S3 Guideline: Sedation for gastrointestinal endoscopy 2008

Endoscopy

Volumn 41, Issue 9, 2009, Pages 787-815

  Riphaus, A ^a   Wehrmann, T ^b   Weber, B ^c   Arnold, J ^c   Beilenhoff, U ^c   Bitter, H ^c   Delius, S Von ^c   Domagk, D ^c   Ehlers, A F ^c   Faiss, S ^c   Hartmann, D ^c   Heinrichs, W ^c   Hermans, M L ^c   Hofmann, C ^c   In Der Smitten, S ^c   Jung, M ^c   Kahler G ^c   Kraus, M ^c   Martin, J ^c   Meining, A ^c   Radke, J ^c   Rosch T ^c   Seifert, H ^c   Sieg, A ^c   Wigginghaus, B ^c   Kopp, I ^c   more..

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b DEUTSCHE KLINIK FÜR DIAGNOSTIK   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALFENTANIL; ANTIARRHYTHMIC AGENT; ATROPINE; DIAZEPAM; FENTANYL; FLUMAZENIL; INFUSION FLUID; KETAMINE; KETOROLAC TROMETAMOL; MIDAZOLAM; NITROUS OXIDE; PENTAZOCINE; PETHIDINE; PROPOFOL; REMIFENTANIL;

ADD ON THERAPY; ANALGESIA; ANESTHESIA; BLOOD PRESSURE; BRADYCARDIA; CLINICAL TRIAL; COMORBIDITY; CONTINUOUS INFUSION; COUGHING; DELIRIUM; DIGESTIVE SYSTEM PERFORATION; DIGESTIVE SYSTEM ULCER; DIGESTIVE TRACT INTUBATION; DIZZINESS; DROWSINESS; DRUG HALF LIFE; DRUG HYPERSENSITIVITY; DRUG MECHANISM; DYSPNEA; EDEMA; EDUCATION; ELECTROENCEPHALOGRAM; FLUID RETENTION; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL IRRITATION; HALLUCINATION; HEADACHE; HEART ARRHYTHMIA; HEART MUSCLE ISCHEMIA; HIGH RISK PATIENT; HUMAN; HYPOTENSION; HYPOXEMIA; HYPOXIA; NAUSEA AND VOMITING; NIGHTMARE; PAIN; PARESTHESIA; PHLEBITIS; PRIORITY JOURNAL; QUALITY CONTROL; RESPIRATION DEPRESSION; REVIEW; RISK ASSESSMENT; SEDATION; SIDE EFFECT; SWEATING; TACHYCARDIA;

EID: 70349664654     PISSN: 0013726X     EISSN: 14388812     Source Type: Journal    
DOI: 10.1055/s-0029-1215035     Document Type: Review

References (232)

1. Daneshmend T K., Bell G D., Logan R F. Sedation for upper gastrointestinal endoscopy: results of a nationwide survey. Gut 1991 32 12-15
2. Keefe E B., OConnor K W. ASGE survey of endoscopic sedation and monitoring practices. Gastrointest Endosc 1990 36 13-18
3. Froehlich F, Gonvers J J., Fried M. Conscious sedation, clinically relevant complications and monitoring of endoscopy: results of a nationwide survey in Switzerland. Endoscopy 1994 26 231-234
4. Frühmorgen P, Kriel L. Guidelines of the German Society of Digestive and Metabolic Diseases. Guidelines for endoscopic colorectal polypectomy with the sling. German Society of Digestive and Metabolic Diseases. Gastroenterol 1998 36 117-119
5. Riphaus A, Rabofski M, Wehrmann T. Sedierung in der gastrointestinalen Endoskopie in Deutschland. Z Gastroenterol 2007 45 782
6. Carlsson U, Grattidge P. Sedation for upper gastrointestinal endoscopy: a comparative study of propofol and midazolam. Endoscopy 1995 27 240-243
7. Patterson K W., Casey P B., Murray J P., et al. Propofol sedation for outpatient upper gastrointestinal endoscopy: comparison with midazolam. Br J Anaesth 1991 67 108-111
8. Riphaus A, Gstettenbauer T, Frenz M B., Wehrmann T. Quality of psychomotor recovery after propofol sedation for routine endoscopy: a randomized and controlled study. Endoscopy 2006 38 677-683
9. Clinical practice guidelines: safety and sedation during endoscopic procedures. Available from: http://www.bsg.org.uk/pdf-word-docs/sedation.doc
10. Stufe 1 Leitlinie Sedierung und Analgesie (Analgosedierung) von Patienten durch Nicht-Anüsthesisten. 2008. Available from: http://www.dgai.de/06pdf/ 13-573-Leitlinie.pdf, http://intranet/awmf11/001011.htm
11. Hofmann C, Jung M. Sedierung und überwachung bei endoskopischen Eingriffen. 2003. Available from: http://www.dgvs.de/media/1.2.Sedierung- ueberwachung.pdf
12. Kulling D, Rothenbuhler R, Inauen W. Safety of nonanesthetist sedation with propofol for outpatient colonoscopy and esophagogastroduodenoscopy. Endoscopy 2003 35 679-682
13. Heuss L T., Drewe J, Schnieper P, et al. Patient-controlled versus nurse-administered sedation with propofol during colonoscopy. A prospective randomized trial. Am J Gastroenterol 2004 99 511-518
14. Heuss L T., Schnieper P, Drewe J, et al. Risk stratification and safe administration of propofol by registered nurses supervised by the gastroenterologist: a prospective observational study of more than 2000 cases. Gastrointest Endosc 2003 57 664-671
15. Rex D K., Heuss L T., Walker J A., Qi R. Trained registered nurses/endoscopy teams can administer propofol safely for endoscopy. Gastroenterology 2005 129 1384-1391
16. Rex D K., Overley C, Kinser K, et al. Safety of propofol administered by registered nurses with gastroenterologist supervision in 2000 endoscopic cases. Am J Gastroenterol 2002 97 1159-1163
17. Walker J A., McIntyre R D., Schleinitz P F., et al. Nurse-administered propofol sedation without anesthesia specialists in 9152 endoscopic cases in an ambulatory surgery center. Am J Gastroenterol 2003 98 1744-1750
18. Tohda G, Higashi S, Wakahara S, et al. Propofol sedation during endoscopic procedures: safe and effective administration by registered nurses supervised by endoscopists. Endoscopy 2006 38 360-367
19. American Society of Anesthesiologists Task Force. Practice guidelines for sedation and analgesis by non-anesthesiologists: an updated report by the American Society of Anestesiologists Task Force on Sedation and Analgesia by Non-Anesthesiologists. Anesthesiology 2002 96 1004-1017
