A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease

Journal of the Neurological Sciences

Volumn 140, Issue 1-2, 1996, Pages 40-45

  Ma, Shuang Yong ^a   Rinne, Juha O ^a   Collan, Yrjö ^a   Röyttä, Matias ^a   Rinne, Urpo K ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

Cell size; Neuromorphometry; Neuropathology; Parkinson's disease; Substantia nigra

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MORPHOMETRICS; NERVE DEGENERATION; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

EID: 0030248106     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-510X(96)00069-X     Document Type: Article

References (43)

1. Abercrombie, M. (1946) Estimation of nucleus population from microtome sections. Anat. Rec., 94: 239-247.
2. Aotsuka, A., H. Shainotoh, K. Hirayama, H. Ikehira and H. Fukuda (1991) MRI in Parkinson's disease and vascular parkinsonism- study on the lesion of substantia nigra. Rinsho-Shinkeigaku, 31: 619-624.
3. Bernheimer, H., W. Birkmayer, O. Hornykiewicz, K. Jellinger and F. Seitelberger (1973) Brain dopamine and the syndromes of Parkinson and Huntington. J. Neurol. Sci., 20: 415-455.
4. Bogerts, B., J. Häntsch and M. Herzer (1983) A morphometric study of the dopamine-containing cell groups in the mesencephalon of normals. Parkinson patients, and schizophrenics. Biol. Psychiatr., 18: 951-969.
5. Braak, H. and E. Braak (1986) Nuclear configuration and neuronal type of the nucleus nigra in the brain of the human adult. Hum. Neurobiol., 5: 71-82.
6. Carlsson, A. (1959) Detection and assay of dopamine. Pharmacol. Rev., 11: 300-304.
7. Chui, H.C., J.A. Mortimer, U. Slager, C. Zarow, W. Bondareff and D.D. Webster (1986) Pathologic correlates of dementia in Parkinson's disease. Arch. Neurol., 43: 991-995.
8. Collan, Y. (1991) Quantitative histopathology of soft tissue calcifications. Proc. Finn. Dent. Soc., 87: 643-650.
9. Collan, Y., E. Oja and W. Whimster (1983) Mathematical background to stereology and morphometry for diagnostic pathologists. Acta Stereol., 2: 214-238.
10. Collan, Y., S.Y. Ma, M. Röyttä, T. Kuopio, J.O. Rinne and Rinne, U.K. (1992) Experiences on the use of the dissector principle in neuropathology. Acta Stereol., 11: 717-722.
11. Drayer, B.P., W. Olanow, P. Burger, G.A. Johnson, R. Herfkens and S. Riederer (1986) Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron. Radiology, 159: 493-498.
12. Duguid, J.R., R. De-La Paz and J. DeGroot (1986) Magnetic resonance imaging of the medbrain in Parkinson's disease. Ann. Neurol., 20: 744-747.
13. Fearnley, J.M. and A.J. Lees (1991) Ageing and Parkinson's disease: Substantia nigra regional selectivity. Brain, 114: 2283-2301.
14. German, D.C., K. Manaye, W.K. Smith, D.J. Woodward and C.B. Saper (1989) Midbrain dopaminergic cell loss in Parkinson's disease: computer visualization. Ann. Neurol., 26: 507-514.
15. Goto, S., A. Hirano and S. Matsumoto (1989) Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration. Ann. Neurol, 26: 766-770.
16. Hartmann, G.K. and P. Riederer (1993) Involvement of transmitter systems in neuropsychiatric diseases. Acta Neurol. Scand., 87: 18-21.
17. Hassler, R. (1937) Zur Normalanatomie der Substantia nigra. Versuch einer architektonische Gliederung. J. Psychol. Neurol., 48: 1-55.
18. Hassler, R. (1938) Zur Pathologie der paralysis agitans und des postenzephalitischen parkinsonismus. J. Psychol. Neurol., 48: 387-476.
19. Hirsch, E., A.M. Graybiel and Y.A. Agid (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature, 334: 345-348.
20. Hornykiewicz, O. (1966) Dopamine (3-Hydroxtyramine) and brain function. Pharmacol. Rev., 18: 925-964.
21. Hornykiewicz, O. and S.J. Kish (1986) Biochemical pathophysiology of Parkinson's disease. Adv. Neurol., 45: 19-34.
22. Javoy-Agid, F., M. Ruberg, H. Taquer, B. Bobobza and Y. Agid (1984) Biochemical neuropathology of Parkinson's disease. Adv. Neurol., 40: 189-197.
