The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation (Captisol®) versus propofol in a lipid formulation (Diprivan®): An electroencephalographic and hemodynamic study in a porcine model

Anesthesia and Analgesia

Volumn 97, Issue 1, 2003, Pages 72-79

  Egan, Talmage D ^a,b   Kern, Steven E ^a   Johnson, Kenward B ^a   Pace, Nathan L ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; BETA CYCLODEXTRIN SULFOBUTYL ETHER; ISOFLURANE; KETAMINE; LIPID EMULSION; NEUROMUSCULAR BLOCKING AGENT; OXYGEN; PANCURONIUM BROMIDE; PROPOFOL; TILETAMINE; XYLAZINE; ZOLAZEPAM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG INFUSION; ELECTROENCEPHALOGRAPHY; HEART OUTPUT; HEART RATE; HEMODYNAMICS; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; SIMULATION;

EID: 0037974454     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000066019.42467.7A     Document Type: Article

References (19)

1. McLeskey CH, Walawander CA, Nahrwold ML, et al. Adverse events in a multicenter phase IV study of propofol: evaluation by anesthesiologists and postanesthesia care unit nurses. Anesth Analg 1993;77:S3-9.
2. Laxenaire MC, Mata-Bermejo E, Moneret-Vautrin DA, Gueant JL. Life-threatening anaphylactoid reactions to propofol (Diprivan). Anesthesiology 1992;77:275-80.
3. de Leon-Casasola OA, Weiss A, Lema MJ. Anaphylaxis due to propofol. Anesthesiology 1992;77:384-6.
4. Sosis MB, Braverman B. Growth of Staphylococcus aureus in four intravenous anesthetics. Anesth Analg 1993;77:766-8.
5. Sosis MB, Braverman B, Villaflor E. Propofol, but not thiopental, supports the growth of Candida albicans. Anesth Analg 1995;81: 132-4.
6. Bennett SN, McNeil MM, Bland LA, et al. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 1995;333:147-54.
7. Eddleston JM, Shelly MP. The effect on serum lipid concentrations of a prolonged infusion of propofol: hypertriglyceridaemia associated with propofol administration. Intensive Care Med 1991;17:424-6.
8. Dutta S, Ebling WF. Formulation-dependent pharmacokinetics and pharmacodynamics of propofol in rats. J Pharm Pharmacol 1998;50:37-42.
9. Bielen SJ, Lysko GS, Gough WB. The effect of a cyclodextrin vehicle on the cardiovascular profile of propofol in rats. Anesth Analg 1996;82:920-4.
10. Dutta S, Ebling WF. Emulsion formulation reduces propofol's dose requirements and enhances safety. Anesthesiology 1997; 87:1394-405.
11. Ko JC, Williams BL, Smith VL, et al. Comparison of Telazol, Telazol-ketamine, Telazol-xylazine, and Telazol-ketaminexylazine as chemical restraint and anesthetic induction combination in swine. Lab Anim Sci 1993;43:476-80.
12. Cockshott ID, Douglas EJ, Plummer GF, Simons PJ. The pharmacokinetics of propofol in laboratory animals. Xenobiotica 1992;22:369-75.
13. Ibrahim A, Park S, Feldman J, et al. Effects of parecoxib, a parenteral COX-2-specific inhibitor, on the pharmacokinetics and pharmacodynamics of propofol. Anesthesiology 2002;96: 88-95.
14. Yamaoka K, Nakagawa T, Uno T. Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm 1978;6:547-58.
15. Varvel JR, Donoho DL, Shafer SL. Measuring the predictive performance of computer-controlled infusion pumps. J Pharmacokinet Biopharm 1992;20:63-94.
16. Sheiner LB, Stanski DR, Vozeh S, et al. Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin Pharmacol Ther 1979;25:358-71.
17. Dutta S, Ebling WF. Formulation-dependent brain and lung distribution kinetics of propofol in rats. Anesthesiology 1998;89: 678-85.
18. Trapani G, Latrofa A, Franco M, et al. Inclusion complexation of propofol with 2-hydroxypropyl-beta-cyclodextrin: physicochemical, nuclear magnetic resonance spectroscopic studies, and anesthetic properties in rat. J Pharm Sci 1998;87:514-8.
19. Viernstein H, Stumpf C, Spiegl P, Reiter S. Preparation and central action of propofol/hydroxypropyl-beta-cyclodextrin complexes in rabbits. Arzneimittelforschung 1993;43:818-21.