Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation- contraction coupling

Circulation

Volumn 117, Issue 14, 2008, Pages 1778-1786

  Gellen, Barnabas ^a   Fernández Velasco, María ^a   Briec, François ^a   Vinet, Laurent ^a   Lequang, Khai ^a   Rouet Benzineb, Patricia ^a   Bénitah, Jean Pierre ^a   Pezet, Mylène ^b   Palais, Gael ^a   Pellegrin, Noémie ^a   Zhang, Andy ^a   Perrier, Romain ^a   Escoubet, Brigitte ^a,b,c   Marniquet, Xavier ^a   Richard, Sylvain ^a   Jaisser, Fréderic ^a   Gómez, Ana María ^a   Charpentier, Flavien ^a   Mercadier, Jean Jacques ^a,b,c  

^a INSERM   (France)

^b Centre National de la Recherche Scientifique   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Arrhythmia; Calcium; Catecholamines; Sarcoplasmic reticulum; Stress

Indexed keywords

CAFFEINE; CALCIUM; FKBP12.6 PROTEIN; ISOPRENALINE; PROTEIN; RYANODINE RECEPTOR 2; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXCITATION CONTRACTION COUPLING; HEART; HEART MUSCLE CELL; HEART VENTRICLE TACHYCARDIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM; STATISTICAL SIGNIFICANCE; STRESS; TRANSGENIC MOUSE;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM SIGNALING; CARDIAC PACING, ARTIFICIAL; CATECHOLAMINES; DOXYCYCLINE; ISOPROTERENOL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT FUSION PROTEINS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TACHYCARDIA, VENTRICULAR; TACROLIMUS BINDING PROTEINS; UP-REGULATION;

EID: 41949085629     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.107.731893     Document Type: Article

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