23. Jellinger, K. (1986) Overview of morphological changes in Parkinson's disease. Adv. Neurol., 45: 1-18.
24. Kitani, M., S. Kobayashi and S. Yamaguchi (1990) Computerized tomography with longitudinal follow-up of brain atrophy in patients with Parkinson' disease. Gerontology, 36: 361-368.
25. Konagaya, M., Y. Konagaya and M. Iida (1994) Clinical and magnetic resonance imaging study of extrapyramidal symptoms in multiple system atrophy. J. Neurol. Neurosurg. Psychiatr., 57: 1528-1531.
26. Langston, J.W. (1985) MPTP and Parkinson's disease. Trends Neurol. Sci., 80: 79-83.
27. Ma, S.Y., Y. Collan, M. Röyttä, J.O. Rinne and U.K. Rinne (1995a) Cell counts in the substantianigra: A comparison of single section counts and dissector counts in patients with Parkinson's disease and in controls. Neuropathol. Appl. Neurobiol., 21: 10-17.
28. Ma, S.Y., M. Röyttä, J.O. Rinne, Y. Collan and U.K. Rinne (1995b) Single section and dissector counts in evaluating neuronal loss from the substantia nigra in patients with Parkinson's disease. Neuropathol. Appl. Neurobiol., 21: 341-343.
29. Mann, D.M.A. and P.O. Yates (1983) Pathological basis for neurotransmitter changes in Parkinson's disease. Neuropathol. Appl. Neurobiol., 9: 3-19.
30. Mayhew, T.M. (1992) A review of recent advances in stereology for quantifying neural structure. J. Neurocytol., 21: 313-328.
31. Pakkenberg, H. and H. Brody (1965) The number of nerve cells in the substantia nigra inparalysis agitans. Acta Neuropathol., 5: 320-324.
32. Pakkenberg, B., A. Mφller, H.J.G. Gundersen, A.M. Dam and H. Pakkenberg (1991) The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. J. Neurol. Neurosurg. Psychiatr., 54: 30-33.
33. Patt, S., H.-J. Gertz, L. Gerhard and J. Cervós-Navarro (1991) Pathological changes in dendrites of substantia nigra neurons in Parkinson's disease: a Golgi study. Histol. Histopathol., 6: 373-380.
34. Paulus, W. and K. Jellinger (1991) The neuropathological basis of different clinical subgroups of Parkinson's disease. J. Neuropathol. Exp. Neurol., 50: 743-755.
35. Piccini, P., N. Pavese, R. Canapicchi, C. Paoli, P. Del Dotto, M. Puglivi, G. Rossi and U. Bonuccelli (1995) White mater hyperintensities in Parkinson's disease. Arch. Neurol., 52: 191-194.
36. Rinne, U.K. and V. Sonninen (1972) Acid monoamine metablites in the cerebrospinal fluid of patients with Parkinson's disease. Neurology, 22: 62-67.
37. Rinne, J.O., J. Rummukainen, L. Paljärvi and U.K. Rinne (1989) Dementia in Parkinson's disease is related to neuronal loss in the medial substantia nigra. Ann. Neurol., 26: 47-50.
38. Starkstein, S.E. and R. Leiguarda (1993) Neuropsychological correlates of brain atrophy in Parkinson's disease: a CT scan study. Mov. Disord., 8: 51-55.
39. Steiner, I., J.M. Gomori and E. Melamed (1985) Features of brain atrophy in Parkinson's disease: a CT scan study. Neuroradiology, 27: 158-160.
40. Tolppanen, L. (1971) Quantitativ-mikroskopische Untersuchungen an der Substantia nigrades Menschen. Fälle ohne Bewegungsstörungen in Vergleich mit Fällen von Parkinson-Syndrom. Dissertation, Universität Göttingen. Göttingen.
41. van Domburg, P.H.M.F. (1990) Human brainstem monoaminergic structures in Parkinson's disease and Alzheimer's disease. A neuroantomical and morphometric analysis. Thesis, University of Nijmegen, Nijmegen.
42. van Domburg, P.H.M.F. and H.J. ten Donkelaar (1992) The human substantia nigra and ventral tegmental area: A neuroanatomical study with notes on aging and aging disease. Adv. Anat. Embryol. Cell Biol., 121: 32-69.
43. Waters, C.M., R. Peck, M. Rossor, G.P. Reynolds and S.P. Hunt (1988) Immunocytochemical studies in the basal ganglia and substantia nigra in Parkinson's disease and Huntington's disease. Neuroscience, 24: 419-438.