Decreased triadin and increased calstabin2 expression in great danes with dilated cardiomyopathy

Journal of Veterinary Internal Medicine

Volumn 23, Issue 5, 2009, Pages 1014-1019

  Oyama, M A ^a   Chittur, S V ^b   Reynolds, C A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Canine; Microarray; Ryanodine

Indexed keywords

CARRIER PROTEIN; FK 506 BINDING PROTEIN; MESSENGER RNA; MUSCLE PROTEIN; TRIADIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; CONGESTIVE CARDIOMYOPATHY; DNA MICROARRAY; DOG; DOG DISEASE; FEMALE; GENE EXPRESSION PROFILING; GENETICS; MALE; METABOLISM; METHODOLOGY; PATHOLOGY; PROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CARDIOMYOPATHY, DILATED; CARRIER PROTEINS; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION PROFILING; MALE; MUSCLE PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TACROLIMUS BINDING PROTEINS;

ANIMALIA; CANIS FAMILIARIS;

EID: 70349666853     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2009.0360.x     Document Type: Article

References (54)

1. Sisson D. Myocardial diseases of dogs. In: Fox PR, Sisson D, Moise NS., eds. Textbook of Canine and Feline Cardiology, 2nd ed. Philadelphia, PA: WB Saunders; 1999:581-620.
2. Ojaimi C, Qanud K, Hintze TH, et al. Altered expression of a limited number of genes contributes to cardiac decompensation during chronic ventricular tachypacing in dogs. Physiol Genom 2007; 29:76-83.
3. Ruiz P, Witt H. Microarray analysis to evaluate different an-imal models for human heart failure. J Mol Cell Cardiol 2006; 40:13-15.
4. Zheng J, Chen Y, Pat B, et al. Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog. Circulation 2009;119:2086-2095.
5. Cardin S, Libby E, Pelletier P, et al. Contrasting gene expres-sion profiles in two canine models of atrial fibrillation. Circ Res 2007;100:425-433.
6. Gao Z, Xu H, DiSilvestre D, et al. Transcriptomic profiling of the canine tachycardia-induced heart failure model: Global com-parison to human and murine heart failure. J Mol Cell Cardiol 2006;40:76-86.
7. Oyama MA, Chittur S. Genomic expression patterns of car-diac tissues from dogs with dilated cardiomyopathy. Am J Vet Res 2005;66:1140-1155.
8. Oyama MA, Reiken S, Lehnart SE, et al. Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency. J Vet Cardiol 2008;10:1-10.
9. Oyama MA, Chittur SV. Genomic expression patterns of mi-tral valve tissues from dogs with degenerative mitral valve disease. Am J Vet Res 2006;67:1307-1318.
10. Hwang JJ, Allen PD, Tseng GC, et al. Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiol Genom 2002;10:31-44.
11. Grzeskowiak R, Witt H, Drungowski M, et al. Expression profiling of human idiopathic dilated cardiomyopathy. Cardiovasc Res 2003;59:400-411.
12. Mirotsou M, Watanabe CM, Schultz PG, et al. Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach. Physiol Genom 2003;15:115-126.
13. Kittleson MD. Echocardiography. In: Kittleson MD, Kienle RD., eds. Small Animal Cardiovascular Medicine. St Louis, MO: Mosby; 1998:95-117.
14. Jiang N, Leach LJ, Hu X, et al. Methods for evaluating gene expression from Affymetrix microarray datasets. BMC Bioinformat 2008;9: doi:10.1186/1471-2105-9-284.
15. Pepper SD, Saunders EK, Edwards LE, et al. The utility of MAS5 expression summary and detection call algorithms. BMC Bioinformat 2007;8: doi:10.1186/1471-2105-8-273.
16. Jeyakumar LH, Ballester L, Cheng DS, et al. FKBP binding characteristics of cardiac microsomes from diverse vertebrates. Biochem Biophys Res Commun 2001;281:979-986.
17. Yano M, Yamamoto T, Ikeda Y, et al. Mechanisms of disease: Ryanodine receptor defects in heart failure and fatal arrhythmia. Nat Clin Pract Cardiovasc Med 2006;3:43-52.
18. Brazma A, Hingamp P, Quackenbush J, et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 2001;29:365-371.
19. Merryman-Simpson AE, Wood SH, Fretwell N, et al. Gene (mRNA) expression in canine atopic dermatitis: Microarray analysis. Vet Dermatol 2008;19:59-66.
20. Rao NA, van Wolferen ME, van den HR, et al. cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype. Anim Genet 2008;39:333-345.
21. Fry MM, Kirk CA, Liggett JL, et al. Changes in hepatic gene expression in dogs with experimentally induced nutritional iron deficiency. Vet Clin Pathol 2009;38:13-19.
22. Clements DN, Carter SD, Innes JF, et al. Gene expression profiling of normal and ruptured canine anterior cruciate ligaments. Osteoarthritis Cartilage 2008;16:195-203.
23. Benkusky NA, Farrell EF, Valdivia HH. Ryanodine receptor channelopathies. Biochem Biophys Res Commun 2004;322: 1280-1285.
