Insulin-induced improvement of postischemic recovery is abolished by inhibition of protein kinase C in rat heart

Journal of Thoracic and Cardiovascular Surgery

Volumn 126, Issue 6, 2003, Pages 1806-1812

  Fischer Rasokat, Ulrich ^a   Doenst, Torsten ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHELERYTHRINE; INSULIN; NEUTRAL INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; STAUROSPORINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GLUCOSE TRANSPORT; HEART FUNCTION; HEART MUSCLE ISCHEMIA; INOTROPISM; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0347694956     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5223(03)01229-7     Document Type: Article

References (29)

1. Doenst T, Richwine TR, Bray MS, Frazier OH, Goodwin GW, Taegtmeyer H. Insulin improves functional and metabolic recovery of reperfused working rat heart. Ann Thorac Surg. 1999;67:1682-8.
2. Diaz RJ, Paolasso EC, Piegas LS, et al. Metabolic modulation of acute myocardial infarction. Circulation. 1998;98:2227-34.
3. Taegtmeyer H, King LM, Jones BE. Energy substrate metabolism, myocardial ischemia, and targets for pharmacotherapy. Am J Cardiol. 1998;82:54K-60K.
4. Baron AD. Hemodynamic actions of insulin. Am J Physiol. 1994;267:E187-222.
5. Jonassen AK, Sack MN, Mjos OD, Yellon DM. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res. 2001;89:1191-8.
6. Zaha V, Francischetti I, Doenst T. Insulin improves postischemic recovery of function through PI3K in isolated working rat heart. Mol Cell Biochem. 2003;247:229-32.
7. Tong H, Chen W, Steenbergen C, Murphy E. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res. 2000;87:309-15.
8. Dorn GW 2nd, Souroujon MC, Liron T, et al. Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proc Natl Acad Sci U S A. 1999;96:12798-803.
9. Chen L, Hahn H, Wu G, et al. Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc Natl Acad Sci U S A. 2001;98:11114-9.
10. Idris I, Gray S, Donnelly R. Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia. 2001;44:659-73.
11. Simonis G, Weinbrenner C, Strasser RH. Ischemic preconditioning promotes a transient, but not sustained translocation of protein kinase C and sensitization of adenylyl cyclase. Basic Res Cardiol. 2003;98:104-13.
12. Doenst T, Taegtmeyer H. α-Adrenergic stimulation mediates glucose uptake through phosphatidylinositol 3-kinase in rat heart. Circ Res. 1999;84:467-74.
13. Taegtmeyer H, Hems R, Krebs HA. Utilization of energy providing substrates in the isolated working rat heart. Biochem J. 1980;186:701-11
14. Herbert JM, Augereau JM, Gleye J, Maffrand JP. Chelerythrine is a potent and specific inhibitor of protein kinase c. Biochem Biophys Res Com. 1990;172:993-9.
15. Zar JH. Biostatistical analysis. 2 ed. Inglewood Cliffs, NJ: Prentice-Hall; 1984.
16. Disatnik MH, Buraggi G, Mochly-Rosen D. Localization of protein kinase C isozymes in cardiac myocytes. Exp Cell Res. 1994;210:287-97.
17. Strasser RH, Simonis G, Schon SP, et al. Two distinct mechanisms mediate a differential regulation of protein kinase C isozymes in acute and prolonged myocardial ischemia. Cir Res. 1999;85:77-87.
18. Bogoyevitch MA, Parker PJ, Sugden PH. Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin. Circ Res. 1993;72:757-67.
19. Liu GS, Cohen MV, Mochly-Rosen D, Downey JM. Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes. J Mol Cell Cardiol. 1999;31:1937-48.
20. Gray MO, Karliner JS, Mochly-Rosen D. A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death. J Biol Chem. 1997;272:30945-51.
21. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000;351:95-105.
22. Watson JE, Karmazyn M. Concentration-dependent effects of protein kinase C-activating and -nonactivating phorbol esters on myocardial contractility, coronary resistance, energy metabolism, prostacyclin synthesis, and ultrastructure in isolated rat hearts. Effects of amiloride. Circ Res. 1991;69:1114-31.
23. Yuan SH, Sunahara FA, Sen AK. Tumor-promoting phorbol esters inhibit cardiac functions and induce redistribution of protein kinase C in perfused beating rat heart. Circ Res. 1987;61:372-8.
24. Lazar HL, Chipkin S, Philippides G, Bao Y, Apstein CS. Glucose-insulin-potassium solutions improve outcomes in diabetics who have coronary artery operations. Ann Thorac Surg. 2000;70:145-50.
25. Maier S, Aulbach F, Simm A, et al. Stimulation of L-type Ca2+ current in human atrial myocytes by insulin. Cardiovasc Res. 1999;44:390-7.
26. Itani SI, Zhou Q, Pories WJ, MacDonald KG, Dohm GL. Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes. 2000;49:1353-8.
27. Ruderman NB, Saha AK, Vavvas D, Witters LA. Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol. 1999;276:E1-18.
28. Doenst T, Guthrie PH, Taegtmeyer H. Ischemic preconditioning in rat heart: no correlation between glycogen content and return of function. Mol Cell Biochem. 1998;180:153-61.
29. Goodwin GW, Taegtmeyer H. Metabolic recovery of the isolated working rat heart after brief global ischemia. Am J Physiol. 1994;267: