Lipoxins: Putative braking signals in host defense, inflammation and hypersensitivity

Current Opinion in Nephrology and Hypertension

Volumn 5, Issue 1, 1996, Pages 20-27

  Brady, Hugh R ^a,b   Serhan, Charles N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Medical Service   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYTOKINE; ICOSANOID; LIPOXIN;

BIOSYNTHESIS; CELL INTERACTION; DRUG EFFECT; HOST RESISTANCE; INFLAMMATION; PRIORITY JOURNAL; REVIEW;

ANIMALS; EICOSANOIDS; HUMANS; HYPERSENSITIVITY; INFLAMMATION; KIDNEY GLOMERULUS;

EID: 0029942693     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199601000-00006     Document Type: Article

References (57)

1. Henderson WR: The role of leukotrienes in inflammation. Ann Intern Med 1994, 121:684-697. An extensive review of the role of LTs in inflammation and hypersensitivity states.
2. Samuelsson B, Dahlen S-E, Lindgren JA, Rouzer CA, Serhan CN: Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 1987, 237:1171-1176.
3. Brady HR, Papayianni A, Serhan CN: Leukocyte adhesion promotes biosynthesis of lipoxygenase products by transcellular routes. Kidney Int 1994, 45:S90-S97. A review of the transcellular eicosanoid biosynthesis and adhesion-eicosanoid networks in inflammation.
4. Serhan CN: Lipoxin biosynthesis and its impact in inflammatory and vascular events. Biochim Biophys Acta 1994, 1212:1-25. Extensive review of LX structures, biochemistry, bioactions, metabolism and potential biologic significance in human diseases.
5. Brady HR, Papayianni A, Serhan CN: Potential vascular roles for lipoxins in the 'stop programs' of host defense and inflammation. Trends Cardiovasc Med 1995, 5:186-192. Reviews the evidence implicating LXs as endogenous LT antagonists.
6. 4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases. Am Rev Respir Dis 1990, 141:1453-1460.
7. 4-ELISA. Lipids 1993, 28:1047-1053.
8. 4 generation, which may potentially feed back to limit further recruitment of leukocytes.
9. Edenius C, Kumlin M, Bjorck T, Anggard A, Lindgren JA: Lipoxin formation in human nasal polyps and bronchial tissue. FEBS Lett 1990, 272:25-31.
10. 4: impact of aspirin therapy. Circulation 1992, 86:56-63.
11. Stenke L, Mansour M, Edenius C, Reizenstein P, Lindgren JA: Formation and proliferative effects of lipoxins in human bone marrow. Biochem Biophys Res Commun 1991, 180:255-261.
12. Edenius C, Haeggstrom J, Lindgren JA: Transcellular conversion of endogeneous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions. Biochem Biophys Res Commun 1988, 157:801-807.
13. Serhan CN, Sheppard K-A: Lipoxin formation during human neutrophil-platelet interactions. J Clin Invest 1990, 85:722-730.
14. Fiore S, Serhan CN: Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils. J Exp Med 1990, 172:1451-1457.
15. Romano M, Serhan CN: Lipoxin generation by permeabilized human platelets. Biochemistry 1990, 31:8269-8276.
16. Romano, M Chen S-X, Takahashi Y, Yamamoto S, Funk CD, Serhan CN: Lipoxin synthase activity of human platelet 12-lipoxygenase. Biochem J 1993, 296:127-133.
17. 4 in rat kidney mesangial cells. Adv Exp Med Biol 1991, 314:361-367.
18. Levy BD, Romano M, Chapman HA, Reilly JJ, Drazen J, Serhan CN: Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13 trans-eicosatetraenoic acid and lipoxins. J Clin Invest 1993, 92:1572-1580.
19. Brady HR, Papayianni A, Serhan CN: Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin generation in acute glomerulonephritis. Adv Exp Med Biol (in press).
20. 4 induces hyperadhesiveness in human endothelial cells for neutrophils. Blood 1993, 82:948-953.
21. 4 (0.1 μmol/l) promotes neutrophil-mediated cytotoxicity to endothelial cells; an action mediated through peroxynitrite and its metabolites.
22. 4 and N-formyl-L-methionyl-L-leucyl-L-phenylananine. Clin Sci 1989, 77:195-203.
23. 4 inhibited receptor-triggered chemotaxis and degranulation of human eosinophils in vitro, extending this group's previous observations with neutrophils and suggesting a role for LXs as braking signals in hypersensitivity reactions.
24. 4-induced mobilization of endothelial P-selectin and endothelial cell hyperadhesiveness for neutrophils. Thus, LXs have the potential to inhibit both neutrophil rolling (selectin-mediated) and firm adhesion (integrin-mediated) to endothelium at sites of inflammation.
25. 4 modulates transmigration of human neutrophils across intestinal epithelial cell monolayers. J Clin Invest 1993, 92:75-82.
26. 4-induced inflammation in the hamster cheek pouch. Acta Physiol Scand 1989, 137:571-581.
27. 4 in rat glomerular mesangial cells: evidence for competition at a common receptor. Proc Natl Acad Sci U S A 1989, 86:3438-3442.
28. Katoh T, Takahashi K, DeBoer DK, Serhan CN, Badr KF: Renal haemodynamic actions of lipoxins in rats: a comparative physiological study. Am J Physiol 1992, 263:F436-F442.
