Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: A randomized, controlled study

Scandinavian Journal of Gastroenterology

Volumn 44, Issue 10, 2009, Pages 1244-1251

  Riphaus, Andrea ^a   Lechowicz, Izabela ^a   Frenz, Markus B ^a   Wehrmann, Till ^a  

^a Klinikum Region Hannover GmbH   (Germany)

Author keywords

Liver cirrhosis; Midazolam; Minimal encephalopathy; Propofol; Upper gastrointestinal endoscopy

Indexed keywords

MIDAZOLAM; PROPOFOL; SERUM ALBUMIN;

ADULT; AGED; ALCOHOLISM; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DISEASE EXACERBATION; FEMALE; GASTROINTESTINAL ENDOSCOPY; HEPATIC ENCEPHALOPATHY; HEPATITIS C; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; SINGLE BLIND PROCEDURE;

AGED; ENDOSCOPY, GASTROINTESTINAL; ESOPHAGEAL AND GASTRIC VARICES; FEMALE; HEPATIC ENCEPHALOPATHY; HUMANS; HYPNOTICS AND SEDATIVES; LIVER CIRRHOSIS; MALE; MIDAZOLAM; MIDDLE AGED; PROPOFOL; TREATMENT OUTCOME;

EID: 70349722065     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520903194591     Document Type: Article

References (55)