20. American Society for Gastrointestinal Endoscopy. Guidelines for conscious sedation and monitoring during gastrointestinal endoscopy. Gastrointest Endosc 2003 58 317-322
21. American Society of Anesthesiologists. Practice guidelines for postanesthetic care: a report by the American Society of Anesthesiologists Task Force on Postanesthetic Care. Anesthesiology 2002 6 742-752
22. Joint statement of a Working Group from the American College of Gastroenterology (ACG), the American Gastroenterological Association (AGA), and the American Society for Gastrointestinal Endoscopy (ASGE). Recommendations on the administration of sedation for the performance of endoscopic procedures. 2006. Available from: www.gi.org/physicians/nataffairs/trisociety.asp
23. Schreiber F. Austrian Society of Gastroenterology and Hepatology (OGGH) guidelines on sedation and monitoring during gastrointestinal endoscopy. Endoscopy 2007 39 259-262
24. American Society for Gastrointestinal Endoscopy. Guidelines for training in patient monitoring and sedation and analgesia. Gastrointest Endosc 1998 48 669-671
25. Waring J P., Baron T H., Hirota W K., et al. Guidelines for conscious sedation and monitoring during gastrointestinal endoscopy. Gastrointest Endosc 2003 58 317-322
26. Probert C S., Jayanthi V, Quinn J, Mayberry J F. Information requirements and sedation preferences of patients undergoing endoscopy of the upper gastrointestinal tract. Endoscopy 1991 23 218-219
27. Rex D K., Imperiale T F., Portish V. Patients willing to try colonoscopy without sedation: associated clinical factors and results of a randomized controlled trial. Gastrointest Endosc 1999 49 554-559
28. Eckardt V F., Kanzler G, Schmitt T, et al. Complications and adverse effects of colonoscopy with selective sedation. Gastrointest Endosc 1999 49 560-565
29. Yoruk G, Aksoz K, Unsal B, et al. Colonoscopy without sedation. Turk J Gastroenterol 2003 14 59-63
30. Early D S., Saifuddin T, Johnson J C., et al. Patient attitudes toward undergoing colonoscopy without sedation. Am J Gastroenterol 1999 94 1862-1865
31. Cohen L B., Wecsler J S., Gaetano J N., et al. Endoscopic sedation in the United States: results from a nationwide survey. Am J Gastroenterol 2006 101 967-974
32. Thompson D G., Lennard-Jones J E., Evans S J., et al. Patients appreciate premedication for endoscopy. Lancet 1980 2 469-470
33. Dillon M, Brown S, Casey W, et al. Colonoscopy under general anesthesia in children. Pediatrics 1998 102 381-383
34. Ely E W., Truman B, Shintani A, et al. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Score (RASS). JAMA 2003 289 2983-2991
35. Cohen L B., Delegge M H., Aisenberg J, et al. AGA Institute review of endoscopic sedation. Gastroenterology 2007 133 675-701
36. Dripps R D., Lamont A, Eckenhoff J E. The role of anesthesia in surgical mortality. JAMA 1961 178 261-266
37. American Society of Anesthesiologists. Practice guidelines for sedation and analgesia by non-anesthesiologists. A report by the American Society of Anesthesiologists Task Force on Sedation and Analgesia by Non-Anesthesiologists. Anesthesiology 1996 84 459-471
38. Society of Gastroenterology Nurses and Associates. SGNA position statement: Statement on the use of sedation and analgesia in the gastrointestinal endoscopy setting. Gastroenterol Nurs 2003 26 209-211
39. Society of Gastroenterology Nurses and Associates. SGNA position statement. Statement on the use of sedation and analgesia in the gastrointestinal endoscopy setting. Gastroenterol Nurs 2004 27 142-144
40. Faigel D O., Baron T H., Goldstein J L., et al. Guidelines for the use of deep sedation and anesthesia for GI endoscopy. Gastrointest Endosc 2002 56 613-617
41. American Society for Gastrointestinal Endoscopy. Sedation and monitoring of patients undergoing gastrointestinal endoscopic procedures. Gastrointest Endosc 1995 42 626-629
42. Deutsche Gesellschaft für Anüsthesiologie und Intensivmedizin. Leitlinie der Deutschen Gesellschaft für Anüsthesiologie und Intensivmedizin. Airway management. Anüsth Intensivmed 2004 45 302-306
43. Koch D G., Arguedas M R., Fallon M B. Risk of aspiration pneumonia in suspected variceal hemorrhage: the value of prophylactic endotracheal intubation prior to endoscopy. Dig Dis Sci 2007 52 2225-2228
44. Rudolph S J., Landsverk B K., Freeman M L. Endotracheal intubation for airway protection during endoscopy for severe upper GI hemorrhage. Gastrointest Endosc 2003 57 58-61
45. Deutsche Gesellschaft für Anüsthesiologie und Intensivmedizin. Vereinbarung des Berufsverbandes Deutscher Anüsthesisten und des Berufverbandes der Deutschen Chirurgen. Verantwortung für die prü-, intra- und postoperative Lagerung des Patienten. Anüsth Intensivmed 1987 28 65
46. Olithselvan A, McIntyre A S., Gorard D A. Are patients sedation preferences at gastroscopy influenced by preceding patients decisions? Aliment Pharmacol Ther 2004 20 989-992
47. Campo R, Brullet E, Montserrat A, et al. Identification of factors that influence tolerance of upper gastrointestinal endoscopy. Eur J Gastroenterol Hepatol 1999 11 201-204
48. Subramanian S, Liangpunsakul S, Rex D K. Preprocedure patient values regarding sedation for colonoscopy. J Clin Gastroenterol 2005 39 516-519
49. Abraham N S., Fallone C A., Mayrand S, et al. Sedation versus no sedation in the performance of diagnostic upper gastrointestinal endoscopy: a Canadian randomized controlled cost-outcome study. Am J Gastroenterol 2004 99 1692-1699