29. Brady HR, Persson U, Ballermann BJ, Brenner BM, Serhan CN: Leukotrienes stimulate neutrophil adhesion to mesangial cells: modulation with lipoxins. Am J Physiol 1990, 259:F809-F815.
30. 4 and related compounds in smooth muscle preparations and on the microcirculation in vitro. Adv Exper Med Biol 1988, 229:107-130.
31. 4 on airway responses in asthmatic subjects. Am Rev Respir Dis 1992, 145:1281-1284.
32. Chavis C, Chanez P, Vachier I, Bousquet J, Michel FB, Godard P: 1,15-diHETE and lipoxins generated by neutrophils from endogenous arachidonic acid as biomarkers of asthma. Biochem Biophys Res Commun 1995, 207:273-279. Presents evidence of enhanced transcellular LX generation in leukocytes isolated from asthmatic subjects.
33. 4 are potent stimuli for migration and adherence of human monocytes. Highlights the importance of rapid dehydrogenation as an initial step for metabolism and inactivation of LXs in monocytes.
34. 4 with human neutrophils. J Biol Chem 1992, 267:16168-16174.
35. 4 receptors in HL-60 cells. Blood 1993, 81:3395-3401.
36. 4 receptor expressed by human neutrophils. The deduced amino acid sequence suggested that the molecule belongs to the seven transmembrane spanning domain family of G protein-coupled receptors.
37. 4 stimulate the release but not oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodelling and adhesion. J Cell Physiol 1990, 143:512-523.
38. Brady HR, Serhan CN: Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions: inhibition by antibodies against CD18 and L-selectin. Biochem Biophys Res Commun 1992, 186:1307-1314.
39. Brady HR, Lamas S, Papayianni A, Takata S, Matsubara M, Marsden PA: Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction. Am J Physiol 1995, 268:F1-F12. Reports the relative contributions of neutrophil and transcellular biosynthetic pathways to LT and LX generation during co-incubations of neutrophils and cultured glomerular endothelial cells. In addition, defines the adhesion molecules that support cell-cell interactions following activation by cytokines and/or chemoattractant peptides and lipid mediators.
40. 4 transfer. Trends Pharmacol Sci 1993, 14:351-354.
41. Marcus AJ: Transcellular metabolism of eicosanoids. Prog Hemost Thromb 1986, 8:127-142.
42. Serhan CN: Cell-cell interactions in the generation of eicosanoids: charting the routes and products of transcellular biosynthesis. J Lab Clin Med 1993, 121:372-374.
43. 4 levels were restored by injection of wild-type platelets into null animals, prior to induction of disease.
44. Katoh T, Lakkis FG, Makita N, Badr KF: Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNA in rat nephrotoxic nephritis. Kidney Int 1994, 46:341-349. Reports co-ordinated expression of 12/15-lipoxygenase and IL-4 in nephrotoxic serum nephritis and suggests a role for TH2 cytokines as inducers of 12/15-lipoxygenase-derived braking signals during inflammation.
45. H2-derived cytokine IL-13 induced 15-lipoxygenase expression in monocytes, suggesting an important role for this cytokine in the induction of 12/15-lipoxygenase-denved braking signals during inflammation.
46. 4 metabolism by human promyelocytic leukemia cells and monocytes: conversion to novel 15-oxo and dihydro products. Biochemistry 1993, 32:6313-6319.
47. 4 by human neutrophil microsomes. FEBS Lett 1993, 315:205-210.
48. 4 ω-hydroxylase (cytochrome P-450LTBω). Biochim Biophys Acts 1993, 1168:87-93.
49. Vane JR, Flower RJ, Botting RM: History of aspirin and its mechanism of action. Stroke 1990, 21(suppl IV):1-12.
50. Weissman G: Aspirin. Sci Am 1991, 264:84-89.
51. Claria J, Serhan CN: Aspirin triggers novel bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci U S A 1995, 92:9475-9479. Aspirin triggers the formation of a unique class of eicosanoids, 15-epi-lipoxins, formed by acetylated prostaglandin G/H synthase-2 and 5-lipoxygenase interactions, which may contribute to the therapeutic efficacy of th drug.
52. 4 and other chemo-attractants. This inhibitory effect of 15(S)-hydroxyeicosatetraenoic acid appeared to be mediated through inhibition of signal transaction events within neutrophil cell membranes.
53. •] provide direct evidence of platelet-leukocyte adhesion through P-selectin within the vascular lumen; an ideal situation for transcellular eicosanoid generation.
54. ••].
55. Brezinski ME, Serhan CN: Selective incorporation of 15(S)-hydroxyeicosatetraenoic acid in phosphotidylinositol of human neutrophils: agonist-induced deacytation and transformation of stored hydroxyeicosanoids. Proc Natl Acad Sci U S A 1990, 87:6248-6252.
56. 4 in the rat Kidney Int 1992, 41:1155-1160.
57. Takata S, Papayianni A, Matsubara M, Pronovost P, Jimenez J, Brady HR: 15(S)-hydroxyeicosatetraenoic acid inhibits neutrophil trafficking across cytokine-activated endothelium. Am J Pathol 1994, 145:541-549. 15(S)-hydroxyeicosatetraenoic acid also blunts neutrophil migration across cytokine-activated endothelium, at least in part, by attenuated neutrophil responsiveness to endothelial cell-derived platelet activating factors.