1. Gitlin N. Subclinical portal-systemic encephalopathy. Am J Gastroenterol 1983;/82:/8-11.
2. Zaman A, Becker T, Lapidus J, Benner K. Risk factors for the presence of varices in cirrhotic patients without a history of variceal haemorrhage. Arch Intern Med 2001;/161:/2564- 70.
3. Pascal J-P, Cales P. Multicenter Study Group. Propranolol in the prevention of first upper gastrointestinal tract hemorrhage in patients with cirrhosis of the liver and esophageal varices. N Engl J Med 1987;/317:/856-61.
4. Keeffe EB, O'Connor KW. ASGE survey of endoscopic sedation and monitoring practices. Gastrointest Endosc 1990;/36:/S13-8.
5. Daneshmend TK, Bell GD, Logan RF. Sedation for upper gastrointestinal endoscopy: results of a nationwide survey. Gut 1991;/32:/12-5.
6. Froehlich F, Gonvers JJ, Fried M. Conscious sedation, clinically relevant complications and monitoring of endoscopy: results of a nationwide survey in Switzerland. Endoscopy 1994;/26:/231-4.
7. Abraham NS, Fallone CA, Mayrand S, Huang J, Wieczorek P, Barkun AN. Sedation versus no sedation in the performance of diagnostic upper gastrointestinal endoscopy: a Canadian randomized controlled cost-outcome study. Am J Gastroenterol 2004;/99:/1692-9.
8. Cohen LB, Wecsler JS, Gaetano JN, Bensen AA, Miller Km, Durkalski V, et al. Endoscopic sedation in the United States: results from a nationwide survey. Am J Gastroenterol 2006;/ 101:/967-74.
9. Froehlich F, Harris JK, Wietlisbach V, Burnand B, Vader JP, Gonvers JJ, et al. Current sedation and monitoring practice for colonoscopy: an International Observational Study (EPAGE). Endoscopy 2006;/38:/461-9. (Pubitemid 43744703)
10. Assy N, Rosser BG, Grahame GR, Minuk GY. Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis. Gastrointest Endosc 1999;/49:/690-4.
11. Vasudevan AE, Goh KL, Bulgiba AM. Impairment of psychomotor responses after conscious sedation in cirrhotic patients undergoing therapeutic upper GI endoscopy. Am J Gastroenterol 2002;/97:/1717-21.
12. Pond SM, Tong T, Benowitz NL, Jacob P, Rigod J. Presystemic metabolism of meperidine to normmeperidine in normal and cirrhotic subjects. Clin Pharmacol Ther 1981;30:183-8.
13. Rinetti M, Ascalone V, Colombi Zinelli L, Cisternino M. Apharmacokinetic study on midazolam in compensated liver cirrhosis. Int J Clin Pharmacol Res 1985;/5:/405-11.
14. MacGilchrist AJ, Birnie GG, Cook A, et al. Pharmacokinetics and pharmacodynamics of intravenous midazolam in patients with severe alcoholic cirrhosis. Gut 1986;/27:/190-5.
15. Tegeder I, Lötsch J, Geisslinger G. Pharmacokinetics of opioids in liver disease. Clin Pharmacokinet 1999;/37:/17-40.
16. Bakti G, Fisch HU, Karlagans G, Minder C, Bircher J. Mechanism of excessive sedative response of cirrhotics to benzodiazepines: Model experiments with triazolam. Hepatology 1987;/7:/629-38.
17. Mackenzie N, Grant IS. Propofol for intravenous sedation. Anaesthesia 1987;/42:/3-6.
18. Morcos WE, Payne JP. The induction of anaesthesia with propofol compared in normal and renal failure patients. Postgrad Med J 1985;/61:/62-3.
19. Servin F, Cockshott ID, Farinotti R, Haberer JP, Winckler C, Desmonts JM. Pharmacokinetics of propofol infusions in patients with cirrhosis. Br J Anaesth 1990;/65:/177-83.
20. Weissenborn K, Ennen J, Rückert N, Schomerus H, Dengler R, Manns M.P. et al. The PSE-test: an attempt to standardize neuropsychological assessment of latent portosystemic encephalopathy (PSE). In: Record C, Al Mordini H, editors. Advances in hepatic encephalopathy and metabolism in liver disease. Newcastle upon Tyne: Medical Faculty of the University of Newcastle upon Tyne; 1997. pp. 489-94.
21. Weissenborn K, Ennen JC, Schomerus H, Ruckert N, Hecker H. Neuropsychological characterization of hepatic encephalopathy. J Hepatol 2001;/34:/768-73.
22. Cohen LB, DeLegge MH, Aisenberg G, Brill J, Inadomi J, Kochman M, et al. AGA Institute review of endoscopic sedation. Gastroenterology 2007;/133:/675-701.
23. Kankaria A, Lewis JH, Ginsberg G, Gallagher J, al-Kawas FH, Nguyen CC, et al. Flumazenil reversal of psychomotor impairment due to midazolam or diazepam for conscious sedation for upper endoscopy. Gastrointest Endosc 1996;/44:/ 416-21.
24. Schomerus H, Hamster W, Blunck H, Reinhard U, Mayer K, DolleW. Latent portosystemic encephalopathy. Nature of cerebral functional defects and their effect on fitness to drive. Dig Dis Sci 1981;/26:/622-30.
25. Gitlin N, Lewis DC, Hinkley L. The diagnosis and prevalence of subclinical hepatic encephalopathy in apparently healthy, ambulant, non-shunted patients with cirrhosis. J Hepatol 1986;/3:/75-82.
26. Amoros A, Aparicio JR, Garmendia M, Casellas J, Martinez J, Jover R. Deep sedation with propofol does not precipitate hepatic encephalopathy elective upper endoscopy. Gastrointest Endosc 2009; Epub ahead of print.
27. Dundee JW, Halliday NJ, Harper KW, Brogden RN. Midazolam. A review of its pharmacological properties and therapeutic use. Drugs 1984;/28:/519-43.
28. Darwin P, Zangara J, Heller T, Haluszka O, Laurin J. Unsedated esophagoscopy for the diagnosis of esophageal varices in patients with cirrhosis. Endoscopy 2001;/32:/971-3.
29. Mosca S, Balzano A. Is routine topical anesthesia or conscious sedation necessary in upper endoscopy, especially in patients with liver cirrhosis? Endoscopy 2001;/33:/639-40.
30. Bryson HM, Fulton BR, Faulds D. Propofol. An update of its use in anesthesia and conscious sedation. Drugs 1995;/50:/ 513-59.
31. Rex DK, Overley C, Kinser K, Coates M, Lee A, Goodwine BW, et al. Safety of propofol administered by registered nurses with gastroenterologist supervision in 2.000 endoscopic cases. Am J Gastroenterol 2002;/97:/1159-63.
32. Hansen JJ, Ulmer BJ, Rex DK. Technical performance of colonoscopy in patients sedated with nurse-administered propofol. Am J Gastroenterol 2003;/98:/52-6.
33. Heuss LT, Schnieper P, Drewe J, Pfilmlin E, Beglinger C. Risk stratification and safe administration of propofol by registered nurses supervised by the gastroenterologist: a prospective observational study of more than 2000 cases. Gastrointest Endosc 2003;/57:/664-71.
34. Heuss LT, Drewe J, Schnieper P, Tapparelli CB, Pfimlin E, Beglinger C. Patient-controlled versus nurse-administered sedation with propofol during colonoscopy. A prospective randomized trial. Am J Gastroenterol 2004;/99:/511-7.
35. Rex DK, Heuss LT, Walker JA, Rong QI. Trained registered nurses/endoscopy teams can administer propofol safely for endoscopy. Gastroenterology 2005;/129:/1384-91.
36. Wehrmann T, Riphaus A. Sedation with propofol for interventional endoscopic procedures: a risk factor analysis. Scand J Gastroenterol 2008;/43:/368-74.
37. Wehrmann T, Kokabpick S, Lembcke B, Caspary WF, Seifert H. Efficacy and safety of intravenous propofol sedation during routine ERCP: a prospective, controlled study. Gastrointest Endosc 1999;/49:/677-83.
38. Jung M, Hofmann C, Kiesslich R, Brackertz A. Improved sedation diagnostic and therapeutic ERCP: propofol is an alternative to midazolam. Endoscopy 2000;/32:/233-8.
39. Seifert H, Schmitt T, Gultekin T, Caspary WF, Wehrmann T. Sedation with propofol plus midazolam versus propofol alone for interventional endoscopic procedures: a prospective, randomized study. Aliment Pharmacol Therap 2000;/14:/ 1207-14.
40. Krugliak P, Ziff B, Rusabrov Y, Rosenthal A, Fich A, Gurman CM. Propofol versus midazolam for conscious sedation guided by processed EEG during endoscopic retrograde cholangiopancreatography: a prospective, randomized, double-blind study. Endoscopy 2000;/32:/677-82.
41. Vargo JJ, Zuccara G, Dumont JA, Shermock KM, Morrow JB, Conwell DL, et al. Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomised trial. Gastroenterology 2002;/123:/8-16.
42. Riphaus A, Stergiou N, Wehrmann T. Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study. Am J Gastroenterol 2005;/100:/ 1957-63.
43. Graber RG. Propofol in the endoscopy suite: An anaesthesiologist's perspective. Gastrointest Endosc 1999;/49:/803-6.
44. Barr J. Propofol: a new drug for sedation in the intensive care unit. Int Anesthesiol Clin 1995;/33:/131-54.
45. Heuss LT, Schnieper P, Drewe J, Pflimline E, Beglinger C. Safety of propofol for conscious sedation during endoscopic procedures in high-risk patients: a prospective, controlled study. Am J Gastroenterol 2003;/98:/1751-7.
46. Wong RC. The menu of endoscopic sedation: all-you-caneat, combination set, menu à la carte; alternative cuisine, or go hungry. Gastrointest Endosc 2001;/54:/122-6.
47. Riphaus A, Stergiou N, Wehrmann T. Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study. Am J Gastroenterol 2005;/100:/ 1957-63.
48. Wehrmann T, Kokabpick S, Lembcke B, Caspary WF, Seifert H. Efficacy and safety of intravenous propofol sedation during routine ERCP: a prospective, controlled study. Gastrointest Endosc 1999;/49:/677-83.
49. Walker J. N.A.P.S. Nurse administered propofol sedation. Available at: www.drnaps.org/2004.
50. Sipe BW, Rex DK, Latinovich D, Overley C, Kinser K, Bratcher L, et al. Propofol versus midazolam/meperidine for outpatient colonoscopy: administration by nurses supervised by endoscopists. Gastrointest Endosc 2002;/55:/815-25.
51. Seifert H, Schmitt TH, Gü ltekin T, Caspary WF, Wehrmann T. Sedation with propofol plus midazolam versus propofol alone for interventional endoscopic procedures: a prospective, randomized study. Aliment Pharmacol Therap 2000;/14:/1207-14.
52. Weston BR, Chadalawada V, Chalasani N, Kwo P, Overley C, Coates M, et al. Nurse-administered propofol versus midazolam and meperidene for upper endoscopy in cirrhotic patients. Am J Gastroenterol 2003;/98:/2440-7.
53. Riphaus A, Gstettenbauer T, Frenz MB, Wehrmann T. Quality of psychomotor recovery after propofol sedation for routine endoscopy: a randomized and controlled study. Endoscopy 2006;/38:/677-83.
54. Norton AC, Dundas CR. Induction agents for day-case anaesthesia. A double-blind comparison of propofol and midazolam antagonised by flumazenil. Anaesthesia 1990;/45:/ 198-203.
55. American Society of Anesthesiologists Task Force. Practice guidelines for sedation and analgesis by non-anesthesiologists: an updated report by the American Society of Anesthesiologists Task Force on sedation and analgesia by non-anesthesiologists. Anesthesiology 2002;961004-17.