50. Hedenbro J L., Ekelund M, Aberg T, Lindblom A. Oral sedation for diagnostic upper endoscopy. Endoscopy 1991 23 8-10
51. Kinoshita Y, Ishido S, Nishiyama K, et al. Arterial oxygen saturation, blood pressure, and pulse rate during upper gastrointestinal endoscopy influence of sedation and age. J Clin Gastroenterol 1991 13 656-660
52. Yuno K, Iishi H, Tatsuta M, et al. Intravenous midazolam as a sedative for colonoscopy: a randomized, double-blind clinical trial. Aliment Pharmacol Ther 1996 10 981-984
53. Marriott P, Laasch H U., Wilbraham L, et al. Conscious sedation for endoscopic and non-endoscopic interventional gastrointestinal procedures: meeting patients expectations, missing the standard. Clin Radiol 2004 59 180-185 (Pubitemid 38159846)
54. Ristikankare M, Hartikainen J, Heikkinen M, et al. Is routinely given conscious sedation of benefit during colonoscopy? Gastrointest Endosc 1999 49 566-572
55. Walmsley R S., Montgomery S M. Factors affecting patient tolerance of upper gastrointestinal endoscopy. J Clin Gastroenterol 1998 26 253-255
56. Roseveare C, Seavell C, Patel P, et al. Patient-controlled sedation and analgesia, using propofol and alfentanil, during colonoscopy: a prospective randomized controlled trial. Endoscopy 1998 30 768-773
57. Ulmer B J., Hansen J J., Overley C A., et al. Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists. Clin Gastroenterol Hepatol 2003 1 425-432
58. Vargo J J., Zuccaro G Jr., Dumot J A., et al. Gastroenterologist- administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial. Gastroenterology 2002 123 8-16
59. Sipe B W., Rex D K., Latinovich D, et al. Propofol versus midazolam/meperidine for outpatient colonoscopy: administration by nurses supervised by endoscopists. Gastrointest Endosc 2002 55 815-825
60. Weston B R., Chadalawada V, Chalasani N, et al. Nurse-administered propofol versus midazolam and meperidine for upper endoscopy in cirrhotic patients. Am J Gastroenterol 2003 98 2440-2447
61. Mui L M., Teoh A Y., Ng E K., et al. Premedication with orally administered midazolam in adults undergoing diagnostic upper endoscopy: a double-blind placebo-controlled randomized trial. Gastrointest Endosc 2005 61 195-200
62. von Delius S, Hollweck R, Schmid R M., Frimberger E. Midazolam pain, but one cannot remember it: a survey among Southern German endoscopists. Eur J Gastroenterol Hepatol 2007 19 465-470
63. Laluna L, Allen M L., Dimarino A J. Jr. The comparison of midazolam and topical lidocaine spray versus the combination of midazolam, meperidine, and topical lidocaine spray to sedate patients for upper endoscopy. Gastrointest Endosc 2001 53 289-293
64. Ng J M., Kong C F., Nyam D. Patient-controlled sedation with propofol for colonoscopy. Gastrointest Endosc 2001 54 8-13
65. Patel S, Vargo J J., Khandwala F, et al. Deep sedation occurs frequently during elective endoscopy with meperidine and midazolam. Am J Gastroenterol 2005 100 2689-2695
66. Jung M, Hofmann C, Kiesslich R, Brackertz A. Improved sedation in diagnostic and therapeutic ERCP: propofol is an alternative to midazolam. Endoscopy 2000 32 233-238
67. Wehrmann T, Kokabpick S, Caspary W F., et al. Efficiacy and safety of intravenous profol sedation during routine ERCP. Gastrointest Endosc 1999 49 677-683
68. Hofmann C, Kiesslich R, Brackertz A, Jung M. Propofol for sedation in gastroscopy a randomized comparison with midazolam [in German]. Z Gastroenterol 1999 37 589-595
69. Koshy G, Nair S, Norkus E P., et al. Propofol versus midazolam and meperidine for conscious sedation in GI endoscopy. Am J Gastroenterol 2000 95 1476-1479
70. Reimann F M., Samson U, Derad I, et al. Synergistic sedation with low-dose midazolam and propofol for colonoscopies. Endoscopy 2000 32 239-244
71. Heuss L T., Schnieper P, Drewe J, et al. Conscious sedation with propofol in elderly patients: a prospective evaluation. Aliment Pharmacol Ther 2003 17 1493-1501
72. Kazama T, Takeuchi K, Ikeda K, et al. Optimal propofol plasma concentration during upper gastrointestinal endoscopy in young, middle-aged, and elderly patients. Anesthesiology 2000 93 662-669
73. Rex D K., Overley C A., Walker J. Registered nurse-administered propofol sedation for upper endoscopy and colonoscopy: Why? When? How? Rev Gastroenterol Disord 2003 3 70-80
74. Gottschling S, Larsen R, Meyer S, et al. Acute pancreatitis induced by short-term propofol administration. Paediatr Anaesth 2005 15 1006-1008
75. Jawaid Q, Presti M E., Neuschwander-Tetri B A., Burton F R. Acute pancreatitis after single-dose exposure to propofol: a case report and review of literature. Dig Dis Sci 2002 47 614-618
76. Fodale V, La Monaca E. Propofol infusion syndrome: an overview of a perplexing disease. Drug Saf 2008 31 293-303
77. Kulling D, Fantin A C., Biro P, et al. Safer colonoscopy with patient-controlled analgesia and sedation with propofol and alfentanil. Gastrointest Endosc 2001 54 1-7
78. Bright E, Roseveare C, Dalgleish D, et al. Patient-controlled sedation for colonoscopy: a randomized trial comparing patient-controlled administration of propofol and alfentanil with physician-administered midazolam and pethidine. Endoscopy 2003 35 683-687
79. Lee D W., Chan A C., Sze T S., et al. Patient-controlled sedation versus intravenous sedation for colonoscopy in elderly patients: a prospective randomized controlled trial. Gastrointest Endosc 2002 56 629-632