24. Lehnart SE, Wehrens XH, Kushnir A, et al. Cardiac ryanodine receptor function and regulation in heart disease. Ann NY Acad Sci 2004;1015:144-159.
25. Bers DM. Macromolecular complexes regulating cardiac ryanodine receptor function. J Mol Cell Cardiol 2004;37:417-429.
26. Flucher BE, Franzini-Armstrong C. Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle. Proc Natl Acad Sci USA 1996;93:8101-8106.
27. Gyorke S, Carnes C. Dysregulated sarcoplasmic reticulum calcium release: Potential pharmacological target in cardiac disease. Pharmacol Ther 2008;119:340-354.
28. 21 handling, contractility, and heart failure. Am J Physiol Heart Circ Physiol 2007;293:H728-H734.
29. Gyorke S, Terentyev D. Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease. Cardiovasc Res 2008;77:245-255.
30. Kobayashi YM, Jones LR. Identification of triadin 1 as the predominant triadin isoform expressed in mammalian myocardium. J Biol Chem 1999;274:28660-28668.
31. Gyorke S. Molecular basis of catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 2009;6:123-129.
32. Terentyev D, Viatchenko-Karpinski S, Vedamoorthyrao S, et al. Protein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytes. J Physiol 2007;583:71-80.
33. Terentyev D, Cala SE, Houle TD, et al. Triadin overexpression stimulates excitation-contraction coupling and increases predisposition to cellular arrhythmia in cardiac myocytes. Circ Res 2005;96:651-658.
34. 21 release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc Natl Acad Sci USA 2009;106:7636-7641.
35. Marx SO, Reiken S, Hisamatsu Y, et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts. Cell 2000;101:365-376.
36. Reiken S, Gaburjakova M, Gaburjakova J, et al. Betaadrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure. Circulation 2001;104:2843-2848.
37. Yano M, Ono K, Ohkusa T, et al. Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(21) leak through ryanodine receptor in heart failure. Circulation 2000;102:2131-2136.
38. Barg S, Copello JA, Fleischer S. Different interactions of cardiac and skeletal muscle ryanodine receptors with FK-506 binding protein isoforms. Am J Physiol 1997;272:C1726-C1733.
39. Xiao J, Tian X, Jones PP, et al. Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. J Biol Chem 2007;282:34828-34838.
40. 21 release, but normal ryanodine receptors, in canine and human heart failure. Circ Res 2002;91:1015-1022.
41. Gyorke S, Terentyev D. Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease. Cardiovasc Res 2008;77:245-255.
42. Huang F, Shan J, Reiken S, et al. Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: Rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci USA 2006;103: 3456-3461.
43. Lehnart SE, Wehrens XH, Laitinen PJ, et al. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation 2004; 109:3208-3214.
44. Lehnart SE, Wehrens XH, Marks AR. Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun 2004;322:1267-1279.
45. Wehrens XH, Lehnart SE, Huang F, et al. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell 2003;113:829-840.
46. Gellen B, Fernandez-Velasco M, Briec F, et al. Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling. Circulation 2008;117:1778-1786.
47. 21) leak from the sarcoplasmic reticulum and increases contractility. Circ Res 2001;88:188-194.
48. Lehnart SE, Terrenoire C, Reiken S, et al. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci USA 2006;103:7906-7910.
49. Keene BW. Canine Cardiomyopathy. In: Kirk RW, Bonagura JD, eds. Current Veterinary Therapy X. Philadelphia, PA: WB Saunders; 1989:240-251.
50. Hogan DF, Green HW III. Dilated cardiomyopathy in dogs. In: Bonagura JD, Twedt DC, eds. Current Veterinary Therapy XIV. Philadelphia, PA: Saunders Elsevier; 2009:800-804.
51. Meurs KM. Primary myocardial disease in the dog. In: Ettinger SJ, Feldman EC, eds. Textbook of Veterinary Internal Medicine, 6th ed. St Louis: Elsevier Saunders; 2009:1077-1082.
52. Russo G, Zegar C, Giordano A. Advantages and limitations of microarray technology in human cancer. Oncogene 2003;22: 6497-6507.
53. Jaluria P, Konstantopoulos K, Betenbaugh M, et al. A perspective on microarrays: Current applications, pitfalls, and potential uses. Microb Cell Fact 2007;6: doi:10.1186/1475-2859-6-4.
54. Meurs KM, Lacombe VA, Dryburgh K, et al. Differential expression of the cardiac ryanodine receptor in normal and arrhythmogenic right ventricular cardiomyopathy canine hearts. Hum Genet 2006;120:111-118.