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Volumn 68, Issue 10, 2009, Pages 1084-1091

Selective nuclear shrinkage of oligodendrocytes lacking glial cytoplasmic inclusions in multiple system atrophy: A 3-Dimensional volumetric study

Author keywords

Glial cytoplasmic inclusions; Multiple system atrophy; Nuclear volume; Three dimensional reconstruction.

Indexed keywords

AGING; ARTICLE; CELL DEGENERATION; CELL INCLUSION; CELL NUCLEUS SHRINKAGE; CELL NUCLEUS VOLUME; CELLULAR PARAMETERS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GLIAL CYTOPLASMIC INCLUSION; HUMAN; HUMAN CELL; HUMAN TISSUE; NERVE DEGENERATION; NEUROPATHOLOGY; NUCLEAR SIZE; OLIGODENDROGLIA; PRIORITY JOURNAL; SHY DRAGER SYNDROME; THREE DIMENSIONAL IMAGING;

EID: 70349748599     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181b67678     Document Type: Article
Times cited : (13)

References (52)
  • 1
    • 0014469501 scopus 로고
    • Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy
    • Graham JG, Oppenheimer DR. Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. J Neurol Neurosurg Psychiatry 1969;32:28-34
    • (1969) J Neurol Neurosurg Psychiatry , vol.32 , pp. 28-34
    • Graham, J.G.1    Oppenheimer, D.R.2
  • 2
    • 0024843373 scopus 로고
    • Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)
    • Papp MI, Kahn JE, Lantos PL. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci 1989;94:79-100
    • (1989) J Neurol Sci , vol.94 , pp. 79-100
    • Papp, M.I.1    Kahn, J.E.2    Lantos, P.L.3
  • 3
    • 11944253337 scopus 로고
    • Oligodendroglial microtubular tangles in olivopontocerebellar atrophy
    • Nakazato Y, Yamazaki H, Hirato J, et al. Oligodendroglial microtubular tangles in olivopontocerebellar atrophy. J Neuropathol Exp Neurol 1990; 49:521-30
    • (1990) J Neuropathol Exp Neurol , vol.49 , pp. 521-30
    • Nakazato, Y.1    Yamazaki, H.2    Hirato, J.3
  • 4
    • 0028339722 scopus 로고
    • The distribution of oligodendroglial inclusions in multiple system atrophy and its relevance to clinical symptomatology
    • Papp MI, Lantos PL. The distribution of oligodendroglial inclusions in multiple system atrophy and its relevance to clinical symptomatology. Brain 1994;117:235-43
    • (1994) Brain , vol.117 , pp. 235-43
    • Papp, M.I.1    Lantos, P.L.2
  • 5
    • 1842678274 scopus 로고    scopus 로고
    • A quantitative study of the pathological changes in ten patients with multiple system atrophy (MSA)
    • Armstrong RA, Cairns NJ, Lantos PL. A quantitative study of the pathological changes in ten patients with multiple system atrophy (MSA). J Neural Transm 2004;111:485-95
    • (2004) J Neural Transm , vol.111 , pp. 485-95
    • Armstrong, R.A.1    Cairns, N.J.2    Lantos, P.L.3
  • 6
    • 10344260246 scopus 로고    scopus 로고
    • The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: Clinicopathological correlations
    • Ozawa T, Paviour D, Quinn NP, et al. The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: Clinicopathological correlations. Brain 2004; 127:2657-71
    • (2004) Brain , vol.127 , pp. 2657-71
    • Ozawa, T.1    Paviour, D.2    Quinn, N.P.3
  • 7
    • 0030915893 scopus 로고    scopus 로고
    • The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: A correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar systems
    • Inoue M, Yagishita S, Ryo M, et al. The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: A correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar systems. Acta Neuropathol 1997;93:585-91
    • (1997) Acta Neuropathol , vol.93 , pp. 585-91
    • Inoue, M.1    Yagishita, S.2    Ryo, M.3
  • 8
    • 0026725657 scopus 로고
    • Argentophilic intra-cytoplasmic inclusions in multiple system atrophy
    • Mochizuki A, Mizusawa H, Ohkoshi N, et al. Argentophilic intra-cytoplasmic inclusions in multiple system atrophy. J Neurol 1992;239: 311-16
    • (1992) J Neurol , vol.239 , pp. 311-16
    • Mochizuki, A.1    Mizusawa, H.2    Ohkoshi, N.3
  • 9
    • 0026701718 scopus 로고
    • Argyrophilic glial intracytoplasmic inclusions in multiple system atrophy: Immunocytochemical and ultra-structural study
    • Abe H, Yagishita S, Amano N, et al. Argyrophilic glial intracytoplasmic inclusions in multiple system atrophy: Immunocytochemical and ultra-structural study. Acta Neuropathol 1992;84:273-77
    • (1992) Acta Neuropathol , vol.84 , pp. 273-77
    • Abe, H.1    Yagishita, S.2    Amano, N.3
  • 11
  • 12
    • 84985280160 scopus 로고
    • The efficiency of systematic sampling in stereology and its prediction
    • Gundersen HJG, Jensen EBV. The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987;147:229-63
    • (1987) J Microsc , vol.147 , pp. 229-63
    • Gundersen, H.J.G.1    Jensen, E.B.V.2
  • 13
    • 70349741263 scopus 로고
    • The Riemann-Stieltjes integral
    • Rudin W ed New York NY: McGraw-Hill
    • Rudin W. The Riemann-Stieltjes integral. In: Rudin W ed. Principles of Mathematical Analysis. 2nd ed. New York, NY: McGraw-Hill, 1964: 104-29
    • (1964) Principles of Mathematical Analysis. 2nd Ed. , pp. 104-29
    • Rudin, W.1
  • 14
    • 0023724640 scopus 로고
    • Liver volume measurements and three-dimensional display from MR images
    • McNeal GR, Maynard WH, Branch RA, et al. Liver volume measurements and three-dimensional display from MR images. Radiology 1988; 169:851-54
    • (1988) Radiology , vol.169 , pp. 851-54
    • McNeal, G.R.1    Maynard, W.H.2    Branch, R.A.3
  • 15
    • 0033011327 scopus 로고    scopus 로고
    • Renal volume measurements: Accuracy and repeatability of US compared with that of MR imaging
    • Bakker J, Olree M, Kaatee R, et al. Renal volume measurements: Accuracy and repeatability of US compared with that of MR imaging. Radiology 1999;211:623-28
    • (1999) Radiology , vol.211 , pp. 623-28
    • Bakker, J.1    Olree, M.2    Kaatee, R.3
  • 16
    • 0345161717 scopus 로고    scopus 로고
    • Comparison of several digital and stereological methods for estimating surface area and volume of cells studied by confocal microscopy
    • Kubínová L, Janácek J, Guilak F, et al. Comparison of several digital and stereological methods for estimating surface area and volume of cells studied by confocal microscopy. Cytometry 1999;36:85-95
    • (1999) Cytometry , vol.36 , pp. 85-95
    • Kubínová, L.1    Janácek, J.2    Guilak, F.3
  • 17
    • 44649167579 scopus 로고    scopus 로고
    • Three-layered structure shared between Lewy bodies and Lewy neurites-three-dimensional reconstruction of triple-labeled sections
    • Kanazawa T, Uchihara T, Takahashi A, et al. Three-layered structure shared between Lewy bodies and Lewy neurites-three-dimensional reconstruction of triple-labeled sections. Brain Pathol 2008;18:415-22
    • (2008) Brain Pathol , vol.18 , pp. 415-22
    • Kanazawa, T.1    Uchihara, T.2    Takahashi, A.3
  • 18
    • 0027033463 scopus 로고
    • The glial framework of central white matter tracts: Segmented rows of contiguous interfascicular oligodendrocytes and solitary astrocytes give rise to a continuous meshwork of transverse and longitudinal processes in the adult rat fimbria
    • Suzuki M, Raisman G. The glial framework of central white matter tracts: Segmented rows of contiguous interfascicular oligodendrocytes and solitary astrocytes give rise to a continuous meshwork of transverse and longitudinal processes in the adult rat fimbria. Glia 1992;6: 222-35
    • (1992) Glia , vol.6 , pp. 222-35
    • Suzuki, M.1    Raisman, G.2
  • 19
    • 0032721769 scopus 로고    scopus 로고
    • Unbiased morphometrical measurements show loss of pigmented nigral neurones with ageing
    • Ma SY, Röytt M, Collan Y, et al. Unbiased morphometrical measurements show loss of pigmented nigral neurones with ageing. Neuropathol Appl Neurobiol 1999;25:394-99
    • (1999) Neuropathol Appl Neurobiol , vol.25 , pp. 394-99
    • Ma, S.Y.1    Röytt, M.2    Collan, Y.3
  • 21
    • 0025808646 scopus 로고
    • Neuronal hypertrophy in the pars reticulata of the substantia nigra in Parkinson's disease
    • Neal JW, Pearson RC, Cole G, et al. Neuronal hypertrophy in the pars reticulata of the substantia nigra in Parkinson's disease. Neuropathol Appl Neurobiol 1991;17:203-6
    • (1991) Neuropathol Appl Neurobiol , vol.17 , pp. 203-6
    • Neal, J.W.1    Pearson, R.C.2    Cole, G.3
  • 22
    • 0030248106 scopus 로고    scopus 로고
    • A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease
    • Ma SY, Rinne JO, Collan Y, et al. A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease. J Neurol Sci 1996;140:40-45
    • (1996) J Neurol Sci , vol.140 , pp. 40-45
    • Ma, S.Y.1    Rinne, J.O.2    Collan, Y.3
  • 23
    • 41149179979 scopus 로고    scopus 로고
    • Morphometry of the human substantia nigra in ageing and Parkinson's disease
    • Rudow G, O' Brien R, Savonenko AV, et al. Morphometry of the human substantia nigra in ageing and Parkinson's disease. Acta Neuropathol 2008;115:461-70
    • (2008) Acta Neuropathol , vol.115 , pp. 461-70
    • Rudow, G.1    O'Brien, R.2    Savonenko, A.V.3
  • 24
    • 0036365707 scopus 로고    scopus 로고
    • Ageing of substantia nigra in humans: Cell loss may be compensated by hypertrophy
    • Cabello CR, Thune JJ, Pakkenberg H, et al. Ageing of substantia nigra in humans: Cell loss may be compensated by hypertrophy. Neuropathol Appl Neurobiol 2002;28:283-91
    • (2002) Neuropathol Appl Neurobiol , vol.28 , pp. 283-91
    • Cabello, C.R.1    Thune, J.J.2    Pakkenberg, H.3
  • 25
    • 36649036150 scopus 로고    scopus 로고
    • The effect of age and gender on the volume and size distribution of neocortical neurons
    • Stark AK, Toft MH, Pakkenberg H, et al. The effect of age and gender on the volume and size distribution of neocortical neurons. Neuroscience 2007;150:121-30
    • (2007) Neuroscience , vol.150 , pp. 121-30
    • Stark, A.K.1    Toft, M.H.2    Pakkenberg, H.3
  • 26
    • 44649147170 scopus 로고    scopus 로고
    • Neuronal hypertrophy in asymptomatic Alzheimer disease
    • Iacono D, O'Brien R, Resnick SM, et al. Neuronal hypertrophy in asymptomatic Alzheimer disease. J Neuropathol Exp Neurol 2008;67: 578-89
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 578-89
    • Iacono, D.1    O'Brien, R.2    Resnick, S.M.3
  • 27
    • 26944495245 scopus 로고    scopus 로고
    • The size distribution of neurons in the motor cortex in amyotrophic lateral sclerosis
    • Toft MH, Gredal O, Pakkenberg B. The size distribution of neurons in the motor cortex in amyotrophic lateral sclerosis. J Anat 2005;207: 399-407
    • (2005) J Anat , vol.207 , pp. 399-407
    • Toft, M.H.1    Gredal, O.2    Pakkenberg, B.3
  • 28
    • 0035399672 scopus 로고    scopus 로고
    • Neuronal hypertrophy in the neocortex of patients with temporal lobe epilepsy
    • Bothwell S, Meredith GE, Phillips J, et al. Neuronal hypertrophy in the neocortex of patients with temporal lobe epilepsy. J Neurosci 2001;21: 4789-800
    • (2001) J Neurosci , vol.21 , pp. 4789-800
    • Bothwell, S.1    Meredith, G.E.2    Phillips, J.3
  • 29
    • 1942535122 scopus 로고    scopus 로고
    • Reduction of Purkinje cell volume in cerebellum of alcoholics
    • Andersen BB. Reduction of Purkinje cell volume in cerebellum of alcoholics. Brain Res 2004;1007:10-18
    • (2004) Brain Res , vol.1007 , pp. 10-18
    • Andersen, B.B.1
  • 30
    • 0028096074 scopus 로고
    • Stability of cell size and nucleolar size in Lewy body containing neurons of substantia nigra in Parkinson's disease
    • Gertz HJ, Siegers A, Kuchinke J. Stability of cell size and nucleolar size in Lewy body containing neurons of substantia nigra in Parkinson's disease. Brain Res 1994;637:339-41
    • (1994) Brain Res , vol.637 , pp. 339-41
    • Gertz, H.J.1    Siegers, A.2    Kuchinke, J.3
  • 31
    • 0024506008 scopus 로고
    • Stability of cell size and nucleolar size in tangle-bearing neurons of the hippocampus in Alzheimer's disease
    • Gertz HJ, Schoknecht G, Krüger H, et al. Stability of cell size and nucleolar size in tangle-bearing neurons of the hippocampus in Alzheimer's disease. Brain Res 1989;487:373-75
    • (1989) Brain Res , vol.487 , pp. 373-75
    • Gertz, H.J.1    Schoknecht, G.2    Krüger, H.3
  • 32
    • 0036445864 scopus 로고    scopus 로고
    • Attenuated nuclear shrinkage in neurons with nuclear aggregates-a morphometric study on pon-tine neurons of Machado-Joseph disease brains
    • Uchihara T, Iwabuchi K, Funata N, et al. Attenuated nuclear shrinkage in neurons with nuclear aggregates-a morphometric study on pon-tine neurons of Machado-Joseph disease brains. Exp Neurol 2002;178: 124-28
    • (2002) Exp Neurol , vol.178 , pp. 124-28
    • Uchihara, T.1    Iwabuchi, K.2    Funata, N.3
  • 33
    • 0037316179 scopus 로고    scopus 로고
    • Influences of intranuclear inclusion on nuclear sizeVMorphometric study on pontine neurons of neuronal intranuclear inclusion disease cases
    • Uchihara T, Tanaka J, Funata N, et al. Influences of intranuclear inclusion on nuclear sizeVMorphometric study on pontine neurons of neuronal intranuclear inclusion disease cases. Acta Neuropathol 2003; 105:103-8
    • (2003) Acta Neuropathol , vol.105 , pp. 103-8
    • Uchihara, T.1    Tanaka, J.2    Funata, N.3
  • 34
    • 0038299961 scopus 로고    scopus 로고
    • Attenuated nuclear shrinkage in neurones with nuclear inclusions of SCA1 brains
    • Nagaoka U, Uchihara T, Iwabuchi K, et al. Attenuated nuclear shrinkage in neurones with nuclear inclusions of SCA1 brains. J Neurol Neurosurg Psychiatry 2003;74:597-601
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 597-601
    • Nagaoka, U.1    Uchihara, T.2    Iwabuchi, K.3
  • 35
    • 0035900182 scopus 로고    scopus 로고
    • Neuronal nuclear alterations in dentatorubral-pallidoluysian atrophy: Ultrastructural and morphometric studies of the cerebellar granule cells
    • Takahashi H, Egawa S, Piao YS, et al. Neuronal nuclear alterations in dentatorubral-pallidoluysian atrophy: Ultrastructural and morphometric studies of the cerebellar granule cells. Brain Res 2001;919:12-19
    • (2001) Brain Res , vol.919 , pp. 12-19
    • Takahashi, H.1    Egawa, S.2    Piao, Y.S.3
  • 36
    • 0032475931 scopus 로고    scopus 로고
    • Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
    • Saudou F, Finkbeiner S, Devys D, et al. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 1998;95:55-66
    • (1998) Cell , vol.95 , pp. 55-66
    • Saudou, F.1    Finkbeiner, S.2    Devys, D.3
  • 37
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • Arrasate M, Mitra S, Schweitzer ES, et al. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 2004;431:805-10
    • (2004) Nature , vol.431 , pp. 805-10
    • Arrasate, M.1    Mitra, S.2    Schweitzer, E.S.3
  • 38
    • 0034737299 scopus 로고    scopus 로고
    • Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
    • Yamamoto A, Lucas JJ, Hen R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell 2000; 101:57-66
    • (2000) Cell , vol.101 , pp. 57-66
    • Yamamoto, A.1    Lucas, J.J.2    Hen, R.3
  • 39
    • 0032475941 scopus 로고    scopus 로고
    • Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
    • Klement IA, Skinner PJ, Kaytor MD, et al. Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell 1998;95:41-53
    • (1998) Cell , vol.95 , pp. 41-53
    • Klement, I.A.1    Skinner, P.J.2    Kaytor, M.D.3
  • 40
    • 19444388207 scopus 로고    scopus 로고
    • Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell death
    • Tsuboi K, Grzesiak JJ, Bouvet M, et al. Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell death. Mol Cell Neurosci 2005;29:259-68