80. Crepeau T, Poincloux L, Bonny C, et al. Significance of patient-controlled sedation during colonoscopy. Results from a prospective randomized controlled study. Gastroenterol Clin Biol 2005 29 1090-1096
81. Lee D W., Chan A C., Wong S K., Chung S C. The safety, feasibility, and acceptability of patient-controlled sedation for colonoscopy: prospective study. Hong Kong Med J 2004 10 84-88
82. Egan T D., Kern S E., Johnson K B., Pace N L. The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation (Captisol) versus propofol in a lipid formulation (Diprivan): an electroencephalographic and hemodynamic study in a porcine model. Anesth Analg 2003 97 72-79
83. Fanti L, Agostoni M, Arcidiacono P G., et al. Target-controlled infusion during monitored anesthesia care in patients undergoing EUS: propofol alone versus midazolam plus propofol. A prospective double-blind randomised controlled trial. Dig Liver Dis 2007 39 81-86
84. Leslie K, Absalom A, Kenny G N. Closed loop control of sedation for colonoscopy using the bispectral index. Anaesthesia 2002 57 693-697
85. Campbell L, Imrie G, Doherty P, et al. Patient maintained sedation for colonoscopy using a target controlled infusion of propofol. Anaesthesia 2004 59 127-132
86. Gillham M J., Hutchinson R C., Carter R, Kenny G N. Patient-maintained sedation for ERCP with a target-controlled infusion of propofol: a pilot study. Gastrointest Endosc 2001 54 14-17
87. Stonell C A., Leslie K, Absalom A R. Effect-site targeted patient-controlled sedation with propofol: comparison with anaesthetist administration for colonoscopy. Anaesthesia 2006 61 240-247
88. Pambianco J, Meroric J, Martin R. Feasibility assessment of computer assisted personalized sedation: a sedation delivery system to administer propofol for gastrointestinal endoscopy. Gastrointest Endosc 2006 63 AB189
89. Reves J G., Fragen R J., Vinik H R., Greenblatt D J. Midazolam: pharmacology and uses. Anesthesiology 1985 62 310-324
90. Donnelly M B., Scott W A., Daly D S. Sedation for upper gastrointestinal endoscopy: a comparison of alfentanil-midazolam and meperidine-diazepam. Can J Anaesth 1994 41 1161-1165
91. Ginsberg G G., Lewis J H., Gallagher J E., et al. Diazepam versus midazolam for colonoscopy: a prospective evaluation of predicted versus actual dosing requirements. Gastrointest Endosc 1992 38 651-656
92. Macken E, Gevers A M., Hendrickx A, Rutgeerts P. Midazolam versus diazepam in lipid emulsion as conscious sedation for colonoscopy with or without reversal of sedation with flumazenil. Gastrointest Endosc 1998 47 57-61
93. Lavies N G., Creasy T, Harris K, Hanning C D. Arterial oxygen saturation during upper gastrointestinal endoscopy: influence of sedation and operator experience. Am J Gastroenterol 1988 83 618-622
94. Carrougher J G., Kadakia S, Shaffer R T., Barrilleaux C. Venous complications of midazolam versus diazepam. Gastrointest Endosc 1993 39 396-399
95. Ladas S D., Aabakken L, Rey J F., et al. Use of sedation for routine diagnostic upper gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy Survey of National Endoscopy Society Members. Digestion 2006 74 69-77
96. Zakko S F., Seifert H A., Gross J B. A comparison of midazolam and diazepam for conscious sedation during colonoscopy in a prospective double-blind study. Gastrointest Endosc 1999 49 684-689
97. Cantor D S., Baldridge E T. Premedication with meperidine and diazepam for upper gastrointestinal endoscopy precludes the need for topical anesthesia. Gastrointest Endosc 1986 32 339-341
98. Lee M G., Hanna W, Harding H. Sedation for upper gastrointestinal endoscopy: a comparative study of midazolam and diazepam. Gastrointest Endosc 1989 35 82-84
99. Lader M, Morton S. Benzodiazepine problems. Br J Addict 1991 86 823-828
100. Christe C, Janssens J P., Armenian B, et al. Midazolam sedation for upper gastrointestinal endoscopy in older persons: a randomized, double-blind, placebo-controlled study. J Am Geriatr Soc 2000 48 1398-1403
101. Froehlich F, Schwizer W, Thorens J, et al. Conscious sedation for gastroscopy: patient tolerance and cardiorespiratory parameters. Gastroenterology 1995 108 697-704
102. Froehlich F, Thorens J, Schwizer W, et al. Sedation and analgesia for colonoscopy: patient tolerance, pain, and cardiorespiratory parameters. Gastrointest Endosc 1997 45 1-9
103. Yano H, Iishi H, Tatsuta M, et al. Oxygen desaturation during sedation for colonoscopy in elderly patients. Hepatogastroenterology 1998 45 2138-2141
104. Hirsh I, Vaissler A, Chernin J, et al. Fentanyl or tramadol, with midazolam, for outpatient colonoscopy: analgesia, sedation, and safety. Dig Dis Sci 2006 51 1946-1951
105. Lee S Y., Son H J., Lee J M., et al. Identification of factors that influence conscious sedation in gastrointestinal endoscopy. J Korean Med Sci 2004 19 536-540
106. Morrow J B., Zuccaro G Jr., Conwell D L., et al. Sedation for colonoscopy using a single bolus is safe, effective, and efficient: a prospective, randomized, double-blind trial. Am J Gastroenterol 2000 95 2242-2247
107. Terruzzi V, Meucci G, Radaelli F, et al. Routine versus on demand sedation and analgesia for colonoscopy: a prospective randomized controlled trial. Gastrointest Endosc 2001 54 169-174
108. Kankaria A, Lewis J H., Ginsberg G, et al. Flumazenil reversal of psychomotor impairment due to midazolam or diazepam for conscious sedation for upper endoscopy. Gastrointest Endosc 1996 44 416-421
109. Saletin M, Malchow H, Muhlhofer H, et al. A randomised controlled trial to evaluate the effects of flumazenil after midazolam premedication in outpatients undergoing colonoscopy. Endoscopy 1991 23 331-333
110. Mora C T., Torjman M, White P F. Sedative and ventilatory effects of midazolam infusion: effect of flumazenil reversal. Can J Anaesth 1995 42 677-684
111. Carter A S., Bell G D., Coady T, et al. Speed of reversal of midazolam-induced respiratory depression by flumazenil a study in patients undergoing upper GI endoscopy. Acta Anaesthesiol Scand Suppl 1990 92 59-64
112. Andrews P J., Wright D J., Lamont M C. Flumazenil in the outpatient. A study following midazolam as sedation for upper gastrointestinal endoscopy. Anaesthesia 1990 45 445-448
113. Bartelsman J F., Sars P R., Tytgat G N. Flumazenil used for reversal of midazolam-induced sedation in endoscopy outpatients. Gastrointest Endosc 1990 36 9-12
114. Norton A C., Dundas C R. Induction agents for day-case anaesthesia. A double-blind comparison of propofol and midazolam antagonised by flumazenil. Anaesthesia 1990 45 198-203
115. Wehrmann T, Grotkamp J, Stergiou N, et al. Electroencephalogram monitoring facilitates sedation with propofol for routine ERCP: a randomized, controlled trial. Gastrointest Endosc 2002 56 817-824
116. Meining A, Semmler V, Kassem A M., et al. The effect of sedation on the quality of upper gastrointestinal endoscopy: an investigator-blinded, randomized study comparing propofol with midazolam. Endoscopy 2007 39 345-349
117. Hansen J J., Ulmer B J., Rex D K. Technical performance of colonoscopy in patients sedated with nurse-administered propofol. Am J Gastroenterol 2004 99 52-56
118. Rudner R, Jalowiecki P, Kawecki P, et al. Conscious analgesia/sedation with remifentanil and propofol versus total intravenous anesthesia with fentanyl, midazolam, and propofol for outpatient colonoscopy. Gastrointest Endosc 2003 57 657-663
119. Qadeer M A., Vargo J J., Khandwala F, et al. Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis. Clin Gastroenterol Hepatol 2005 3 1049-1056
120. Krugliak P, Ziff B, Rusabrov Y, et al. Propofol versus midazolam for conscious sedation guided by processed EEG during endoscopic retrograde cholangiopancreatography: a prospective, randomized, double-blind study. Endoscopy 2000 32 677-682
121. Riphaus A, Stergiou N, Wehrmann T. Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study. Am J Gastroenterol 2005 100 1957-1963
122. Wehrmann T, Riphaus A. Sedation with propofol for interventional endoscopic procedures: a risk factor analysis. Scand J Gastroenterol 2007 10 1-7
123. Ishiguro T, Ishiguro C, Ishiguro G, Nagawa H. Midazolam sedation for upper gastrointestinal endoscopy: comparison between the states of patients in partial and complete amnesia. Hepatogastroenterology 2002 49 438-440
124. Arrowsmith J B., Gerstman B B., Fleischer D E., Benjamin S B. Results from the American Society for Gastrointestinal Endoscopy/US Food and Drug Administration collaborative study on complication rates and drug use during gastrointestinal endoscopy. Gastrointest Endosc 1991 37 421-427
125. Basu S, Krishnamurthy B, Walsh T H. Value of fentanyl in flexible sigmoidoscopy. World J Surg 2004 28 930-934
126. Ishido S, Kinoshita Y, Kitajima N, et al. Fentanyl for sedation during upper gastrointestinal endoscopy. Gastrointest Endosc 1992 38 689-692
127. Akcaboy Z N., Akcaboy E Y., Albayrak D, et al. Can remifentanil be a better choice than propofol for colonoscopy during monitored anesthesia care? Acta Anaesthesiol Scand 2006 50 736-741
128. Green S M., Li J. Ketamine in adults: what emergency physicians need to know about patient selection and emergence reactions. Acad Emerg Med 2000 7 278-281
129. White P F., Way W L., Trevor A J. Ketamine its pharmacology and therapeutic uses. Anesthesiology 1982 56 119-136
130. Aggarwal A, Ganguly S, Anand V K., Patwari A K. Efficacy and safety of intravenous ketamine for sedation and analgesia during pediatric endoscopic procedures. Indian Pediatr 1998 35 1211-1214
131. Gilger M A., Spearman R S., Dietrich C L., et al. Safety and effectiveness of ketamine as a sedative agent for pediatric GI endoscopy. Gastrointest Endosc 2004 59 659-663
132. Rosing C, Trinkl W, Rosing K, Gebhardt B. Midazolam plus ketamine as premedication for colonoscopies. A double-blind, randomized study [in German]. Med Klin (Munich) 1991 86 190-193
133. Ong W C., Santosh D, Lakhtakia S, Reddy D N. A randomized controlled trial on use of propofol alone versus propofol with midazolam, ketamine, and pentazocine sedato-analgesic cocktail for sedation during ERCP. Endoscopy 2007 39 807-812
134. Saunders B P., Fukumoto M, Halligan S, et al. Patient-administered nitrous oxide/oxygen inhalation provides effective sedation and analgesia for colonoscopy. Gastrointest Endosc 1994 40 418-421
135. Forbes G M., Collins B J. Nitrous oxide for colonoscopy: a randomized controlled study. Gastrointest Endosc 2000 51 271-277
136. Maslekar S K., Hughes M, Skinn E, et al. Randomised controlled trial of sedation for colonoscopy: entonox versus intravenous sedation. Gastrointest Endosc 2006 63 AB 97S
137. Mui W L., Kwong W H., Li A C., et al. Premedication with intravenous ketorolac trometamol (Toradol) in colonoscopy: a randomized controlled trial. Am J Gastroenterol 2005 100 2669-2673
138. Lieberman D A., Wuerker C K., Katon R M. Cardiopulmonary risk of esophagogastroduodenoscopy. Role of endoscope diameter and systemic sedation. Gastroenterology 1985 88 468-472
139. Mizuno J, Matsuki M, Gouda Y, et al. Sedation with intravenous midazolam during upper gastrointestinal endoscopy changes in hemodynamics, oxygen saturation and memory [in Japanes]. Masui 2003 52 976-980
140. Oei-Lim V L., Kalkman C J., Makkes P C., Ooms W G. Patient-controlled versus anesthesiologist-controlled conscious sedation with propofol for dental treatment in anxious patients. Anesth Analg 1998 86 967-972
141. Ristikankare M, Julkunen R, Heikkinen M, et al. Sedation, topical pharyngeal anesthesia and cardiorespiratory safety during gastroscopy. J Clin Gastroenterol 2006 40 899-905
142. Boldy D A., Lever L R., Unwin P R., et al. Sedation for endoscopy: midazolam or diazepam and pethidine? Br J Anaesth 1988 61 698-701
143. Milligan K R., Howe J P., McLoughlin J, et al. Midazolam sedation for outpatient fibreoptic endoscopy: evaluation of alfentanil supplementation. Ann R Coll Surg Engl 1988 70 304-306
144. Radaelli F, Meucci G, Terruzzi V, et al. Single bolus of midazolam versus bolus midazolam plus meperidine for colonoscopy: a prospective, randomized, double-blind trial. Gastrointest Endosc 2003 57 329-335
145. Paspatis G A., Manolaraki M, Xirouchakis G, et al. Synergistic sedation with midazolam and propofol versus midazolam and pethidine in colonoscopies: a prospective, randomized study. Am J Gastroenterol 2002 97 1963-1967
146. Seifert H, Schmitt T H., Gultekin T, et al. Sedation with propofol plus midazolam versus propofol alone for interventional endoscopic procedures: a prospective, randomized study. Aliment Pharmacol Ther 2000 14 1207-1214
147. DiPalma J A., Herrera J L., Weis F R., et al. Alfentanil for conscious sedation during colonoscopy. South Med J 1995 88 630-634
148. Moerman A T., Struys M M., Vereecke H E., et al. Remifentanil used to supplement propofol does not improve quality of sedation during spontaneous respiration. J Clin Anesth 2004 16 237-243
149. Rembacken B J., Axon A T. The role of pethidine in sedation for colonoscopy. Endoscopy 1995 27 244-247
150. VanNatta M E., Rex D K. Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to moderate sedation for colonoscopy. Am J Gastroenterol 2006 101 2209-2217
151. Cordruwisch W, Doroschko M, Wurbs D. Deep sedation in gastrointestinal endoscopic interventions: safety and reliability of a combination of midazolam and propofol [in German]. Dtsch Med Wochenschr 2000 125 619-622
152. Mui L M., Ng E K., Chan K C., et al. Randomized, double-blinded, placebo-controlled trial of intravenously administered hyoscine N-butyl bromide in patients undergoing colonoscopy with patient-controlled sedation. Gastrointest Endosc 2004 59 22-27
153. Vargo J J., Holub J L., Faigel D O., et al. Risk factors for cardiopulmonary events during propofol-mediated upper endoscopy and colonoscopy. Aliment Pharmacol Ther 2006 24 955-963
154. Iber F L., Sutberry M, Gupta R, Kruss D. Evaluation of complications during and after conscious sedation for endoscopy using pulse oximetry. Gastrointest Endosc 1993 39 620-625
155. Thompson A M., Park K G., Kerr F, Munro A. Safety of fibreoptic endoscopy: analysis of cardiorespiratory events. Br J Surg 1992 79 1046-1049
156. Assy N, Rosser B G., Grahame G R., Minuk G Y. Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis. Gastrointest Endosc 1999 49 690-694
157. Vasudevan A E., Goh K L., Bulgiba A M. Impairment of psychomotor responses after conscious sedation in cirrhotic patients undergoing therapeutic upper GI endoscopy. Am J Gastroenterol 2002 97 1717-1721
158. Muravchick S. Anesthesia for the geriatric patient. In: Barash PG, Cullen BF, Stoelting RK, eds. Clinical anesthesia. 4th edn. Philadelphia Lippincott-Raven 2001 1205-1216
159. Qureshi W A., Zuckerman M J., Adler D G., et al. ASGE guideline: modifications in endoscopic practice for the elderly. Gastrointest Endosc 2006 63 566-569
160. Darling E. Practical considerations in sedating the elderly. Crit Care Nurs Clin North Am 1997 9 371-380
161. Dhariwal A, Plevris J N., Lo N T., et al. Age, anemia, and obesity-associated oxygen desaturation during upper gastrointestinal endoscopy. Gastrointest Endosc 1992 38 684-688
162. Scholer S G., Schafer D F., Potter J F. The effect of age on the relative potency of midazolam and diazepam for sedation in upper gastrointestinal endoscopy. J Clin Gastroenterol 1990 12 145-147
163. Hamdy N A., Kennedy H J., Nicholl J, Triger D R. Sedation for gastroscopy: a comparative study of midazolam and Diazemuls in patients with and without cirrhosis. Br J Clin Pharmacol 1986 22 643-647
164. Riphaus A, Lechowicz I, Frenz M B., et al. Profol sedation for upper GI endoscopy in patients with liver cirrhosis as alternative to avoid acute deterioration of minimal encephalopathy. A randomized controlled study. Scand J Gastroenterol 2009 in press ü
165. Heuss L T., Schnieper P, Drewe J, et al. Safety of propofol for conscious sedation during endoscopic procedures in high-risk patients a prospective, controlled study. Am J Gastroenterol 2003 98 1751-1757
