The metabolic modulators, Etomoxir and NVP-LAB121, fail to reverse pressure overload induced heart failure in vivo

Basic Research in Cardiology

Volumn 104, Issue 5, 2009, Pages 547-557

  Schwarzer, Michael ^a   Faerber, Gloria ^a   Rueckauer, Tilmann ^b   Blum, Daniel ^a   Pytel, Gracjan ^a   Mohr, Friedrich W ^a   Doenst, Torsten ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Contractile function; Etomoxir; Heart failure; Substrate switch

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; ENZYME INHIBITOR; ETOMOXIR; MUSCLE PROTEIN; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; N [2 CHLORO 4 (PIPERAZINE 1 SULFONYL)PHENYL] 3,3,3 TRIFLUORO 2 HYDROXY 2 METHYL PROPIONAMIDE; NVP LAB 121; PYRUVATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG MECHANISM; DRUG TREATMENT FAILURE; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME SUBSTRATE; FATTY ACID OXIDATION; GLUCOSE OXIDATION; HEART EJECTION FRACTION; HEART FAILURE; HEART PERFUSION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; HEART WEIGHT; IN VIVO STUDY; ISOLATED HEART; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CARDIOMEGALY; CARNITINE O-PALMITOYLTRANSFERASE; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; ENZYME INHIBITORS; EPOXY COMPOUNDS; FATTY ACIDS; GLUCOSE; HEART FAILURE; HYPERTENSION; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOSIN HEAVY CHAINS; OXIDATION-REDUCTION; PIPERAZINES; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; STROKE VOLUME;

EID: 70349658838     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-009-0015-5     Document Type: Article

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