    • (2005) Mol Cell Neurosci , vol.29 , pp. 259-68
    • Tsuboi, K.1    Grzesiak, J.J.2    Bouvet, M.3
  • 41
    • 15444376598 scopus 로고    scopus 로고
    • Mouse model of multiple system atrophy >-synuclein expression in oligodendrocytes causes glial and neuronal degeneration
    • Yazawa I, Giasson BI, Sasaki R, et al. Mouse model of multiple system atrophy >-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron 2005;45:847-59
    • (2005) Neuron , vol.45 , pp. 847-59
    • Yazawa, I.1    Giasson, B.I.2    Sasaki, R.3
  • 42
    • 0036304315 scopus 로고    scopus 로고
    • Hyperphosphorylation and insolubility of >-synuclein in transgenic mouse oligodendrocytes
    • Kahle PJ, Neumann M, Ozmen L, et al. Hyperphosphorylation and insolubility of >-synuclein in transgenic mouse oligodendrocytes. EMBO Rep 2002;3:583-88
    • (2002) EMBO Rep , vol.3 , pp. 583-88
    • Kahle, P.J.1    Neumann, M.2    Ozmen, L.3
  • 43
    • 27944436033 scopus 로고    scopus 로고
    • Neurological and neuro-degenerative alterations in a transgenic mouse model expressing human >-synuclein under oligodendrocyte promoter: Implications for multiple system atrophy
    • Shults CW, Rockenstein E, Crews L, et al. Neurological and neuro-degenerative alterations in a transgenic mouse model expressing human >-synuclein under oligodendrocyte promoter: Implications for multiple system atrophy. J Neurosci 2005;25:10689-99
    • (2005) J Neurosci , vol.25 , pp. 10689-99
    • Shults, C.W.1    Rockenstein, E.2    Crews, L.3
  • 44
    • 14644417871 scopus 로고    scopus 로고
    • Oxidative stress in transgenic mice with oligodendroglial >-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
    • Stefanova N, Reindl M, Neumann M, et al. Oxidative stress in transgenic mice with oligodendroglial >-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy. Am J Pathol 2005;166:869-76
    • (2005) Am J Pathol , vol.166 , pp. 869-76
    • Stefanova, N.1    Reindl, M.2    Neumann, M.3
  • 45
    • 27944487985 scopus 로고    scopus 로고
    • Progressive accumulation of ubiquitin and disappearance of >-synuclein epitope in multiple system atrophy-associated glial cytoplasmic inclusions: Triple fluorescence study combined with Gallyas-Braak method
    • Sakamoto M, Uchihara T, Nakamura A, et al. Progressive accumulation of ubiquitin and disappearance of >-synuclein epitope in multiple system atrophy-associated glial cytoplasmic inclusions: Triple fluorescence study combined with Gallyas-Braak method. Acta Neuropathol 2005;110:417-25
    • (2005) Acta Neuropathol , vol.110 , pp. 417-25
    • Sakamoto, M.1    Uchihara, T.2    Nakamura, A.3
  • 47
    • 0034520112 scopus 로고    scopus 로고
    • The enigma of cell death in neuro-degenerative disorders
    • Jellinger KA, Stadelmann CH. The enigma of cell death in neuro-degenerative disorders. J Neural Transm Suppl 2000;(60):21-36
    • (2000) J Neural Transm Suppl , Issue.60 , pp. 21-36
    • Jellinger, K.A.1    Stadelmann, C.H.2
  • 48
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-57
    • (1972) Br J Cancer , vol.26 , pp. 239-57
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 50
    • 0031713491 scopus 로고    scopus 로고
    • Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble >-synuclein
    • Tu PH, Galvin JE, Baba M, et al. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble >-synuclein. Ann Neurol 1998;44:415-22
    • (1998) Ann Neurol , vol.44 , pp. 415-22
    • Tu, P.H.1    Galvin, J.E.2    Baba, M.3
  • 52
    • 0032576605 scopus 로고    scopus 로고
    • Aggresomes: A cellular response to misfolded proteins
    • Johnston JA, Ward CL, Kopito RR. Aggresomes: A cellular response to misfolded proteins. J Cell Biol 1998;143:1883-98
    • (1998) J Cell Biol , vol.143 , pp. 1883-98
    • Johnston, J.A.1    Ward, C.L.2    Kopito, R.R.3


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