166. Harikumar R, Raj M, Paul A, et al. Listening to music decreases need for sedative medication during colonoscopy: a randomized, controlled trial. Indian J Gastroenterol 2006 25 3-5
167. Rudin D, Kiss A, Wetz R V., Sottile V M. Music in the endoscopy suite: a meta-analysis of randomized controlled studies. Endoscopy 2007 39 507-510
168. Aisenberg J, Cohen L B. Sedation in endoscopic practice. Gastrointest Endosc Clin N Am 2006 16 695-708
169. American Medical Association. The use of pulse oximetry during conscious sedation. Council on Scientific Affairs. JAMA 1993 270 1463-1468
170. Conigliaro R, Rossi A. Implementation of sedation guidelines in clinical practice in Italy: results of a prospective longitudinal multicenter study. Endoscopy 2006 38 1137-1143
171. Eisenbacher S, Heard L. Capnography in the gastroenterology lab. Gastroenterol Nurs 2005 28 99-105
172. Graber R G. Propofol in the endoscopy suite: an anesthesiologists perspective. Gastrointest Endosc 1999 49 803-806
173. Harris J K., Froehlich F, Wietlisbach V, et al. Factors associated with the technical performance of colonoscopy: An EPAGE Study. Dig Liver Dis 2007 39 678-689
174. Jamieson J. Anesthesia and sedation in the endoscopy suite? (influences and options). Curr Opin Anaesthesiol 1999 12 417-423
175. Kulling D, Orlandi M, Inauen W. Propofol sedation during endoscopic procedures: how much staff and monitoring are necessary? Gastrointest Endosc 2007 66 443-449
176. Leslie K, Stonell C A. Anaesthesia and sedation for gastrointestinal endoscopy. Curr Opin Anaesthesiol 2005 18 431-436
177. Lopez R L., Subcomite de Protocolos of The Spanish Society of Gastrointestinal Endoscopy (SEED). Sedation/analgesia guidelines for endoscopy. Rev Esp Enferm Dig 2006 98 685-692
178. Mahoney L B., Lightdale J R. Sedation of the pediatric and adolescent patient for GI procedures. Curr Treat Options Gastroenterol 2007 10 412-421
179. Moos D D., Cuddeford J D. Methemoglobinemia and benzocaine. Gastroenterol Nurs 2007 30 342-345
180. Morlote E B., Zweng T N., Strodel W E. Hemodynamic monitoring and pulse oximetry during percutaneous gastrostomy and jejunostomy: necessity or nuisance? Surg Endosc 1991 5 130-134
181. Overley C A., Rex D K. A nursing perspective on sedation and nurse-administered propofol for endoscopy. Gastrointest Endosc Clin N Am 2004 14 325-333
182. Robbertze R, Posner K L., Domino K B. Closed claims review of anesthesia for procedures outside the operating room. Curr Opin Anaesthesiol 2006 19 436-442
183. Society of Gastroenterology Nurses and Associates. Guidelines for nursing care of the patient receiving sedation and analgesia in the gastrointestinal endoscopy setting. Gastroenterol Nurs 1997 20 (Suppl) 1-6
184. American Society for Gastrointestinal Endoscopy. Training guideline for use of propofol in gastrointestinal endoscopy. Gastrointest Endosc 2004 60 167-172
185. Vargo J J., Ahmad A S., Aslanian H R., et al. Training in patient monitoring and sedation and analgesia. Gastrointest Endosc 2007 66 7-10
186. Zebris J, Maurer W. Quality assurance in the endoscopy suite: sedation and monitoring. Gastrointest Endosc Clin N Am 2004 14 415-429
187. Silvermann W, Chotiprasidhi R, Chuttani J, et al. Monitoring equipment for endoscopy. Gastrointest Endosc 2003 59 761-765
188. Kiesslich R, Moenk S, Reinhardt K, et al. Combined simulation training: a new concept and workshop is useful for crisis management in gastrointestinal endoscopy [in German]. Z Gastroenterol 2005 43 1031-1039
189. Sieg A. Propofol sedation in outpatient colonoscopy by trained practice nurses supervised by the gastroenterologist: a prospective evaluation of over 3000 cases. Z Gastroenterol 2007 45 697-701
190. Heuss L T., Froehlich F, Beglinger C. Changing patterns of sedation and monitoring practice during endoscopy: results of a nationwide survey in Switzerland. Endoscopy 2005 37 161-166
191. Froehlich F, Harris J K., Wietlisbach V, et al. Current sedation and monitoring practice for colonoscopy: an International Observational Study (EPAGE). Endoscopy 2006 38 461-469 (Pubitemid 43744703)
192. Anderson J L., Junkins E, Pribble C, Guenther E. Capnography and depth of sedation during propofol sedation in children. Ann Emerg Med 2007 49 9-13
193. Levine D A., Platt S L. Novel monitoring techniques for use with procedural sedation. Curr Opin Pediatr 2005 17 351-354
194. Soto R G., Fu E S., Vila H Jr., Miguel R V. Capnography accurately detects apnea during monitored anesthesia care. Anesth Analg 2004 99 379-382
195. Vargo J J., Zuccaro G Jr., Dumot J A., et al. Automated graphic assessment of respiratory activity is superior to pulse oximetry and visual assessment for the detection of early respiratory depression during therapeutic upper endoscopy. Gastrointest Endosc 2002 55 826-831
196. Koniaris L G., Wilson S, Drugas G, Simmons W. Capnographic monitoring of ventilatory status during moderate (conscious) sedation. Surg Endosc 2003 17 1261-1265
197. Chen S C., Rex D K. An initial investigation of bispectral monitoring as an adjunct to nurse-administered propofol sedation for colonoscopy. Am J Gastroenterol 2004 99 1081-1086
198. Drake L M., Chen S C., Rex D K. Efficacy of bispectral monitoring as an adjunct to nurse-administered propofol sedation for colonoscopy: a randomized controlled trial. Am J Gastroenterol 2006 101 2003-2007
