receptor EP4 contributes to inflammatory pain hypersensitivity. J Pharcacol Exp Ther 319 (2006) 1096-1103
5. Hu V.Y., Malley S., Dattilio A., Folsom J., Zvara P., and Vizzard M.A. COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat. Am J Physiol Regul Integr Comp Physiol 284 (2003) R574-R585
6. 2 production are upregulated in a rat bladder inflammation model. Eur J Pharmocol 417 (2001) 239-248
7. Smith C.P., and Chancellor M.B. Emerging role of botulinum toxin in the treatment of voiding dysfunction. J Urol 171 (2004) 2128-2137
8. Chapple C., and Patel A. Botulinum toxin-new mechanisms, new therapeutic directions?. Eur Urol 49 (2006) 606-608
9. Chuang Y.C., Yoshimura N., Huang C.C., Chiang P.H., and Chancellor M.B. Intravesical botulinum toxin A administration produces analgesia against acetic acid induced bladder pain responses in rats. J Urol 172 (2004) 1529-1532
10. Vemulakonda V.M., Somogyi G.T., Kiss S., Salas N.A., Boone T.B., and Smith C.P. Inhibitory effect of intravesically applied botulinum toxin A in chronic bladder inflammation. J Urol 173 (2005) 621-624
11. Giannantoni A., Costantini E., Di Stasi S.M., Tascini M.C., Bini V., and Porena M. Botulinum A toxin intravesical injections in the treatment of painful bladder syndrome: a pilot study. Eur Urol 49 (2006) 704-709
12. Saban R., Saban M.R., Nguyen N.B., Lue B., et al. Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. Am J Pathol 156 (2000) 775-780
13. Chuang Y.-C., Yoshimura N., Wu M., et al. Intraprostatic capsaicin injection as a novel model for nonbacterial prostatitis and effects of botulinum toxin A. Eur Urol 51 (2007) 1119-1127
14. Klinger M.B., Dattilio A., and Vizzard M.A. Expression of cyclooxygenase-2 (COX-2) in urinary bladder in rats with cyclophosphamide (CYP)-induced cystitis. Am J Physiol Regul Integr Comp Physiol 293 (2007) R677-R685
15. Lecci A., Birder L.A., Meini S., et al. Pharmacological evaluation of the role of cyclooxygenase isoenzymes on the micturition reflex following experimental cystitis in rats. Br J Pharmacol 130 (2000) 331-338
16. Cruz C.D., Avelino A., McMahon S.B., and Cruz F. Increased spinal cord phosphorylation of extracellular signal-regulated kinase mediates micturition overactivity in rats with chronic bladder inflammation. Eur J Neurosci. 21 (2005) 773-781
17. Lee T., Hedlund P., Newgreen D., and Andersson K.E. Urodynamic effects of a novel EP1 receptor antagonist in normal rats and rats with bladder outlet obstruction. J Urol 177 (2007) 1562-1567
18. Chuang Y.C., Yoshimura N., Huang C.C., et al. Intraprostatic botulinum toxin A injection inhibits COX-2 expression and suppresses prostatic pain on capsaicin induced prostatitis model in rat. J Urol 180 (2008) 742-748
19. Apostolidis A., Dasgupta P., and Fowler C.J. Proposed mechanism for the efficacy of injected botulinum toxin in the treatment of human detrusor overactivity. Eur Urol 49 (2006) 644-650
20. Smith C.P., Gangitano D.A., Munoz A., et al. Botulinum toxin type A normalizes alterations in urothelial ATP and NO release induced by chronic spinal cord injury. Neurochem Int 52 (2008) 1068-1075
21. ®) intradetrusor injections in adults with neurogenic detrusor overactivity/neurogenic overactive bladder: a systematic literature review. Eur Urol 53 (2008) 275-287
22. Patel A.K., Patterson J.M., and Chapple C.R. Botulinum toxin injections for neurogenic and idiopathic detrusor overactivity: a critical analysis of results. Eur Urol 50 (2006) 684-710
23. Liu H.T., and Kuo H.C. Intravesical botulinum toxin injection plus hydrodistension can reduce nerve growth factor production and control bladder pain in interstitial cystitis. Urology 70 (2007) 463-468
24. Zermann D., Ishigooka M., Schubert J., and Schmidt R.A. Perisphincteric injection of botulinum toxin type A. A treatment option for patients with chronic prostatic pain?. Eur Urol 38 (2000) 393-399
25. Chuang Y.C., Kim D.Y., Chiang P.H., and Chancellor M.B. Bladder botulinum toxin A injection can benefit patients with radiation and chemical cystitis. BJU Int 102 (2008) 704-706
26. Yoshimura N., and de Groat W.C. Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. Neuroscience 19 (1999) 4644-4653
27. Atiemo H., Wynes J., Chuo J., Nipkow L., Sklar G.N., and Chai T.C. Effect of botulinum toxin on detrusor overactivity induced by intravesical adenosine triphosphate and capsaicin in a rat model. Urology 65 (2005) 622-626
28. Mungan M.U., Gurel D., Canda A.E., Tuna B., Yorukoglu K., and Kirkali Z. Expression of COX-2 in normal and pyelonephritic kidney, renal intraepithelial neoplasia, and renal cell carcinoma. Eur Urol 50 (2006) 92-97