199. Parzreller M, Wenk M. Aufklürung und Einwilligung bei ürztlichen Eingriffen. Dtsch ürztebl 2007 109 A576-A586
200. Christopher J. Gastrointestinal bleeding in the elderly patient. Am J Gastroenterol 2000 95 590-595
201. Hochberger J. Die Einverstündniserklürung zu endoskopischen Eingriffen. In: Sauerbruch T, Scheurlen C, eds. Empfehlungen der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) zur Durchführung endoskopischer Untersuchungen. 3rd edn. Stuttgart Demeter 2002 1-11
202. Rieger H J. Zur Rechtzeitigkeit der Patientenaufklürung. Dtsch Med Wochschr 2003 28 1728-1729
203. Sieg A, Hachmoeller-Eisenbach U, Eisenbach T. Prospective evaluation of complications in outpatient GI endoscopy: a survey among German gastroenterologists. Gastrointest Endosc 2001 53 620-627
204. Mahajan R J., Johnson J C., Marshall J B. Predictors of patient cooperation during gastrointestinal endoscopy. J Clin Gastroenterol 1997 24 220-223
205. Pena L R., Mardini H E., Nickl N J. Development of an instrument to assess and predict satisfaction and poor tolerance among patients undergoing endoscopic procedures. Dig Dis Sci 2005 50 1860-1871
206. Lazzaroni M, Bianchi P G. Preparation, premedication, and surveillance. Endoscopy 2005 37 101-109
207. Laufs A, Uhlenbruck W. Handbuch des Arztrechts. 3rd edn. 2002
208. Oberlandesgericht Stuttgart MedR4142. 1986
209. Oberlandesgericht Zweibrücken MedR407408. 1995
210. Hayes A, Buffum M. Educating patients after conscious sedation for gastrointestinal procedures. Gastroenterol Nurs 2001 24 54-57
211. Smith M R., Bell G D., Fulton B, et al. A comparison of winged steel needles and Teflon cannulas in maintaining intravenous access during gastrointestinal endoscopy. Gastrointest Endosc 1993 39 33-36
212. Alcain G, Guillen P, Escolar A, et al. Predictive factors of oxygen desaturation during upper gastrointestinal endoscopy in nonsedated patients. Gastrointest Endosc 1998 48 143-147
213. Sieg A, Theilmeier A. Results of coloscopy screening in 2005 an Internet-based documentation [in German]. Dtsch Med Wochenschr 2006 131 379-383
214. Jurell K R., OConnor K W., Slack J, et al. Effect of supplemental oxygen on cardiopulmonary changes during gastrointestinal endoscopy. Gastrointest Endosc 1994 40 665-670
215. Reshef R, Shiller M, Kinberg R, et al. A prospective study evaluating the usefulness of continuous supplemental oxygen in various endoscopic procedures. Isr J Med Sci 1996 32 736-740
216. Wang C Y., Ling L C., Cardosa M S., et al. Hypoxia during upper gastrointestinal endoscopy with and without sedation and the effect of pre-oxygenation on oxygen saturation. Anaesthesia 2000 55 654-658
217. Ristikankare M, Julkunen R, Mattila M, et al. Conscious sedation and cardiorespiratory safety during colonoscopy. Gastrointest Endosc 2000 52 48-54 (Pubitemid 30469713)
218. Petelenz M, Gonciarz M, Macfarlane P, et al. Sympathovagal balance fluctuates during colonoscopy. Endoscopy 2004 36 508-514
219. Bhalla A, Sood A, Sachdeva A, et al. Cardiorespiratory compromise under conscious sedation during upper gastrointestinal endoscopy. J Coll Physicians Surg Pak 2006 16 585-589
220. Lewalter T. Notfall Herzrhythmusstürungen. Dtsch ürztebl 2007 104 A1172-A1180
221. Leslie K, Tay T, Neo E. Intravenous fluid to prevent hypotension in patients undergoing elective colonoscopy. Anaesth Intensive Care 2006 34 316-321
222. Ristikankare M, Julkunen R, Laitinen T, et al. Effect of conscious sedation on cardiac autonomic regulation during colonoscopy. Scand J Gastroenterol 2000 35 990-996
223. Sieg A, Hachmoeller-Eisenbach U, Heisenbach T. How safe is premedication in ambulatory endoscopy in Germany? A prospective study in gastroenterology specialty practices [in German]. Dtsch Med Wochenschr 2000 125 1288-1293
224. Royal College of Surgeons of England Commission on the Provision of Surgical Services. Report of the working party on guidelines for sedation by non-anesthetists. 1993. www.rcseng.ac.uk/fds/clinical-guidelines-31k
225. Aldrete J A. The post-anesthesia recovery score revisited. J Clin Anesth 1995 7 89-91
226. Willey J, Vargo J J., Connor J T., et al. Quantitative assessment of psychomotor recovery after sedation and analgesia for outpatient EGD. Gastrointest Endosc 2002 56 810-816
227. Nuotto E J., Korttila K T., Lichtor J L., et al. Sedation and recovery of psychomotor function after intravenous administration of various doses of midazolam and diazepam. Anesth Analg 1992 74 265-271
228. Thapar P, Zacny J P., Thompson W, Apfelbaum J L. Using alcohol as a standard to assess the degree of impairment induced by sedative and analgesic drugs used in ambulatory surgery. Anesthesiology 1995 82 53-59
229. Korttila K, Linnoila M. Psychomotor skills related to driving after intramuscular administration of diazepam and meperidine. Anesthesiology 1975 125 619-622
230. Korttila K, Linnoila M. Recovery and skills related to driving after intravenous sedation: dose-response relationship with diazepam. Br J Anaesth 1975 47 457-463
231. Korttila K. Recovery after intravenous sedation. A comparison of clinical and paper and pencil tests used in assessing late effects of diazepam. Anaesthesia 1976 31 724-731
232. Piletti R, Davis P J., Redlinger R, et al. Effect on hospital wide sedation practice after implentation of the 2001 JCAHO procedural sedation and analgesia guidelines. Arch Adolesc Med 2006 160 211-216